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| Item Type: | Article |
|---|---|
| Title: | Serum anti-NMDA receptor antibodies are linked to memory impairment 12 months after stroke |
| Creators Name: | Arlt, F.A., Sperber, P.S., von Rennenberg, R., Gebert, P., Teegen, B., Georgakis, M.K., Fang, R., Dewenter, A., Görtler, M., Petzold, G.C., Wunderlich, S., Zerr, I., Dichgans, M., Prüss, H. and Endres, M. |
| Abstract: | Patients suffering from strokes are at increased risk of developing post-stroke dementia. Serum anti-NMDA receptor autoantibodies (NMDAR1-abs) have been associated with unfavorable post-stroke outcomes. However, their effect on specific cognitive domains remains unclear. We used data from the prospective multicenter DZNE-mechanisms after stroke (DEMDAS) cohort, and measured NMDAR1-abs in serum at baseline. Cognitive function was assessed with a comprehensive neuropsychological test battery at 6- and 12-months follow-up. We employed crude and stepwise confounder adjusted linear and logistic regression models as well as generalized estimating equation models (GEE) to determine the relevance of NMDAR1-abs seropositivity on cognitive function after stroke. 10.2% (58/569) DEMDAS patients were NMDAR1-abs seropositive (IgM:n = 44/IgA:n = 21/IgG:n = 2). Seropositivity was not associated with global cognitive impairment after stroke. However, NMDAR1-abs seropositive patients performed lower in the memory domain (β adjusted = -0.11; 95%CI = -0.57 to -0.03) and were at increased risk for memory impairment (OR=adjusted 3.8; 95%CI = 1.33-10.82) compared to seronegative patients, 12 months after stroke. Further, NMDAR1-abs were linked to memory impairment over time in GEE from 6- to 12-months follow-up (OR=adjusted 2.41; 95%CI = 1.05-5.49). Our data suggests that NMDAR1-abs contribute to memory dysfunction 1 year after stroke while not affecting other cognitive subdomains. Hence, antineuronal autoimmunity may be involved in distinct mechanisms of post-stroke memory impairment. Clinical trial name and registration number: The Determinants of Dementia After Stroke (DEMDAS; study identifier on clinical trials.gov: NCT01334749). |
| Source: | Molecular Psychiatry |
| ISSN: | 1359-4184 |
| Publisher: | Springer Nature |
| Date: | 30 October 2024 |
| Official Publication: | https://doi.org/10.1038/s41380-024-02744-w |
| PubMed: | View item in PubMed |
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