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2008

The structure of the anti-c-myc antibody 9E10 Fab fragment/epitope peptide complex reveals a novel binding mode dominated by the heavy chain hypervariable loops.
Krauss, N. and Wessner, H. and Welfle, K. and Welfle, H. and Scholz, C. and Seifert, M. and Zubow, K. and Ay, J. and Hahn, M. and Scheerer, P. and Skerra, A. and Hoehne, W.
Proteins: Structure, Function, and Bioinformatics 73 (3): 552-565. 15 November 2008

2007

Helicobacter exploits integrin for type IV secretion and kinase activation.
Kwok, T. and Zabler, D. and Urman, S. and Rohde, M. and Hartig, R. and Wessler, S. and Misselwitz, R. and Berger, J.M. and Sewald, N. and Koenig, W. and Backert, S.
Nature 449 (7164): 862-866. 18 October 2007

Binding of regulatory protein omega from Streptococcus pyogenes plasmid pSM19035 to direct and inverted 7-base pair repeats of operator DNA.
Dostal, L. and Pratto, F. and Alonso, J.C. and Welfle, H.
Journal of Raman Spectroscopy 38 (2): 166-175. February 2007

2006

Mn2+-DNA interactions in aqueous systems: A Raman spectroscopic study.
Muntean, C.M. and Misselwitz, R. and Dostal, L. and Welfle, H.
Spectroscopy 20 (1): 29-35. January 2006

The influence of Mn2+ on DNA structure in the presence of Na+ ions: a Raman spectroscopic study.
Muntean, C.M. and Misselwitz, R. and Welfle, H.
Spectroscopy 20 (5-6): 261-268. 2006

2005

DNA structure at low pH values, in the presence of Mn2+ ions: a Raman study.
Muntean, C.M. and Dostal, L. and Misselwitz, R. and Welfle, H.
Journal of Raman Spectroscopy 36 (11): 1047-1051. November 2005

Role of the N-terminal region and of beta-sheet residue Thr29 on the activity of the omega(2) global regulator from the broad-host range Streptococcus pyogenes plasmid pSM19035.
Welfle, K. and Pratto, F. and Misselwitz, R. and Behlke, J. and Alonso, J.C. and Welfle, H.
Biological Chemistry 386 (9): 881-894. 1 September 2005

Arc repressor-operator DNA interactions and contribution of Phe10 to binding specificity.
Dostal, L. and Misselwitz, R. and Welfle, H.
Biochemistry 44 (23): 8387-8396. 1 January 2005

Thermodynamic and structural equivalence of two HLA-B27 subtypes complexed with a self-peptide.
Huelsmeyer, M. and Welfle, K. and Poehlmann, T. and Misselwitz, R. and Alexiev, U. and Welfle, H. and Saenger, W. and Uchanska-Ziegler, B. and Ziegler, A.
Journal of Molecular Biology 346 (5): 1367-1379. 1 January 2005

2004

Partial B-to-A DNA transition upon minor groove binding of protein Sac7d monitored by Raman spectroscopy.
Dostal, L. and Chen, C.Y. and Wang, A.H. and Welfle, H.
Biochemistry 43 (30): 9600-9609. 3 August 2004

Recognition of DNA by omega protein from the broad-host range Streptococcus pyogenes plasmid pSM19035: analysis of binding to operator DNA with one to four heptad repeats.
de la Hoz, A.B. and Pratto, F. and Misselwitz, R. and Speck, C. and Weihofen, W. and Welfle, K. and Saenger, W. and Welfle, H. and Alonso, J.C.
Nucleic Acids Research 32 (10): 3136-3147. 9 June 2004

Thermodynamic and structural analysis of peptide- and allele-dependent properties of two HLA-B27 subtypes exhibiting differential disease association.
Hillig, R.C. and Huelsmeyer, M. and Saenger, W. and Welfle, K. and Misselwitz, R. and Welfle, H. and Kozerski, C. and Volz, A. and Uchanska-Ziegler, B. and Ziegler, A.
Journal of Biological Chemistry 279 (1): 652-663. 1 January 2004

2003

Design and characterization of a hybrid miniprotein that specifically inhibits porcine pancreatic elastase.
Hilpert, K. and Wessner, H. and Schneider-Mergener, J. and Welfle, K. and Misselwitz, R. and Welfle, H. and Hocke, A.C. and Hippenstiel, S. and Hoehne, W.
Journal of Biological Chemistry 278 (27): 24986-24993. 4 July 2003

X-ray structure of the cyclomaltohexaicosaose triiodide inclusion complex provides a model for amylose-iodine at atomic resolution.
Nimz, O. and Gessler, K. and Uson, I. and Laettig, S. and Welfle, H. and Sheldrick, G.M. and Saenger, W.
Carbohydrate Research 338 (9): 977-986. 22 April 2003

Interaction of epitope-related and -unrelated peptides with anti-p24 (HIV-1) monoclonal antibody CB4-1 and its Fab fragment.
Welfle, K. and Misselwitz, R. and Hoehne, W. and Welfle, H.
Journal of Molecular Recognition 16 (1): 54-62. 1 January 2003

RP4 repressor protein KorB binds to the major groove of the operator DNA: A Raman study.
Dostal, L. and Khare, D. and Bok, J. and Heinemann, U. and Lanka, E. and Welfle, H.
Biochemistry 42 (49): 14476-14482. 1 January 2003

Raman spectroscopy of regulatory protein Omega from Streptococcus pyogenes plasmid pSM19035 and complexes with operator DNA.
Dostal, L. and Misselwitz, R. and Laettig, S. and Alonso, J.C. and Welfle, H.
Spectroscopy 17 (2-3): 435-445. 2003

2002

The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor.
Muller, Y.A. and Heiring, C. and Misselwitz, R. and Welfle, K. and Welfle, H.
Journal of Biological Chemistry 277 (45): 43410-43416. 8 November 2002

In vitro and in vivo stability of the epsilon2zeta2 protein complex of the broad host-range Streptococcus pyogenes pSM19035 addiction system.
Camacho, A.G. and Misselwitz, R. and Behlke, J. and Ayora, S. and Welfle, K. and Meinhart, A. and Lara, B. and Saenger, W. and Welfle, H. and Alonso, J.C.
Biological Chemistry 383 (11): 1701-1713. November 2002

NblA from Anabaena sp PCC 7120 is a mostly alpha-helical protein undergoing reversible trimerization in solution.
Strauss, H. and Misselwitz, R. and Labudde, D. and Nicklisch, S. and Baier, K.
European Journal of Biochemistry 269 (18): 4617-4624. 1 January 2002

2001

Anti-c-myc antibody 9E10: epitope key positions and variability characterized using peptide spot synthesis on cellulose.
Hilpert, K. and Hansen, G. and Wessner, H. and Kuettner, G. and Welfle, K. and Seifert, M. and Hoehne, W.
Protein Engineering 14 (10): 803-806. 1 January 2001

Cross-reactive binding of cyclic peptides to an anti-TGFalpha antibody fab fragment: an X-ray structural and thermodynamic analysis.
Hahn, M. and Winkler, D. and Welfle, K. and Misselwitz, R. and Welfle, H. and Wessner, H. and Zahn, G. and Scholz, C. and Seifert, M. and Harkins, R. and Schneider-Mergener, J. and Hoehne, W.G.
Journal of Molecular Biology 314 (2): 293-309. 1 January 2001

Efficient eukaryotic expression system for authentic human sex hormone-binding globulin.
Hilpert, J. and Vorum, H. and Burmeister, R. and Spoelgen, R. and Grishkovskaya, I. and Misselwitz, R. and Nykjaer, A. and Willnow, T.E.
Biochemical Journal 360 (3): 609-615. 1 January 2001

Interaction of a designed interleukin-10 epitope mimic with an antibody studied by isothermal titration microcalorimetry.
Welfle, K. and Misselwitz, R. and Sabat, R. and Volk, H.D. and Schneider-Mergener, J. and Reineke, U. and Welfle, H.
Journal of Molecular Recognition 14 (2): 89-98. 1 January 2001

Stability and DNA-binding properties of the omega regulator protein from the broad-host range Streptococcus pyogenes plasmid pSM19035.
Misselwitz, R. and de la Hoz, A.B. and Ayora, S. and Welfle, K. and Behlke, J. and Murayama, K. and Saenger, W. and Alonso, J.C. and Welfle, H.
FEBS Letters 505 (3): 436-440. 1 January 2001

2000

Interaction of fMet-tRNAfMet with the C-terminal domain of translational initiation factor IF2 from Bacillus stearothermophilus.
Krafft, C. and Diehl, A. and Laettig, S. and Behlke, J. and Heinemann, U. and Pon, C.L. and Gualerzi, C.O. and Welfle, H.
FEBS Letters 471 (2-3): 128-132. 14 April 2000

Structural heterogeneity in intramolecular DNA triple helices.
Weisz, K. and Leitner, D. and Krafft, C. and Welfle, H.
Biological Chemistry 381 (4): 275-283. 1 April 2000

The C-terminal subdomain (IF2 C-2) contains the entire fMet-tRNA binding site of initiation factor IF2.
Spurio, R. and Brandi, L. and Caserta, E. and Pon, C.L. and Gualerzi, C.O. and Misselwitz, R. and Krafft, C. and Welfle, K. and Welfle, H.
Journal of Biological Chemistry 275 (4): 2447-2454. 28 January 2000

Expression and purification of dynamin II domains and initial studies on structure and function.
Dong, J. and Misselwitz, R. and Welfle, H. and Westermann, P.
Protein Expression and Purification 20 (2): 314-323. 1 January 2000

1999

The fMet-tRNA binding domain of translational initiation factor IF2: role and environment of its two Cys residues.
Misselwitz, R. and Welfle, K. and Krafft, C. and Welfle, H. and Brandi, L. and Caserta, E. and Gualerzi, C.O.
FEBS Letters 459 (3): 332-336. 15 October 1999

Conformation, pH-induced conformational changes, and thermal unfolding of anti-p24 (HIV-1) monoclonal antibody CB4-1 and its Fab and Fc fragments.
Welfle, K. and Misselwitz, R. and Hausdorf, G. and Hoehne, W. and Welfle, H.
Biochimica et Biophysica Acta 1431 : 120-131. 12 April 1999

A synthetic mimic of a discontinuous binding site on interleukin-10.
Reineke, U. and Sabat, R. and Misselwitz, R. and Welfle, H. and Volk, H.D. and Schneider-Mergener, J.
Nature Biotechnology 17 : 271-275. 1 March 1999

Preliminary characterization by X-ray diffraction and Raman spectroscopy of a crystalline complex of Bacillus stearothermophilus initiation factor 2 C-domain and fMet-tRNA(fMet).
Foerster, C. and Krafft, C. and Welfle, H. and Gualerzi, C.O. and Heinemann, U.
Acta Crystallographica Section D 55 Pt. 3 : 712-716. 1 March 1999

Interaction of the capsid protein p24 (HIV-1) with sequence-derived peptides: influence on p24 dimerization.
Hilpert, K. and Behlke, J. and Scholz, C. and Misselwitz, R. and Schneider-Mergener, J. and Hoehne, W.
Virology 254 : 6-10. 1 January 1999

1998

The laminarinase from thermophilic eubacterium Rhodothermus marinus - Conformation, stability, and identification of active site carboxylic residues by site-directed mutagenesis.
Krah, M. and Misselwitz, R. and Politz, O. and Thomsen, K.K. and Welfle, H. and Borriss, R.
European Journal of Biochemistry 257 : 101-111. 1 October 1998

Melting points of lysozyme and ribonuclease A crystals correlated with protein unfolding: a Raman spectroscopic study.
Jacob, J. and Krafft, C. and Welfle, K. and Welfle, H. and Saenger, W.
Acta Crystallographica Section D 54 : 74-80. 1 January 1998

Raman spectroscopic analysis of Tet repressor - operator DNA interaction in deuterium oxide.
Krafft, C. and Hinrichs, W. and Orth, P. and Saenger, W. and Welfle, H.
Cellular and Molecular Biology 44 : 239-250. 1 January 1998

Interaction of Tet repressor with operator DNA and with tetracycline studied by infrared and Raman spectroscopy.
Krafft, C. and Hinrichs, W. and Orth, P. and Saenger, W. and Welfle, H.
Biophysical Journal 74 (1): 63-71. January 1998

1997

C repeats of the streptococcal M1 protein achieve the human serum albumin binding ability by flanking regions which stabilize the coiled-coil conformation.
Gubbe, K. and Misselwitz, R. and Welfle, K. and Reichardt, W. and Schmidt, K.H. and Welfle, H.
Biochemistry 36 : 8107-8113. 1 January 1997

Conformation and stability of streptokinases from nephritogenic and nonnephritogenic strains of Streptococci.
Welfle, K. and Misselwitz, R. and Schaup, A. and Gerlach, D. and Welfle, H.
Proteins: Structure, Function, and Bioinformatics 27 : 26-35. 1 January 1997

Translational initiation factor IF2 from Bacillus stearothermophilus: a spectroscopic and microcalorimetric study of the C-domain.
Misselwitz, R. and Welfle, K. and Krafft, C. and Gualerzi, C.O. and Welfle, H.
Biochemistry 36 : 3170-3178. 1 January 1997

1996

Chemical modification of recombinant HIV-1 capsid protein p24 leads to the release of a hidden epitope prior to changes of the overall folding of the protein.
Ehrhard, B. and Misselwitz, R. and Welfle, K. and Hausdorf, G. and Glaser, R.W. and Schneider-Mergener, J. and Welfle, H.
Biochemistry 35 : 9097-9105. 1 January 1996

Individual amino acids in the N-terminal loop region determine the thermostability and unfolding characteristics of bacterial glucanases.
Welfle, K. and Misselwitz, R. and Politz, O. and Borriss, R. and Welfle, H.
Protein Science 5 : 2255-2265. 1 January 1996

1995

Conformation and stability of recombinant HIV-1 capsid protein p24 (rp24).
Misselwitz, R. and Hausdorf, G. and Welfle, K. and Hoehne, W.E. and Welfle, H.
Biochimica et Biophysica Acta 1250 (1): 9-18. 1 January 1995

Influence of Ca2+ on conformation and stability of three bacterial hybrid glucanases.
Welfle, K. and Misselwitz, R. and Welfle, H. and Politz, O. and Borriss, R.
European Journal of Biochemistry 229 (3): 726-735. 1 January 1995

Stability of Escherichia coli single-stranded DNA binding protein (EcoSSB).
Misselwitz, R. and Welfle, K. and Curth, U. and Urbanke, C. and Welfle, H.
Journal of Biomolecular Structure & Dynamics 12 (5): 1041-1054. 1 January 1995

1994

Conformations and stabilities of human Glu1 and Lys78- plasminogen and of the fragments mini- and microplasminogen, analysed by circular dichroism and differential scanning calorimetry.
Misselwitz, R. and Welfle, K. and Welfle, H.
International Journal of Biological Macromolecules 16 : 187-194. 1 January 1994

Microcalorimetric deterimination of the thermostability of three hybrid (1-3,1-4)-beta-glucanases.
Welfle, K. and Misselwitz, R. and Welfle, H. and Simon, O. and Politz, O. and Borriss, R.
Journal of Biomolecular Structure & Dynamics 11 : 1417-1424. 1 January 1994

The thermostability of natural variants of bacterial plasminogen- activator staphylokinase.
Gase, A. and Birch-Hirschfeld, E. and Guehrs, K.H. and Hartmann, M. and Vetterman, S. and Damaschun, G. and Damaschun, H. and Gast, K. and Misselwitz, R. and Zirwer, D. and Collen, D. and Schlott, B.
European Journal of Biochemistry 223 : 303-308. 1 January 1994

1993

Cold denaturation-induced conformational changes in phosphoglycerate kinase from yeast.
Damaschun, G. and Damaschun, H. and Gast, K. and Misselwitz, R. and Mueller, J.J. and Pfeil, W. and Zirwer, D.
Biochemistry 32 (30): 7739-7746. 3 August 1993

Conformation of d (GGGATCCC) 2 in crystals and in solution studied by X-ray diffraction, Raman spectroscopy and molecular modelling.
Fabian, H. and Hoelzer, W. and Heinemann, U. and Sklenar, H. and Welfle, H.
Nucleic Acids Research 21 (3): 569-576. 11 February 1993

Cold denaturation of yeast phosphoglycerate kinase: kinetics of changes in secondary structure and compactness on unfolding and refolding.
Gast, K. and Damaschun, G. and Damaschun, H. and Misselwitz, R. and Zirwer, D.
Biochemistry 32 : 7747-7752. 1 January 1993

Conformational stability of the DNA-binding histone-like protein, HBsu, from Bacillus subtilis, and of the four HBsu variants [F29W],[F47W],[F50W] and [F79W].
Welfle, H. and Welfle, K. and Misselwitz, R. and Groch, N. and Heinemann, U.
Journal of Biomolecular Structure & Dynamics 11 : 381-394. 1 January 1993

Conformations and conformational changes of four Phe->Trp variants of the DNA-binding histone-like protein, HBsu, from Bacillus subtilis studied by circular dichroism and fluorescence spectroscopy.
Welfle, H. and Misselwitz, R. and Welfle, K. and Schindelin, H. and Scholtz, A.S. and Heinemann, U.
European Journal of Biochemistry 217 : 849-856. 1 January 1993

Physical and conformational properties of staphylokinase in solution.
Damaschun, G. and Damaschun, H. and Gast, K. and Misselwitz, R. and Zirwer, D. and Guehrs, K.H. and Hartmann, M. and Schlott, B. and Triebel, H. and Behnke, H.
Biochimica et Biophysica Acta 1161 : 244-248. 1 January 1993

1992

Secondary structure of streptokinase in aqueous solution - a fourier transform infrared spectroscopic study.
Fabian, H. and Naumann, D. and Misselwitz, R. and Ristau, O. and Gerlach, D. and Welfle, H.
Biochemistry 31 (28): 6532-6538. 21 July 1992

Conformational properties of streptokinase - differential scanning calorimetric investigations.
Welfle, K. and Pfeil, W. and Misselwitz, R. and Welfle, H. and Gerlach, D.
International Journal of Biological Macromolecules 14 : 19-22. 1 January 1992

Conformational properties of streptokinase - secondary structure and localization of aromatic amino acids.
Welfle, H. and Misselwitz, R. and Fabian, H. and Damerau, W. and Hoelzer, W. and Gerlach, D. and Kalnin, N.N. and Venyaminov, S.Y.
International Journal of Biological Macromolecules 14 : 9-18. 1 January 1992

Limited proteolysis of streptokinase and properties of some fragments.
Misselwitz, R. and Kraft, R. and Kostka, S. and Fabian, H. and Welfle, K. and Pfeil, W. and Welfle, H. and Gerlach, D.
International Journal of Biological Macromolecules 14 : 107-116. 1 January 1992

Salt-dependent and protein-concentration-dependent changes in the solution structure of DNA-binding histone-like protein, HBsn, from Bacillus subtilis.
Welfle, H. and Misselwitz, R. and Welfle, K. and Groch, N. and Heinemann, U.
European Journal of Biochemistry 204 : 1049-1055. 1 January 1992

Streptokinase is a flexible multi-domain protein.
Damaschun, G. and Damaschun, H. and Gast, K. and Gerlach, D. and Misselwitz, R. and Welfle, H. and Zirwer, D.
European Biophysics Journal with Biophysics Letters 20 : 355-361. 1 January 1992

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