Browse by Research Team

2014

Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells.
Wang, J. and Xie, G. and Singh, M. and Ghanbarian, A.T. and Raskó, T. and Szvetnik, A. and Cai, H. and Besser, D. and Prigione, A. and Fuchs, N.V. and Schumann, G.G. and Chen, W. and Lorincz, M.C. and Ivics, Z. and Hurst, L.D. and Izsvák, Z.
Nature 516 (7531): 405-409. 18 December 2014

2012

Mesenchymal stromal cells (MSCs): science and f(r)iction.
Bieback, K. and Wuchter, P. and Besser, D. and Franke, W. and Becker, M. and Ott, M. and Pacher, M. and Ma, N. and Stamm, C. and Klueter, H. and Mueller, A. and Ho, A.D.
Journal of Molecular Medicine 90 (7): 773-782. July 2012

Stem cell biology-from basic research to regenerative medicine.
Besser, D.
Journal of Molecular Medicine 90 (7): 731-733. July 2012

Replicative aging and differentiation potential of human adipose tissue-derived mesenchymal stromal cells expanded in pooled human or fetal bovine serum.
Bieback, K. and Hecker, A. and Schlechter, T. and Hofmann, I. and Brousos, N. and Redmer, T. and Besser, D. and Klueter, H. and Mueller, A.M. and Becker, M.
Cytotherapy 14 (5): 570-583. May 2012

Where do you come from; where do you go? Pluripotency, differentiation and malfunction of stem cells.
Spagnoli, F.M. and Besser, D. and Benitah, S.A.
EMBO Reports 13 (1): 9-11. January 2012

2011

E-cadherin is crucial for embryonic stem cell pluripotency and can replace OCT4 during somatic cell reprogramming.
Redmer, T. and Diecke, S. and Grigoryan, T. and Quiroga-Negreira, A. and Birchmeier, W. and Besser, D.
EMBO Reports 12 (7): 720-726. 1 July 2011

2010

Bone morphogenetic protein-7 release from endogenous neural precursor cells suppresses the tumourigenicity of stem-like glioblastoma cells.
Chirasani, S.R. and Sternjak, A. and Wend, P. and Momma, S. and Campos, B. and Herrmann, I.M. and Graf, D. and Mitsiadis, T. and Herold-Mende, C. and Besser, D. and Synowitz, M. and Kettenmann, H. and Glass, R.
Brain 133 (Pt 7): 1961-1972. July 2010

Two isoforms of human RNA polymerase III with specific functions in cell growth and transformation.
Haurie, V. and Durrieu-Gaillard, S. and Dumay-Odelot, H. and Da Silva, D. and Rey, C. and Prochazkova, M. and Roeder, R.G. and Besser, D. and Teichmann, M.
Proceedings of the National Academy of Sciences of the United States of America 107 (9): 4176-4181. 2 March 2010

2009

The tyrosine phosphatase Shp2 (PTPN11) directs neuregulin-1/ErbB signaling throughout schwann cell development.
Grossmann, K.S. and Wende, H. and Paul, F.E. and Cheret, C. and Garratt, A.N. and Zurborg, S. and Feinberg, K. and Besser, D. and Schulz, H. and Peles, E. and Selbach, M. and Birchmeier, W. and Birchmeier, C.
Proceedings of the National Academy of Sciences of the United States of America 106 (39): 16704-16709. 29 September 2009

A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential.
Fritzmann, J. and Morkel, M. and Besser, D. and Budczies, J. and Kosel, F. and Brembeck, F.H. and Stein, U. and Fichtner, I. and Schlag, P.M. and Birchmeier, W.
Gastroenterology 137 (11): 165-175. July 2009

2008

Homogeneity and persistence of transgene expression by omitting antibiotic selection in cell line isolation.
Kaufman, W.L. and Kocman, I. and Agrawal, V. and Rahn, H.P. and Besser, D. and Gossen, M.
Nucleic Acids Research 36 (17): e111. October 2008

FGF2 signaling in mouse embryonic fibroblasts is crucial for self-renewal of embryonic stem cells.
Diecke, S. and Quiroga-Negreira, A. and Redmer, T. and Besser, D.
Cells Tissues Organs 188 (1-2): 52-61. July 2008

2005

TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells.
James, D. and Levine, A.J. and Besser, D. and Hemmati-Brivanlou, A.
Development 132 (6): 1273-1282. March 2005

2004

Expression of nodal, lefty-A, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3.
Besser, D.
Journal of Biological Chemistry 279 (43): 45076-45084. 1 January 2004

2003

Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization.
Wolfrum, C. and Besser, D. and Luca, E. and Stoffel, M.
Proceedings of the National Academy of Sciences of the United States of America 100 (20): 11624-11629. 30 September 2003

Independent and cooperative activation of chromosomal c-fos promoter by STAT3.
Yang, E. and Lerner, L. and Besser, D. and Darnell, J.E.
Journal of Biological Chemistry 278 (18): 15794-15799. 2 May 2003

2002

WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase.
Su, F. and Overholtzer, M. and Besser, D. and Levine, A.J.
Genes & Development 16 (1): 46-57. 2002

2001

Protein kinase B beta/Akt2 plays a specific role in muscle differentiation.
Vandromme, M. and Rochat, A. and Meier, R. and Carnac, G. and Besser, D. and Hemmings, B.A. and Fernandez, A. and Lamb, N.J.
Journal of Biological Chemistry 276 (11): 8173-8179. 16 March 2001

1999

TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src.
Wong, B.R. and Besser, D. and Kim, N. and Arron, J.R. and Vologodskaia, M. and Hanafusa, H. and Choi, Y.
Molecular Cell 4 (6): 1041-1049. December 1999

Transcriptional regulation of the murine urokinase-type plasminogen activator gene in skeletal myoblasts.
Miralles, F. and Ibanez-Tallon, I. and Parra, M. and Crippa, M. and Blasi, F. and Besser, D. and Nagamine, Y. and Munoz-Canoves, P.
Thrombosis and Haemostasis 81 (5): 767-774. May 1999

A single amino acid substitution in the v-Eyk intracellular domain results in activation of Stat3 and enhances cellular transformation.
Besser, D. and Bromberg, J.F. and Darnell, J.E. and Hanafusa, H.
Molecular and Cellular Biology 19 (2): 1401-1409. February 1999

1998

Stat3 activation is required for cellular transformation by v-src.
Bromberg, J.F. and Horvath, C.M. and Besser, D. and Lathem, W.W. and Darnell, J.E.
Molecular and Cellular Biology 18 (5): 2553-2558. May 1998

1997

12-O-Tetradecanoylphorbol-13-acetate activates the Ras/extracellular signal-regulated kinase (ERK) signaling pathway upstream of SOS involving serine phosphorylation of Shc in NIH3T3 cells.
El-Shemerly, M.Y. and Besser, D. and Nagasawa, M. and Nagamine, Y.
Journal of Biological Chemistry 272 (49): 30599-30602. 5 December 1997

Cooperation of two PEA3/AP1 sites in uPA gene induction by TPA and FGF-2.
D'Orazio, D. and Besser, D. and Marksitzer, R. and Kunz, C. and Hume, D.A. and Kiefer, B. and Nagamine, Y.
Gene 201 (1-2): 179-187. 12 November 1997

Regulation of the urokinase-type plasminogen activator gene by the oncogene Tpr-Met involves GRB2.
Besser, D. and Bardelli, A. and Didichenko, S. and Thelen, M. and Comoglio, P.M. and Ponzetto, C. and Nagamine, Y.
Oncogene 14 (6): 705-711. 13 February 1997

Cytoskeleton reorganization induces the urokinase-type plasminogen activator gene via the Ras/extracellular signal-regulated kinase (ERK) signaling pathway.
Irigoyen, J.P. and Besser, D. and Nagamine, Y.
Journal of Biological Chemistry 272 (3): 1904-1909. 17 January 1997

1996

SH2 and SH3-containing adaptor proteins: redundant or independent mediators of intracellular signal transduction.
Birge, R.B. and Knudsen, B.S. and Besser, D. and Hanafusa, H.
Genes to Cells 1 (7): 595-613. July 1996

Signal transduction and the u-PA/u-PAR system.
Besser, D. and Verde, P. and Nagamine, Y. and Blasi, F.
Fibrinolysis 10 (4): 215-237. July 1996

1995

Activation and nuclear translocation of mitogen-activated protein kinases by polyomavirus middle-T or serum depend on phosphatidylinositol 3-kinase.
Urich, M. and el Shemerly, M.Y. and Besser, D. and Nagamine, Y. and Ballmer-Hofer, K.
Journal of Biological Chemistry 270 (49): 29286-29292. 8 December 1995

Urokinase-type plasminogen activator gene regulation by polyomavirus middle-T antigen.
Besser, D. and Urich, M. and Sakaue, M. and Messerschmitt, A. and Ballmer-Hofer, K. and Nagamine, Y.
Oncogene 11 (11): 2383-2391. 7 December 1995

Elucidation of a signaling pathway induced by FGF-2 leading to uPA gene expression in NIH 3T3 fibroblasts.
Besser, D. and Presta, M. and Nagamine, Y.
Cell Growth & Differentiation 6 (8): 1009-1017. August 1995

1990

DNA methylation inhibits transcription by RNA polymerase III of a tRNA gene, but not of a 5S rRNA gene.
Besser, D. and Goetz, F. and Schulze-Forster, K. and Wagner, H. and Kroeger, H. and Simon, D.
FEBS Letters 269 (2): 358-362. 3 September 1990