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Article

Studies in zebrafish and rat models support dual blockade of EP2 and EP4 (prostaglandin E(2) receptors type 2 and 4) for renoprotection in glomerular hyperfiltration and albuminuria.
Kourpa, A., Schulz, A., Mangelsen, E., Kaiser-Graf, D., Koppers, N., Stoll, M., Rothe, M., Bader, M., Purfürst, B., Kunz, S., Gladytz, T., Niendorf, T., Bachmann, S., Mutig, K., Bolbrinker, J., Panakova, D. and Kreutz, R.
Hypertension 80 (4): 771-782. April 2023

Structural remodeling of AAA+ ATPase p97 by adaptor protein ASPL facilitates posttranslational methylation by METTL21D.
Petrović, S., Roske, Y., Rami, B., Phan, M.H.Q., Panakova, D. and Heinemann, U.
Proceedings of the National Academy of Sciences of the United States of America 120 (4): e2208941120. 24 January 2023

15-keto-Prostaglandin E(2) exhibits bioactive role by modulating glomerular cytoarchitecture through EP2/EP4 receptors.
Kourpa, A., Kaiser-Graf, D., Sporbert, A., Philippe, A., Catar, R., Rothe, M., Mangelsen, E., Schulz, A., Bolbrinker, J., Kreutz, R. and Panáková, D.
Life Sciences 310 : 121114. 1 December 2022

Origin and function of activated fibroblast states during zebrafish heart regeneration.
Hu, B., Lelek, S., Spanjaard, B., El-Sammak, H., Simões, M.G., Mintcheva, J., Aliee, H., Schäfer, R., Meyer, A.M., Theis, F., Stainier, D.Y.R., Panáková, D. and Junker, J.P.
Nature Genetics 54 (8): 1227-1237. August 2022

Single-cell-resolved dynamics of chromatin architecture delineate cell and regulatory states in zebrafish embryos.
McGarvey, A.C., Kopp, W., Vučićević, D., Mattonet, K., Kempfer, R., Hirsekorn, A., Bilić, I., Gil, M., Trinks, A., Merks, A.M., Panáková, D., Pombo, A., Akalin, A., Junker, J.P., Stainier, D.Y.R., Garfield, D., Ohler, U. and Lacadie, S.A.
Cell Genomics 2 (1): 100083. 13 January 2022

The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled.
Kratzer, M.C., Becker, S.F.S., Grund, A., Merks, A., Harnoš, J., Bryja, V., Giehl, K., Kashef, J. and Borchers, A.
Development 147 (10): dev186338. 22 May 2020

Concerted EP2 and EP4 receptor signaling stimulates autocrine prostaglandin E(2) activation in human podocytes.
Mangelsen, E., Rothe, M., Schulz, A., Kourpa, A., Panáková, D., Kreutz, R. and Bolbrinker, J.
Cells 9 (5): 1256. 19 May 2020

Ninjurin1 regulates striated muscle growth and differentiation.
Kny, M., Csályi, K.D., Klaeske, K., Busch, K., Meyer, A.M., Merks, A.M., Darm, K., Dworatzek, E., Fliegner, D., Baczko, I., Regitz-Zagrosek, V., Butter, C., Luft, F.C., Panáková, D. and Fielitz, J.
PLoS ONE 14 (5): e0216987. 15 May 2019

Advantages and challenges of cardiovascular and lymphatic studies in zebrafish research.
Santoro, M.M., Beltrame, M., Panáková, D., Siekmann, A.F., Tiso, N., Venero Galanternik, M., Jung, H.M. and Weinstein, B.M.
Frontiers in Cell and Developmental Biology 7 : 89. May 2019

Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage.
Schulz, A., Müller, N.V., van de Lest, N.A., Eisenreich, A., Schmidbauer, M., Barysenka, A., Purfürst, B., Sporbert, A., Lorenzen, T., Meyer, A.M., Herlan, L., Witten, A., Rühle, F., Zhou, W., de Heer, E., Scharpfenecker, M., Panáková, D., Stoll, M. and Kreutz, R.
eLife 8 : e42068. 22 March 2019

Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/β-catenin signaling.
Cantù, C., Felker, A., Zimmerli, D., Prummel, K.D., Cabello, E.M., Chiavacci, E., Méndez-Acevedo, K.M., Kirchgeorg, L., Burger, S., Ripoll, J., Valenta, T., Hausmann, G., Vilain, N., Aguet, M., Burger, A., Panáková, D., Basler, K. and Mosimann, C.
Genes & Development 32 (21-22): 1443-1458. 1 November 2018

Therapeutic intranasal vaccine HB-ATV-8 prevents atherogenesis and non-alcoholic fatty liver disease in a pig model of atherosclerosis.
Gutiérrez-Vidal, R., Delgado-Coello, B., Méndez-Acevedo, K.M., Calixto-Tlacomulco, S., Damián-Zamacona, S. and Mas-Oliva, J.
Archives of Medical Research 49 (7): 456-470. October 2018

Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity.
Merks, A.M., Swinarski, M., Meyer, A.M., Müller, N.V., Özcan, I., Donat, S., Burger, A., Gilbert, S., Mosimann, C., Abdelilah-Seyfried, S. and Panáková, D.
Nature Communications 9 (1): 2161. 4 June 2018

Continuous addition of progenitors forms the cardiac ventricle in zebrafish.
Felker, A., Prummel, K.D., Merks, A.M., Mickoleit, M., Brombacher, E.C., Huisken, J., Panáková, D. and Mosimann, C.
Nature Communications 9 (1): 2001. 21 May 2018

Cell-accurate optical mapping across the entire developing heart.
Weber, M., Scherf, N., Meyer, A.M., Panáková, D., Kohl, P. and Huisken, J.
eLife 6 : e28307. 29 December 2017

Ascorbic acid alters cell fate commitment of human neural progenitors in a WNT/β-catenin/ROS signaling dependent manner.
Rharass, T., Lantow, M., Gbankoto, A., Weiss, D.G., Panáková, D. and Lucas, S.
Journal of Biomedical Science 24 (1): 78. 16 October 2017

SignaFish: A zebrafish-specific signaling pathway resource.
Csalyi, K., Fazekas, D., Kadlecsik, T., Tuerei, D., Gul, L., Horvath, B., Modos, D., Demeter, A., Papai, N., Lenti, K., Csermely, P., Vellai, T., Korcsmaros, T. and Varga, M.
Zebrafish 13 (6): 541-544. 1 December 2016

Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.
Arumughan, A., Roske, Y., Barth, C., Lleras Forero, L., Bravo-Rodriguez, K., Redel, Al., Kostova, S., McShane, E., Opitz, R., Faelber, K., Rau, K., Mielke, T., Daumke, O., Selbach, M., Sanchez-Garcia, E., Rocks, O., Panáková, D., Heinemann, U. and Wanker, E.E.
Nature Communications 7 : 13047. 20 October 2016

Nuclear translocation of the cardiac L-type calcium channel C-terminus is regulated by sex and 17β-estradiol.
Mahmoodzadeh, S., Haase, H., Sporbert, A., Rharass, T., Panáková, D. and Morano, I.
Journal of Molecular and Cellular Cardiology 97 : 226-234. August 2016

Oxidative stress does not play a primary role in the toxicity induced with clinical doses of doxorubicin in myocardial H9c2 cells.
Rharass, T., Gbankoto, A., Canal, C., Kurşunluoğlu, G., Bijoux, A., Panáková, D. and Ribou, A.C.
Molecular and Cellular Biochemistry 413 (1): 199-215. February 2016

Generating and evaluating a ranked candidate gene list for potential vertebrate heart field regulators.
Musso, G., Mosimann, C., Panáková, D., Burger, A., Zhou, Y., Zon, L.I. and MacRae, C.A.
Genomics Data 6 : 199-201. December 2015

Chamber identity programs drive early functional partitioning of the heart.
Mosimann, C., Panáková, D., Werdich, A.A., Musso, G., Burger, A., Lawson, K.L., Carr, L.A., Nevis, K.R., Sabeh, M.K, Zhou, Y., Davidson, A.J., DiBiase, A., Burns, C.E., Burns, C.G., MacRae, C.A. and Zon, L.I.
Nature Communications 6 : 8146. 26 August 2015

Spatio-temporal model of endogenous ROS and raft-dependent WNT/β-catenin signaling driving cell fate commitment in human neural progenitor cells.
Haack, F., Lemcke, H., Ewald, R., Rharass, T. and Uhrmacher, A.M.
PLoS Computational Biology 11 (3): e1004106. 20 March 2015

Discrete Notch signaling requirements in the specification of hematopoietic stem cells.
Kim, A.D., Melick, C.H., Clements, W.K., Stachura, D.L., Distel, M., Panáková, D., MacRae, C., Mork, L.A., Crump, J.G. and Traver, D.
EMBO Journal 33 (20): 2363-2373. 16 October 2014

Ca(2+)-mediated mitochondrial ROS metabolism augments Wnt/β-catenin pathway activation to facilitate cell differentiation.
Rharass, T., Lemcke, H., Lantow, M., Kuznetsov, S.A., Weiss, D.G. and Panáková, D.
Journal of Biological Chemistry 289 (40): 27937-27951. 3 October 2014

Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development.
Becker, J.R., Chatterjee, S., Robinson, T.Y., Bennett, J.S., Panáková, D., Galindo, C.L., Zhong, L., Shin, J.T., Coy, S.M., Kelly, A.E., Roden, D.M., Lim, C.C. and MacRae, C.A.
Development 141 (2): 335-345. January 2014

The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion.
Wang, J., Panakova, D., Kikuchi, K., Holdway, J.E., Gemberling, M., Burris, J.S., Singh, S.P., Dickson, A.L., Lin, Y.F., Sabeh, M.K., Werdich, A.A., Yelon, D., Macrae, C.A. and Poss, K.D.
Development 138 (16): 3421-3430. August 2011

Human cardiomyopathy mutations induce myocyte hyperplasia and activate hypertrophic pathways during cardiogenesis in zebrafish.
Becker, J.R., Deo, R.C., Werdich, A.A., Panakova, D., Coy, S. and MacRae, C.A.
Disease Models & Mechanisms 4 (3): 400-410. May 2011

C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling.
Bostroem, P., Mann, N., Wu, J., Quintero, P.A., Plovie, E.R., Panakova, D., Gupta, R.K., Xiao, C., MacRae, C.A., Rosenzweig, A. and Spiegelman, B.M.
Cell 143 (7): 1072-1083. 23 December 2010

Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel.
Panakova, D., Werdich, A.A. and Macrae, C.A.
Nature 466 (7308): 874-878. 12 August 2010

Review

Roles of cholesterol and PtdIns(4,5)P(2) in the regulation of STIM1-Orai1 channel function.
Pacheco, J., Bohórquez-Hernández, A., Méndez-Acevedo, K.M., Sampieri, A. and Vaca, L.
Advances in Experimental Medicine and Biology 1422 : 305-326. 2023

Tailoring cardiac synthetic transcriptional modulation towards precision medicine.
Schoger, E., Lelek, S., Panáková, D. and Zelarayán, L.C.
Frontiers in Cardiovascular Medicine 8 : 783072. 14 January 2022

Editorial

Transient activated fibroblasts contribute to zebrafish heart regeneration.
Junker, J.P. and Panáková, D.
Nature Genetics 54 (8): 1076-1077. August 2022

Preprint

Morphine alleviates pain after heart cryoinjury in zebrafish without impeding regeneration.
Lelek, S., Simões, M., Hu, B., Alameldeen, A.M.A., Czajkowski, M.T., Meyer, A.M., Ferrara, F., Junker, J.P. and Panáková, D.
bioRxiv : 2020.10.01.322560. 2 October 2020

Wnt11/Fzd7 signaling compartmentalizes AKAP2/PKA to regulate L-type Ca(2+) channel.
Csalyi, K.D., Rharass, T., Schulz, M., Phan, M.H.Q., Wakula, P., Mhatre, K.N., Plotnick, D., Werdich, A.A., Zauber, H., Sury, M.D., Selbach, M., Heinzel, F.R., Klussmann, E. and Panakova, D.
bioRxiv : 741637. 20 August 2019