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Article

Studies in zebrafish and rat models support dual blockade of EP2 and EP4 (prostaglandin E(2) receptors type 2 and 4) for renoprotection in glomerular hyperfiltration and albuminuria.
Kourpa, A. and Schulz, A. and Mangelsen, E. and Kaiser-Graf, D. and Koppers, N. and Stoll, M. and Rothe, M. and Bader, M. and Purfürst, B. and Kunz, S. and Gladytz, T. and Niendorf, T. and Bachmann, S. and Mutig, K. and Bolbrinker, J. and Panakova, D. and Kreutz, R.
Hypertension 80 (4): 771-782. April 2023

Structural remodeling of AAA+ ATPase p97 by adaptor protein ASPL facilitates posttranslational methylation by METTL21D.
Petrović, S. and Roske, Y. and Rami, B. and Phan, M.H.Q. and Panakova, D. and Heinemann, U.
Proceedings of the National Academy of Sciences of the United States of America 120 (4): e2208941120. 24 January 2023

15-keto-Prostaglandin E(2) exhibits bioactive role by modulating glomerular cytoarchitecture through EP2/EP4 receptors.
Kourpa, A. and Kaiser-Graf, D. and Sporbert, A. and Philippe, A. and Catar, R. and Rothe, M. and Mangelsen, E. and Schulz, A. and Bolbrinker, J. and Kreutz, R. and Panáková, D.
Life Sciences 310 : 121114. 1 December 2022

Origin and function of activated fibroblast states during zebrafish heart regeneration.
Hu, B. and Lelek, S. and Spanjaard, B. and El-Sammak, H. and Simões, M.G. and Mintcheva, J. and Aliee, H. and Schäfer, R. and Meyer, A.M. and Theis, F. and Stainier, D.Y.R. and Panáková, D. and Junker, J.P.
Nature Genetics 54 (8): 1227-1237. August 2022

Single-cell-resolved dynamics of chromatin architecture delineate cell and regulatory states in zebrafish embryos.
McGarvey, A.C. and Kopp, W. and Vučićević, D. and Mattonet, K. and Kempfer, R. and Hirsekorn, A. and Bilić, I. and Gil, M. and Trinks, A. and Merks, A.M. and Panáková, D. and Pombo, A. and Akalin, A. and Junker, J.P. and Stainier, D.Y.R. and Garfield, D. and Ohler, U. and Lacadie, S.A.
Cell Genomics 2 (1): 100083. 13 January 2022

The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled.
Kratzer, M.C. and Becker, S.F.S. and Grund, A. and Merks, A. and Harnoš, J. and Bryja, V. and Giehl, K. and Kashef, J. and Borchers, A.
Development 147 (10): dev186338. 22 May 2020

Concerted EP2 and EP4 receptor signaling stimulates autocrine prostaglandin E(2) activation in human podocytes.
Mangelsen, E. and Rothe, M. and Schulz, A. and Kourpa, A. and Panáková, D. and Kreutz, R. and Bolbrinker, J.
Cells 9 (5): 1256. 19 May 2020

Ninjurin1 regulates striated muscle growth and differentiation.
Kny, M. and Csályi, K.D. and Klaeske, K. and Busch, K. and Meyer, A.M. and Merks, A.M. and Darm, K. and Dworatzek, E. and Fliegner, D. and Baczko, I. and Regitz-Zagrosek, V. and Butter, C. and Luft, F.C. and Panáková, D. and Fielitz, J.
PLoS ONE 14 (5): e0216987. 15 May 2019

Advantages and challenges of cardiovascular and lymphatic studies in zebrafish research.
Santoro, M.M. and Beltrame, M. and Panáková, D. and Siekmann, A.F. and Tiso, N. and Venero Galanternik, M. and Jung, H.M. and Weinstein, B.M.
Frontiers in Cell and Developmental Biology 7 : 89. May 2019

Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage.
Schulz, A. and Müller, N.V. and van de Lest, N.A. and Eisenreich, A. and Schmidbauer, M. and Barysenka, A. and Purfürst, B. and Sporbert, A. and Lorenzen, T. and Meyer, A.M. and Herlan, L. and Witten, A. and Rühle, F. and Zhou, W. and de Heer, E. and Scharpfenecker, M. and Panáková, D. and Stoll, M. and Kreutz, R.
eLife 8 : e42068. 22 March 2019

Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/β-catenin signaling.
Cantù, C. and Felker, A. and Zimmerli, D. and Prummel, K.D. and Cabello, E.M. and Chiavacci, E. and Méndez-Acevedo, K.M. and Kirchgeorg, L. and Burger, S. and Ripoll, J. and Valenta, T. and Hausmann, G. and Vilain, N. and Aguet, M. and Burger, A. and Panáková, D. and Basler, K. and Mosimann, C.
Genes & Development 32 (21-22): 1443-1458. 1 November 2018

Therapeutic intranasal vaccine HB-ATV-8 prevents atherogenesis and non-alcoholic fatty liver disease in a pig model of atherosclerosis.
Gutiérrez-Vidal, R. and Delgado-Coello, B. and Méndez-Acevedo, K.M. and Calixto-Tlacomulco, S. and Damián-Zamacona, S. and Mas-Oliva, J.
Archives of Medical Research 49 (7): 456-470. October 2018

Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity.
Merks, A.M. and Swinarski, M. and Meyer, A.M. and Müller, N.V. and Özcan, I. and Donat, S. and Burger, A. and Gilbert, S. and Mosimann, C. and Abdelilah-Seyfried, S. and Panáková, D.
Nature Communications 9 (1): 2161. 4 June 2018

Continuous addition of progenitors forms the cardiac ventricle in zebrafish.
Felker, A. and Prummel, K.D. and Merks, A.M. and Mickoleit, M. and Brombacher, E.C. and Huisken, J. and Panáková, D. and Mosimann, C.
Nature Communications 9 (1): 2001. 21 May 2018

Cell-accurate optical mapping across the entire developing heart.
Weber, M. and Scherf, N. and Meyer, A.M. and Panáková, D. and Kohl, P. and Huisken, J.
eLife 6 : e28307. 29 December 2017

Ascorbic acid alters cell fate commitment of human neural progenitors in a WNT/β-catenin/ROS signaling dependent manner.
Rharass, T. and Lantow, M. and Gbankoto, A. and Weiss, D.G. and Panáková, D. and Lucas, S.
Journal of Biomedical Science 24 (1): 78. 16 October 2017

SignaFish: A zebrafish-specific signaling pathway resource.
Csalyi, K. and Fazekas, D. and Kadlecsik, T. and Tuerei, D. and Gul, L. and Horvath, B. and Modos, D. and Demeter, A. and Papai, N. and Lenti, K. and Csermely, P. and Vellai, T. and Korcsmaros, T. and Varga, M.
Zebrafish 13 (6): 541-544. 1 December 2016

Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.
Arumughan, A. and Roske, Y. and Barth, C. and Lleras Forero, L. and Bravo-Rodriguez, K. and Redel, Al. and Kostova, S. and McShane, E. and Opitz, R. and Faelber, K. and Rau, K. and Mielke, T. and Daumke, O. and Selbach, M. and Sanchez-Garcia, E. and Rocks, O. and Panáková, D. and Heinemann, U. and Wanker, E.E.
Nature Communications 7 : 13047. 20 October 2016

Nuclear translocation of the cardiac L-type calcium channel C-terminus is regulated by sex and 17β-estradiol.
Mahmoodzadeh, S. and Haase, H. and Sporbert, A. and Rharass, T. and Panáková, D. and Morano, I.
Journal of Molecular and Cellular Cardiology 97 : 226-234. August 2016

Oxidative stress does not play a primary role in the toxicity induced with clinical doses of doxorubicin in myocardial H9c2 cells.
Rharass, T. and Gbankoto, A. and Canal, C. and Kurşunluoğlu, G. and Bijoux, A. and Panáková, D. and Ribou, A.C.
Molecular and Cellular Biochemistry 413 (1): 199-215. February 2016

Generating and evaluating a ranked candidate gene list for potential vertebrate heart field regulators.
Musso, G. and Mosimann, C. and Panáková, D. and Burger, A. and Zhou, Y. and Zon, L.I. and MacRae, C.A.
Genomics Data 6 : 199-201. December 2015

Chamber identity programs drive early functional partitioning of the heart.
Mosimann, C. and Panáková, D. and Werdich, A.A. and Musso, G. and Burger, A. and Lawson, K.L. and Carr, L.A. and Nevis, K.R. and Sabeh, M.K and Zhou, Y. and Davidson, A.J. and DiBiase, A. and Burns, C.E. and Burns, C.G. and MacRae, C.A. and Zon, L.I.
Nature Communications 6 : 8146. 26 August 2015

Spatio-temporal model of endogenous ROS and raft-dependent WNT/β-catenin signaling driving cell fate commitment in human neural progenitor cells.
Haack, F. and Lemcke, H. and Ewald, R. and Rharass, T. and Uhrmacher, A.M.
PLoS Computational Biology 11 (3): e1004106. 20 March 2015

Discrete Notch signaling requirements in the specification of hematopoietic stem cells.
Kim, A.D. and Melick, C.H. and Clements, W.K. and Stachura, D.L. and Distel, M. and Panáková, D. and MacRae, C. and Mork, L.A. and Crump, J.G. and Traver, D.
EMBO Journal 33 (20): 2363-2373. 16 October 2014

Ca(2+)-mediated mitochondrial ROS metabolism augments Wnt/β-catenin pathway activation to facilitate cell differentiation.
Rharass, T. and Lemcke, H. and Lantow, M. and Kuznetsov, S.A. and Weiss, D.G. and Panáková, D.
Journal of Biological Chemistry 289 (40): 27937-27951. 3 October 2014

Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development.
Becker, J.R. and Chatterjee, S. and Robinson, T.Y. and Bennett, J.S. and Panáková, D. and Galindo, C.L. and Zhong, L. and Shin, J.T. and Coy, S.M. and Kelly, A.E. and Roden, D.M. and Lim, C.C. and MacRae, C.A.
Development 141 (2): 335-345. January 2014

The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion.
Wang, J. and Panakova, D. and Kikuchi, K. and Holdway, J.E. and Gemberling, M. and Burris, J.S. and Singh, S.P. and Dickson, A.L. and Lin, Y.F. and Sabeh, M.K. and Werdich, A.A. and Yelon, D. and Macrae, C.A. and Poss, K.D.
Development 138 (16): 3421-3430. August 2011

Human cardiomyopathy mutations induce myocyte hyperplasia and activate hypertrophic pathways during cardiogenesis in zebrafish.
Becker, J.R. and Deo, R.C. and Werdich, A.A. and Panakova, D. and Coy, S. and MacRae, C.A.
Disease Models & Mechanisms 4 (3): 400-410. May 2011

C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling.
Bostroem, P. and Mann, N. and Wu, J. and Quintero, P.A. and Plovie, E.R. and Panakova, D. and Gupta, R.K. and Xiao, C. and MacRae, C.A. and Rosenzweig, A. and Spiegelman, B.M.
Cell 143 (7): 1072-1083. 23 December 2010

Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel.
Panakova, D. and Werdich, A.A. and Macrae, C.A.
Nature 466 (7308): 874-878. 12 August 2010

Review

Roles of cholesterol and PtdIns(4,5)P(2) in the regulation of STIM1-Orai1 channel function.
Pacheco, J. and Bohórquez-Hernández, A. and Méndez-Acevedo, K.M. and Sampieri, A. and Vaca, L.
Advances in Experimental Medicine and Biology 1422 : 305-326. 2023

Tailoring cardiac synthetic transcriptional modulation towards precision medicine.
Schoger, E. and Lelek, S. and Panáková, D. and Zelarayán, L.C.
Frontiers in Cardiovascular Medicine 8 : 783072. 14 January 2022

Editorial

Transient activated fibroblasts contribute to zebrafish heart regeneration.
Junker, J.P. and Panáková, D.
Nature Genetics 54 (8): 1076-1077. August 2022

Preprint

Cellular drivers of injury response and regeneration in the adult zebrafish heart.
Hu, B. and Lelek, S. and Spanjaard, B. and Simões, M.G. and Aliee, H. and Schäfer, R. and Theis, F. and Panáková, D. and Junker, J.P.
bioRxiv : 2021.01.07.425670. 7 January 2021

Morphine alleviates pain after heart cryoinjury in zebrafish without impeding regeneration.
Lelek, S. and Simões, M. and Hu, B. and Alameldeen, A.M.A. and Czajkowski, M.T. and Meyer, A.M. and Ferrara, F. and Junker, J.P. and Panáková, D.
bioRxiv : 2020.10.01.322560. 2 October 2020

Single-cell-resolved dynamics of chromatin architecture delineate cell and regulatory states in wildtype and cloche/npas4l mutant zebrafish embryos.
McGarvey, A.C. and Kopp, W. and Vučićević, D. and Kempfer, R. and Mattonet, K. and Hirsekorn, A. and Bilić, I. and Trinks, A. and Merks, A.M. and Panáková, D. and Pombo, A. and Akalin, A. and Junker, J.P. and Stainier, D.Y.R. and Garfield, D. and Ohler, U. and Lacadie, S.A.
bioRxiv : 2020.06.26.173377. 26 June 2020

Wnt11/Fzd7 signaling compartmentalizes AKAP2/PKA to regulate L-type Ca(2+) channel.
Csalyi, K.D. and Rharass, T. and Schulz, M. and Phan, M.H.Q. and Wakula, P. and Mhatre, K.N. and Plotnick, D. and Werdich, A.A. and Zauber, H. and Sury, M.D. and Selbach, M. and Heinzel, F.R. and Klussmann, E. and Panakova, D.
bioRxiv : 741637. 20 August 2019

Continuous addition of progenitors forms the cardiac ventricle in zebrafish.
Felker, A. and Prummel, K.D. and Merks, A.M. and Mickoleit, M. and Brombacher, E.C. and Huisken, J. and Panakova, D. and Mosimann, C.
bioRxiv : 230649. 7 December 2017