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Soluble ACE2 correlates with severe COVID-19 and can impair antibody responses.
Lebedin, M. and Ratswohl, C. and Garg, A. and Schips, M. and Vazquez Garcia, C. and Spatt, L. and Thibeault, C. and Obermayer, B. and Weiner, J. and Moreno Velásquez, I. and Gerhard, C. and Stubbemann, P. and Hanitsch, L.G. and Pischon, T. and Witzenrath, M. and Sander, L.E. and Kurth, F. and Meyer-Hermann, M. and de la Rosa, K.
iScience 27 (3): 109330. 15 March 2024

Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis.
Li, X. and Wirtz, T. and Weber, T. and Lebedin, M. and Lowenstein, E.D. and Sommermann, T. and Zach, A. and Yasuda, T. and de la Rosa, K. and Chu, V.T. and Schulte, J.H. and Müller, I. and Kocks, C. and Rajewsky, K.
Science Immunology 9 (92): eadi0042. 2 February 2024


LMP1 and EBNA2 constitute a minimal set of EBV genes for transformation of human B cells.
Zhang, J. and Sommermann, T. and Li, X. and Gieselmann, L. and de la Rosa, K. and Stecklum, M. and Klein, F. and Kocks, C. and Rajewsky, K.
Frontiers in Immunology 14 : 1331730. 19 December 2023

A bead-based multiplex assay covering all coronaviruses pathogenic for humans for sensitive and specific surveillance of SARS-CoV-2 humoral immunity.
Stern, D. and Meyer, T.C. and Treindl, F. and Mages, H.W. and Krüger, M. and Skiba, M. and Krüger, J.P. and Zobel, C.M. and Schreiner, M. and Grossegesse, M. and Rinner, T. and Peine, C. and Stoliaroff-Pépin, A. and Harder, T. and Hofmann, N. and Michel, J. and Nitsche, A. and Stahlberg, S. and Kneuer, A. and Sandoni, A. and Kubisch, U. and Schlaud, M. and Mankertz, A. and Schwarz, T. and Corman, V.M. and Müller, M.A. and Drosten, C. and de la Rosa, K. and Schaade, L. and Dorner, M.B. and Dorner, B.G.
Scientific Reports 13 (1): 21846. 9 December 2023

A design strategy to generate a SARS-CoV-2 RBD vaccine that abrogates ACE2 binding and improves neutralizing antibody responses.
Ratswohl, C. and Vázquez García, C. and Ahmad, A.U.W. and Gonschior, H. and Lebedin, M. and Silvis, C.E. and Spatt, L. and Gerhard, C. and Lehmann, M. and Sander, L.E. and Kurth, F. and Olsson, S. and de la Rosa, K.
European Journal of Immunology 53 (10): e2350408. October 2023

Pandemieforschung: von Autoantikörpern und Impfstoff-Innovationen.
de la Rosa, K.
BIOspektrum 29 (6): 614-616. October 2023

New MERS-CoV Vaccine.
Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft.
22164013.9. 27 September 2023

Discriminating promiscuous from target-specific autoantibodies in COVID-19.
Lebedin, M. and Vazquez Garcia, C. and Spatt, L. and Ratswohl, C. and Thibeault, C. and Ostendorf, L. and Alexander, T. and Paul, F. and Sander, L.E. and Kurth, F. and de la Rosa, K.
European Journal of Immunology 53 (5): e2250210. May 2023

Application of a spacer-nick gene-targeting approach to repair disease-causing mutations with increased safety.
Tran, N.T. and Lebedin, M. and Danner, E. and Kühn, R. and Rajewsky, K. and Chu, V.T.
Bio-protocol 13 (8): e4661. 20 April 2023


Different classes of genomic inserts contribute to human antibody diversity.
Lebedin, M. and Foglierini, M. and Khorkova, S. and Vázquez García, C. and Ratswohl, C. and Davydov, A.N. and Turchaninova, M.A. and Daubenberger, C. and Chudakov, D.M. and Lanzavecchia, A. and de la Rosa, K.
Proceedings of the National Academy of Sciences of the United States of America 119 (36): e2205470119. 6 September 2022

SARS-CoV-2 mRNA vaccinations fail to elicit humoral and cellular immune responses in patients with multiple sclerosis receiving fingolimod.
Meyer-Arndt, L. and Braun, J. and Fauchere, F. and Vanshylla, K. and Loyal, L. and Henze, L. and Kruse, B. and Dingeldey, M. and Jürchott, K. and Mangold, M. and Maraj, A. and Braginets, A. and Böttcher, C. and Nitsche, A. and de la Rosa, K. and Ratswohl, C. and Sawitzki, B. and Holenya, P. and Reimer, U. and Sander, L.E. and Klein, F. and Paul, F. and Bellmann-Strobl, J. and Thiel, A. and Giesecke-Thiel, C.
Journal of Neurology Neurosurgery and Psychiatry 93 (9): 960-971. September 2022

Precise CRISPR/Cas-mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells.
Tran, N.T. and Danner, E. and Li, X. and Graf, R. and Lebedin, M. and de la Rosa, K. and Kühn, R. and Rajewsky, K. and Chu, V.T.
Science Advances 8 (22): eabm9106. 3 June 2022


A barcoded flow cytometric assay to explore the antibody responses against SARS-CoV-2 spike and its variants.
Vesper, N. and Ortiz, Y. and Bartels-Burgahn, F. and Yang, J. and de la Rosa, K. and Tenbusch, M. and Schulz, S. and Finzel, S. and Jäck, H.M. and Eibel, H. and Voll, R.E. and Reth, M.
Frontiers in Immunology 12 : 730766. September 2021

A public health antibody screening indicates a 6-fold higher SARS-CoV-2 exposure rate than reported cases in children.
Hippich, M. and Holthaus, L. and Assfalg, R. and Zapardiel Gonzalo, J.M. and Kapfelsperger, H. and Heigermoser, M. and Haupt, F. and Ewald, D.A. and Welzhofer, T.C. and Marcus, B.A. and Heck, S. and Koelln, A. and Stock, J. and Voss, F. and Secchi, M. and Piemonti, L. and de la Rosa, K. and Protzer, U. and Boehmer, M. and Achenbach, P. and Lampasona, V. and Bonifacio, E. and Ziegler, A.G.
Med 2 (2): 149-163. 12 February 2021

A homology independent sequence replacement strategy in human cells using a CRISPR nuclease.
Danner, E. and Lebedin, M. and de la Rosa, K. and Kühn, R.
Open Biology 11 (1): 200283. January 2021


A homology independent sequence replacement strategy in human cells using a CRISPR nuclease.
Danner, E.W. and Lebedin, M. and de la Rosa, K. and Kühn, R.
bioRxiv : 2020.05.11.088252. 12 May 2020


Incomplete genetic reconstitution of B cell pools contributes to prolonged immunosuppression after measles.
Petrova, V.N. and Sawatsky, B. and Han, A.X. and Laksono, B.M. and Walz, L. and Parker, E. and Pieper, K. and Anderson, C.A. and de Vries, R.D. and Lanzavecchia, A. and Kellam, P. and von Messling, V. and de Swart, R.L. and Russell, C.A.
Science Immunology 4 (41): eaay6125. 1 November 2019


Public antibodies to malaria antigens generated by two LAIR1 insertion modalities.
Pieper, K. and Tan, J. and Piccoli, L. and Foglierini, M. and Barbieri, S. and Chen, Y. and Silacci-Fregni, C. and Wolf, T. and Jarrossay, D. and Anderle, M. and Abdi, A. and Ndungu, F.M. and Doumbo, O.K. and Traore, B. and Tran, T.M. and Jongo, S. and Zenklusen, I. and Crompton, P.D. and Daubenberger, C. and Bull, P.C. and Sallusto, F. and Lanzavecchia, A.
Nature 548 (7669): 597-601. 31 August 2017


A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens.
Tan, J. and Pieper, K. and Piccoli, L. and Abdi, A. and Foglierini, M. and Geiger, R. and Tully, C.M. and Jarrossay, D. and Ndungu, F.M. and Wambua, J. and Bejon, P. and Silacci Fregni, C. and Fernandez-Rodriguez, B. and Barbieri, S. and Bianchi, S. and Marsh, K. and Thathy, V. and Corti, D. and Sallusto, F. and Bull, P. and Lanzavecchia, A.
Nature 529 (7584): 105-109. 7 January 2016


A common single nucleotide polymorphism impairs B-cell activating factor receptor's multimerization, contributing to common variable immunodeficiency.
Pieper, K. and Rizzi, M. and Speletas, M. and Smulski, C.R. and Sic, H. and Kraus, H. and Salzer, U. and Fiala, G.J. and Schamel, W.W. and Lougaris, V. and Plebani, A. and Hammarstrom, L. and Recher, M. and Germenis, A.E. and Grimbacher, B. and Warnatz, K. and Rolink, A.G. and Schneider, P. and Notarangelo, L.D. and Eibel, H.
Journal of Allergy and Clinical Immunology 133 (4): 1222-1225. April 2014


B-cell biology and development.
Pieper, K. and Grimbacher, B. and Eibel, H.
Journal of Allergy and Clinical Immunology 131 (4): 959-971. April 2013

This list was generated on Mon May 20 02:24:34 2024 CEST.
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