Helmholtz Gemeinschaft


Introducing the scanning air puff tonometer for biological studies

[thumbnail of 10932oa.pdf] PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader

Item Type:Article
Title:Introducing the scanning air puff tonometer for biological studies
Creators Name:Fleury, V., Al-Kilani, A., Boryskina, O.P., Cornelissen, A.J.M., Nguyen, T.H., Unbekandt, M., Leroy, L., Baffet, G., le Noble, F., Sire, O., Lahaye, E. and Burgaud, V.
Abstract:It is getting increasingly evident that physical properties such as elastoviscoplastic properties of living materials are quite important for the process of tissue development, including regulation of genetic pathways. Measuring such properties in vivo is a complicated and challenging task. In this paper, we present an instrument, a scanning air puff tonometer, which is able to map point by point the viscoelastic properties of flat or gently curved soft materials. This instrument is an improved version of the air puff tonometer used by optometrists, with important modifications. The instrument allows one to obtain a direct insight into gradients of material properties in vivo. The instrument capabilities are demonstrated on substances with known elastoviscoplastic properties and several biological objects. On the basis of the results obtained, the role of the gradients of elastoviscoplastic properties is outlined for the process of angiogenesis, limb development, bacterial colonies expansion, etc. which is important for bridging the gaps in the theory of the tissue development and highlighting new possibilities for tissue engineering, based on a clarification of the role of physical features in developing biological material.
Keywords:Primitive Streak Formation, Limb Development, Morphogenesis, Tissue, Cells, Animals
Source:Physical Review E
Publisher:American Physical Society
Page Range:021920
Date:February 2010
Official Publication:https://doi.org/10.1103/PhysRevE.81.021920
PubMed:View item in PubMed

Repository Staff Only: item control page


Downloads per month over past year

Open Access
MDC Library