Browse by Research Team

2023

RIF1 regulates early replication timing in murine B cells.
Malzl, D. and Peycheva, M. and Rahjouei, A. and Gnan, S. and Klein, K.N. and Nazarova, M. and Schoeberl, U.E. and Gilbert, D.M. and Buonomo, S.C.B. and Di Virgilio, M. and Neumann, T. and Pavri, R.
Nature Communications 14 (1): 8049. 11 December 2023

Turning science into cover art.
Dauben, H. and Matic, I. and Kidmose, R.T. and Pedersen, B.P. and Saha, T. and Di Virgilio, M. and Sung, J.H.
Trends in Biochemical Sciences 48 (12): 1009-1011. December 2023

DNA repair and antibody diversification: the 53BP1 paradigm.
Kabrani, E. and Saha, T. and Di Virgilio, M.
Trends in Immunology 44 (10): 782-791. October 2023

RIF1 acts as a gatekeeper of B cell identity during late differentiation.
Rahjouei, A. and Kabrani, E. and Berruezo-Llacuna, M. and Altwasser, R. and Delgado-Benito, V. and Pavri, R. and Di Virgilio, M.
bioRxiv : 2023.07.18.549543v2. 20 July 2023

Disintegration of the NuRD complex in primary human muscle stem cells in critical illness myopathy.
Schneider, J. and Sundaravinayagam, D. and Blume, A. and Marg, A. and Grunwald, S. and Metzler, E. and Escobar, H. and Müthel, S. and Wang, H. and Wollersheim, T. and Weber-Carstens, S. and Akalin, A. and Di Virgilio, M. and Tursun, B. and Spuler, S.
International Journal of Molecular Sciences 24 (3): 2772. 1 February 2023

2022

TSG101 associates with PARP1 and is essential for PARylation and DNA damage-induced NF-κB activation.
Tufan, A.B. and Lazarow, K. and Kolesnichenko, M. and Sporbert, A. and von Kries, J.P. and Scheidereit, C.
EMBO Journal 41 (21): e110372. 2 November 2022

Therapeutic targeting of ATR in alveolar rhabdomyosarcoma.
Dorado Garcia, H. and Pusch, F. and Bei, Y. and von Stebut, J. and Ibáñez, G. and Guillan, K. and Imami, K. and Gürgen, D. and Rolff, J. and Helmsauer, K. and Meyer-Liesener, S. and Timme, N. and Bardinet, V. and Chamorro González, R. and MacArthur, I.C. and Chen, C.Y. and Schulz, J. and Wengner, A.M. and Furth, C. and Lala, B. and Eggert, A. and Seifert, G. and Hundsoerfer, P. and Kirchner, M. and Mertins, P. and Selbach, M. and Lissat, A. and Dubois, F. and Horst, D. and Schulte, J.H. and Spuler, S. and You, D. and Dela Cruz, F. and Kung, A.L. and Haase, K. and Di Virgilio, M. and Scheer, M. and Ortiz, M.V. and Henssen, A.G.
Nature Communications 13 (1): 4297. 25 July 2022

Protection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region.
Balasubramanian, S. and Andreani, M. and Goncalves Andrade, J. and Saha, T. and Sundaravinayagam, D. and Garzón, J. and Zhang, W. and Popp, O. and Hiraga, S. and Rahjouei, A. and Rosen, D.B. and Mertins, P. and Chait, B.T. and Donaldson, A.D. and Di Virgilio, M.
eLife 11 : e75047. 13 April 2022

2021

Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Inak, G. and Rybak-Wolf, A. and Lisowski, P. and Pentimalli, T.M. and Jüttner, R. and Glažar, P. and Uppal, K. and Bottani, E. and Brunetti, D. and Secker, C. and Zink, A. and Meierhofer, D. and Henke, M.T. and Dey, M. and Ciptasari, U. and Mlody, B. and Hahn, T. and Berruezo-Llacuna, M. and Karaiskos, N. and Di Virgilio, M. and Mayr, J.A. and Wortmann, S.B. and Priller, J. and Gotthardt, M. and Jones, D.P. and Mayatepek, E. and Stenzel, W. and Diecke, S. and Kühn, R. and Wanker, E.E. and Rajewsky, N. and Schuelke, M. and Prigione, A.
Nature Communications 12 (1): 1929. 26 March 2021

Charting a DNA repair roadmap for immunoglobulin class switch recombination.
Saha, T. and Sundaravinayagam, D. and Di Virgilio, M.
Trends in Biochemical Sciences 46 (3): 184-199. March 2021

2020

PDGFA-associated protein 1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification.
Delgado-Benito, V. and Berruezo-Llacuna, M. and Altwasser, R. and Winkler, W. and Sundaravinayagam, D. and Balasubramanian, S. and Caganova, M. and Graf, R. and Rahjouei, A. and Henke, M.T. and Driesner, M. and Keller, L. and Prigione, A. and Janz, M. and Akalin, A. and Di Virgilio, M.
Journal of Experimental Medicine 217 (10): e20200137. 5 October 2020

Pdap1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification.
Delgado-Benito, V. and Berruezo-Llacuna, M. and Altwasser, R. and Winkler, W. and Balasubramanian, S. and Sundaravinayagam, D. and Graf, R. and Rahjouei, A. and Driesner, M. and Keller, L. and Janz, M. and Akalin, A. and Di Virgilio, M.
bioRxiv : 2020.01.30.917062. 31 January 2020

2019

53BP1 supports immunoglobulin class switch recombination independently of its DNA double-strand break end protection function.
Sundaravinayagam, D. and Rahjouei, A. and Andreani, M. and Tupiņa, D. and Balasubramanian, S. and Saha, T. and Delgado-Benito, V. and Coralluzzo, V. and Daumke, O. and Di Virgilio, M.
Cell Reports 28 (6): 1389-1399. 6 August 2019

2018

The chromatin reader ZMYND8 regulates Igh enhancers to promote immunoglobulin class switch recombination.
Delgado-Benito, V. and Rosen, D.B. and Wang, Q. and Gazumyan, A. and Pai, J.A. and Oliveira, T.Y. and Sundaravinayagam, D. and Zhang, W. and Andreani, M. and Keller, L. and Kieffer-Kwon, K.R. and Pękowska, A. and Jung, S. and Driesner, M. and Subbotin, R.I. and Casellas, R. and Chait, B.T. and Nussenzweig, M.C. and Di Virgilio, M.
Molecular Cell 72 (4): 636-649. 15 November 2018

SETD1A protects HSCs from activation-induced functional decline in vivo.
Arndt, K. and Kranz, A. and Fohgrub, J. and Jolly, A. and Bledau, A.S. and Di Virgilio, M. and Lesche, M. and Dahl, A. and Höfer, T. and Stewart, A.F. and Waskow, C.
Blood 131 (12): 1311-1324. 22 March 2018

2017

A dual role of Caspase-8 in triggering and sensing proliferation-associated DNA damage, a key determinant of liver cancer development.
Boege, Y. and Malehmir, M. and Healy, M.E. and Bettermann, K. and Lorentzen, A. and Vucur, M. and Ahuja, A.K. and Böhm, F. and Mertens, J.C. and Shimizu, Y. and Frick, L. and Remouchamps, C. and Mutreja, K. and Kähne, T. and Sundaravinayagam, D. and Wolf, M.J. and Rehrauer, H. and Koppe, C. and Speicher, T. and Padrissa-Altés, S. and Maire, R. and Schattenberg, J.M. and Jeong, J.S. and Liu, Lei and Zwirner, S. and Boger, R. and Hüser, N. and Davis, R.J. and Müllhaupt, B. and Moch, H. and Schulze-Bergkamen, H. and Clavien, P.A. and Werner, S. and Borsig, L. and Luther, S.A. and Jost, P.J. and Weinlich, R. and Unger, K. and Behrens, A. and Hillert, L. and Dillon, C. and Di Virgilio, M. and Wallach, D. and Dejardin, E. and Zender, L. and Naumann, M. and Walczak, H. and Green, D.R. and Lopes, M. and Lavrik, I. and Luedde, T. and Heikenwalder, M. and Weber, A.
Cancer Cell 32 (3): 342-359. 11 September 2017

MAD2L2 promotes open chromatin in embryonic stem cells and derepresses the Dppa3 locus.
Rahjouei, A. and Pirouz, M. and Di Virgilio, M. and Kamin, D. and Kessel, M.
Stem Cell Reports 8 (4): 813-821. 11 April 2017

2015

DCLRE1C (ARTEMIS) mutations causing phenotypes ranging from atypical severe combined immunodeficiency to mere antibody deficiency.
Volk, T. and Pannicke, U. and Reisli, I. and Bulashevska, A. and Ritter, J. and Björkman, A. and Schäffer, A.A. and Fliegauf, M. and Sayar, E.H. and Salzer, U. and Fisch, P. and Pfeifer, D. and Di Virgilio, M. and Cao, H. and Yang, F. and Zimmermann, K. and Keles, S. and Caliskaner, Z. and Güner, S.Ü. and Schindler, D. and Hammarström, L. and Rizzi, M. and Hummel, M. and Pan-Hammarstroem, Q. and Schwarz, K. and Grimbacher, B.
Human Molecular Genetics 24 (25): 7361-7372. 20 December 2015

PI3 kinase and FOXO1 transcription factor activity differentially control B cells in the germinal center light and dark zones.
Sander, S. and Chu, V.T. and Yasuda, T. and Franklin, A. and Graf, R. and Calado, D.P. and Li, S. and Imami, K. and Selbach, M. and Di Virgilio, M. and Bullinger, L. and Rajewsky, K.
Immunity 43 (6): 1075-1086. 15 December 2015

An inherited immunoglobulin class-switch recombination deficiency associated with a defect in the INO80 chromatin remodeling complex.
Kracker, S. and Di Virgilio, M. and Schwartzentruber, J. and Cuenin, C. and Forveille, M. and Deau, M.C. and McBride, K.M. and Majewski, J. and Gazumyan, A. and Seneviratne, S. and Grimbacher, B. and Kutukculer, N. and Herceg, Z. and Cavazzana, M. and Jabado, N. and Nussenzweig, M.C. and Fischer, A. and Durandy, A.
Journal of Allergy and Clinical Immunology 135 (4): 998-1007. April 2015

2013

53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.
Callen, E. and Di Virgilio, M. and Kruhlak, M.J. and Nieto-Soler, M. and Wong, N. and Chen, H.T. and Faryabi, R.B. and Polato, F. and Santos, M. and Starnes, L.M. and Wesemann, D.R. and Lee, J.E. and Tubbs, A. and Sleckman, B.P. and Daniel, J.A. and Ge, K. and Alt, F.W. and Fernandez-Capetillo, O. and Nussenzweig, M.C. and Nussenzweig, A.
Cell 153 (6): 1266-1280. 6 June 2013

Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching.
Di Virgilio, M. and Callen, E. and Yamane, A. and Zhang, W. and Jankovic, M. and Gitlin, A.D. and Feldhahn, N. and Resch, W. and Oliveira, T.Y. and Chait, B.T. and Nussenzweig, A. and Casellas, R. and Robbiani, D.F. and Nussenzweig, M.C.
Science 339 (6120): 711-715. 8 February 2013

2011

Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes.
Klein, I.A. and Resch, W. and Jankovic, M. and Oliveira, T. and Yamane, A. and Nakahashi, H. and Di Virgilio, M. and Bothmer, A. and Nussenzweig, A. and Robbiani, D.F. and Casellas, R. and Nussenzweig, M.C.
Cell 147 (1): 95-106. 30 September 2011

Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1.
Bothmer, A. and Robbiani, D.F. and Di Virgilio, M. and Bunting, S.F. and Klein, I.A. and Feldhahn, N. and Barlow, J. and Chen, H.T. and Bosque, D. and Callen, E. and Nussenzweig, A. and Nussenzweig, M.C.
Molecular Cell 42 (3): 319-329. 6 May 2011

Amino-terminal phosphorylation of activation-induced cytidine deaminase suppresses c-myc/IgH translocation.
Gazumyan, A. and Timachova, K. and Yuen, G. and Siden, E. and Di Virgilio, M. and Woo, E.M. and Chait, B.T. and Reina San-Martin, B. and Nussenzweig, M.C. and McBride, K.M.
Molecular and Cellular Biology 31 (3): 442-429. February 2011

2010

Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5.
Pavri, R. and Gazumyan, A. and Jankovic, M. and Di Virgilio, M. and Klein, I. and Ansarah-Sobrinho, C. and Resch, W. and Yamane, A. and Reina San-Martin, B. and Barreto, V. and Nieland, T.J. and Root, D.E. and Casellas, R. and Nussenzweig, M.C.
Cell 143 (1): 122-133. 1 October 2010

2009

PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin.
Di Virgilio, M. and Ying, C.Y. and Gautier, J.
DNA Repair 8 (11): 1311-1320. 2 November 2009

Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes.
Callen, E. and Jankovic, M. and Wong, N. and Zha, S. and Chen, H.T. and Difilippantonio, S. and Di Virgilio, M. and Heidkamp, G. and Alt, F.W. and Nussenzweig, A. and Nussenzweig, M.
Molecular Cell 34 (3): 285-297. 15 May 2009

2008

MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation.
Dorsett, Y. and McBride, K.M. and Jankovic, M. and Gazumyan, A. and Thai, T.H. and Robbiani, D.F. and Di Virgilio, M. and Reina San-Martin, B. and Heidkamp, G. and Schwickert, T.A. and Eisenreich, T. and Rajewsky, K. and Nussenzweig, M.C.
Immunity 28 (5): 630-638. 16 May 2008

2005

Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11.
Di Virgilio, M. and Gautier, J.
Journal of Cell Biology 171 (5): 765-771. 5 December 2005

2002

Novel pathogenic mechanisms of congenital insensitivity to pain with anhidrosis genetic disorder unveiled by functional analysis of neurotrophic tyrosine receptor kinase type 1/nerve growth factor receptor mutations.
Miranda, C. and Di Virgilio, M. and Selleri, S. and Zanotti, G. and Pagliardini, S. and Pierotti, M.A. and Greco, A.
Journal of Biological Chemistry 277 (8): 6455-6462. 22 February 2002