Browse by Research Team

Article

Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis.
Lange, C., Turrero Garcia, M., Decimo, I., Bifari, F., Eelen, G., Quaegebeur, A., Boon, R., Zhao, H., Boeckx, B., Chang, J., Wu, C., le Noble, F., Lambrechts, D., Dewerchin, M., Kuo, C.J., Huttner, W.B. and Carmeliet, P.
EMBO Journal 35 (9): 924-941. 2 May 2016

MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2.
Hinkel, R., Trenkwalder, T., Petersen, B., Husada, W., Gesenhues, F., Lee, S., Hannappel, E., Bock-Marquette, I., Theisen, D., Leitner, L., Boekstegers, P., Cierniewski, C., Mueller, O.J., le Noble, F., Adams, R.H., Weinl, C., Nordheim, A., Reichart, B., Weber, C., Olson, E., Posern, G., Deindl, E., Niemann, H. and Kupatt, C.
Nature Communications 5 : 3970. 9 June 2014

Inhibition of Notch signaling induces extensive intussusceptive neo-angiogenesis by recruitment of mononuclear cells.
Dimova, I., Hlushchuk, R., Makanya, A., Styp-Rekowska, B., Ceausu, A., Flueckiger, S., Lang, S., Semela, D., le Noble, F., Chatterjee, S. and Djonov, V.
Angiogenesis 16 (4): 921-937. October 2013

miR-30a regulates endothelial tip cell formation and arteriolar branching.
Jiang, Q., Lagos-Quintana, M., Liu, D., Shi, Y., Helker, C., Herzog, W. and le Noble, F.
Hypertension 62 (3): 592-598. September 2013

Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models.
Cristofaro, B., Shi, Y., Faria, M., Suchting, S., Leroyer, A.S., Trindade, A., Duarte, A., Zovein, A.C., Iruela-Arispe, M.L., Nih, L.R., Kubis, N., Henrion, D., Loufrani, L., Todiras, M., Schleifenbaum, J., Gollasch, M., Zhuang, Z.W., Simons, M., Eichmann, A. and le Noble, F.
Development 140 (8): 1720-1729. April 2013

Circular RNAs are a large class of animal RNAs with regulatory potency.
Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S.D., Gregersen, L.H., Munschauer, M., Loewer, A., Ziebold, U., Landthaler, M., Kocks, C., le Noble, F. and Rajewsky, N.
Nature 495 (7441): 333-338. 21 March 2013

Altered microtubule equilibrium and impaired thrombus stability in mice lacking RanBP10.
Meyer, I., Kunert, S., Schwiebert, S., Hagedorn, I., Italiano, J.E., Duetting, S., Nieswandt, B., Bachmann, S. and Schulze, H.
Blood 120 (17): 3594-602. 25 October 2012

Extrinsic notch ligand delta-like 1 regulates tip cell selection and vascular branching morphogenesis.
Napp, L.C., Augustynik, M., Paesler, F., Krishnasamy, K., Woiterski, J., Limbourg, A., Bauersachs, J., Drexler, H., le Noble, F. and Limbourg, F.P.
Circulation Research 110 (4): 530-550. 17 February 2012

Arteriogenesis is modulated on bradykinin receptor signaling.
Hillmeister, P., Gatzke, N., Duelsner, A., Bader, M., Schadock, I., Hoefer, I., Hamann, I., Infante-Duarte, C., Jung, G., Troidl, K., Urban, D., Stawowy, P., Frentsch, M., Li, M., Nagorka, S., Wang, H., Shi, Y., le Noble, F. and Buschmann, I.
Circulation Research 109 (5): 524-533. 19 August 2011

Neuron navigator 3a regulates liver organogenesis during zebrafish embryogenesis.
Klein, C., Mikutta, J., Krueger, J., Scholz, K., Brinkmann, J., Liu, D., Veerkamp, J., Siegel, D., Abdelilah-Seyfried, S. and le Noble, F.
Development 138 (10): 1935-1945. 15 May 2011

Flt1 acts as a negative regulator of tip cell formation and branching morphogenesis in the zebrafish embryo.
Krueger, J., Liu, D., Scholz, K., Zimmer, A., Shi, Y., Klein, C., Siekmann, A., Schulte-Merker, S., Cudmore, M., Ahmed, A. and le Noble, F.
Development 138 (10): 2111-2120. May 2011

The role of blood flow and microRNAs in blood vessel development.
Liu, D., Krueger, J. and le Noble, F.
International Journal of Developmental Biology 55 (4-5): 419-429. 2011

Pulsatile shear and Gja5 modulate arterial identity and remodeling events during flow-driven arteriogenesis.
Buschmann, I., Pries, A., Styp-Rekowska, B., Hillmeister, P., Loufrani, L., Henrion, D., Shi, Y., Duelsner, A., Hoefer, I., Gatzke, N., Wang, H., Lehmann, K., Ulm, L., Ritter, Z., Hauff, P., Hlushchuk, R., Djonov, V., van Veen, T. and le Noble, F.
Development 137 (13): 2187-2196. July 2010

Fetal growth restriction results in remodeled and less efficient hearts in children.
Crispi, F., Bijnens, B., Figueras, F., Bartrons, J., Eixarch, E., le Noble, F., Ahmed, A. and Gratacos, E.
Circulation 121 (22): 2427-2436. 8 June 2010

Introducing the scanning air puff tonometer for biological studies.
Fleury, V., Al-Kilani, A., Boryskina, O.P., Cornelissen, A.J.M., Nguyen, T.H., Unbekandt, M., Leroy, L., Baffet, G., le Noble, F., Sire, O., Lahaye, E. and Burgaud, V.
Physical Review E 81 (2): 021920. February 2010

Improvement of fractional flow reserve and collateral flow by treatment with external counterpulsation (Art.Net.-2 Trial).
Buschmann, E.E., Utz, W., Pagonas, N., Schulz-Menger, J., Busjahn, A., Monti, J., Maerz, W., le Noble, F., Thierfelder, L., Dietz, R., Klauss, V., Gross, M. and Buschmann, I.R.
European Journal of Clinical Investigation 39 (10): 866-875. October 2009

Immunology in hypertension, preeclampsia, and target-organ damage.
Verlohren, S., Mueller, D.N., Luft, F.C. and Dechend, R.
Hypertension 54 (3): 439-443. September 2009

Hypoxia induces dilated cardiomyopathy in the chick embryo: mechanism, intervention, and long-term consequences.
Tintu, A., Rouwet, E., Verlohren, S., Brinkmann, J., Ahmad, S., Crispi, F., van Bilsen, M., Carmeliet, P., Staff, A.C., Tjwa, M., Cetin, I., Gratacos, E., Hernandez-Andrade, E., Hofstra, L., Jacobs, M., Lamers, W.H., Morano, I., Safak, E., Ahmed, A. and le Noble, F.
PLoS ONE 4 (4): e5155. 9 April 2009

Prevalence of agonistic autoantibodies against the angiotensin II type 1 receptor and soluble fms-like tyrosine kinase 1 in a gestational age-matched case study.
Herse, F., Verlohren, S., Wenzel, K., Pape, J., Mueller, D.N., Modrow, S., Wallukat, G., Luft, F.C., Redman, C.W. and Dechend, R.
Hypertension 53 (2): 393-398. February 2009

Cardiac dysfunction and cell damage across clinical stages of severity in growth-restricted fetuses.
Crispi, F., Hernandez-Andrade, E., Pelsers, M.M., Plasencia, W., Benavides-Serralde, J.A., Eixarch, E., le Noble, F., Ahmed, A., Glatz, J.F., Nicolaides, K.H. and Gratacos, E.
American Journal of Obstetrics and Gynecology 199 (3): 254.e1-254.e8. September 2008

Endovascular trophoblast invasion, spiral artery remodelling and uteroplacental haemodynamics in a transgenic rat model of pre-eclampsia.
Geusens, N., Verlohren, S., Luyten, C., Taube, M., Hering, L., Vercruysse, L., Hanssens, M., Dudenhausen, J.W., Dechend, R. and Pijnenborg, R.
Placenta 29 (7): 614-623. July 2008

During vertebrate development, arteries exert a morphological control over the venous pattern through physical factors.
Al-Kilani, A., Lorthois, S., Nguyen, T.H., le Noble, F., Cornelissen, A., Unbekandt, M., Boryskina, O., Leroy, L. and Fleury, V.
Physical Review E 77 (5 Pt 1): 051912. May 2008

Trophoblasts reduce the vascular smooth muscle cell proatherogenic response.
Hering, L., Herse, F., Verlohren, S., Park, J.K., Wellner, M., Qadri, F., Pijnenborg, R., Staff, A.C., Huppertz, B., Mueller, D.N., Luft, F.C. and Dechend, R.
Hypertension 51 (2): 554-559. February 2008

Uterine vascular function in a transgenic preeclampsia rat model.
Verlohren, S., Niehoff, M., Hering, L., Geusens, N., Herse, F., Tintu, A.N., Plagemann, A., le Noble, F., Pijnenborg, R., Mueller, D.N., Luft, F.C., Dudenhausen, J.W., Gollasch, M. and Dechend, R.
Hypertension 51 (2): 547-553. February 2008

Hypoxia disturbs fetal hemodynamics and growth.
Tintu, A.N., le Noble, F.A.C. and Rouwet, E.V.
Endothelium 14 (6): 353-360. November 2007

The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching.
Suchting, S., Freitas, C., le Noble, F., Benedito, R., Breant, C., Duarte, A. and Eichmann, A.
Proceedings of the National Academy of Sciences of the United States of America 104 (9): 3225-3230. 27 February 2007

Direct evidence for endothelial vascular endothelial growth factor receptor-1 function in nitric oxide-mediated angiogenesis.
Ahmad, S., Hewett, P.W., Wang, P., Al-Ani, B., Cudmore, M., Fujisawa, T., Haigh, J.J., le Noble, F., Wang, L., Mukhopadhyay, D. and Ahmed, A.
Circulation Research 99 (7): 715-722. 29 September 2006

Dynamics of vascular branching morphogenesis: the effect of blood and tissue flow.
Nguyen, T.H., Eichmann, A., le Noble, F. and Fleury, V.
Physical Review E 73 (6 Pt 1): 061907. June 2006

The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system.
Lu, X., le Noble, F., Yuan, L., Jiang, Q., de Lafarge, B., Sugiyama, D., Breant, C., Claes, F., de Smet, F., Thomas, J.L., Autiero, M., Carmeliet, P., Tessier-Lavigne, M. and Eichmann, A.
Nature 432 (7014): 179-186. 11 November 2004

A short synthetic peptide inhibits signal transduction, migration and angiogenesis mediated by Tie2 receptor.
Tournaire, R., Simon, M.P., le Noble, F., Eichmann, A., England, P. and Pouyssegur, J.
EMBO Reports 5 (3): 262-267. March 2004

Flow regulates arterial-venous differentiation in the chick embryo yolk sac.
le Noble, F., Moyon, D., Pardanaud, L., Yuan, L., Djonov, V., Matthijsen, R., Breant, C., Fleury, V. and Eichmann, A.
Development 131 (2): 361-375. January 2004

Hypoxia induces aortic hypertrophic growth, left ventricular dysfunction, and sympathetic hyperinnervation of peripheral arteries in the chick embryo.
Rouwet, E.V., Tintu, A.N., Schellings, M.W., van Bilsen, M., Lutgens, E., Hofstra, L., Slaaf, D.W., Ramsay, G. and le Noble, F.A.C.
Circulation 105 (23): 2791-2796. 11 June 2002

Chronic hypoxia stimulates periarterial sympathetic nerve development in chicken embryo.
Ruijtenbeek, K., le Noble, F.A.C., Janssen, G.M.J., Kessels, C.G.A., Fazzi, G.E., Blanco, C.E. and De Mey, J.G.R.
Circulation 102 (23): 2892-2897. 5 December 2000

Development of vasomotor responses in fetal mesenteric arteries.
Rouwet, E.V., De Mey, J.G.R., Slaaf, D.W., Heineman, E., Ramsay, G. and le Noble, F.A.C.
American Journal of Physiology Heart and Circulatory Physiology 279 (3): H1097-H1105. September 2000

Contractile and relaxing reactivity in carotid and femoral arteries of chicken embryos.
le Noble, F.A.C., Ruijtenbeek, K., Gommers, S., De Mey, J.G.R. and Blanco, C.E.
American Journal of Physiology Heart and Circulatory Physiology 278 (4): H1261-H1268. April 2000

The chick embryo chorioallantoic membrane as a model to investigate the angiogenic properties of human endometrium.
Maas, J.W.M., le Noble, F.A.C., Dunselman, G.A.J., de Goeij, A.F.M., Struyker-Boudier, H.A.J. and Evers, J.L.H.
Gynecologic and Obstetric Investigation 48 (2): 108-112. 1999

The role of angiotensin II and prostaglandins in arcade formation in a developing microvascular network.
le Noble, F.A.C., Kessels-van Wylick, L.C.G.A., Hacking, W.J.G., Slaaf, D.W., Oude Egbrink, M.G.A. and Struijker-Boudier, H.A.J.
Journal of Vascular Research 33 (6): 480-8. November 1996

Evidence for a novel angiotensin II receptor involved in angiogenesis in chick embryo chorioallantoic membrane.
le Noble, F.A.C., Schreurs, N.H.J.S., van Straaten, H.W.M., Slaaf, D.W., Smits, J.F.M., Rogg, H. and Struijker-Boudier, H.A.J.
American Journal of Physiology 264 (2 Pt 2): R460-R465. February 1993

The microcirculation and hypertension.
Struijker Boudier, H.A.J., Le Noble, J.L.M.L., Messing, M.W.J., Huijberts, M.S.P., le Noble, F.A.C. and van Essen, H.
Journal of Hypertension 10 (Suppl 7): S147-S156. December 1992

Hypertension, the microcirculation and serotonin.
Struyker-Boudier, H.A.J., Le Noble, J.L.M., le Noble, F.A.C., Messing, M.W.J. and van Essen, H.
Clinical Physiology and Biochemistry 8 (Suppl 3): 28-39. 1990

Book Section

Negative regulators of vessel patterning.
Suchting, S., Freitas, C., le Noble, F., Benedito, R., Breant, C., Duarte, A. and Eichmann, A.
In: Novartis Foundation Symposium 283 - Vascular Development. Novartis Foundation Symposia, 283 (283). Wiley, 77-80. ISBN 9780470034286 11 September 2007

Review

The shunt problem: control of functional shunting in normal and tumour vasculature.
Pries, A.R., Hoepfner, M., le Noble, F., Dewhirst, M.W. and Secomb, T.W.
Nature Reviews Cancer 10 (8): 587-593. August 2010

Neural guidance molecules, tip cells and mechanical factors in vascular development.
le Noble, F., Klein, C., Tintu, A., Pries, A. and Buschmann, I.
Cardiovascular Research 78 (2): 232-241. 1 May 2008

What determines blood vessel structure? Genetic prespecification vs. hemodynamics.
Jones, E.A., le Noble, F. and Eichmann, A.
Physiology 21 (6): 388-395. December 2006

Control of arterial branching morphogenesis in embryogenesis: go with the flow.
le Noble, F., Fleury, V., Pries, A., Corvol, P., Eichmann, A. and Reneman, R.S.
Cardiovascular Research 65 (3): 619-628. 15 February 2005

Guidance of vascular and neural network formation.
Eichmann, A., le Noble, F., Autiero, M. and Carmeliet, P.
Current Opinion in Neurobiology 15 (1): 108-115. February 2005

Angiogenesis and hypertension.
le Noble, F.A.C., Stassen, F.R.M., Hacking, W.J.G. and Struijker-Boudier, H.A.J.
Journal of Hypertension 16 (11): 1563-1572. November 1998

Letter

Angiotensin II stimulates angiogenesis in the chorio-allantoic membrane of the chick embryo.
le Noble, F.A.C., Hekking, J.W.M., Van Straaten, H.W.M., Slaaf, D.W. and Struyker Boudier, H.A.J.
European Journal of Pharmacology - Molecular Pharmacology Section 195 (2): 305-306. 26 March 1991

Editorial

Bone biology: vessels of rejuvenation.
le Noble, F. and le Noble, J.
Nature 507 (7492): 313-314. 20 March 2014

Physics meets molecules: is modulation of shear stress the link to vascular prevention?
Buschmann, I.R., Lehmann, K. and le Noble, F.
Circulation Research 102 (5): 510-512. 14 March 2008

Other

OC247: Uteroplacental hemodynamics and trophoblast invasion in a transgenic rat model of pre-eclampsia.
Verlohren, S., Geusens, N., Luyten, C., Taube, M., Hering, L., Vercruysse, L., Hanssens, M., Dudenhausen, J.W., Dechend, R., Pijnenborg, R. and Henrich, W.
John Wiley & Sons. 11 October 2007