Browse by Research Team

Article

A systematic approach to decipher crosstalk in the p53 signaling pathway using single cell dynamics.
Konrath, F. and Mittermeier, A. and Cristiano, E. and Wolf, J. and Loewer, A.
PLoS Computational Biology 16 (6): e1007901. 26 June 2020

Disentangling pro-mitotic signaling during cell cycle progression using time-resolved single-cell imaging.
Benary, M. and Bohn, S. and Lüthen, M. and Nolis, I.K. and Blüthgen, N. and Loewer, A.
Cell Reports 31 (2): 107514. 14 April 2020

PCNA-mediated degradation of p21 coordinates the DNA damage response and cell cycle regulation in individual cells.
Sheng, C. and Mendler, I.H. and Rieke, S. and Snyder, P. and Jentsch, M. and Friedrich, D. and Drossel, B. and Loewer, A.
Cell Reports 27 (1): 48-58. 2 April 2019

Comparing agent‐based delivery of DNA and PNA forced intercalation (FIT) probes for multicolor mRNA imaging.
Chamiolo, J. and Fang, G.M. and Hövelmann, F. and Friedrich, D. and Knoll, A. and Loewer, A. and Seitz, O.
ChemBioChem 20 (4): 595-604. 15 February 2019

A bright FIT-PNA hybridization probe for the hybridization state specific analysis of a C → U RNA edit via FRET in a binary system.
Fang, G.M. and Chamiolo, J. and Kankowski, S. and Hövelmann, F. and Friedrich, D. and Löwer, A. and Meier, J.C. and Seitz, O.
Chemical Science 9 (21): 4794-4800. 7 June 2018

Cell-specific responses to the cytokine TGFβ are determined by variability in protein levels.
Strasen, J. and Sarma, U. and Jentsch, M. and Bohn, S. and Sheng, C. and Horbelt, D. and Knaus, P. and Legewie, S. and Loewer, A.
Molecular Systems Biology 14 (1): e7733. 25 January 2018

Excitability in the p53 network mediates robust signaling with tunable activation thresholds in single cells.
Mönke, G. and Cristiano, E. and Finzel, A. and Friedrich, D. and Herzel, H. and Falcke, M. and Loewer, A.
Scientific Reports 7 : 46571. 18 April 2017

Hyper-activation of ATM upon DNA-PKcs inhibition modulates p53 dynamics and cell fate in response to DNA damage.
Finzel, A. and Grybowski, A. and Strasen, J. and Cristiano, E. and Loewer, A.
Molecular Biology of the Cell 27 (15): 2360-2367. 1 August 2016

Impaired myocardial development resulting in neonatal cardiac hypoplasia alters postnatal growth and stress response in the heart.
Drenckhahn, J.D. and Strasen, J. and Heinecke, K. and Langner, P. and Yin, K.V. and Skole, F. and Hennig, M. and Spallek, B. and Fischer, R. and Blaschke, F. and Heuser, A. and Cox, T.C. and Black, M.J. and Thierfelder, L.
Cardiovascular Research 106 (1): 43-54. 1 April 2015

PIEZO2 is required for mechanotransduction in human stem cell-derived touch receptors.
Schrenk-Siemens, K. and Wende, H. and Prato, V. and Song, K. and Rostock, C. and Loewer, A. and Utikal, J. and Lewin, G.R. and Lechner, S.G. and Siemens, J.
Nature Neuroscience 18 (1): 10-16. January 2015

Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells.
Borcherds, W. and Theillet, F.X. and Katzer, A. and Finzel, A. and Mishall, K.M. and Powell, A.T. and Wu, H. and Manieri, W. and Dieterich, C. and Selenko, P. and Loewer, A. and Daughdrill, G.W.
Nature Chemical Biology 10 (12): 1000-1002. December 2014

Chlamydia infection depends on a functional MDM2-p53 axis.
Gonzalez, E. and Rother, M. and Kerr, M.C. and Al-Zeer, M.A. and Abu-Lubad, M. and Kessler, M. and Brinkmann, V. and Loewer, A. and Meyer, T.F.
Nature Communications 5 : 5201. 13 November 2014

Differential protein occupancy profiling of the mRNA transcriptome.
Schueler, M. and Munschauer, M. and Gregersen, L.H. and Finzel, A. and Loewer, A. and Chen, W. and Landthaler, M. and Dieterich, C.
Genome Biology 15 (1): R15. 13 January 2014

The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold.
Loewer, A. and Karanam, K. and Mock, C. and Lahav, G.
BMC Biology 11 (1): 114. 19 November 2013

Circular RNAs are a large class of animal RNAs with regulatory potency.
Memczak, S. and Jens, M. and Elefsinioti, A. and Torti, F. and Krueger, J. and Rybak, A. and Maier, L. and Mackowiak, S.D. and Gregersen, L.H. and Munschauer, M. and Loewer, A. and Ziebold, U. and Landthaler, M. and Kocks, C. and le Noble, F. and Rajewsky, N.
Nature 495 (7441): 333-338. 21 March 2013

Dynamics of the DNA damage response: insights from live-cell imaging.
Karanam, K and Loewer, A. and Lahav, G.
Briefings in Functional Genomics 12 (2): 109-117. March 2013

Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase.
Karanam, K. and Kafri, R. and Loewer, A. and Lahav, G.
Molecular Cell 47 (2): 320-329. 27 July 2012

p53 dynamics control cell fate.
Purvis, J.E. and Karhohs, K.W. and Mock, C. and Batchelor, E. and Loewer, A. and Lahav, G.
Science 336 (6087): 1440-1444. 15 June 2012

Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction.
Orth, J.D. and Loewer, A. and Lahav, G. and Mitchison, T.J.
Molecular Biology of the Cell 23 (4): 567-576. 15 February 2012

Stimulus-dependent dynamics of p53 in single cells.
Batchelor, E. and Loewer, A. and Mock, C. and Lahav, G.
Molecular Systems Biology 7 : 488. 10 May 2011

A synthetic-natural hybrid oscillator in human cells.
Toettcher, J.E. and Mock, C. and Batchelor, E. and Loewer, A. and Lahav, G.
Proceedings of the National Academy of Sciences of the United States of America 107 (39): 17047-17052. 28 September 2010

Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.
Loewer, A. and Batchelor, E. and Gaglia, G. and Lahav, G.
Cell 142 (1): 89-100. 9 July 2010

In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.
Stempfle, D. and Kanwar, R. and Loewer, A. and Fortini, M.E. and Merdes, G.
Molecular and Cellular Biology 30 (13): 3165-3175. July 2010

The ups and downs of p53: understanding protein dynamics in single cells.
Batchelor, E. and Loewer, A. and Lahav, G.
Nature Reviews Cancer 9 (5): 371-377. May 2009

Distinct mechanisms act in concert to mediate cell cycle arrest.
Toettcher, J.E. and Loewer, A. and Ostheimer, G.J. and Yaffe, M.B. and Tidor, B. and Lahav, G.
Proceedings of the National Academy of Sciences of the United States of America 106 (3): 785-790. 20 January 2009

Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage.
Batchelor, E. and Mock, C.S. and Bhan, I. and Loewer, A. and Lahav, G.
Molecular Cell 30 (3): 277-289. 9 May 2008

Axonal accumulation of synaptic markers in APP transgenic Drosophila depends on the NPTY motif and is paralleled by defects in synaptic plasticity.
Rusu, P. and Jansen, A. and Soba, P. and Kirsch, J. and Loewer, A. and Merdes, G. and Kuan, Y.H. and Jung, A. and Beyreuther, K. and Kjaerulff, O. and Kins, S.
European Journal of Neuroscience 25 (4): 1079-1086. February 2007

Homo- and heterodimerization of APP family members promotes intercellular adhesion.
Soba, P. and Eggert, S. and Wagner, K. and Zentgraf, H. and Siehl, K. and Kreger, S. and Loewer, A. and Langer, A. and Merdes, G. and Paro, R. and Masters, C.L. and Mueller, U. and Kins, S. and Beyreuther, K.
EMBO Journal 24 (20): 3624-3634. 19 October 2005

Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila.
Merdes, G. and Soba, P. and Loewer, A. and Bilic, M.V. and Beyreuther, K. and Paro, R.
EMBO Journal 23 (20): 4082-4095. 13 October 2004

Cell-type-specific processing of the amyloid precursor protein by Presenilin during Drosophila development.
Loewer, A. and Soba, P. and Beyreuther, K. and Paro, R. and Merdes, G.
EMBO Reports 5 (4): 405-411. April 2004

Book Section

Information flow in a mammalian signal transduction pathway.
Benary, M. and Nolis, I. and Blüthgen, N. and Loewer, A.
In: Information- and Communication Theory in Molecular Biology. Lecture Notes in Bioengineering . Springer, Cham, Switzerland, 101-114. ISBN 978-3-319-54728-2 2018

Review

We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells.
Loewer, A. and Lahav, G.
Current opinion in genetics & development 21 (6): 753-758. December 2011

Editorial

Cellular conference call: external feedback affects cell-fate decisions.
Loewer, A. and Lahav, G.
Cell 124 (6): 1128-1130. 24 March 2006

Preprint

Stochastic transcription in the p53-mediated response to DNA damage is modulated by burst frequency.
Friedrich, D. and Friedel, L. and Herrmann, A. and Preibisch, S. and Loewer, A.
bioRxiv : 679449. 21 June 2019

Excitability in the p53 network mediates robust signaling with tunable activation thresholds in single cells.
Moenke, G. and Cristiano, E. and Finzel, A. and Friedrich, D. and Herzel, H. and Falcke, M. and Loewer, A.
bioRxiv : 068668. 28 November 2016