Article

Cell-based immune anticipation of the omicron variant in SARS-CoV-2 triple-vaccinated cancer patients.
Mairhofer, Mario ORCID: https://orcid.org/0000-0002-7218-6284, Kausche, Lea, Kaltenbrunner, Sabine, Pammer, Maria, Ghanem, Riad, Stegemann, Maike and Schmitt, Clemens A. ORCID: https://orcid.org/0000-0002-4731-2226
iScience 28 (11): 113727. 21 November 2025

Phosphorylation of presynaptic PLPPR3 controls synaptic vesicle release.
Kroon, Cristina, Bareesel, Shannon, Aguilar Perez, Gerard, Nagy-Herczeg, Domonkos, Ranti, Dimitra, Syropoulou, Vasiliki, Coveney, Sandra, Kirchner, Marieluise ORCID: https://orcid.org/0000-0002-7049-534X, Gimber, Niclas ORCID: https://orcid.org/0000-0001-9456-3063, Bintig, Willem, Brosig, Annika, Braune, Georg, Textoris-Taube, Kathrin, Zolnik, Timothy A., Mertins, Philipp ORCID: https://orcid.org/0000-0002-2245-528X, Schmoranzer, Jan, Milovanovic, Dragomir, Leondaritis, George and Eickholt, Britta J. ORCID: https://orcid.org/0000-0001-7873-8687
iScience 28 (9): 113435. 19 September 2025

Comprehensive analysis of B cell repopulation in ocrelizumab-treated patients with multiple sclerosis by mass cytometry and proteomics.
Wang, M., Otto, C., Fernández Zapata, C. ORCID: https://orcid.org/0000-0003-4795-6053, Dehlinger, A., Gallaccio, G. ORCID: https://orcid.org/0000-0002-1060-5244, Diekmann, L.M., Niederschweiberer, M., Schindler, P., Körtvélyessy, P., Kunkel, D., Paul, F. ORCID: https://orcid.org/0000-0002-6378-0070, Ruprecht, K. and Böttcher, C. ORCID: https://orcid.org/0000-0002-6226-586X
iScience 28 (5): 112383. 16 May 2025

Arginine methylation of the p30 C/EBPα oncoprotein regulates progenitor proliferation and myeloid differentiation.
Nguyen, L.T. ORCID: https://orcid.org/0000-0002-3228-6520, Zimmermann, K., Kowenz-Leutz, E., Dörr, D. ORCID: https://orcid.org/0000-0001-8575-7560, Schütz, A. ORCID: https://orcid.org/0000-0002-0606-2574, Schönheit, J., Mildner, A. ORCID: https://orcid.org/0000-0002-2019-8427 and Leutz, A. ORCID: https://orcid.org/0000-0001-8259-927X
iScience 27 (11): 111199. 15 November 2024

Activity dependent modulation of glial gap junction coupling in the thalamus.
Baum, P., Beinhauer, A., Zirwes, L., Loenneker, L., Jabs, R., Narayanan, R.T., Oberlaender, M., Seifert, G., Kettenmann, H. ORCID: https://orcid.org/0000-0001-8208-0291 and Steinhäuser, C. ORCID: https://orcid.org/0000-0003-2579-8357
iScience 27 (10): 111043. 18 October 2024

Copy-number dosage regulates telomere maintenance and disease-associated pathways in neuroblastoma.
Burkert, M. ORCID: https://orcid.org/0000-0002-6721-9985, Blanc, E. ORCID: https://orcid.org/0000-0002-4369-0254, Thiessen, N., Weber, C., Toedling, J. ORCID: https://orcid.org/0000-0003-1471-1295, Monti, R. ORCID: https://orcid.org/0000-0002-6354-8319, Dombrowe, V.M. ORCID: https://orcid.org/0000-0002-1466-1518, de Biase, M.S. ORCID: https://orcid.org/0000-0003-0383-5161, Kaufmann, T.L. ORCID: https://orcid.org/0000-0003-4374-1338, Haase, K. ORCID: https://orcid.org/0000-0002-0944-5618, Waszak, S.M., Eggert, A., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201, Ohler, U. ORCID: https://orcid.org/0000-0002-0881-3116 and Schwarz, R.F. ORCID: https://orcid.org/0000-0001-9155-4268
iScience 27 (10): 110918. 18 October 2024

A novel developmental critical period of orexinergic signaling in the primary visual thalamus.
Sanetra, A.M., Jeczmien-Lazur, J.S., Pradel, K., Klich, J.D. ORCID: https://orcid.org/0000-0003-2951-3582, Palus-Chramiec, K., Janik, M.E., Bajkacz, S., Izowit, G., Nathan, C., Piggins, H.D., Delogu, A., Belle, M.D.C., Lewandowski, M.H. and Chrobok, L.
iScience 27 (7): 110352. 19 July 2024

Atypical KCNQ1/Kv7 channel function in a neonatal diabetes patient: hypersecretion preceded the failure of pancreatic β-cells.
Zhou, Z., Gong, M. ORCID: https://orcid.org/0000-0001-7384-3429, Pande, A. ORCID: https://orcid.org/0009-0008-0826-973X, Margineanu, A. ORCID: https://orcid.org/0000-0002-6634-9729, Lisewski, U., Purfürst, B. ORCID: https://orcid.org/0000-0002-9887-7577, Zhu, H., Liang, L., Jia, S. ORCID: https://orcid.org/0000-0001-8595-9314, Froehler, S. ORCID: https://orcid.org/0000-0001-8000-2927, Zeng, C., Kühnen, P., Khodaverdi, S., Krill, W., Röpke, T., Chen, W. ORCID: https://orcid.org/0000-0003-3263-1627, Raile, K. ORCID: https://orcid.org/0000-0002-0842-1737, Sander, M. ORCID: https://orcid.org/0000-0001-5308-7785 and Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384
iScience 27 (7): 110291. 19 July 2024

Soluble ACE2 correlates with severe COVID-19 and can impair antibody responses.
Lebedin, M. ORCID: https://orcid.org/0000-0002-3877-7195, Ratswohl, C. ORCID: https://orcid.org/0000-0001-5413-0730, Garg, A., Schips, M., Vazquez Garcia, C. ORCID: https://orcid.org/0000-0003-4583-7616, Spatt, L., Thibeault, C., Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Weiner, J. ORCID: https://orcid.org/0000-0003-1438-7819, Moreno Velásquez, I. ORCID: https://orcid.org/0000-0001-6058-8983, Gerhard, C. ORCID: https://orcid.org/0000-0001-6956-7249, Stubbemann, P., Hanitsch, L.G., Pischon, T. ORCID: https://orcid.org/0000-0003-1568-767X, Witzenrath, M., Sander, L.E., Kurth, F., Meyer-Hermann, M. and de la Rosa, K. ORCID: https://orcid.org/0000-0003-4809-3157
iScience 27 (3): 109330. 15 March 2024

SORCS2 activity in pancreatic α-cells safeguards insulin granule formation and release from glucose-stressed β-cells.
Kalnytska, O. ORCID: https://orcid.org/0009-0005-8276-3849, Qvist, P., Kunz, S. ORCID: https://orcid.org/0000-0002-0131-3506, Conrad, T. ORCID: https://orcid.org/0000-0001-5618-6295, Willnow, T.E. ORCID: https://orcid.org/0000-0001-9515-7921 and Schmidt, V. ORCID: https://orcid.org/0000-0002-5851-1087
iScience 27 (1): 108725. 19 January 2024

Kinin B1 receptor controls maternal adiponectin levels and influences offspring weight gain.
Alves-Silva, T. ORCID: https://orcid.org/0000-0002-6300-7790, Húngaro, T.G.R., Freitas-Lima, L.C., de Melo Arthur, G., Arruda, A.C., Santos, R.B., Oyama, L.M., Mori, M.A.S., Bader, M. ORCID: https://orcid.org/0000-0003-4780-4164 and Araujo, R.C. ORCID: https://orcid.org/0000-0002-6300-7790
iScience 26 (12): 108409. 15 December 2023

A computational model of the DNA damage-induced IKK/ NF-κB pathway reveals a critical dependence on irradiation dose and PARP-1.
Konrath, F. ORCID: https://orcid.org/0000-0002-6843-6252, Willenbrock, M., Busse, D., Scheidereit, C. ORCID: https://orcid.org/0000-0002-0446-6129 and Wolf, J. ORCID: https://orcid.org/0000-0003-3254-5868
iScience 26 (10): 107917. 20 October 2023

Similar neural pathways link psychological stress and brain-age in health and multiple sclerosis.
Schulz, M.A., Hetzer, S., Eitel, F., Asseyer, S., Meyer-Arndt, L. ORCID: https://orcid.org/0000-0002-7909-020X, Schmitz-Hübsch, T. ORCID: https://orcid.org/0000-0003-4833-5937, Bellmann-Strobl, J. ORCID: https://orcid.org/0000-0003-2615-1643, Cole, J.H., Gold, S.M., Paul, F. ORCID: https://orcid.org/0000-0002-6378-0070, Ritter, K. and Weygandt, M. ORCID: https://orcid.org/0000-0001-9962-4582
iScience 26 (9): 107679. 15 September 2023

Ablation of collagen XII disturbs joint extracellular matrix organization and causes patellar subluxation.
Zhu, M., Metzen, F., Hopkinson, M., Betz, J., Heilig, J., Sodhi, J., Imhof, T., Niehoff, A., Birk, D.E., Izu, Y., Krüger, M., Pitsillides, A. A., Altmüller, J. ORCID: https://orcid.org/0000-0003-4372-1521, van Osch, G.J.V.M., Straub, V., Schreiber, G., Paulsson, M., Koch, M. and Brachvogel, B.
iScience 26 (7): 107225. 21 July 2023

Preclinical safety and efficacy of a therapeutic antibody that targets SARS-CoV-2 at the sotrovimab face but is escaped by Omicron.
Kreye, J. ORCID: https://orcid.org/0000-0003-2913-1015, Reincke, S.M. ORCID: https://orcid.org/0000-0002-8132-3527, Edelburg, S., Jeworowski, L.M., Kornau, H.C., Trimpert, J., Hombach, P., Halbe, S., Nölle, V., Meyer, M., Kattenbach, S., Sánchez-Sendin, E., Schmidt, M.L., Schwarz, T., Rose, R., Krumbholz, A., Merz, S., Adler, J.M., Eschke, K., Abdelgawad, A., Schmitz, D. ORCID: https://orcid.org/0000-0003-2741-5241, Sander, L.E., Janssen, U., Corman, V.M. and Prüss, H.
iScience 26 (4): 106323. 21 April 2023

Constitutive depletion of brain serotonin differentially affects rats’ social and cognitive abilities.
Alonso, L. ORCID: https://orcid.org/0000-0001-9495-8401, Peeva, P. ORCID: https://orcid.org/0000-0001-9937-2397, Stasko, S., Bader, M. ORCID: https://orcid.org/0000-0003-4780-4164, Alenina, N. ORCID: https://orcid.org/0000-0002-6071-5433, Winter, Y. and Rivalan, M. ORCID: https://orcid.org/0000-0002-1642-7522
iScience 26 (2): 105998. 17 February 2023

Rapid nuclear deadenylation of mammalian messenger RNA.
Alles, J. ORCID: https://orcid.org/0000-0003-0681-0410, Legnini, I. ORCID: https://orcid.org/0000-0002-8984-5215, Pacelli, M. and Rajewsky, N. ORCID: https://orcid.org/0000-0002-4785-4332
iScience 26 (1): 105878. 20 January 2023

Induced pluripotent stem cells and cerebral organoids from the critically endangered Sumatran rhinoceros.
Zywitza, V. ORCID: https://orcid.org/0000-0003-3055-8569, Frahm, S. ORCID: https://orcid.org/0000-0001-5645-2557, Krüger, N., Weise, A., Göritz, F., Hermes, R., Holtze, S., Colleoni, S., Galli, C., Drukker, M., Hildebrandt, T.B. and Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992
iScience 25 (11): 105414. 18 November 2022

4-phenylbutyrate restores localization and membrane repair to human dysferlin mutations.
Tominaga, K., Tominaga, N., Williams, E.O., Rufibach, L., Schöwel, V. ORCID: https://orcid.org/0000-0002-5924-3088, Spuler, S. ORCID: https://orcid.org/0000-0002-0155-1117, Viswanathan, M. and Guarente, L.P.
iScience 25 (1): 103667. 21 January 2022

Reduced mitochondrial respiration in T cells of patients with major depressive disorder.
Gamradt, S., Hasselmann, H., Taenzer, A., Brasanac, J., Stiglbauer, V., Sattler, A., Sajitz-Hermstein, M., Kierszniowska, S., Ramien, C., Nowacki, J., Mascarell-Maricic, L., Wingenfeld, K., Piber, D., Ströhle, A., Kotsch, K., Paul, F. ORCID: https://orcid.org/0000-0002-6378-0070, Otte, C. and Gold, S.M.
iScience 24 (11): 103312. 19 November 2021

Depletion of cardiac cardiolipin synthase alters systolic and diastolic function.
Smeir, E., Leberer, S. ORCID: https://orcid.org/0000-0001-9763-6694, Blumrich, A. ORCID: https://orcid.org/0000-0003-4720-8717, Vogler, G., Vasiliades, A., Dresen, S., Jaeger, C. ORCID: https://orcid.org/0000-0003-2192-1792, Gloaguen, Y. ORCID: https://orcid.org/0000-0003-0493-8592, Klose, C., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Schulze, P.C., Bodmer, R., Foryst-Ludwig, A. and Kintscher, U.
iScience 24 (11): 103314. 19 November 2021

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.
Ramberger, E. ORCID: https://orcid.org/0000-0003-2760-2696, Sapozhnikova, V., Kowenz-Leutz, E., Zimmermann, K., Nicot, N., Nazarov, P.V., Perez-Hernandez, D. ORCID: https://orcid.org/0000-0003-0266-9050, Reimer, U., Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Dittmar, G. ORCID: https://orcid.org/0000-0003-3647-8623 and Leutz, A. ORCID: https://orcid.org/0000-0001-8259-927X
iScience 24 (6): 102686. 25 June 2021

Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy.
Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Mösbauer, K., Franke, V. ORCID: https://orcid.org/0000-0003-3606-6792, Diag, A., Gottula, L.T., Arsiè, R. ORCID: https://orcid.org/0000-0002-7869-7624, Klironomos, F., Koppstein, D. ORCID: https://orcid.org/0000-0002-8618-7237, Hönzke, K., Ayoub, S. ORCID: https://orcid.org/0000-0001-5043-8922, Buccitelli, C. ORCID: https://orcid.org/0000-0002-2637-2131, Hoffmann, K., Richter, A., Legnini, I. ORCID: https://orcid.org/0000-0002-8984-5215, Ivanov, A. ORCID: https://orcid.org/0000-0002-4824-1925, Mari, T. ORCID: https://orcid.org/0000-0001-6011-9386, Del Giudice, S. ORCID: https://orcid.org/0000-0003-0194-3767, Papies, J., Praktiknjo, S. ORCID: https://orcid.org/0000-0002-0186-5271, Meyer, T.F., Müller, M.A., Niemeyer, D. ORCID: https://orcid.org/0000-0002-1897-6365, Hocke, A., Selbach, M. ORCID: https://orcid.org/0000-0003-2454-8751, Akalin, A. ORCID: https://orcid.org/0000-0002-0468-0117, Rajewsky, N. ORCID: https://orcid.org/0000-0002-4785-4332, Drosten, C. and Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734
iScience 24 (3): 102151. 19 March 2021

Single synapse glutamate imaging reveals multiple levels of release mode regulation in mammalian synapses.
Farsi, Z. ORCID: https://orcid.org/0000-0001-7274-981X, Walde, M. ORCID: https://orcid.org/0000-0002-4071-7677, Klementowicz, A.E., Paraskevopoulou, F. and Woehler, A. ORCID: https://orcid.org/0000-0001-5157-9313
iScience 24 (1): 101909. 22 January 2021

A network of microRNAs acts to promote cell cycle exit and differentiation of human pancreatic endocrine cells.
Jin, W., Mulas, F., Gaertner, B., Sui, Y., Wang, J., Matta, I., Zeng, C., Vinckier, N., Wang, A., Nguyen-Ngoc, K.V., Chiou, J., Kaestner, K.H., Frazer, K.A., Carrano, A.C., Shih, H.P. and Sander, M. ORCID: https://orcid.org/0000-0001-5308-7785
iScience 21 : 681-694. 22 November 2019

Quantitative proteome landscape of the NCI-60 cancer cell lines.
Guo, T., Luna, A., Rajapakse, V.N., Koh, C.C., Wu, Z., Liu, W., Sun, Y., Gao, H., Menden, M.P., Xu, C., Calzone, L., Martignetti, L., Auwerx, C., Buljan, M., Banaei-Esfahani, A., Ori, A., Iskar, M., Gillet, L., Bi, R., Zhang, J., Zhang, H., Yu, C., Zhong, Q., Varma, S., Schmitt, U., Qiu, P., Zhang, Q., Zhu, Y., Wild, P.J., Garnett, M.J., Bork, P. ORCID: https://orcid.org/0000-0002-2627-833X, Beck, M., Liu, K., Saez-Rodriguez, J., Elloumi, F., Reinhold, W.C., Sander, C., Pommier, Y. and Aebersold, R.
iScience 21 : 664-680. 31 October 2019

Long and repeat-rich intronic sequences favor circular RNA formation under conditions of reduced spliceosome activity.
Wang, M., Hou, J., Müller-McNicoll, M., Chen, W. ORCID: https://orcid.org/0000-0003-3263-1627 and Schuman, E.M.
iScience 20 : 237-247. 25 October 2019

PRISMA: Protein Interaction Screen on Peptide Matrix reveals interaction footprints and modifications- dependent interactome of intrinsically disordered C/EBPb.
Dittmar, G. ORCID: https://orcid.org/0000-0003-3647-8623, Perez Hernandez, D. ORCID: https://orcid.org/0000-0003-0266-9050, Kowenz-Leutz, E., Kirchner, M. ORCID: https://orcid.org/0000-0002-7049-534X, Kahlert, G., Wesolowski, R. ORCID: https://orcid.org/0009-0002-7228-1051, Baum, K. ORCID: https://orcid.org/0000-0001-7256-0566, Knoblich, M., Hofstätter, M. ORCID: https://orcid.org/0000-0002-6198-2859, Muller, A., Wolf, J. ORCID: https://orcid.org/0000-0003-3254-5868, Reimer, U. and Leutz, A. ORCID: https://orcid.org/0000-0001-8259-927X
iScience 13 : 351-370. 29 March 2019

Review

Divergent transcription of the Nkx2-5 locus generates two enhancer RNAs with opposing functions.
Salamon, I., Serio, S., Bianco, S. ORCID: https://orcid.org/0000-0001-5819-060X, Pagiatakis, C., Crasto, S., Chiariello, A.M. ORCID: https://orcid.org/0000-0002-6112-0167, Conte, M. ORCID: https://orcid.org/0000-0002-6670-9800, Cattaneo, P., Fiorillo, L., Felicetta, A., di Pasquale, E., Kunderfranco, P., Nicodemi, M. ORCID: https://orcid.org/0000-0002-8416-6416, Papait, R. and Condorelli, G.
iScience 23 (9): 101539. 25 September 2020