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2018

Small heat shock protein speciation: novel non-canonical 44 kDa HspB5-related protein species in rat and human tissues.
Benndorf, R. and Gilmont, R.R. and Hirano, S. and Ransom, R.F. and Jungblut, P.R. and Bommer, M. and Goldman, J.E. and Welsh, M.J.
Cell Stress & Chaperones 23 (5): 813-826. September 2018

Solvent networks tune thermodynamics of oligosaccharide complex formation in an extended protein binding site.
Kunstmann, S. and Gohlke, U. and Broeker, N.K. and Roske, Y. and Heinemann, U. and Santer, M. and Barbirz, S.
Journal of the American Chemical Society 140 (33): 10447-10455. 22 August 2018

Crystal structures of the single PDZ domains from GRASP65 and their interaction with the golgin GM130.
Jurk, C.M. and Roske, Y. and Heinemann, U.
Croatica Chemica Acta 91 (2): 255-264. June 2018

Structural changes of TasA in biofilm formation of Bacillus subtilis.
Diehl, A. and Roske, Y. and Ball, L. and Chowdhury, A. and Hiller, M. and Molière, N. and Kramer, R. and Stöppler, D. and Worth, C.L. and Schlegel, B. and Leidert, M. and Cremer, N. and Erdmann, N. and Lopez, D. and Stephanowitz, H. and Krause, E. and van Rossum, B.J. and Schmieder, P. and Heinemann, U. and Turgay, K. and Akbey, Ü. and Oschkinat, H.
Proceedings of the National Academy of Sciences of the United States of America 115 (13): 3237-3242. 27 March 2018

Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family.
Ming, Q. and Roske, Y. and Schuetz, A. and Walentin, K. and Ibraimi, I. and Schmidt-Ott, K.M. and Heinemann, U.
Nucleic Acids Research 46 (4): 2082-2095. 28 February 2018

A novel form of RNA double helix based on G·U and C·A(+) wobble base pairing.
Garg, A. and Heinemann, U.
RNA 24 (2): 209-218. February 2018

2017

Different inhibitory potencies of oseltamivir carboxylate, zanamivir, and several tannins on bacterial and viral neuraminidases as assessed in a cell-free fluorescence-based enzyme inhibition assay.
Quosdorf, S. and Schuetz, A. and Kolodziej, H.
Molecules 22 (11): 1989. 17 November 2017

Crystal structure of the tricellulin C-terminal coiled-coil domain reveals a unique mode of dimerization.
Schuetz, A. and Radusheva, V. and Krug, S.M. and Heinemann, U.
Annals of the New York Academy of Sciences 1405 (1): 147-159. October 2017

Combining EPR spectroscopy and X-ray crystallography to elucidate the structure and dynamics of conformationally constrained spin labels in T4 lysozyme single crystals.
Consentius, P. and Gohlke, U. and Loll, B. and Alings, C. and Heinemann, U. and Wahl, M.C. and Risse, T.
Physical Chemistry Chemical Physics 19 (31): 20723-20734. 9 August 2017

Identification of a novel benzimidazole pyrazolone scaffold that inhibits KDM4 lysine demethylases and reduces proliferation of prostate cancer cells.
Carter, D.M. and Specker, E. and Przygodda, J. and Neuenschwander, M. and von Kries, J.P. and Heinemann, U. and Nazaré, M. and Gohlke, U.
SLAS Discovery 22 (7): 801-812. August 2017

Tricellulin is a target of the ubiquitin ligase Itch.
Jennek, S. and Mittag, S. and Reiche, J. and Westphal, J.K. and Seelk, S. and Dörfel, M.J. and Pfirrmann, T. and Friedrich, K. and Schütz, A. and Heinemann, U. and Huber, O.
Annals of the New York Academy of Sciences 1397 (1): 157-168. June 2017

Internal dynamics of the 3-pyrroline-N-oxide ring in spin-labeled proteins.
Consentius, P. and Loll, B. and Gohlke, U. and Alings, C. and Müller, C. and Müller, R. and Teutloff, C. and Heinemann, U. and Kaupp, M. and Wahl, M.C. and Risse, T.
Journal of Physical Chemistry Letters 8 (6): 1113-1117. 16 March 2017

2016

Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.
Arumughan, A. and Roske, Y. and Barth, C. and Lleras Forero, L. and Bravo-Rodriguez, K. and Redel, Al. and Kostova, S. and McShane, E. and Opitz, R. and Faelber, K. and Rau, K. and Mielke, T. and Daumke, O. and Selbach, M. and Sanchez-Garcia, E. and Rocks, O. and Panáková, D. and Heinemann, U. and Wanker, E.E.
Nature Communications 7 : 13047. 20 October 2016

Tracking transient conformational states of T4 lysozyme at room temperature combining X-ray crystallography and site-directed spin labeling.
Consentius, P. and Gohlke, U. and Loll, B. and Alings, C. and Mueller, R. and Heinemann, U. and Kaupp, M. and Wahl, M. and Risse, T.
Journal of the American Chemical Society 138 (39): 12868-12875. 5 October 2016

Bacteriophage tailspikes and bacterial O-antigens as a model system to study weak-affinity protein-polysaccharide interactions.
Kang, Y. and Gohlke, U. and Engström, O. and Hamark, C. and Scheidt, T. and Kunstmann, S. and Heinemann, U. and Widmalm, G. and Santer, M. and Barbirz, S.
Journal of the American Chemical Society 138 (29): 9109-9118. 27 July 2016

Functional interaction of CCAAT/enhancer-binding-protein-α basic region mutants with E2F transcription factors and DNA.
Kowenz-Leutz, E. and Schuetz, A. and Liu, Q. and Knoblich, M. and Heinemann, U. and Leutz, A.
Biochimica et Biophysica Acta - Gene Regulatory Mechanisms 1859 (7): 841-847. July 2016

AKAP18:PKA-RIIα structure reveals crucial anchor points for recognition of regulatory subunits of PKA.
Götz, F. and Roske, Y. and Schulz, M.S. and Autenrieth, K. and Bertinetti, D. and Faelber, K. and Zühlke, K. and Kreuchwig, A. and Kennedy, E. and Krause, G. and Daumke, O. and Herberg, F.W. and Heinemann, U. and Klussmann, E.
Biochemical Journal 473 (13): 1881-1894. 28 June 2016

XDSAPP2.0.
Sparta, K.M. and Krug, M. and Heinemann, U. and Mueller, U. and Weiss, M.S.
Journal of Applied Crystallography 49 (3): 1085-1092. June 2016

2015

RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.
Murakawa, Y. and Hinz, M. and Mothes, J. and Schuetz, A. and Uhl, M. and Wyler, E. and Yasuda, T. and Mastrobuoni, G. and Friedel, C.C. and Dölken, L. and Kempa, S. and Schmidt-Supprian, M. and Blüthgen, N. and Backofen, R. and Heinemann, U. and Wolf, J. and Scheidereit, C. and Landthaler, M.
Nature Communications 6 : 7367. 14 July 2015

The macromolecular crystallography beamlines at BESSY II of the Helmholtz-Zentrum Berlin: current status and perspectives.
Mueller, U. and Foerster, R. and Hellmig, M. and Huschmann, F.U. and Kastner, A. and Malecki, P. and Puehringer, S. and Roewer, M. and Sparta, K. and Steffien, M. and Uehlein, M. and Wilk, P. and Weiss, M.S.
European Physical Journal Plus 130 (7): 141. July 2015

Light-switched inhibitors of protein tyrosine phosphatase PTP1B based on phosphonocarbonyl phenylalanine as photoactive phosphotyrosine mimetic.
Wagner, S. and Schütz, A. and Rademann, J.
Bioorganic and Medicinal Chemistry 23 (12): 2839-2847. 15 June 2015

Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivo.
Grosskopf, S. and Eckert, C. and Arkona, C. and Radetzki, S. and Böhm, K. and Heinemann, U. and Wolber, G. and von Kries, J.P. and Birchmeier, W. and Rademann, J.
ChemMedChem 10 (5): 815-826. May 2015

A modular toolkit to inhibit proline-rich motif-mediated protein-protein interactions.
Opitz, R. and Mueller, M. and Reuter, C. and Barone, M. and Soicke, A. and Roske, Y. and Piotukh, K. and Huy, P. and Beerbaum, M. and Wiesner, B. and Beyermann, M. and Schmieder, P. and Freund, C. and Volkmer, R. and Oschkinat, H. and Schmalz, H.G. and Kuehne, R.
Proceedings of the National Academy of Sciences of the United States of America 112 (16): 5011-5016. 21 April 2015

2014

Roquin binding to target mRNAs involves a winged helix-turn-helix motif.
Schuetz, A. and Murakawa, Y. and Rosenbaum, E. and Landthaler, M. and Heinemann, U.
Nature Communications 5 : 5701. 11 December 2014

Structural identification of the VPS18 β-propeller reveals a critical role in the HOPS complex stability and function.
Behrmann, H. and Lürick, A. and Kuhlee, A. and Kleine Balderhaar, H. and Bröcker, C. and Kümmel, D. and Engelbrecht-Vandré, S. and Gohlke, U. and Raunser, S. and Heinemann, U. and Ungermann, C.
Journal of Biological Chemistry 289 (48): 33503-33512. 28 November 2014

Crystal structure of the yeast TRAPP-associated protein Tca17.
Wang, C. and Gohlke, U. and Roske, Y. and Heinemann, U.
FEBS Journal 281 (18): 4195-4206. September 2014

Bacteriophage P22 tailspike: structure of the complete protein and function of the interdomain linker.
Seul, A. and Müller, J.J. and Andres, D. and Stettner, E. and Heinemann, U. and Seckler, R.
Acta Crystallographica Section D 70 (Pt 5): 1336-1345. May 2014

Atomistic Monte Carlo simulation of lipid membranes.
Wuestner, D. and Sklenar, H.
International Journal of Molecular Sciences 15 (2): 1767-803. 24 January 2014

2013

Crystal structure of native and a mutant of Lampyris turkestanicus luciferase implicate in bioluminescence color shift.
Kheirabadi, M. and Sharafian, Z. and Naderi-Manesh, H. and Heinemann, U. and Gohlke, U. and Hosseinkhani, S.
Biochimica et Biophysica Acta - Proteins and Proteomics 1834 (12): 2729-2735. 6 October 2013

Mechanisms of Lin28-mediated miRNA and mRNA regulation : a structural and functional perspective.
Mayr, F. and Heinemann, U.
International Journal of Molecular Sciences 14 (8): 16532-16553. 9 August 2013

Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation.
Graf, R. and Munschauer, M. and Mastrobuoni, G. and Mayr, F. and Heinemann, U. and Kempa, S. and Rajewsky, N. and Landthaler, M.
RNA Biology 10 (7): 1146-1159. 1 July 2013

An essential serotype recognition pocket on phage P22 tailspike protein forces Salmonella enterica serovar Paratyphi A O-antigen fragments to bind as nonsolution conformers.
Andres, D. and Gohlke, U. and Broeker, N.K. and Schulze, S. and Rabsch, W. and Heinemann, U. and Barbirz, S. and Seckler, R.
Glycobiology 23 (4): 486-494. April 2013

Single amino acid exchange in bacteriophage HK620 tailspike protein results in thousand-fold increase of its oligosaccharide affinity.
Broeker, N.K. and Gohlke, U. and Müller, J.J. and Uetrecht, C. and Heinemann, U. and Seckler, R. and Barbirz, S.
Glycobiology 23 (1): 59-68. January 2013

2012

Peptide linkage to the α-subunit of MHCII creates a stably inverted antigen presentation complex.
Schlundt, A. and Guenther, S. and Sticht, J. and Wieczorek, M. and Roske, Y. and Heinemann, U. and Freund, C.
Journal of Molecular Biology 423 (3): 294-302. 26 October 2012

Benzoylphosphonate-based photoactive phosphopeptide mimetics for modulation of protein tyrosine phosphatases and highly specific labeling of SH2 domains.
Horatscheck, A. and Wagner, S. and Ortwein, J. and Kim, B.G. and Lisurek, M. and Beligny, S. and Schuetz, A. and Rademann, J.
Angewandte Chemie International Edition 51 (37): 9441-9447. 10 September 2012

Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations.
Kirchner, F. and Schuetz, A. and Boldt, L.H. and Martens, K. and Dittmar, G. and Haverkamp, W. and Thierfelder, L. and Heinemann, U. and Gerull, B.
Circulation Cardiovascular Genetics 5 (4): 400-411. 1 August 2012

The Lin28 cold-shock domain remodels pre-let-7 microRNA.
Mayr, F. and Schütz, A. and Dge, N. and Heinemann, U.
Nucleic Acids Research 40 (15): 7492-7506. 1 August 2012

XDSAPP: a graphical user interface for the convenient processing of diffraction data using XDS.
Krug, M. and Weiss, M.S. and Heinemann, U. and Mueller, U.
Journal of Applied Crystallography 45 (3): 568-572. June 2012

Structural and biochemical basis of Yos9 protein dimerization and possible contribution to self-association of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation ubiquitin-ligase complex.
Hanna, J. and Schütz, A. and Zimmermann, F. and Behlke, J. and Sommer, T. and Heinemann, U.
Journal of Biological Chemistry 287 (11): 8633-8640. 9 March 2012

Tail morphology controls DNA release in two Salmonella phages with one lipopolysaccharide receptor recognition system.
Andresen, D. and Roske, Y. and Doering, C. and Heinemann, U. and Seckler, R. and Barbirz, S.
Molecular Microbiology 83 (6): 1244-1253. March 2012

Strong antiviral activity of the new l-hydroxycytidine derivative, l-Hyd4FC, in HBV-infected human chimeric uPA/SCID mice.
Volz, T. and Luetgehetmann, M. and Allweiss, L. and Warlich, M. and Bierwolf, J. and Pollok, J.M. and Petersen, J. and Matthes, E. and Dandri, M.
Antiviral Therapy 17 (4): 623-631. 27 February 2012

The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation.
von Eyss, B. and Maaskola, J. and Memczak, S. and Möllmann, K. and Schuetz, A. and Loddenkemper, C. and Tanh, M.D. and Otto, A. and Muegge, K. and Heinemann, U. and Rajewsky, N. and Ziebold, U.
EMBO Journal 31 (4): 972-985. 15 February 2012

RNA single strands bind to a conserved surface of the major cold shock protein in crystals and solution.
Sachs, R. and Max, K.E. and Heinemann, U. and Balbach, J.
RNA 18 (1): 65-76. January 2012

2011

PAN-modular structure of microneme protein SML-2 from the parasite Sarcocystis muris at 1.95 Å resolution and its complex with 1-thio-β-D-galactose.
Mueller, J.J. and Weiss, M.S. and Heinemann, U.
Acta Crystallographica Section D 67 (Pt 11): 936-944. November 2011

Crystal structure of nucleotide-free dynamin.
Faelber, K. and Posor, Y. and Gao, S. and Held, M. and Roske, Y. and Schulze, D. and Haucke, V. and Noe, F. and Daumke, O.
Nature 477 (7366): 556-560. 29 September 2011

The structure of the Klf4 DNA-binding domain links to self-renewal and macrophage differentiation.
Schuetz, A. and Nana, D. and Rose, C. and Zocher, G. and Milanovic, M. and Koenigsmann, J. and Blasig, R. and Heinemann, U. and Carstanjen, D.
Cellular and Molecular Life Sciences 68 (18): 3121-3131. September 2011

Discovery, structure-activity relationship studies, and crystal structure of nonpeptide inhibitors bound to the Shank3 PDZ domain.
Saupe, J. and Roske, Y. and Schillinger, C. and Kamdem, N. and Radetzki, S. and Diehl, A. and Oschkinat, H. and Krause, G. and Heinemann, U. and Rademann, J.
ChemMedChem 6 (8): 1411-1422. 1 August 2011

Expression of protein complexes using multiple E. coli protein co-expression systems: a benchmarking study.
Busso, D. and Peleg, Y. and Heidebrecht, T. and Romier, C. and Jacobovitch, Y. and Dantes, A. and Salim, L. and Troesch, E. and Schuetz, A. and Heinemann, U. and Folkers, G.E. and Geerlof, A. and Wilmanns, M. and Polewacz, A. and Quedenau, C. and Büssow, K. and Adamson, R. and Blagova, E. and Walton, J. and Cartwright, J.L. and Bird, L.E. and Owens, R.J. and Berrow, N.S. and Wilson, K.S. and Sussman, J.L. and Perrakis, A. and Celie, P.H.
Journal of Structural Biology 175 (2): 159-170. August 2011

Structural and thermodynamic characterization of the adrenodoxin-like domain of the electron-transfer protein Etp1 from Schizosaccharomyces pombe.
Mueller, J.J. and Hannemann, F. and Schiffler, B. and Ewen, K.M. and Kappl, R. and Heinemann, U. and Bernhardt, R.
Journal of Inorganic Biochemistry 105 (7): 957-965. July 2011

2010

Bidirectional binding of invariant chain peptides to an MHC class II molecule.
Guenther, S. and Schlundt, A. and Sticht, J. and Roske, Y. and Heinemann, U. and Wiesmueller, K.H. and Jung, G. and Falk, K. and Roetzschke, O. and Freund, C.
Proceedings of the National Academy of Sciences of the United States of America 107 (51): 22219-22224. 21 December 2010

Conserved beta-hairpin recognition by the GYF domains of Smy2 and GIGYF2 in mRNA surveillance and vesicular transport complexes.
Ash, M.R. and Faelber, K. and Kosslick, D. and Albert, G.I. and Roske, Y. and Kofler, M. and Schuemann, M. and Krause, E. and Freund, C.
Structure 18 (8): 944-954. 11 August 2010

Characterization of the self-palmitoylation activity of the transport protein particle component Bet3.
Kuemmel, D. and Walter, J. and Heck, M. and Heinemann, U. and Veit, M.
Cellular and Molecular Life Sciences 67 (15): 2653-2664. August 2010

Repression of transcriptional activity of C/EBPα by E2F-DP complexes.
Zaragoza, K. and Bégay, V. and Schuetz, A. and Heinemann, U. and Leutz, A.
Molecular and Cellular Biology 30 (9): 2293-2304. May 2010

A MAS NMR study of the bacterial ABC transporter ArtMP.
Lange, V. and Becker-Baldus, J. and Kunert, B. and van Rossum, B.J. and Casagrande, F. and Engel, A. and Roske, Y. and Scheffel, F.M. and Schneider, E. and Oschkinat, H.
Chembiochem 11 (4): 547-555. 1 March 2010

Crystal structure of Klebsiella sp. ASR1 phytase suggests substrate binding to a preformed active site that meets the requirements of a plant rhizosphere enzyme.
Boehm, K. and Herter, T. and Mueller, J.J. and Borriss, R. and Heinemann, U.
FEBS Journal 277 (5): 1284-1296. March 2010

The coxsackievirus-adenovirus receptor reveals complex homophilic and heterophilic interactions on neural cells.
Patzke, C. and Max, K.E. and Behlke, J. and Schreiber, J. and Schmidt, H. and Dorner, A.A. and Kroeger, S. and Henning, M. and Otto, A. and Heinemann, U. and Rathjen, F.G.
Journal of Neuroscience 30 (8): 2897-2910. 24 February 2010

Armadillo motifs involved in vesicular transport.
Striegl, H. and Andrade-Navarro, M.A. and Heinemann, U.
PLoS ONE 5 (2): e8991. 1 February 2010

Cellular pharmacology of the anti-hepatitis B virus agent beta-L-2',3'-didehydro-2',3'-dideoxy-N4-hydroxycytidine: relevance for activation in HepG2 cells.
Matthes, E. and Buenger, H.
Antimicrobial Agents and Chemotherapy 54 (1): 341-345. 16 January 2010

2009

Usa1 functions as a scaffold of the HRD-ubiquitin ligase.
Horn, S.C. and Hanna, J. and Hirsch, C. and Volkwein, C. and Schütz, A. and Heinemann, U. and Sommer, T. and Jarosch, E.
Molecular Cell 36 (5): 782-793. 11 December 2009

Dimer formation of a stabilized Gbeta1 variant. A structural and energetic analysis.
Thoms, S. and Max, K.E. and Wunderlich, M. and Jacso, T. and Lilie, H. and Reif, B. and Heinemann, U. and Schmid, F.X.
Journal of Molecular Biology 391 (5): 918-932. 4 September 2009

The dipole moment of the electron carrier adrenodoxin is not critical for redox partner interaction and electron transfer.
Hannemann, F. and Guyot, A. and Zoellner, A. and Mueller, J.J. and Heinemann, U. and Bernhardt, R.
Journal of Inorganic Biochemistry 103 (7): 997-1004. July 2009

Purification and preliminary X-ray crystallographic studies of beta-microseminoprotein from human seminal plasma.
Kumar, V. and Roske, Y. and Singh, N. and Heinemann, U. and Singh, T.P. and Yadav, S.
Acta Crystallographica Section F 65 (5): 518-521. 1 May 2009

Crystal structure of KorA bound to operator DNA: insight into repressor cooperation in RP4 gene regulation.
Koenig, B. and Mueller, J.J. and Lanka, E. and Heinemann, U.
Nucleic Acids Research 37 (6): 1915-1924. April 2009

Unusual armadillo fold in the human general vesicular transport factor p115.
Striegl, H. and Roske, Y. and Kuemmel, D. and Heinemann, U.
PLoS ONE 4 (2): e4656. 27 February 2009

Clinical variability in distal spinal muscular atrophy type 1 (DSMA1): determination of steady-state IGHMBP2 protein levels in five patients with infantile and juvenile disease.
Guenther, U.P. and Handoko, L. and Varon, R. and Stephani, U. and Tsao, C.Y. and Mendell, J.R. and Lützkendorf, S. and Hübner, C. and von Au, K. and Jablonka, S. and Dittmar, G. and Heinemann, U. and Schuetz, A. and Schuelke, M.
Journal of Molecular Medicine 87 (1): 31-41. January 2009

2008

Distinct isocomplexes of the TRAPP trafficking factor coexist inside human cells.
Kuemmel, D. and Oeckinghaus, A. and Wang, C. and Krappmann, D. and Heinemann, U.
FEBS Letters 582 (27): 3729-3733. 12 November 2008

Structural and functional characterization of human Iba proteins.
Schulze, J.O. and Quedenau, C. and Roske, Y. and Adam, T. and Schueler, H. and Behlke, J. and Turnbull, A.P. and Sievert, V. and Scheich, C. and Mueller, U. and Heinemann, U. and Buessow, K.
FEBS Journal 275 (18): 4627-4640. September 2008

Crystal structure of Escherichia coli phage HK620 tailspike: podoviral tailspike endoglycosidase modules are evolutionarily related.
Barbirz, S. and Mueller, J.J. and Uetrecht, C. and Clark, A.J. and Heinemann, U. and Seckler, R.
Molecular Microbiology 69 (2): 303-316. July 2008

An approach to quality management in structural biology: Biophysical selection of proteins for successful crystallization.
Niesen, F.H. and Koch, A. and Lenski, U. and Harttig, U. and Roske, Y. and Heinemann, U. and Hofmann, K.P.
Journal of Structural Biology 162 (3): 451-459. June 2008

An intersubunit active site between supercoiled parallel beta helices in the trimeric tailspike endorhamnosidase of Shigella flexneri phage Sf6.
Mueller, J.J. and Barbirz, S. and Heinle, K. and Freiberg, A. and Seckler, R. and Heinemann, U.
Structure 16 (5): 766-775. 7 May 2008

Diversity in structure and function of tethering complexes: Evidence for different mechanisms in vesicular transport regulation.
Kuemmel, D. and Heinemann, U.
Current Protein & Peptide Science 9 (2): 197-209. April 2008

Protein production and purification.
Gräslund, S. and Nordlund, P. and Weigelt, J. and Hallberg, M. and Bray, J. and Gileadi, O. and Knapp, S. and Oppermann, U. and Arrowsmith, C. and Hui, R. and Ming, J. and dhe-Paganon, S. and Park, H.W. and Savchenko, A. and Yee, A. and Edwards, A. and Vincentelli, R. and Cambillau, C. and Kim, R. and Kim, S.H. and Rao, Z. and Shi, Y. and Terwilliger, T.C. and Kim, C.Y. and Hung, L.W. and Waldo, G.S. and Peleg, Y. and Albeck, S. and Unger, T. and Dym, O. and Prilusky, J. and Sussman, J.L. and Stevens, R.C. and Lesley, S.A. and Wilson, I.A. and Joachimiak, A. and Collart, F. and Dementieva, I. and Donnelly, M.I. and Eschenfeldt, W.H. and Kim, Y.M. and Stols, L. and Wu, R. and Zhou, M. and Burley, S.K. and Emtage, J.S. and Sauder, J.M. and Thompson, D. and Bain, K. and Luz, J. and Gheyi, T. and Zhang, F. and Atwell, S. and Almo, S.C. and Bonanno, J.B. and Fiser, A. and Swaminathan, S. and Studier, F.W. and Chance, M.R. and Sali, A. and Acton, T.B. and Xiao, R. and Zhao, L. and Ma, L.C. and Hunt, J.F. and Tong, L. and Cunningham, K. and Inouye, M. and Anderson, S. and Janjua, H. and Shastry, R. and Ho, C.K. and Wang, D. and Wang, H. and Jiang, M. and Montelione, G.T. and Stuart, D.I. and Owens, R.J. and Daenke, S. and Schütz, A. and Heinemann, U. and Yokoyama, S. and Büssow, K. and Gunsalus, K.C.
Nature Methods 5 (2): 135-146. February 2008

2007

An idea whose time has come.
Banci, L. and Baumeister, W. and Heinemann, U. and Schneider, G. and Silman, I. and Stuart, D.I. and Sussman, J.L.
Genome Biology 8 (11): 408. 7 November 2007

Optimization of the Gbeta1 domain by computational design and by in vitro evolution: structural and energetic basis of stabilization.
Wunderlich, M. and Max, K.E. and Roske, Y. and Mueller, U. and Heinemann, U. and Schmid, F.X.
Journal of Molecular Biology 373 (3): 775-784. 26 October 2007

Optimized Variants of the Cold Shock Protein from in Vitro Selection: Structural Basis of Their High Thermostability.
Max, K.E. and Wunderlich, M. and Roske, Y. and Schmid, F.X. and Heinemann, U.
Journal of Molecular Biology 369 (4): 1087-1097. 15 June 2007

Sequence specificity of single-stranded DNA-binding proteins: a novel DNA microarray approach.
Morgan, H.P. and Estibeiro, P. and Wear, M.A. and Max, K.E. and Heinemann, U. and Cubeddu, L. and Gallagher, M.P. and Sadler, P.J. and Walkinshaw, M.D.
Nucleic Acids Research 35 (10): e75. May 2007

Common mode of DNA binding to cold shock domains: Crystal structure of hexathymidine bound to the domain-swapped form of a major cold shock protein from Bacillus caldolyticus.
Max, K.E. and Zeeb, M. and Bienert, R. and Balbach, J. and Heinemann, U.
FEBS Journal 274 (5): 1265-1279. March 2007

Vectors for co-expression of an unrestricted number of proteins.
Scheich, C. and Kuemmel, D. and Soumailakakis, D. and Heinemann, U. and Buessow, K.
Nucleic Acids Research 35 (6): e43. March 2007

Structural proteomics: from the molecule to the system.
Banci, L. and Baumeister, W. and Enfedaque, J. and Heinemann, U. and Schneider, G. and Silman, I. and Sussman, J.L.
Nature Structural & Molecular Biology 14 (1): 3-4. January 2007

2006

Eukaryotic expression: developments for structural proteomics.
Aricescu, A.R. and Assenberg, R. and Bill, R.M. and Busso, D. and Chang, V.T. and Davis, S.J. and Dubrovsky, A. and Gustafsson, L. and Hedfalk, K. and Heinemann, U. and Jones, I.M. and Ksiazek, D. and Lang, C. and Maskos, K. and Messerschmidt, A. and Macieira, S. and Peleg, Y. and Perrakis, A. and Poterszman, A. and Schneider, G. and Sixma, T.K. and Sussman, J.L. and Sutton, G. and Tarboureich, N. and Zeev-Ben-Mordehai, T. and Jones, E.Y.
Acta Crystallographica Section D 62 (Pt. 10): 1114-1124. October 2006

First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value.
Banci, L. and Bertini, I. and Cusack, S. and de Jong, R.N. and Heinemann, U. and Jones, E.Y. and Kozielski, F. and Maskos, K. and Messerschmidt, A. and Owens, R. and Perrakis, A. and Poterszman, A. and Schneider, G. and Siebold, C. and Silman, I. and Sixma, T. and Stewart-Jones, G. and Sussman, J.L. and Thierry, J.C. and Moras, D.
Acta Crystallographica Section D 62 (Pt. 10): 1208-1217. October 2006

Building functional modules from molecular interactions.
Hofmann, K.P. and Spahn, C.M.T. and Heinrich, R. and Heinemann, U.
Trends in Biochemical Sciences 31 (9): 497-508. September 2006

Unique self-palmitoylation activity of the transport protein particle component Bet3: A mechanism required for protein stability.
Kuemmel, D. and Heinemann, U. and Veit, M.
Proceedings of the National Academy of Sciences of the United States of America 103 (34): 12701-12706. 22 August 2006

Structure of the Bet3-Tpc6B core of TRAPP: two Tpc6 paralogs form trimeric complexes with Bet3 and Mum2.
Kuemmel, D. and Mueller, J.J. and Roske, Y. and Henke, N. and Heinemann, U.
Journal of Molecular Biology 361 (1): 22-32. 4 August 2006

T-rich DNA single strands bind to a preformed site on the bacterial cold shock protein Bs-CspB.
Max, K.E.A. and Zeeb, M. and Bienert, R. and Balbach, J. and Heinemann, U.
Journal of Molecular Biology 360 (3): 702-714. 14 July 2006

The phosphotyrosine peptide binding specificity of Nck1 and Nck2 Src homology 2 domains.
Frese, S. and Schubert, W.D. and Findeis, A.C. and Marquardt, T. and Roske, Y.S. and Stradal, T.E. and Heinz, D.W.
Journal of Biological Chemistry 281 (26): 18236-18245. 30 June 2006

Conformation and stability of the Streptococcus pyogenes pSM19035-encoded site-specific beta recombinase, and identification of a folding intermediate.
Bhardwaj, A. and Welfle, K. and Misselwitz, R. and Ayora, S. and Alonso, J.C. and Welfle, H.
Biological Chemistry 387 (5): 525-533. May 2006

Low-resolution ab initio phasing of Sarcocystis muris lectin SML-2.
Mueller, J.J. and Lunina, N.L. and Urzhumtsev, A. and Weckert, E. and Heinemann, U. and Lunin, V.Y.
Acta Crystallographica Section D 62 (Pt 5): 533-540. May 2006

Structural basis for the substrate specificity of a Bacillus 1,3-1,4-beta-glucanase.
Gaiser, O.J. and Piotukh, K. and Ponnuswamy, W.N. and Planas, A. and Borriss, R. and Heinemann, U.
Journal of Molecular Biology 357 (4): 1211-1225. 7 April 2006

Crystal structure of Homo sapiens PTD012 reveals a zinc-containing hydrolase fold.
Manjasetty, B.A. and Buessow, K. and Fieber-Erdmann, M. and Roske, Y. and Gobom, J. and Scheich, C. and Goetz, F. and Niesen, F.H. and Heinemann, U.
Protein Science 15 (4): 914-920. 1 April 2006

Crystal structure of NblA from Anabaena sp. PCC 7120, a small protein playing a key role in phycobilisome degradation.
Bienert, R. and Baier, K. and Volkmer, R. and Lockau, W. and Heinemann, U.
Journal of Biological Chemistry 281 (8): 5216-5223. 24 February 2006

Light-induced reduction of bovine adrenodoxin via the covalently bound ruthenium(II) bipyridyl complex: Intramolecular electron transfer and crystal structure.
Halavaty, A. and Mueller, J.J. and Contzen, J. and Jung, C. and Hannemann, F. and Bernhardt, R. and Galander, M. and Lendzian, F. and Heinemann, U.
Biochemistry 45 (3): 709-718. 24 January 2006

Mn2+-DNA interactions in aqueous systems: A Raman spectroscopic study.
Muntean, C.M. and Misselwitz, R. and Dostal, L. and Welfle, H.
Spectroscopy 20 (1): 29-35. January 2006

MAD phasing.
Mueller, J.J. and Heinemann, U.
In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2. Springer, Berlin [u.a.], 1002-1008. ISBN 3-540-44244-8 2006

Recognition of T-rich single-stranded DNA by the cold shock protein Bs-CspB in solution.
Zeeb, M. and Max, K.E.A. and Weininger, U. and Loew, C. and Sticht, H. and Balbach, J.
Nucleic Acids Research 34 (16): 4561-4571. 2006

Structural genomics: structure-to-function approaches.
Heinemann, U.
In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2. Springer, Berlin [u.a.], 1810-1816. ISBN 3-540-44244-8 2006

Structural studies of the human tethering complex TRAPP involved in vesicular transport.
Kuemmel, D. and Turnbull, A.P. and Mueller, J.J. and Roske, Y. and Heinemann, U.
2006

2005

X-ray structure of engineered human Aortic Preferentially Expressed Protein-1 (APEG-1).
Manjasetty, B.A. and Niesen, F.H. and Scheich, C. and Roske, Y. and Goetz, F. and Behlke, J. and Sievert, V. and Heinemann, U. and Buessow, K.
BMC Structural Biology 5 (14): 21. 14 December 2005

The interaction domain of the redox protein adrenodoxin is mandatory for binding of the electron acceptor CYP11A1, but is not required for binding of the electron donor adrenodoxin reductase.
Heinz, A. and Hannemann, F. and Mueller, J.J. and Heinemann, U. and Bernhardt, R.
Biochemical and Biophysical Research Communications 338 (9): 491-498. 29 August 2005

The structure of the TRAPP subunit TPC6 suggests a model for a TRAPP subcomplex.
Kuemmel, D. and Mueller, J.J. and Roske, Y. and Misselwitz, R. and Buessow, K. and Heinemann, U.
EMBO Reports 6 (8): 787-793. 6 August 2005

Kristallstrukturanalyse des kohlenhydratbindenden Moduls 27-1 der Beta-Mannanase 26 aus Caldicellulosiruptor saccharolyticus im Komplex mit Mannohexaose und Kristallisation der ATPase HP0525 aus Helicobacter pylori.
Roske, Y.
UNSPECIFIED thesis, UNSPECIFIED. 28 July 2005

Structural genomics of human proteins - target selection and generation of a public catalog of expression clones.
Buessow, K. and Scheich, C. and Sievert, V. and Harttig, U. and Schultz, J. and Simon, B. and Bork, P. and Lehrach, H. and Heinemann, U.
Microbial Cell Factories 4 : 21. 5 July 2005

Detection of dynamic water molecules in a microcrystalline sample of the SH3 domain of alpha-spectrin by MAS solid-state NMR.
Chevelkov, V. and Faelber, K. and Diehl, A. and Heinemann, U. and Oschkinat, H. and Reif, B.
Journal of Biomolecular NMR 31 (4): 295-310. 1 January 2005

Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization.
Turnbull, A.P. and Kuemmel, D. and Prinz, B. and Holz, C. and Schultchen, J. and Lang, C. and Niesen, F.H. and Hofmann, K.P. and Delbrueck, H. and Behlke, J. and Mueller, E.C. and Jarosch, E. and Sommer, T. and Heinemann, U.
EMBO Journal 24 (5): 875-884. 1 January 2005

2004

High-resolution crystal structures of Caldicellulosiruptor strain Rt8B.4 carbohydrate-binding module CBM27-1 and its complex with mannohexaose.
Roske, Y. and Sunna, A. and Pfeil, W. and Heinemann, U.
Journal of Molecular Biology 340 (3): 543-554. 9 July 2004

X-ray structure of human gankyrin, the product of a gene linked to hepatocellular carcinoma.
Manjasetty, B.A. and Quedenau, C. and Sievert, V. and Buessow, K. and Niesen, F. and Delbrueck, H. and Heinemann, U.
Proteins: Structure, Function, and Bioinformatics 55 (1): 214-217. April 2004

Crystal structure of Homo sapiens protein hp14.5.
Manjasetty, B.A. and Delbrueck, H. and Pham, D.T. and Mueller, U. and Fieber-Erdmann, M. and Scheich, C. and Sievert, V. and Buessow, K. and Niesen, F.H. and Weihofen, W. and Loll, B. and Saenger, W. and Heinemann, U.
Proteins: Structure, Function, and Bioinformatics 54 (3): 797-800. 1 March 2004

1H, 13C and 15N resonance assignments of the C-terminal BRCT domain from human BRCA1.
Gaiser, O.J. and Oschkinat, H. and Heinemann, U. and Ball, L.J.
Journal of Biomolecular NMR 30 (2): 221-222. 1 January 2004

Sequence-specific DNA binding determined by contacts outside the helix-turn-helix motif of the ParB homolog KorB.
Khare, D. and Ziegelin, G. and Lanka, E. and Heinemann, U.
Nature Structural & Molecular Biology 11 (7): 656-663. 1 January 2004

Single-stranded DNA bound to bacterial cold-shock proteins: preliminary crystallographic and Raman analysis.
Bienert, R. and Zeeb, M. and Dostal, L. and Feske, A. and Magg, C. and Max, K. and Welfle, H. and Balbach, J. and Heinemann, U.
Acta Crystallographica Section D 60 (4): 755-757. 1 January 2004

Solution structure, backbone dynamics, and association behavior of the C-terminal BRCT domain from the breast cancer-associated protein BRCA1.
Gaiser, O.J. and Ball, L.J. and Schmieder, P. and Leitner, D. and Strauss, H. and Wahl, M. and Kuehne, R. and Oschkinat, H. and Heinemann, U.
Biochemistry 43 (51): 15983-15995. 1 January 2004

Structure of circularly permuted DsbAQ100T99: preserved global fold and local structural adjustments.
Manjasetty, B.A. and Hennecke, J. and Glockshuber, R. and Heinemann, U.
Acta Crystallographica Section D 60 (2): 304-309. 1 January 2004

X-ray structure of fumarylacetoacetate hydrolase family member Homo sapiens FLJ36880.
Manjasetty, B.A. and Niesen, F.H. and Delbrueck, H. and Goetz, F. and Sievert, V. and Buessow, K. and Behlke, J. and Heinemann, U.
Biological Chemistry 385 (10): 935-942. 1 January 2004

2003

Effect of environmental conditions on aggregation and fibril formation of barstar.
Gast, K. and Modler, A.J. and Damaschun, H. and Kroeber, R. and Lutsch, G. and Zirwer, D. and Golbik, R. and Damaschun, G.
European Biophysics Journal with Biophysics Letters 32 (8): 710-723. December 2003

Rapid purification and crystal structure analysis of a small protein carrying two terminal affinity tags.
Mueller, U. and Buessow, K. and Diehl, A. and Bartl, F.J. and Niesen, F.H. and Nyarsik, L. and Heinemann, U.
Journal of Structural and Functional Genomics 4 (4): 217-225. December 2003

Formation of critical oligomers is a key event during conformational transition of recombinant Syrian hamster prion protein.
Sokolowski, F. and Modler, A.J. and Masuch, R. and Zirwer, D. and Baier, M. and Lutsch, G. and Moss, D.A. and Gast, K. and Naumann, D.
Journal of Biological Chemistry 278 (42): 40481-40492. 17 October 2003

The DNA-bending protein HMGB1 is a cellular cofactor of Sleeping Beauty transposition.
Zayed, H. and Izsvak, Z. and Khare, D. and Heinemann, U. and Ivics, Z.
Nucleic Acids Research 31 (9): 2313-2322. 1 May 2003

Facilities and methods for the high-throughput crystal structural analysis of human proteins.
Heinemann, U. and Buessow, K. and Mueller, U. and Umbach, P.
Accounts of Chemical Research 36 (3): 157-163. March 2003

Molekuelmodelle und Modellmolekuele: Strukturanalyse grosser biologischer Molekuele fuer die Medizin.
Muller, Y.A. and Heinemann, U.
In: Grundlagen der Molekularen Medizin. Molekulare Medizin . Springer, Berlin [u.a.], 340-359. ISBN 3-540-43207-8 1 January 2003

RP4 repressor protein KorB binds to the major groove of the operator DNA: A Raman study.
Dostal, L. and Khare, D. and Bok, J. and Heinemann, U. and Lanka, E. and Welfle, H.
Biochemistry 42 (49): 14476-14482. 1 January 2003

Secure web book to store structural genomics research data.
Manjasetty, B.A. and Hoppner, K. and Mueller, U. and Heinemann, U.
Journal of Structural and Functional Genomics 4 (2-3): 121-127. 1 January 2003

Molekuelmodelle und Modellmolekuele: Strukturanalyse grosser biologischer Molekuele fuer die Medizin.
Muller, Y.A. and Heinemann, U.
In: Handbuch der molekularen Medizin, Band 1, Molekular- und zellbiologische Grundlagen. Springer, Berlin [u.a.], 340-359. ISBN 978-3-662-07589-0 2003

2002

Modeling of electrostatic recognition processes in the mammalian mitochondrial steroid hydroxylase system.
Mueller, J.J. and Lapko, A. and Ruckpaul, K. and Heinemann, U.
Biophysical Chemistry 100 (1-3): 281-292. December 2002

Crystal structure of human sex hormone-binding globulin in complex with 2-methoxyestradiol reveals the molecular basis for high affinity interactions with C-2 derivatives of estradiol.
Avvakumov, G.V. and Grishkovskaya, I. and Muller, Y.A. and Hammond, G.L.
Journal of Biological Chemistry 277 (47): 45219-45225. 22 November 2002

The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor.
Muller, Y.A. and Heiring, C. and Misselwitz, R. and Welfle, K. and Welfle, H.
Journal of Biological Chemistry 277 (45): 43410-43416. 8 November 2002

Establishing a structural genomics platform: The Berlin-based Protein Structure Factory.
Heinemann, U.
Gene Function and Disease 3 (1-2): 25-32. October 2002

Thermostabilitaet und funktionelle Vielfalt ubiquitaerer Proteinfaltungsdomaenen [Thermostability and functional diversity of ubiquitous protein domains].
Delbrueck, H.
UNSPECIFIED thesis, UNSPECIFIED. 20 September 2002

High resolution crystal structure of domain I of the Saccharomyces cerevisiae homing endonuclease PI-SceI.
Werner, E. and Wende, W. and Pingoud, A. and Heinemann, U.
Nucleic Acids Research 30 (18): 3962-3971. 15 September 2002

Involvement of a bifunctional, paired-like DNA-binding domain and a transpositional enhancer in Sleeping Beauty transposition.
Izsvak, Z. and Khare, D. and Behlke, J. and Heinemann, U. and Plasterk, R.H. and Ivics, Z.
Journal of Biological Chemistry 277 (37): 34581-34588. 13 September 2002

Steroid ligands bind human sex hormone-binding globulin in specific orientations and produce distinct changes in protein conformation.
Grishkovskaya, I. and Avvakumov, G.V. and Hammond, G.L. and Catalano, M.G. and Muller, Y.A.
Journal of Biological Chemistry 277 (35): 32086-32093. 30 August 2002

Verfahren zur Ermittlung von Faltungsbedingungen fuer rekombinante Proteine [Method for determining folding conditions for recombinant proteins].
Heiring, C. and Heinemann, U. and Muller, Y.A.
DE10054059A1 ; WO0237116. 8 May 2002

Resolution of a disordered region at the entrance of the human sex hormone-binding globulin steroid-binding site.
Grishkovskaya, I. and Avvakumov, G.V. and Hammond, G.L. and Muller, Y.A.
Journal of Molecular Biology 318 (3): 621-626. 3 May 2002

Crystal structure of human nicotinamide mononucleotide adenylyltransferase in complex with NMN.
Werner, E. and Ziegler, M. and Lerner, F. and Schweiger, M. and Heinemann, U.
FEBS Letters 516 (1-3): 239-244. 10 April 2002

An Src homology 3-like domain is responsible for dimerization of the repressor protein KorB encoded by the promiscuous IncP plasmid RP4.
Delbrueck, H. and Ziegelin, G. and Lanka, E. and Heinemann, U.
Journal of Biological Chemistry 277 (6): 4191-4198. 1 January 2002

Crystallization and preliminary X-ray analysis of human nicotinamide mononucleotide adenylyltransferase (NMNAT).
Werner, E. and Ziegler, M. and Lerner, F. and Schweiger, M. and Muller, Y.A. and Heinemann, U.
Acta Crystallographica Section D 58 (1): 140-142. 1 January 2002

Structure and recognition of components of the mitochondrial steroid hydroxylating system in adrenal cortex of vertebrates.
Mueller, J.J. and Mueller, E.C. and Otto, A. and Ruckpaul, K. and Heineman, U. and Lapko, A.
In: Flavins and Flavoproteins 2002. Proceedings of the Fourteenth International Symposium. Rudolf Weber, Berlin, 491-499. 1 January 2002

Structure of ribonucleases.
Heinemann, U. and Mueller, J.J. and Polyakov, K.M.
In: Landolt-Boernstein, New Series: Numerical data...; Gr.7: Biophysics; Vol.2: Proteins; Subvol.A: Structural and physical data I. Springer, Berlin. ISBN 3-540-56083-1 1 January 2002

2001

A standard reference frame for the description of nucleic acid base-pair geometry.
Olson, W.K. and Bansal, M. and Burley, S.K. and Dickerson, R.E. and Gerstein, M. and Harvey, S.C. and Heinemann, U. and Lu, X.J. and Neidle, S. and Shakked, Z. and Sklenar, H. and Suzuki, M. and Tung, C.S. and Westhof, E. and Wolberger, C. and Berman, H.M.
Journal of Molecular Biology 313 : 229-237. 12 October 2001

Three-dimensional model of the SHBG-like region of anticoagulant protein S: new structure-function insights.
Villoutreix, B.O. and Dahlback, B. and Borgel, D. and Gandrille, S. and Muller, Y.A.
Proteins: Structure, Function, and Bioinformatics 43 : 203-216. 1 May 2001

Adrenodoxin reductase-adrenodoxin complex structure suggests electron transfer path in steroid biosynthesis.
Mueller, J.J. and Lapko, A. and Bourenkov, G. and Ruckpaul, K. and Heinemann, U.
Journal of Biological Chemistry 276 (4): 2786-2789. 1 January 2001

Characterization and crystallization of a novel Sarcocystis muris lectin, SML-2.
Mueller, J.J. and Mueller, E.C. and Montag, T. and Zyto, N. and Loeschner, B. and Klein, H. and Heineman, U. and Otto, A.
Acta Crystallographica Section D 57 (7): 1042-1045. 1 January 2001

Covalently crosslinked complexes of bovine adrenodoxin with adrenodoxin reductase and cytochrome P450scc. Mass spectrometry and Edman degradation of complexes of the steroidogenic hydroxylase system.
Mueller, E.C. and Lapko, A. and Otto, A. and Mueller, J.J. and Ruckpaul, K. and Heinemann, U.
European Journal of Biochemistry 268 (6): 1837-1843. 1 January 2001

Crystal structures of mutant forms of the Bacillus caldolyticus cold shock protein differing in thermal stability.
Delbrueck, H. and Mueller, U. and Perl, D. and Schmid, F.X. and Heinemann, U.
Journal of Molecular Biology 313 (2): 359-369. 1 January 2001

Die Proteinstrukturfabrik - Strukturanalyse mit hohem Durchsatz im Berliner Forschungsverbund.
Umbach, P. and Heinemann, U.
Biospektrum 7 (3): 247-249. 1 January 2001

Folding screening assayed by proteolysis: application to various cystine deletion mutants of vascular endothelial growth factor.
Heiring, C. and Muller, Y.A.
Protein Engineering 14 (3): 183-188. 1 January 2001

High-throughput three-dimensional protein structure determination.
Heinemann, U. and Illing, G. and Oschkinat, H.
Current Opinion in Biotechnology 12 (4): 348-354. 1 January 2001

LG/LNS domains: multiple functions - one business end?
Rudenko, G. and Hohenester, E. and Muller, Y.A.
Trends in Biochemical Sciences 26 (6): 363-368. 1 January 2001

Protein crystallography with neutrons - status and perspectives.
Gutberlet, T. and Heinemann, U. and Steiner, M.
Acta Crystallographica Section D 57 (2): 349-354. 1 January 2001

Structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-binding proteins.
Schwartz, T. and Behlke, J. and Lowenhaupt, K. and Heineman, U. and Rich, A.
Nature Structural Biology 8 (9): 761-765. 1 January 2001

The 1.85 angstrom resolution crystal structures of tissue factor in complex with humanized Fab D3h44 and of free humanized Fab D3h44: Revisiting the solvation of antigen combining sites.
Faelber, K. and Kirchhofer, D. and Presta, L. and Kelley, R.F. and Muller, Y.A.
Journal of Molecular Biology 313 (1): 83-97. 1 January 2001

The Berlin "protein structure factory" initiative: a technology-oriented approach to structural genomics.
Heinemann, U.
Ernst Schering Research Foundation Workshop 34 : 101-121. 2001

2000

Structural genomics in Europe: slow start, strong finish?
Heinemann, U.
Nature Structural Biology 7 (Suppl): 940-942. 1 November 2000

Crystal structures of recombinant histones HMfA and HMfB from the hyperthermophilic archaeon Methanothermus fervidus.
Decanniere, K. and Babu, A.M. and Sandman, K. and Reeve, J.N. and Heinemann, U.
Journal of Molecular Biology 303 (1): 35-47. 13 October 2000

Adrenodoxin: Structure, stability, and electron transfer properties.
Grinberg, A.V. and Hannemann, F. and Schiffler, B. and Mueller, J. and Heinemann, U. and Bernhardt, R.
Proteins: Structure, Function, and Bioinformatics 40 : 590-612. 1 September 2000

Steroid-binding specificity of human sex hormone-binding globulin is influenced by occupancy of a zinc-binding site.
Avvakumov, G.V. and Muller, Y.A. and Hammond, G.L.
Journal of Biological Chemistry 275 (34): 25920-25925. 25 August 2000

Two exposed amino acid residues confer thermostability on a cold shock protein.
Perl, D. and Mueller, U. and Heinemann, U. and Schmid, F.X.
Nature Structural Biology 7 : 380-383. 1 May 2000

Interaction of fMet-tRNAfMet with the C-terminal domain of translational initiation factor IF2 from Bacillus stearothermophilus.
Krafft, C. and Diehl, A. and Laettig, S. and Behlke, J. and Heinemann, U. and Pon, C.L. and Gualerzi, C.O. and Welfle, H.
FEBS Letters 471 (2-3): 128-132. 14 April 2000

Thermal stability and atomic-resolution crystal structure of the Bacillus caldolyticus cold shock protein.
Mueller, U. and Perl, D. and Schmid, F.X. and Heinemann, U.
Journal of Molecular Biology 297 (4): 975-988. 7 April 2000

Crystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domain.
Grishkovskaya, I. and Avvakumov, G.V. and Sklenar, G. and Dales, D. and Hammond, G.L. and Muller, Y.A.
EMBO Journal 19 (4): 504-512. 15 February 2000

An integrated approach to structural genomics.
Heinemann, U. and Frevert, J. and Hofmann, K.P. and Illing, G. and Maurer, C. and Oschkinat, H. and Saenger, W.
Progress in Biophysics & Molecular Biology 73 (5): 347-362. 1 January 2000

Ligand-binding sites in Ig-like domains of receptor tyrosine kinases.
Wiesmann, C. and Muller, Y.A. and de Vos, A.M.
Journal of Molecular Medicine 78 (5): 247-260. 1 January 2000

Linking structural biology with genome research: The Berlin "Protein Structure Factory" initiative.
Heineman, U. and Frevert, J. and Hofman, K.P. and Illing, G. and Oschkinat, H. and Saenger, W. and Zettl, R.
In: Genomics and Proteomics - Functional and Computational Aspects. Kluwer Acad./Plenum, New York, 179-189. ISBN 978-0-306-46312-9 1 January 2000

Structural biology: the foundation of molecular medicine.
Heinemann, U.
Journal of Molecular Medicine 78 (5): 245-246. 1 January 2000

Structural studies of model RNA helices with relevance to aminoacyl-tRNA synthetase specificity and HIV reverse transcription.
Heinemann, U. and Mueller, U. and Heumann, H. and Sprinzl, M.
Journal of Biomolecular Structure & Dynamics 17 (Special Iss. S1): 39-45. 1 January 2000

1999

Crystallization of the N-terminal domain of human sex hormone-binding globulin, the major sex steroid carrier in blood.
Grishkovskaya, I. and Sklenar, G. and Avvakumov, G.V. and Dales, D. and Behlke, J. and Hammond, G.L. and Muller, Y.A.
Acta Crystallographica Section D 55 (Pt 12): 2053-2055. December 1999

Vertebrate-type and plant-type ferredoxins: Crystal structure comparison and electron transfer pathway modelling.
Mueller, J.J. and Mueller, A. and Rottmann, M. and Bernhardt, R. and Heinemann, U.
Journal of Molecular Biology 294 (2): 501-513. 26 November 1999

Disorder and twin refinement of RNA heptamer double helices.
Mueller, U. and Muller, Y.A. and Herbst-Irmer, R. and Sprinzl, M. and Heinemann, U.
Acta Crystallographica Section D 55 Part 8 : 1405-1413. 1 August 1999

Crystal structure of acceptor stem of tRNA(Ala) from Escherichia coli shows unique G * U wobble base pair at 1.16 angstrom resolution.
Mueller, U. and Schuebel, H. and Sprinzl, M. and Heinemann, U.
RNA 5 : 670-677. 1 May 1999

The Opitz syndrome gene product, MID1, associates with microtubules.
Schweiger, S. and Foerster, J. and Lehman, T. and Suckow, V. and Muller, Y.A. and Walter, G. and Davies, T. and Porter, H. and van Bokhoven, H. and Lunt, P.W. and Traub, P. and Ropers, H.H.
Proceedings of the National Academy of Sciences of the United States of America 96 : 2794-2799. 16 March 1999

Crystallization and X-ray diffraction data of a tRNA(Sec) acceptor-stem helix.
Foerster, C. and Eickmann, A. and Schubert, U. and Hollmann, S. and Mueller, U. and Heinemann, U. and Fuerste, J.P.
Acta Crystallographica Section D 55 Pt.3 : 664-666. 1 March 1999

Preliminary characterization by X-ray diffraction and Raman spectroscopy of a crystalline complex of Bacillus stearothermophilus initiation factor 2 C-domain and fMet-tRNA(fMet).
Foerster, C. and Krafft, C. and Welfle, H. and Gualerzi, C.O. and Heinemann, U.
Acta Crystallographica Section D 55 Pt. 3 : 712-716. 1 March 1999

Comparing crystallographic and solution structures of nitrogenase complexes.
Grossmann, J.G. and Hasnain, S.S. and Yousafzai, F.K. and Smith, B.E. and Eady, R.R. and Schindelin, H. and Kisker, C. and Howard, J.B. and Tsuruta, H. and Mueller, J. and Rees, D.C.
Acta Crystallographica Section D 55 : 727-728. 1 January 1999

1998

VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 angstrom resolution and mutational analysis of the interface.
Muller, Y.A. and Chen, Y. and Christinger, H.W. and Li, B. and Cunningham, B.C. and Lowman, H.B. and deVos, A.M.
Structure 6 (9): 1153-1167. 15 September 1998

Crystal structure of an eight-base pair duplex containing the 3'-DNA-RNA-5' junction formed during initiation of minus-strand synthesis of HIV replication.
Mueller, U. and Maier, G. and Onori, A.M. and Cellai, L. and Heumann, H. and Heinemann, U.
Biochemistry 37 : 12005-12011. 1 September 1998

Structure and function of the Bacillus hybrid enzyme GluXyn-1: Native-like jellyroll fold preserved after insertion of autonomous globular domain.
Ay, J. and Goetz, F. and Borriss, R. and Heinemann, U.
Proceedings of the National Academy of Sciences of the United States of America 95 (12): 6613-6618. 9 June 1998

New aspects of electron transfer revealed by the crystal structure of a truncated bovine adrenodoxin, Adx(4-108).
Mueller, A. and Mueller, J.J. and Muller, Y.A. and Uhlmann, H. and Bernhardt, R. and Heinemann, U.
Structure 6 (3): 269-280. 15 March 1998

Crystal structure of barley 1,3-1,4-beta-glucanase at 2.0-A resolution and comparison with Bacillus 1,3-1,4-beta-glucanase.
Mueller, J.J. and Thomsen, K.K. and Heinemann, U.
Journal of Biological Chemistry 273 (6): 3438-3446. 6 February 1998

Crystal structures and properties of de novo circularly permuted 1,3-1,4-beta-glucanases.
Ay, J. and Hahn, M. and Decanniere, K. and Piotukh, K. and Borriss, R. and Heinemann, U.
Proteins: Structure, Function, and Bioinformatics 30 : 155-167. 1 January 1998

Detection of a monomeric intermediate associated with dimerization of protein HU by mass spectrometry.
Vis, H. and Heinemann, U. and Dobson, C.M. and Robinson, C.V.
Journal of the American Chemical Society 120 : 6427-6428. 1 January 1998

Hinge bending within the cytokine receptor superfamily revealed by the 2.4 A crystal structure of the extracellular domain of rabbit tissue factor.
Muller, Y.A. and Kelley, R.F. and de Vos, A.M.
Protein Science 7 : 1106-1115. 1 January 1998

Potential modelling of acrylic acid copolymer nanoparticles by small angle X-ray scattering.
Lukowski, G. and Mueller, J.J.
International Journal of Pharmaceutics 168 : 173-179. 1 January 1998

Roentgenstrukturanalyse grosser Biomolekuele. Wie die dreidimensionale Strukturaufklaerung die Biochemie revolutioniert.
Muller, Y.A. and Heinemann, U.
Chemie in unserer Zeit 32 : 22-33. 1 January 1998

Structure of adrenodoxin and function in mitochondrial steroid hydroxylation.
Bernhardt, R. and Mueller, A. and Uhlmann, H. and Grinberg, A. and Mueller, J.J. and Heinemann, U.
Endocrine Research 24 : 531-539. 1 January 1998

1997

The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93 A resolution: multiple copy flexibility and receptor binding.
Muller, Y.A. and Christinger, H.W. and Keyt, B.A. and de Vos, A.M.
Structure with Folding & Design 5 (10): 1325-1338. 15 October 1997

Preparation and crystallization of a cross-linked complex of bovine adrenodoxin and adrenodoxin reductase.
Lapko, A. and Mueller, A. and Heese, O. and Ruckpaul, K. and Heinemann, U.
Proteins: Structure, Function, and Bioinformatics 28 : 289-292. 1 January 1997

1996

The use of small-angle scattering and the maximum-entropy method for shape-model determination from distance-distribution functions.
Mueller, J.J. and Hansen, S. and Puerschel, H.V.
Journal of Applied Crystallography 29 (Pt 5): 547-554. 1 October 1996

Crystallization and preliminary X-ray characterization of the Methanothermus fervidus histones HMfA and HMfB.
Decanniere, K. and Sandman, K. and Reeve, J. and Heinemann, U.
Proteins: Structure, Function, and Bioinformatics 24 : 269-271. 1 January 1996

Crystals of the chemically synthesized acceptor stem of tRNAala from Escherichia coli diffracting to high resolution.
Ott, G. and Doerfler, S. and Sprinzl, M. and Mueller, U. and Heinemann, U.
Acta Crystallographica Section D 52 Part 4 : 871-873. 1 January 1996

Enzymology and folding of natural and engineered bacterial beta-glucanases studied by X- ray crystallography.
Heinemann, U. and Ay, J. and Gaiser, O. and Mueller, J.J. and Ponnuswamy, W.N.
Biological Chemistry 377 : 447-454. 1 January 1996

The maximum-entropy method in small-angle scattering.
Hansen, S. and Mueller, J.J.
In: Maximum Entropy and Bayesian Methods. Kluwer, Netherlands, 69-78. 1996

1995

Glass-capillary collimator for distance compensation and partial monochromatization at rotating-anode X-ray generators.
Mueller, J.J. and Gorny, H.E. and Schmalz, J. and Heinemann, U.
Journal of Applied Crystallography 28 (Pt 6): 853-855. 1 December 1995

Multimodal particle size distribution or fractal surface of acrylic acid copolymer nanoparticles: A small-angle X-ray scattering study using direct Fourier and indirect maximum entropy methods.
Mueller, J.J. and Hansen, S. and Lukowski, G. and Gast, K.
Journal of Applied Crystallography 28 (Pt 6): 774-781. 1 December 1995

Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif.
Engel, K. and Schultz, H. and Martin, F. and Kotlyarov, A. and Plath, K. and Hahn, M. and Heinemann, U. and Gaestel, M.
Journal of Biological Chemistry 270 (45): 27213-27221. 10 November 1995

Crystal structure and site-directed mutagenesis of Bacillus macerans endo-1,3-1,4-beta-glucanase.
Hahn, M. and Olsen, O. and Politz, O. and Borriss, R. and Heinemann, U.
Journal of Biological Chemistry 270 (7): 3081-3088. 17 February 1995

AKIMA interpolation: A tool used in direct slit-length desmearing procedures of non-frequency- limited X-ray scattering curves.
Mueller, J.J. and Mueller, E.C. and Gernat, C. and Kroeber, R.
Journal of Applied Crystallography 28 (Pt 1): 38-42. 1 February 1995

Chemical cross-linking and analytical ultracentrifugation study of the histone-like protein HBsu: Quaternary structure and DNA binding.
Timmermann, C. and Behlke, J. and Ristau, O. and Gerst, H. and Heinemann, U.
Progress Colloid Polymers Science 99 : 74-81. 1 January 1995

Circular permutation of polypeptide chains: implications for protein folding and stability.
Heinemann, U. and Hahn, M.
Progress in Biophysics & Molecular Biology 64 : 121-143. 1 January 1995

Circular permutations of protein sequence: not so rare?
Heinemann, U. and Hahn, M.
Trends in Biochemical Sciences 20 (9): 349-350. 1 January 1995

Computer simulations of X-ray scattering curves: Gelation and crystallization process in amylose solutions.
Mueller, J.J. and Gernat, C. and Schulz, W. and Mueller, E.C. and Vorwerg, W. and Damaschun, G.
Biopolymers 35 : 271-288. 1 January 1995

Crystal and molecular structure at 0.16-nm resolution of the hybrid Bacillus endo-1,3-1,4-beta-D-glucan 4-glucanohydrolase H(A16-M).
Hahn, M. and Keitel, T. and Heinemann, U.
European Journal of Biochemistry 232 (3): 849-858. 1 January 1995

Crystal structure of Bacillus licheniformis 1,3-1,4-beta-D-glucan 4-glucanohydrolase at 1.8A resolution.
Hahn, M. and Pons, J. and Planas, A. and Querol, E. and Heinemann, U.
FEBS Letters 374 : 221-224. 1 January 1995

Crystal structure of an RNA dodecamer containing the Escherichia Coli Shine-Dalgarno sequence.
Schindelin, H. and Zhang, M. and Bald, R. and Fuerste, J.P. and Erdmann, V.A. and Heinemann, U.
Journal of Molecular Biology 249 (3): 595-603. 1 January 1995

Biopolymer-Modellierung mit erhoehter Strukturaufloesung unter Verwendung von Roentgen-Weitwinkelstreudaten und der Datenbank OBIOSCAT.
Mueller, E.C. and Mueller, J.J.
In: Strukturuntersuchungen an nichtkristallinen und partiellkristalinen Stoffen. Universitaet Jena, Jena, 204-216. 1995

1994

A study of high-resolution x-ray scattering data evaluation by the maximum-entropy method.
Mueller, J.J. and Hansen, S.
Journal of Applied Crystallography 27 (Pt 3): 257-270. 1 June 1994

Crystal structure of CspA, the major cold shock protein of Escherichia coli.
Schindelin, H. and Jiang, W. and Inouye, M. and Heinemann, U.
Proceedings of the National Academy of Sciences of the United States of America 91 (11): 5119-5123. 24 May 1994

Acrylic acid copolymer nanoparticles for drug delivery: structural characterization of nanoparticles by small-angle x-ray scattering.
Mueller, J.J. and Lukowski, G. and Kroeber, R. and Damaschun, G. and Dittgen, M.
Colloid and Polymer Science 272 : 755-769. 1 January 1994

Cation binding to a Bacillus (1,3-1,4)-beta-glucanase. Geometry, affinity and effect on protein stability.
Keitel, T. and Meldgaard, M. and Heinemann, U.
European Journal of Biochemistry 222 : 203-214. 1 January 1994

Crystal structure of chloromuconate cycloisomerase from Alcaligenes eutrophus JMP134 (pJP4) at 3 A resolution.
Hoier, H. and Schloemann, M. and Hammer, A. and Glusker, J.P. and Carrell, H.L. and Goldmann, A. and Stezowski, J.J. and Heinemann, U.
Acta Crystallographica Section D 50 : 75-84. 1 January 1994

Crystallographic studies of DNA helix structure.
Heinemann, U. and Alings, C. and Hahn, M.
Biophysical Chemistry 50 : 157-167. 1 January 1994

Crystallographic study of Glu58Ala RNase T1 x·2'-guanosine monophosphate at 1.9-Å resolution.
Pletinckx, J. and Steyaert, J. and Zegers, I. and Choe, H.W. and Heinemann, U. and Wyns, L.
Biochemistry 33 : 1654-1662. 1 January 1994

Native-like in vivo folding of a circularly permuted jellyroll protein shown by crystal structure analysis.
Hahn, M. and Piotukh, K. and Borriss, R. and Heinemann, U.
Proceedings of the National Academy of Sciences of the United States of America 91 : 10417-10421. 1 January 1994

Structure determination, modeling and site-directed mutagenesis studies.
Hahn, U. and Heinemann, U.
In: Concepts in Protein Egineering and Design. Walter de Gruyter, Berlin, 109-167. 1 January 1994

The cold shock domain: crystal structures of the major shock protein of Bacillus subtilis.
Schindelin, H. and Marahiel, M.A. and Heinemann, U.
In: Structural Biology: The State of the Art. Proceedings of the Eighth Conversation, State University of New York, Albany. Adenine Press, New York, 83-92. 1 January 1994

1993

Cold denaturation-induced conformational changes in phosphoglycerate kinase from yeast.
Damaschun, G. and Damaschun, H. and Gast, K. and Misselwitz, R. and Mueller, J.J. and Pfeil, W. and Zirwer, D.
Biochemistry 32 (30): 7739-7746. 3 August 1993

Universal nucleic acid-binding domain revealed by crystal structure of the B. subtilis major cold-shock protein.
Schindelin, H. and Marahiel, M.A. and Heinemann, U.
Nature 364 (6433): 164-168. 8 July 1993

Conformation of d (GGGATCCC) 2 in crystals and in solution studied by X-ray diffraction, Raman spectroscopy and molecular modelling.
Fabian, H. and Hoelzer, W. and Heinemann, U. and Sklenar, H. and Welfle, H.
Nucleic Acids Research 21 (3): 569-576. 11 February 1993

Conformational stability of the DNA-binding histone-like protein, HBsu, from Bacillus subtilis, and of the four HBsu variants [F29W],[F47W],[F50W] and [F79W].
Welfle, H. and Welfle, K. and Misselwitz, R. and Groch, N. and Heinemann, U.
Journal of Biomolecular Structure & Dynamics 11 : 381-394. 1 January 1993

Conformations and conformational changes of four Phe->Trp variants of the DNA-binding histone-like protein, HBsu, from Bacillus subtilis studied by circular dichroism and fluorescence spectroscopy.
Welfle, H. and Misselwitz, R. and Welfle, K. and Schindelin, H. and Scholtz, A.S. and Heinemann, U.
European Journal of Biochemistry 217 : 849-856. 1 January 1993

Crystallization of barley (1-3,1-4)-beta-glucanase, isoenzyme II.
Keitel, T. and Thomsen, K.K. and Heinemann, U.
Journal of Molecular Biology 232 : 1003-1004. 1 January 1993

DNA helix structure and refinement algorithm: comparison of models for d(CCAGGCm5CTGG) derived from NUCLSQ, TNT, and X-PLOR.
Hahn, M. and Heinemann, U.
Acta Crystallographica Section D 49 : 468-477. 1 January 1993

Molecular and active-site structure of a Bacillus (1-3,1-4)-beta-glucanase.
Keitel, T. and Simon, O. and Borriss, R. and Heinemann, U.
Proceedings of the National Academy of Sciences of the United States of America 90 : 5287-5291. 1 January 1993

Synthesis of the Bacillus subtilis histone-like DNA-binding protein HBsu in Escherichia coli and secretion into the periplasm.
Groch, N. and Hahn, U. and Heinemann, U.
Gene 124 : 99-103. 1 January 1993

Three-dimensional structure of the ternary complex between ribonuclease T1, guanosine 3',5'-bisphosphate and inorganic phosphate at 0.19 nm resolution.
Lenz, A. and Choe, H.W. and Granzin, J. and Heinemann, U. and Saenger, W.
European Journal of Biochemistry 211 : 311-316. 1 January 1993

Trp59 to Tyr substitution enhances the catalytic activity of RNase T1 and of the Tyr to Trp variants in positions 24, 42, and 45.
Grunert, H.P. and Landt, O. and Zierpel-Giesebrecht, M. and Backmann, J. and Heinemann, U. and Saenger, W. and Hahn, U.
Protein Engineering 6 : 739-744. 1 January 1993

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