Article

Extrachromosomal DNA-driven oncogene dosage heterogeneity promotes rapid adaptation to therapy in MYCN-amplified cancers.
Montuori, Giulia, Tu, Fengyu, Qin, Di ORCID: https://orcid.org/0000-0002-9730-4072, Schmargon, Rachel ORCID: https://orcid.org/0009-0009-3535-7185, Rodriguez-Fos, Elias ORCID: https://orcid.org/0000-0002-2555-0178, Helmsauer, Konstantin ORCID: https://orcid.org/0000-0003-0773-4114, Hui, Hui, Mandal, Susmita, Purshouse, Karin, Fankhänel, Lara, Bosco, Bartolomeo ORCID: https://orcid.org/0000-0002-3069-714X, Spanjaard, Bastiaan ORCID: https://orcid.org/0000-0003-1309-8839, Seyboldt, Hannah, Grunewald, Laura, Schmitt, Matthias Jürgen ORCID: https://orcid.org/0000-0001-8296-5858, Gürgen, Dennis, Buck, Viktoria, Rosenfeldt, Mathias T, Dubois, Frank P.B. ORCID: https://orcid.org/0000-0002-7654-6208, Schallenberg, Simon, Lehmann, Annika, Theißen, Jessica, Taschner-Mandl, Sabine, Koch, Arend, Hundsdoerfer, Patrick, Künkele, Annette, Eggert, Angelika, Fischer, Matthias, Gargiulo, Gaetano ORCID: https://orcid.org/0000-0001-5414-4251, Krieger, Teresa G, Chavez, Lukas, Coscia, Fabian ORCID: https://orcid.org/0000-0002-2244-5081, Werner, Benjamin, Huang, Weini, Henssen, Anton G. ORCID: https://orcid.org/0000-0003-1534-778X and Dörr, Jan R. ORCID: https://orcid.org/0000-0002-4927-6548
Cancer Discovery 15 (10): 2054-2077. 6 October 2025

Spatial-temporal diversity of extrachromosomal DNA shapes urothelial carcinoma evolution and tumor-immune microenvironment.
Lv, W. ORCID: https://orcid.org/0009-0004-0820-8620, Zeng, Y. ORCID: https://orcid.org/0000-0001-5873-5948, Li, C. ORCID: https://orcid.org/0000-0002-1540-8231, Liang, Y. ORCID: https://orcid.org/0000-0003-3535-3394, Tao, H. ORCID: https://orcid.org/0009-0000-5463-9633, Zhu, Y. ORCID: https://orcid.org/0000-0003-2310-5545, Sui, X. ORCID: https://orcid.org/0000-0001-7004-1973, Li, Y. ORCID: https://orcid.org/0009-0009-6031-518X, Jiang, S. ORCID: https://orcid.org/0009-0006-2889-9697, Gao, Q. ORCID: https://orcid.org/0009-0004-6381-9432, Rodriguez-Fos, E. ORCID: https://orcid.org/0000-0002-2555-0178, Prasad, G. ORCID: https://orcid.org/0000-0003-4590-1278, Wang, Y. ORCID: https://orcid.org/0000-0002-0068-5148, Zhou, R. ORCID: https://orcid.org/0000-0003-3485-8294, Xu, Z. ORCID: https://orcid.org/0000-0002-8999-3234, Pan, X. ORCID: https://orcid.org/0000-0002-2688-9245, Chen, L. ORCID: https://orcid.org/0009-0000-5602-4704, Xiang, X. ORCID: https://orcid.org/0000-0002-5590-7289, Teng, H. ORCID: https://orcid.org/0000-0001-9952-3618, Sun, C. ORCID: https://orcid.org/0000-0003-2469-1638, Qin, T. ORCID: https://orcid.org/0000-0002-5897-871X, Dong, W. ORCID: https://orcid.org/0000-0001-6386-0831, Li, Y. ORCID: https://orcid.org/0000-0002-4843-5447, Lan, X. ORCID: https://orcid.org/0000-0002-6523-046X, Li, X. ORCID: https://orcid.org/0000-0002-7030-0856, Lin, L. ORCID: https://orcid.org/0000-0002-7546-4948, Bolund, L. ORCID: https://orcid.org/0009-0005-5995-8197, Yang, H. ORCID: https://orcid.org/0000-0002-0858-3410, Verhaak, R.G.W. ORCID: https://orcid.org/0000-0003-2773-0436, Faltas, B.M. ORCID: https://orcid.org/0000-0002-6432-1693, Hansen, J.B. ORCID: https://orcid.org/0000-0001-5249-2586, Wu, S. ORCID: https://orcid.org/0000-0001-8329-7492, Mischel, P.S. ORCID: https://orcid.org/0000-0002-4560-2211, Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Bafna, V. ORCID: https://orcid.org/0000-0002-5810-6241, Luebeck, J. ORCID: https://orcid.org/0000-0003-4391-979X, Regenberg, B. ORCID: https://orcid.org/0000-0003-4996-7012, Luo, Y. ORCID: https://orcid.org/0000-0002-0007-7759, Lin, C. ORCID: https://orcid.org/0000-0001-5225-3518 and Han, P. ORCID: https://orcid.org/0000-0002-3405-087X
Cancer Discovery 15 (6): 1225-1246. 3 June 2025

Cell states in cancer: drivers, passengers, and trailers.
Gargiulo, G. ORCID: https://orcid.org/0000-0001-5414-4251, Serresi, M. ORCID: https://orcid.org/0000-0001-6839-8658 and Marine, J.C. ORCID: https://orcid.org/0000-0003-2433-9837
Cancer Discovery 14 (4): 610-614. 4 April 2024

Passenger gene coamplifications create collateral therapeutic vulnerabilities in cancer.
Bei, Y. ORCID: https://orcid.org/0000-0002-2104-8025, Brame, Luca ORCID: https://orcid.org/0000-0001-5316-2992, Kirchner, M. ORCID: https://orcid.org/0000-0002-7049-534X, Fritsche-Guenther, R. ORCID: https://orcid.org/0000-0002-6965-0226, Kunz, S. ORCID: https://orcid.org/0000-0002-0131-3506, Bhattacharya, A. ORCID: https://orcid.org/0000-0003-3733-7670, Rusu, M.C. ORCID: https://orcid.org/0000-0002-8369-3580, Gürgen, D. ORCID: https://orcid.org/0000-0001-9241-6537, Dubois, F.P.B. ORCID: https://orcid.org/0000-0002-7654-6208, Köppke, J.K.C. ORCID: https://orcid.org/0000-0002-1293-7250, Proba, J. ORCID: https://orcid.org/0009-0006-8293-1248, Wittstruck, N. ORCID: https://orcid.org/0009-0000-4378-3226, Sidorova, O.A. ORCID: https://orcid.org/0009-0004-1459-1662, Chamorro González, R. ORCID: https://orcid.org/0000-0002-5653-7259, Dorado Garcia, H. ORCID: https://orcid.org/0000-0002-2578-3350, Brückner, L. ORCID: https://orcid.org/0000-0002-6155-2277, Xu, R. ORCID: https://orcid.org/0000-0002-5618-246X, Giurgiu, M. ORCID: https://orcid.org/0000-0001-5007-7442, Rodriguez-Fos, E. ORCID: https://orcid.org/0000-0002-2555-0178, Yu, Q. ORCID: https://orcid.org/0000-0002-2151-9624, Spanjaard, B. ORCID: https://orcid.org/0000-0003-1309-8839, Koche, R.P. ORCID: https://orcid.org/0000-0002-6820-5083, Schmitt, C.A. ORCID: https://orcid.org/0000-0002-4731-2226, Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201, Eggert, A. ORCID: https://orcid.org/0000-0003-3476-8184, Haase, K. ORCID: https://orcid.org/0000-0002-0944-5618, Kirwan, J. ORCID: https://orcid.org/0000-0002-5423-1651, Hagemann, A.I. ORCID: https://orcid.org/0000-0001-5491-4607, Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Dörr, J.R. ORCID: https://orcid.org/0000-0002-4927-6548 and Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X
Cancer Discovery 14 (3): 492-507. 1 March 2024

Longitudinal single-cell dynamics of chromatin accessibility and mitochondrial mutations in chronic lymphocytic leukemia mirror disease history.
Penter, L., Gohil, S.H., Lareau, C. ORCID: https://orcid.org/0000-0003-4179-4807, Ludwig, L.S. ORCID: https://orcid.org/0000-0002-2916-2164, Parry, E.M., Huang, T., Li, S., Zhang, W., Livitz, D., Leshchiner, I., Parida, L., Getz, G., Rassenti, L.Z., Kipps, T.J., Brown, J.R., Davids, M.S., Neuberg, D.S., Livak, K.J., Sankaran, V.G. and Wu, C.J.
Cancer Discovery 11 (12): 3048-3063. December 2021

Phenotypic mapping of pathologic cross-talk between glioblastoma and innate immune cells by synthetic genetic tracing.
Schmitt, M.J. ORCID: https://orcid.org/0000-0001-8296-5858, Company, C. ORCID: https://orcid.org/0000-0002-7975-0642, Dramaretska, Y. ORCID: https://orcid.org/0000-0002-9792-0465, Barozzi, I., Göhrig, A., Kertalli, S., Großmann, M., Naumann, H. ORCID: https://orcid.org/0000-0003-3883-0432, Sánchez-Bailón, M.P. ORCID: https://orcid.org/0000-0001-6929-2273, Hulsman, D., Glass, R., Squatrito, M., Serresi, M. ORCID: https://orcid.org/0000-0001-6839-8658 and Gargiulo, G. ORCID: https://orcid.org/0000-0001-5414-4251
Cancer Discovery 11 (3): 754-777. March 2021

Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B cell activation and proliferation.
Heinig, K., Gätjen, M., Grau, M., Stache, V. ORCID: https://orcid.org/0000-0003-3755-6793, Anagnostopoulos, I., Gerlach, K., Niesner, R.A. ORCID: https://orcid.org/0000-0001-8969-5432, Cseresnyes, Z. ORCID: https://orcid.org/0000-0002-6574-2588, Hauser, A.E., Lenz, P., Hehlgans, T., Brink, R., Westermann, J., Dörken, B. ORCID: https://orcid.org/0000-0001-7991-3643, Lipp, M. ORCID: https://orcid.org/0000-0002-0087-2672, Lenz, G., Rehm, A. ORCID: https://orcid.org/0000-0001-7490-1950 and Höpken, U.E. ORCID: https://orcid.org/0000-0002-0776-4893
Cancer Discovery 4 : 1448-1465. December 2014

CD74–NRG1 fusions in lung adenocarcinoma.
Fernandez-Cuesta, L., Plenker, D., Osada, H., Sun, R., Menon, R., Leenders, F., Ortiz-Cuaran, S., Peifer, M., Bos, M., Daßler, J., Malchers, F., Schöttle, J., Vogel, W., Dahmen, I., Koker, M., Ullrich, R.T., Wright, G.M., Russell, P.A., Wainer, Z., Solomon, B., Brambilla, E., Nagy-Mignotte, H., Moro-Sibilot, D., Brambilla, C.G., Lantuejoul, S., Altmüller, J. ORCID: https://orcid.org/0000-0003-4372-1521, Becker, C., Nürnberg, P., Heuckmann, J.M., Stoelben, E., Petersen, I., Clement, J.H., Sänger, J., Muscarella, L.A., la Torre, A., Fazio, V.M., Lahortiga, I., Perera, T., Ogata, S., Parade, M., Brehmer, D., Vingron, M., Heukamp, L.C., Buettner, R., Zander, T., Wolf, J., Perner, S., Ansén, S., Haas, S.A., Yatabe, Y. and Thomas, R.K.
Cancer Discovery 4 (4): 415-22. 1 April 2014

Review

Cancer evolution: a multifaceted affair.
Ciriello, G. ORCID: https://orcid.org/0000-0003-2021-8683, Magnani, L. ORCID: https://orcid.org/0000-0002-7534-0785, Aitken, S.J. ORCID: https://orcid.org/0000-0002-1897-4140, Akkari, L. ORCID: https://orcid.org/0000-0001-5479-641X, Behjati, S. ORCID: https://orcid.org/0000-0002-6600-7665, Hanahan, D. ORCID: https://orcid.org/0000-0002-0883-5251, Landau, D.A. ORCID: https://orcid.org/0000-0003-2346-9541, Lopez-Bigas, N. ORCID: https://orcid.org/0000-0003-4925-8988, Lupiáñez, D.G. ORCID: https://orcid.org/0000-0002-3165-036X, Marine, J.C. ORCID: https://orcid.org/0000-0003-2433-9837, Martin-Villalba, A. ORCID: https://orcid.org/0000-0002-9405-8910, Natoli, G. ORCID: https://orcid.org/0000-0003-0711-2411, Obenauf, A.C. ORCID: https://orcid.org/0000-0002-9556-5914, Oricchio, E. ORCID: https://orcid.org/0000-0002-1690-0447, Scaffidi, P. ORCID: https://orcid.org/0000-0002-3642-4193, Sottoriva, A. ORCID: https://orcid.org/0000-0001-6709-9533, Swarbrick, A. ORCID: https://orcid.org/0000-0002-3051-5676, Tonon, G. ORCID: https://orcid.org/0000-0003-2973-5038, Vanharanta, S. ORCID: https://orcid.org/0000-0001-5619-7963 and Zuber, J. ORCID: https://orcid.org/0000-0001-8810-6835
Cancer Discovery 14 (1): 36–48. 1 January 2024

Editorial

A deep dive into the circulating ctDNA cosmos to vanquish neuroblastoma.
Deubzer, H.E. ORCID: https://orcid.org/0000-0002-6115-4893, Astrahantseff, K. ORCID: https://orcid.org/0000-0002-7872-1997 and Lodrini, M. ORCID: https://orcid.org/0000-0003-4434-529X
Cancer Discovery 12 (12): 2727-2729. 2 December 2022

Shedding light on ecDNA behavior using CRISPR-based live-cell imaging.
Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X
Cancer Discovery 12 (2): 293-295. 9 February 2022

Targeting HDAC3 in CREBBP-mutant lymphomas counterstrikes unopposed enhancer deacetylation of B-cell signaling and immune response genes.
Höpken, U.E. ORCID: https://orcid.org/0000-0002-0776-4893
Cancer Discovery 7 (1): 14-16. January 2017