Browse by Research Team

Annual Review of Cell and Developmental Biology

Diversification of antibodies: from V(D)J recombination to somatic exon shuffling.
Lebedin, M. and de la Rosa, K.
Annual Review of Cell and Developmental Biology 40 (1): 265-281. October 2024

BIOspektrum

Pandemieforschung: von Autoantikörpern und Impfstoff-Innovationen.
de la Rosa, K.
BIOspektrum 29 (6): 614-616. October 2023

Bio-protocol

Application of a spacer-nick gene-targeting approach to repair disease-causing mutations with increased safety.
Tran, N.T., Lebedin, M., Danner, E., Kühn, R., Rajewsky, K. and Chu, V.T.
Bio-protocol 13 (8): e4661. 20 April 2023

European Journal of Immunology

A design strategy to generate a SARS-CoV-2 RBD vaccine that abrogates ACE2 binding and improves neutralizing antibody responses.
Ratswohl, C., Vázquez García, C., Ahmad, A.U.W., Gonschior, H., Lebedin, M., Silvis, C.E., Spatt, L., Gerhard, C., Lehmann, M., Sander, L.E., Kurth, F., Olsson, S. and de la Rosa, K.
European Journal of Immunology 53 (10): e2350408. October 2023

Discriminating promiscuous from target-specific autoantibodies in COVID-19.
Lebedin, M., Vazquez Garcia, C., Spatt, L., Ratswohl, C., Thibeault, C., Ostendorf, L., Alexander, T., Paul, F., Sander, L.E., Kurth, F. and de la Rosa, K.
European Journal of Immunology 53 (5): e2250210. May 2023

Frontiers in Immunology

LMP1 and EBNA2 constitute a minimal set of EBV genes for transformation of human B cells.
Zhang, J., Sommermann, T., Li, X., Gieselmann, L., de la Rosa, K., Stecklum, M., Klein, F., Kocks, C. and Rajewsky, K.
Frontiers in Immunology 14 : 1331730. 19 December 2023

A barcoded flow cytometric assay to explore the antibody responses against SARS-CoV-2 spike and its variants.
Vesper, N., Ortiz, Y., Bartels-Burgahn, F., Yang, J., de la Rosa, K., Tenbusch, M., Schulz, S., Finzel, S., Jäck, H.M., Eibel, H., Voll, R.E. and Reth, M.
Frontiers in Immunology 12 : 730766. September 2021

Journal of Allergy and Clinical Immunology

A common single nucleotide polymorphism impairs B-cell activating factor receptor's multimerization, contributing to common variable immunodeficiency.
Pieper, K., Rizzi, M., Speletas, M., Smulski, C.R., Sic, H., Kraus, H., Salzer, U., Fiala, G.J., Schamel, W.W., Lougaris, V., Plebani, A., Hammarstrom, L., Recher, M., Germenis, A.E., Grimbacher, B., Warnatz, K., Rolink, A.G., Schneider, P., Notarangelo, L.D. and Eibel, H.
Journal of Allergy and Clinical Immunology 133 (4): 1222-1225. April 2014

B-cell biology and development.
Pieper, K., Grimbacher, B. and Eibel, H.
Journal of Allergy and Clinical Immunology 131 (4): 959-971. April 2013

Journal of Immunology

Orientation regulation of class-switch recombination in human B cells.
Du, L., Oksenych, V., Wan, H., Ye, X., Dong, J., Ye, A.Y., Abolhassani, H., Vlachiotis, S., Zhang, X., de la Rosa, K., Hammarström, L., van der Burg, M., Alt, F.W. and Pan-Hammarström, Q.
Journal of Immunology 213 (8): 1093-1104. 15 October 2024

Journal of Neurology Neurosurgery and Psychiatry

SARS-CoV-2 mRNA vaccinations fail to elicit humoral and cellular immune responses in patients with multiple sclerosis receiving fingolimod.
Meyer-Arndt, L., Braun, J., Fauchere, F., Vanshylla, K., Loyal, L., Henze, L., Kruse, B., Dingeldey, M., Jürchott, K., Mangold, M., Maraj, A., Braginets, A., Böttcher, C., Nitsche, A., de la Rosa, K., Ratswohl, C., Sawitzki, B., Holenya, P., Reimer, U., Sander, L.E., Klein, F., Paul, F., Bellmann-Strobl, J., Thiel, A. and Giesecke-Thiel, C.
Journal of Neurology Neurosurgery and Psychiatry 93 (9): 960-971. September 2022

Med

A public health antibody screening indicates a 6-fold higher SARS-CoV-2 exposure rate than reported cases in children.
Hippich, M., Holthaus, L., Assfalg, R., Zapardiel Gonzalo, J.M., Kapfelsperger, H., Heigermoser, M., Haupt, F., Ewald, D.A., Welzhofer, T.C., Marcus, B.A., Heck, S., Koelln, A., Stock, J., Voss, F., Secchi, M., Piemonti, L., de la Rosa, K., Protzer, U., Boehmer, M., Achenbach, P., Lampasona, V., Bonifacio, E. and Ziegler, A.G.
Med 2 (2): 149-163. 12 February 2021

Nature

Public antibodies to malaria antigens generated by two LAIR1 insertion modalities.
Pieper, K., Tan, J., Piccoli, L., Foglierini, M., Barbieri, S., Chen, Y., Silacci-Fregni, C., Wolf, T., Jarrossay, D., Anderle, M., Abdi, A., Ndungu, F.M., Doumbo, O.K., Traore, B., Tran, T.M., Jongo, S., Zenklusen, I., Crompton, P.D., Daubenberger, C., Bull, P.C., Sallusto, F. and Lanzavecchia, A.
Nature 548 (7669): 597-601. 31 August 2017

A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens.
Tan, J., Pieper, K., Piccoli, L., Abdi, A., Foglierini, M., Geiger, R., Tully, C.M., Jarrossay, D., Ndungu, F.M., Wambua, J., Bejon, P., Silacci Fregni, C., Fernandez-Rodriguez, B., Barbieri, S., Bianchi, S., Marsh, K., Thathy, V., Corti, D., Sallusto, F., Bull, P. and Lanzavecchia, A.
Nature 529 (7584): 105-109. 7 January 2016

Open Biology

A homology independent sequence replacement strategy in human cells using a CRISPR nuclease.
Danner, E., Lebedin, M., de la Rosa, K. and Kühn, R.
Open Biology 11 (1): 200283. January 2021

Proceedings of the National Academy of Sciences of the United States of America

Different classes of genomic inserts contribute to human antibody diversity.
Lebedin, M., Foglierini, M., Khorkova, S., Vázquez García, C., Ratswohl, C., Davydov, A.N., Turchaninova, M.A., Daubenberger, C., Chudakov, D.M., Lanzavecchia, A. and de la Rosa, K.
Proceedings of the National Academy of Sciences of the United States of America 119 (36): e2205470119. 6 September 2022

Science Advances

Precise CRISPR/Cas-mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells.
Tran, N.T., Danner, E., Li, X., Graf, R., Lebedin, M., de la Rosa, K., Kühn, R., Rajewsky, K. and Chu, V.T.
Science Advances 8 (22): eabm9106. 3 June 2022

Science Immunology

Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis.
Li, X., Wirtz, T., Weber, T., Lebedin, M., Lowenstein, E.D., Sommermann, T., Zach, A., Yasuda, T., de la Rosa, K., Chu, V.T., Schulte, J.H., Müller, I., Kocks, C. and Rajewsky, K.
Science Immunology 9 (92): eadi0042. 2 February 2024

Incomplete genetic reconstitution of B cell pools contributes to prolonged immunosuppression after measles.
Petrova, V.N., Sawatsky, B., Han, A.X., Laksono, B.M., Walz, L., Parker, E., Pieper, K., Anderson, C.A., de Vries, R.D., Lanzavecchia, A., Kellam, P., von Messling, V., de Swart, R.L. and Russell, C.A.
Science Immunology 4 (41): eaay6125. 1 November 2019

Scientific Reports

A bead-based multiplex assay covering all coronaviruses pathogenic for humans for sensitive and specific surveillance of SARS-CoV-2 humoral immunity.
Stern, D., Meyer, T.C., Treindl, F., Mages, H.W., Krüger, M., Skiba, M., Krüger, J.P., Zobel, C.M., Schreiner, M., Grossegesse, M., Rinner, T., Peine, C., Stoliaroff-Pépin, A., Harder, T., Hofmann, N., Michel, J., Nitsche, A., Stahlberg, S., Kneuer, A., Sandoni, A., Kubisch, U., Schlaud, M., Mankertz, A., Schwarz, T., Corman, V.M., Müller, M.A., Drosten, C., de la Rosa, K., Schaade, L., Dorner, M.B. and Dorner, B.G.
Scientific Reports 13 (1): 21846. 9 December 2023

bioRxiv

SARS-CoV-2 neutralization and protection of hamsters via nasal administration of a humanized neutralizing antibody.
Lebedin, M., Petrovsky, N., Tabynov, K., Tabynov, K. and Lebedin, Y.
bioRxiv : 2024.07.08.602557. 8 July 2024

iScience

Soluble ACE2 correlates with severe COVID-19 and can impair antibody responses.
Lebedin, M., Ratswohl, C., Garg, A., Schips, M., Vazquez Garcia, C., Spatt, L., Thibeault, C., Obermayer, B., Weiner, J., Moreno Velásquez, I., Gerhard, C., Stubbemann, P., Hanitsch, L.G., Pischon, T., Witzenrath, M., Sander, L.E., Kurth, F., Meyer-Hermann, M. and de la Rosa, K.
iScience 27 (3): 109330. 15 March 2024