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Molecular Therapy Nucleic Acids 35
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Breakthrough infections in SARS-CoV-2-vaccinated multiple myeloma patients improve cross-protection against omicron variants.
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Vaccines 12
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CAR affinity modulates the sensitivity of CAR-T cells to PD-1/PD-L1-mediated inhibition.
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Nature Communications 15
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Gauging antigen recognition by human primary T-cells featuring orthotopically exchanged TCRs of choice.
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Methods in Cell Biology
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CAR-mediated targeting of NK cells overcomes tumor immune escape caused by ICAM-1 downregulation.
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Journal for ImmunoTherapy of Cancer 12
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Nature Immunology 24
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Monomeric agonist peptide/MHCII complexes activate T-cells in an autonomous fashion.
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Linoleic acid potentiates CD8(+) T cell metabolic fitness and antitumor immunity.
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Nature Immunology 24
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SARS-CoV-2-specific antibody (Ab) levels and the kinetic of ab decline determine Ab persistence over 1 year.
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The frequency of differentiated CD3(+)CD27(-)CD28(-) T cells predicts response to CART cell therapy in diffuse large B-cell lymphoma.
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Frontiers in Immunology 13
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Automated two-dimensional spatiotemporal analysis of mobile single-molecule FRET probes.
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Three-dimensional single molecule localization microscopy reveals the topography of the immunological synapse at isotropic precision below 15 nm.
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Nano letters 21
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10 November 2021
Prospective tracking of donor-reactive T-cell clones in the circulation and rejecting human kidney allografts.
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Frontiers in Immunology 12
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14 October 2021
Strategies for the site-specific decoration of DNA origami nanostructures with functionally intact proteins.
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Characterization of CD8 T cell-mediated mutations in the immunodominant epitope GP33-41 of lymphocytic choriomeningitis virus.
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Temporal analysis of T-cell receptor-imposed forces via quantitative single molecule FRET measurements.
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Histone deacetylase 1 controls CD4(+) T cell trafficking in autoinflammatory diseases.
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Science Immunology 6
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A multimodal platform for simultaneous T-cell imaging, defined activation, and mechanobiological characterization.
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DNA origami demonstrate the unique stimulatory power of single pMHCs as T cell antigens.
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Functionalized bead assay to measure three-dimensional traction forces during T-cell activation.
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The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-mediated immune responses.
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Unscrambling fluorophore blinking for comprehensive cluster detection via photoactivated localization microscopy.
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Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function.
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Nature Communications 11
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Inefficient CAR-proximal signaling blunts antigen sensitivity.
Gudipati, V., Rydzek, J., Doel-Perez, I., Gonçalves, V.D.R., Scharf, L., Königsberger, S., Lobner, E., Kunert, R., Einsele, H., Stockinger, H., Hudecek, M. and Huppa, J.B.
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European Journal of Immunology 50
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The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity.
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Science Immunology 5
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Getting CD19 into shape: expression of natively folded "difficult-to-express" CD19 for staining and stimulation of CAR-T cells.
Lobner, E., Wachernig, A., Gudipati, V., Mayrhofer, P., Salzer, B., Lehner, M., Huppa, J.B. and Kunert, R.
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Biophysical Journal 117
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19 November 2019
How drag sharpens a T cell's view on antigen.
Schütz, G.J. and Huppa, J.B.
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20 August 2019
Mutations affecting the actin regulator WD repeat-containing protein 1 lead to aberrant lymphoid immunity.
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TCRs are randomly distributed on the plasma membrane of resting antigen-experienced T cells.
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Extracellular purine metabolism is the switchboard of immunosuppressive macrophages and a novel target to treat diseases with macrophage imbalances.
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Assessment of costimulation and coinhibition in a triple parameter T cell reporter line: Simultaneous measurement of NF-κB, NFAT and AP-1.
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Science Signaling 8
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Distinct TCR signaling pathways drive proliferation and cytokine production in T cells.
Guy, C.S., Vignali, K.M., Temirov, J., Bettini, M.L., Overacre, A.E., Smeltzer, M., Zhang, H., Huppa, J.B., Tsai, Y.H., Lobry, C., Xie, J., Dempsey, P.J., Crawford, H.C., Aifantis, I., Davis, M.M. and Vignali, D.A.A.
Nature Immunology 14
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Determination of interaction kinetics between the T cell receptor and peptide-loaded MHC class II via single-molecule diffusion measurements.
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Photocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be 'preferentially' transported to the cSMAC.
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Nature Immunology 13
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Evidence for a functional sidedness to the (α)(β)TCR.
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Book Section
Measurement of forces acting on single T-cell receptors.
Schrangl, L., Göhring, J., Kellner, F., Huppa, J.B. and Schütz, G.J.
In:
Imaging cell signaling.
Methods in Molecular Biology, 2800
.
Humana New York, NY, New York, NY, USA, 147-165.
ISBN 978-1-0716-3834-7
7 May 2024
Mechanistic insights into T-Cell antigen recognition through single molecule microscopy.
Huppa, J.B. and Schütz, G.J.
In:
Encyclopedia of Cell Biology.
Encyclopedia of Cell Biology, 5
.
Elsevier, 536-552.
ISBN 978-0-12-821624-8
2023
Förster resonance energy transfer to study TCR-pMHC interactions in the immunological synapse.
Schütz, G.J. and Huppa, J.B.
In:
The immune synapse.
Methods in Molecular Biology, 1584
.
Springer Nature, New York, NY, USA, 207-229.
ISBN 978-1-4939-8327-8
3 March 2017
Single molecule methods to measure receptor–ligand interaction in immunological synapses.
Huppa, J.B. and Schütz, G.J.
In:
Encyclopedia of Cell Biology.
Reference Module in Biomedical Sciences, 3
.
Elsevier, 660-666.
ISBN 978-0-12-394796-3
2016
The interdisciplinary science of T-cell recognition.
Huppa, J.B. and Davis, M.M.
In:
Advances in Immunology.
Advances in Immunology, 119
.
Elsevier, 1-50.
ISBN 978-0-12-407707-2
22 July 2013
Conference or Workshop Item
Quantitative analysis of lymphocyte membrane protein redistribution from fluorescence microscopy.
Kasson, P.M., Huppa, J.B., Davis, M.M. and Brunger, A.T.
In: International Conference on Image Processing, ICIP 2004, 18-21 Oct 2004.
2004
Quantitative analysis of membrane protein localization and signaling.
Kasson, P.M., Huppa, J.B., Davis, M.M. and Brunger, A.T.
In: IEEE Computational Systems Bioinformatics Conference, CSB 20041, 16-19 Aug 2004.
2004
Review
Mechanosurveillance: Tiptoeing T cells.
Göhring, J., Schrangl, L., Schütz, G.J. and Huppa, J.B.
Frontiers in Immunology 13
: 886328.
26 May 2022
Time 2EVOLVE: predicting efficacy of engineered T-cells - how far is the bench from the bedside?
Guedan, S., Luu, M., Ammar, D., Barbao, P., Bonini, C., Bousso, P., Buchholz, C.J., Casucci, M., De Angelis, B., Donnadieu, E., Espie, D., Greco, B., Groen, R., Huppa, J.B., Kantari-Mimoun, C., Laugel, B., Mantock, M., Markman, J.L., Morris, E., Quintarelli, C., Rade, M., Reiche, K., Rodriguez-Garcia, A., Rodriguez-Madoz, J.R., Ruggiero, E., Themeli, M., Hudecek, M. and Marchiq, I.
Journal for ImmunoTherapy of Cancer 10
(5): e003487.
May 2022
Functional development of the T cell receptor for antigen.
Ebert, P.J.R., Li, Q.J., Huppa, J.B. and Davis, M.M.
Progress in Molecular Biology and Translational Science 92
: 65-100.
2010
T cells as a self-referential, sensory organ.
Davis, M.M., Krogsgaard, M., Huse, M., Huppa, J., Lillemeier, B.F. and Li, Q.J.
Annual Review of Immunology 25
: 681-95.
2 January 2007
T-cell-antigen recognition and the immunological synapse.
Huppa, J.B. and Davis, M.M.
Nature Reviews Immunology 3
(12): 973-83.
1 December 2003
Linking molecular and cellular events in T-cell activation and synapse formation.
Krogsgaard, M., Huppa, J.B., Purbhoo, M.A. and Davis, M.M.
Seminars in Immunology 15
(6): 307-15.
December 2003
Dynamics of cell surface molecules during T cell recognition.
Davis, M.M., Krogsgaard, M., Huppa, J.B., Sumen, C., Purbhoo, M.A., Irvine, D.J., Wu, L.C. and Ehrlich, L.
Annual review of biochemistry 72
: 717-42.
July 2003
The eS-Sence of -SH in the ER.
Huppa, J.B. and Ploegh, H.L.
Cell 92
(2): 145-8.
23 January 1998
Editorial
T-cell antigen recognition: catch-as-catch-can or catch-22?
Huppa, J.B. and Schütz, G.J.
EMBO Journal 42
(7): e113507.
3 April 2023
Video
Automated two-dimensional spatiotemporal analysis of mobile single-molecule FRET probes.
Schrangl, L., Göhring, J., Kellner, F., Huppa, J.B. and Schütz, G.J.
[Video]
23 November 2021
This list was generated on Thu Nov 21 14:20:32 2024 UTC.
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