2025
Recombination junctions from antibody isotype switching classify immune and DNA repair dysfunction.
Vázquez García, Clara 
ORCID: https://orcid.org/0000-0003-4583-7616, Obermayer, Benedikt ORCID: https://orcid.org/0000-0002-9116-630X, Keller, Baerbel, Lebedin, Mikhail ORCID: https://orcid.org/0000-0002-3877-7195, Ratswohl, Christoph ORCID: https://orcid.org/0000-0001-5413-0730, Abolhassani, Hassan ORCID: https://orcid.org/0000-0002-4838-0407, Busse, Antonia ORCID: https://orcid.org/0000-0002-3470-6947, Di Virgilio, Michela ORCID: https://orcid.org/0000-0001-5189-0793, Mathas, Stephan ORCID: https://orcid.org/0000-0001-9626-1413, Speiser, Dorothee, Beule, Dieter ORCID: https://orcid.org/0000-0002-3284-0632, Pan-Hammarström, Qiang ORCID: https://orcid.org/0000-0003-1990-8804, Warnatz, Klaus ORCID: https://orcid.org/0000-0002-1172-865X and de la Rosa, Kathrin ORCID: https://orcid.org/0000-0003-4809-3157
Nature Communications 16
(1): 11331.
19 December 2025
SARS-CoV-2 neutralization and protection of hamsters via nasal administration of a humanized neutralizing antibody.
Lebedin, Mikhail ORCID: https://orcid.org/0000-0002-3877-7195, Petrovsky, Nikolai ORCID: https://orcid.org/0000-0002-1580-5245, Tabynov, Kairat, Tabynov, Kaissar and Lebedin, Yuri
Antiviral Research 241
: 106235.
September 2025
New MERS-CoV Vaccine.
Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft.
EP-4499140-A1.
5 February 2025
2024
Orientation regulation of class-switch recombination in human B cells.
Du, L. ORCID: https://orcid.org/0000-0002-8448-2187, Oksenych, V., Wan, H., Ye, X., Dong, J., Ye, A.Y., Abolhassani, H. ORCID: https://orcid.org/0000-0002-4838-0407, Vlachiotis, S., Zhang, X., de la Rosa, K. ORCID: https://orcid.org/0000-0003-4809-3157, Hammarström, L., van der Burg, M., Alt, F.W. and Pan-Hammarström, Q. ORCID: https://orcid.org/0000-0003-1990-8804
Journal of Immunology 213
(8): 1093-1104.
15 October 2024
Diversification of antibodies: from V(D)J recombination to somatic exon shuffling.
Lebedin, M. ORCID: https://orcid.org/0000-0002-3877-7195 and de la Rosa, K. ORCID: https://orcid.org/0000-0003-4809-3157
Annual Review of Cell and Developmental Biology 40
(1): 265-281.
October 2024
LONG-read sequencing of human immunoglobulin gene introns to define a biomarker for in vivo DNA break repair.
Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft.
WO-2024194255-A1.
26 September 2024
New coronavirus vaccine and method for designing and obtaining a virus vaccine.
Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft.
EP-4396198-A2.
10 July 2024
Soluble ACE2 correlates with severe COVID-19 and can impair antibody responses.
Lebedin, M. ORCID: https://orcid.org/0000-0002-3877-7195, Ratswohl, C. ORCID: https://orcid.org/0000-0001-5413-0730, Garg, A., Schips, M., Vazquez Garcia, C. ORCID: https://orcid.org/0000-0003-4583-7616, Spatt, L., Thibeault, C., Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Weiner, J. ORCID: https://orcid.org/0000-0003-1438-7819, Moreno Velásquez, I. ORCID: https://orcid.org/0000-0001-6058-8983, Gerhard, C. ORCID: https://orcid.org/0000-0001-6956-7249, Stubbemann, P., Hanitsch, L.G., Pischon, T. ORCID: https://orcid.org/0000-0003-1568-767X, Witzenrath, M., Sander, L.E., Kurth, F., Meyer-Hermann, M. and de la Rosa, K. ORCID: https://orcid.org/0000-0003-4809-3157
iScience 27
(3): 109330.
15 March 2024
Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis.
Li, X. ORCID: https://orcid.org/0000-0002-1173-1066, Wirtz, T. ORCID: https://orcid.org/0009-0005-5677-9804, Weber, T. ORCID: https://orcid.org/0000-0003-2079-842X, Lebedin, M. ORCID: https://orcid.org/0000-0002-3877-7195, Lowenstein, E.D. ORCID: https://orcid.org/0000-0003-3755-0818, Sommermann, T. ORCID: https://orcid.org/0000-0003-2899-0256, Zach, A., Yasuda, T. ORCID: https://orcid.org/0000-0001-9997-6852, de la Rosa, K. ORCID: https://orcid.org/0000-0003-4809-3157, Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696, Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201, Müller, I. ORCID: https://orcid.org/0000-0002-7477-6632, Kocks, C. ORCID: https://orcid.org/0000-0003-1749-3334 and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Science Immunology 9
(92): eadi0042.
2 February 2024
2023
LMP1 and EBNA2 constitute a minimal set of EBV genes for transformation of human B cells.
Zhang, J., Sommermann, T. ORCID: https://orcid.org/0000-0003-2899-0256, Li, X. ORCID: https://orcid.org/0000-0002-1173-1066, Gieselmann, L., de la Rosa, K. ORCID: https://orcid.org/0000-0003-4809-3157, Stecklum, M., Klein, F., Kocks, C. ORCID: https://orcid.org/0000-0003-1749-3334 and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Frontiers in Immunology 14
: 1331730.
19 December 2023
A bead-based multiplex assay covering all coronaviruses pathogenic for humans for sensitive and specific surveillance of SARS-CoV-2 humoral immunity.
Stern, D., Meyer, T.C., Treindl, F., Mages, H.W., Krüger, M., Skiba, M., Krüger, J.P., Zobel, C.M., Schreiner, M., Grossegesse, M., Rinner, T., Peine, C., Stoliaroff-Pépin, A., Harder, T., Hofmann, N., Michel, J., Nitsche, A., Stahlberg, S., Kneuer, A., Sandoni, A., Kubisch, U., Schlaud, M., Mankertz, A., Schwarz, T., Corman, V.M., Müller, M.A., Drosten, C., de la Rosa, K. ORCID: https://orcid.org/0000-0003-4809-3157, Schaade, L., Dorner, M.B. and Dorner, B.G.
Scientific Reports 13
(1): 21846.
9 December 2023
A design strategy to generate a SARS-CoV-2 RBD vaccine that abrogates ACE2 binding and improves neutralizing antibody responses.
Ratswohl, C. ORCID: https://orcid.org/0000-0001-5413-0730, Vázquez García, C. ORCID: https://orcid.org/0000-0003-4583-7616, Ahmad, A.U.W. ORCID: https://orcid.org/0009-0003-0734-7904, Gonschior, H. ORCID: https://orcid.org/0000-0002-1775-8120, Lebedin, M. ORCID: https://orcid.org/0000-0002-3877-7195, Silvis, C.E. ORCID: https://orcid.org/0009-0005-0433-2197, Spatt, L., Gerhard, C. ORCID: https://orcid.org/0000-0001-6956-7249, Lehmann, M. ORCID: https://orcid.org/0000-0002-8370-6353, Sander, L.E. ORCID: https://orcid.org/0000-0002-0476-9947, Kurth, F. ORCID: https://orcid.org/0000-0002-3807-473X, Olsson, S. ORCID: https://orcid.org/0000-0002-3927-7897 and de la Rosa, K. ORCID: https://orcid.org/0000-0003-4809-3157
European Journal of Immunology 53
(10): e2350408.
October 2023
Pandemieforschung: von Autoantikörpern und Impfstoff-Innovationen.
de la Rosa, K. ORCID: https://orcid.org/0000-0003-4809-3157
BIOspektrum 29
(6): 614-616.
October 2023
New MERS-CoV Vaccine.
Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft.
22164013.9.
27 September 2023
Discriminating promiscuous from target-specific autoantibodies in COVID-19.
Lebedin, M. ORCID: https://orcid.org/0000-0002-3877-7195, Vazquez Garcia, C. ORCID: https://orcid.org/0000-0003-4583-7616, Spatt, L., Ratswohl, C. ORCID: https://orcid.org/0000-0001-5413-0730, Thibeault, C., Ostendorf, L. ORCID: https://orcid.org/0000-0003-3553-6406, Alexander, T. ORCID: https://orcid.org/0000-0003-1193-0097, Paul, F. ORCID: https://orcid.org/0000-0002-6378-0070, Sander, L.E., Kurth, F. and de la Rosa, K. ORCID: https://orcid.org/0000-0003-4809-3157
European Journal of Immunology 53
(5): e2250210.
May 2023
Application of a spacer-nick gene-targeting approach to repair disease-causing mutations with increased safety.
Tran, N.T. ORCID: https://orcid.org/0000-0003-0896-8641, Lebedin, M. ORCID: https://orcid.org/0000-0002-3877-7195, Danner, E. ORCID: https://orcid.org/0000-0003-3277-5727, Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696
Bio-protocol 13
(8): e4661.
20 April 2023
2022
Different classes of genomic inserts contribute to human antibody diversity.
Lebedin, M. ORCID: https://orcid.org/0000-0002-3877-7195, Foglierini, M., Khorkova, S. ORCID: https://orcid.org/0000-0002-7873-2290, Vázquez García, C. ORCID: https://orcid.org/0000-0003-4583-7616, Ratswohl, C. ORCID: https://orcid.org/0000-0001-5413-0730, Davydov, A.N., Turchaninova, M.A. ORCID: https://orcid.org/0000-0002-8874-0286, Daubenberger, C. ORCID: https://orcid.org/0000-0001-7136-0642, Chudakov, D.M. ORCID: https://orcid.org/0000-0003-0430-790X, Lanzavecchia, A. and de la Rosa, K. ORCID: https://orcid.org/0000-0003-4809-3157
Proceedings of the National Academy of Sciences of the United States of America 119
(36): e2205470119.
6 September 2022
SARS-CoV-2 mRNA vaccinations fail to elicit humoral and cellular immune responses in patients with multiple sclerosis receiving fingolimod.
Meyer-Arndt, L. ORCID: https://orcid.org/0000-0002-7909-020X, Braun, J., Fauchere, F., Vanshylla, K., Loyal, L., Henze, L., Kruse, B., Dingeldey, M., Jürchott, K., Mangold, M., Maraj, A., Braginets, A., Böttcher, C. ORCID: https://orcid.org/0000-0002-6226-586X, Nitsche, A., de la Rosa, K. ORCID: https://orcid.org/0000-0003-4809-3157, Ratswohl, C. ORCID: https://orcid.org/0000-0001-5413-0730, Sawitzki, B., Holenya, P., Reimer, U. ORCID: https://orcid.org/0000-0002-3375-6889, Sander, L.E., Klein, F., Paul, F. ORCID: https://orcid.org/0000-0002-6378-0070, Bellmann-Strobl, J. ORCID: https://orcid.org/0000-0003-2615-1643, Thiel, A. and Giesecke-Thiel, C. ORCID: https://orcid.org/0000-0002-5927-7018
Journal of Neurology Neurosurgery and Psychiatry 93
(9): 960-971.
September 2022
Precise CRISPR/Cas-mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells.
Tran, N.T. ORCID: https://orcid.org/0000-0003-0896-8641, Danner, E. ORCID: https://orcid.org/0000-0003-3277-5727, Li, X. ORCID: https://orcid.org/0000-0002-1173-1066, Graf, R. ORCID: https://orcid.org/0000-0002-5400-9938, Lebedin, M. ORCID: https://orcid.org/0000-0002-3877-7195, de la Rosa, K. ORCID: https://orcid.org/0000-0003-4809-3157, Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696
Science Advances 8
(22): eabm9106.
3 June 2022
2021
A barcoded flow cytometric assay to explore the antibody responses against SARS-CoV-2 spike and its variants.
Vesper, N., Ortiz, Y., Bartels-Burgahn, F., Yang, J., de la Rosa, K. ORCID: https://orcid.org/0000-0003-4809-3157, Tenbusch, M., Schulz, S., Finzel, S., Jäck, H.M., Eibel, H., Voll, R.E. and Reth, M.
Frontiers in Immunology 12
: 730766.
September 2021
A public health antibody screening indicates a 6-fold higher SARS-CoV-2 exposure rate than reported cases in children.
Hippich, M., Holthaus, L., Assfalg, R., Zapardiel Gonzalo, J.M., Kapfelsperger, H., Heigermoser, M., Haupt, F., Ewald, D.A., Welzhofer, T.C., Marcus, B.A., Heck, S., Koelln, A., Stock, J., Voss, F., Secchi, M., Piemonti, L., de la Rosa, K. ORCID: https://orcid.org/0000-0003-4809-3157, Protzer, U., Boehmer, M., Achenbach, P., Lampasona, V., Bonifacio, E. and Ziegler, A.G.
Med 2
(2): 149-163.
12 February 2021
A homology independent sequence replacement strategy in human cells using a CRISPR nuclease.
Danner, E. ORCID: https://orcid.org/0000-0003-3277-5727, Lebedin, M. ORCID: https://orcid.org/0000-0002-3877-7195, de la Rosa, K. ORCID: https://orcid.org/0000-0003-4809-3157 and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Open Biology 11
(1): 200283.
January 2021
2019
Incomplete genetic reconstitution of B cell pools contributes to prolonged immunosuppression after measles.
Petrova, V.N., Sawatsky, B., Han, A.X., Laksono, B.M., Walz, L., Parker, E., Pieper, K. ORCID: https://orcid.org/0000-0003-4809-3157, Anderson, C.A., de Vries, R.D., Lanzavecchia, A., Kellam, P., von Messling, V., de Swart, R.L. and Russell, C.A.
Science Immunology 4
(41): eaay6125.
1 November 2019
2017
Public antibodies to malaria antigens generated by two LAIR1 insertion modalities.
Pieper, K. ORCID: https://orcid.org/0000-0003-4809-3157, Tan, J., Piccoli, L., Foglierini, M., Barbieri, S., Chen, Y., Silacci-Fregni, C., Wolf, T., Jarrossay, D., Anderle, M., Abdi, A., Ndungu, F.M., Doumbo, O.K., Traore, B., Tran, T.M., Jongo, S., Zenklusen, I., Crompton, P.D., Daubenberger, C., Bull, P.C., Sallusto, F. and Lanzavecchia, A.
Nature 548
(7669): 597-601.
31 August 2017
2016
A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens.
Tan, J., Pieper, K. ORCID: https://orcid.org/0000-0003-4809-3157, Piccoli, L., Abdi, A., Foglierini, M., Geiger, R. ORCID: https://orcid.org/0000-0002-8016-1669, Tully, C.M., Jarrossay, D., Ndungu, F.M. ORCID: https://orcid.org/0000-0002-8977-0030, Wambua, J., Bejon, P., Silacci Fregni, C., Fernandez-Rodriguez, B., Barbieri, S., Bianchi, S. ORCID: https://orcid.org/0000-0002-5100-8905, Marsh, K., Thathy, V. ORCID: https://orcid.org/0000-0001-7797-8638, Corti, D., Sallusto, F., Bull, P. ORCID: https://orcid.org/0000-0002-7674-6752 and Lanzavecchia, A.
Nature 529
(7584): 105-109.
7 January 2016
2014
A common single nucleotide polymorphism impairs B-cell activating factor receptor's multimerization, contributing to common variable immunodeficiency.
Pieper, K. ORCID: https://orcid.org/0000-0003-4809-3157, Rizzi, M., Speletas, M., Smulski, C.R., Sic, H., Kraus, H., Salzer, U., Fiala, G.J., Schamel, W.W., Lougaris, V., Plebani, A., Hammarstrom, L., Recher, M., Germenis, A.E., Grimbacher, B., Warnatz, K., Rolink, A.G., Schneider, P., Notarangelo, L.D. and Eibel, H.
Journal of Allergy and Clinical Immunology 133
(4): 1222-1225.
April 2014
2013
B-cell biology and development.
Pieper, K. ORCID: https://orcid.org/0000-0003-4809-3157, Grimbacher, B. and Eibel, H.
Journal of Allergy and Clinical Immunology 131
(4): 959-971.
April 2013
This list was generated on Mon Jun 22 05:14:52 2026 UTC.
![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
