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| Item Type: | Article |
|---|---|
| Title: | Uterine vascular function in a transgenic preeclampsia rat model |
| Creators: |
Verlohren, S.  ORCID: https://orcid.org/0000-0003-3507-8636, Niehoff, M., Hering, L., Geusens, N., Herse, F. ORCID: https://orcid.org/0000-0002-9305-8134, Tintu, A.N., Plagemann, A., le Noble, F. ORCID: https://orcid.org/0000-0001-6195-7672, Pijnenborg, R., Mueller, D.N. ORCID: https://orcid.org/0000-0003-3650-5644, Luft, F.C. ORCID: https://orcid.org/0000-0002-8635-1199, Dudenhausen, J.W., Gollasch, M. ORCID: https://orcid.org/0000-0003-2797-1934 and Dechend, R. ORCID: https://orcid.org/0000-0001-6636-3080
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| Abstract: | We investigated intrauterine growth restriction, endothelial function, and uterine artery blood flow characteristics in a transgenic preeclampsia rat model with an activated renin-angiotensin system. We compared preeclamptic Sprague-Dawley (SD-PE) rats with normal pregnant Sprague-Dawley and nonpregnant Sprague-Dawley rats. We used transabdominal ultrasound and found that SD-PE rat embryos developed intrauterine growth restriction. Isolated uterine arteries from SD-PE rats incubated with phenylephrine exhibited an increased contractile response, whereas a single high dose of acetylcholine resulted in an impaired vasorelaxation compared with controls. Incremental acetylcholine doses increased relaxation of SD-PE vessels at low acetylcholine doses but caused a paradoxical contraction at higher acetylcholine doses. Indomethacin and a thromboxane-receptor antagonist (SQ 29,548) blocked this effect, suggesting maternal prostanoid-dependent endothelial dysfunction. SD-PE rats had a decreased prostacyclin (6-keto-prostaglandin F1alpha):thromboxane ratio in the serum compared with normal pregnant Sprague-Dawley rats or nonpregnant Sprague-Dawley. Surprisingly, the Doppler resistance index decreased during pregnancy in SD-PE compared with normal pregnant Sprague-Dawley rats, suggesting unimpaired uteroplacental flow in the uterine artery. Umbilical flow was unchanged with absent end-diastolic flow in all of the groups. Renin-angiotensin system activation-induced preeclampsia is associated with altered placentation, modified resistance index, and endothelial dysfunction. A disturbed prostacyclin:thromboxane ratio could be an important mediator. |
| Keywords: | Preeclampsia, Uterine artery, Intrauterine growth restriction, Endothelial dysfunction, Doppler ultrasound, Animals, Rats |
| Source: | Hypertension |
| ISSN: | 0194-911X |
| Publisher: | American Heart Association |
| Volume: | 51 |
| Number: | 2 |
| Page Range: | 547-553 |
| Date: | February 2008 |
| Official Publication: | https://doi.org/10.1161/HYPERTENSIONAHA.107.103176 |
| PubMed: | View item in PubMed |
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