Browse by Research Team

2023

Novel candidate regulators and developmental trajectory of pituitary thyrotropes.
Cheung, L.Y.M., Menage, L., Rizzoti, K., Hamilton, G., Dumontet, T., Basham, K., Daly, A.Z., Brinkmeier, M.L., Masser, B.E., Treier, M., Cobb, J., Delogu, A., Lovell-Badge, R., Hammer, G.D. and Camper, S.A.
Endocrinology 164 (6): bqad076. June 2023

2021

Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4.
Diener, J., Baggiolini, A., Pernebrink, M., Dalcher, D., Lerra, L., Cheng, P.F., Varum, S., Häusel, J., Stierli, S., Treier, M., Studer, L., Basler, K., Levesque, M.P., Dummer, R., Santoro, R., Cantù, C. and Sommer, L.
Nature Communications 12 (1): 5056. 20 August 2021

MicroRNA-7a2 regulates prolactin in developing lactotrophs and prolactinoma cells.
LaPierre, M.P., Godbersen, S., Esteban, M.T., Schad, A.N., Treier, M., Ghoshdastider, U. and Stoffel, M.
Endocrinology 162 (2): bqaa220. February 2021

2020

Human follicle-stimulating hormone β subunit expression depends on FOXL2 and SMAD4.
Ongaro, L., Schang, G., Zhou, Z., Kumar, T.R., Treier, M., Deng, C.X., Boehm, U. and Bernard, D.J.
Endocrinology 161 (5): bqaa045. May 2020

2019

BigStitcher: reconstructing high-resolution image datasets of cleared and expanded samples.
Hörl, D., Rojas Rusak, F., Preusser, F., Tillberg, P., Randel, N., Chhetri, R.K., Cardona, A., Keller, P.J., Harz, H., Leonhardt, H., Treier, M. and Preibisch, S.
Nature Methods 16 (9): 870-874. September 2019

Functional identity of hypothalamic melanocortin neurons depends on Tbx3.
Quarta, C., Fisette, A., Xu, Y., Colldén, G., Legutko, B., Tseng, Y.T., Reim, A., Wierer, M., De Rosa, M.C., Klaus, V., Rausch, R., Thaker, V.V., Graf, E., Strom, T.M., Poher, A.L., Gruber, T., Le Thuc, O., Cebrian-Serrano, A., Kabra, D., Bellocchio, L., Woods, S.C., Pflugfelder, G.O., Nogueiras, R., Zeltser, L., Grunwald Kadow, I.C., Moon, A., García-Cáceres, C., Mann, M., Treier, M., Doege, C.A. and Tschöp, M.H.
Nature Metabolism 1 (2): 222-235. February 2019

2018

MacroH2A histone variants limit chromatin plasticity through two distinct mechanisms.
Kozlowski, M., Corujo, D., Hothorn, M., Guberovic, I., Mandemaker, I.K., Blessing, C., Sporn, J., Gutierrez-Triana, A., Smith, R., Portmann, T., Treier, M., Scheffzek, K., Huet, S., Timinszky, G., Buschbeck, M. and Ladurner, A.G.
EMBO Reports 19 (10): e44445. 1 October 2018

Conditional deletion of FOXL2 and SMAD4 in gonadotropes of adult mice causes isolated FSH deficiency.
Li, Y., Schang, G., Wang, Y., Zhou, X., Levasseur, A., Boyer, A., Deng, C.X., Treier, M., Boehm, U., Boerboom, D. and Bernard, D.J.
Endocrinology 159 (7): 2641-2655. 1 July 2018

NOTCH activity differentially affects alternative cell fate acquisition and maintenance.
Cheung, L., Le Tissier, P., Goldsmith, S.G., Treier, M., Lovell-Badge, R. and Rizzoti, K.
eLife 7 : e33318. 26 March 2018

2015

Targeting of MYCN by means of DNA vaccination is effective against neuroblastoma in mice.
Stermann, A., Huebener, N., Seidel, D., Fest, S., Eschenburg, G., Stauder, M., Schramm, A., Eggert, A. and Lode, H.N.
Cancer Immunology Immunotherapy 64 (10): 1215-1227. October 2015

Role of Foxl2 in uterine maturation and function.
Bellessort, B., Bachelot, A., Heude, É., Alfama, G., Fontaine, A., Le Cardinal, M., Treier, M. and Levi, G.
Human Molecular Genetics 24 (11): 3092-3103. 1 June 2015

Disialoganglioside-specific human natural killer cells are effective against drug-resistant neuroblastoma.
Seidel, D., Shibina, A., Siebert, N., Wels, W.S., Reynolds, C.P., Huebener, N. and Lode, H.N.
Cancer Immunology Immunotherapy 64 (5): 621-634. May 2015

Etiology of craniofacial malformations in mouse models of blepharophimosis, ptosis, and epicanthus inversus syndrome.
Heude, É., Bellessort, B., Fontaine, A., Hamazaki, M., Treier, A.C., Treier, M., Levi, G. and Narboux-Neme, N.
Human Molecular Genetics 24 (6): 1670-1681. 15 March 2015

2014

Follicle-stimulating hormone synthesis and fertility depend on SMAD4 and FOXL2.
Fortin, J., Boehm, U., Deng, C.X., Treier, M. and Bernard, D.J.
FASEB Journal 28 (8): 3396-3410. August 2014

2013

Fenretinide sensitizes multidrug-resistant human neuroblastoma cells to antibody-independent and ch14.18-mediated NK cell cytotoxicity.
Shibina, A., Seidel, D., Somanchi, S.S., Lee, D.A., Stermann, A., Maurer, B.J., Lode, H.N., Reynolds, C.P. and Huebener, N.
Journal of Molecular Medicine 91 (4): 459-472. April 2013

Impaired fertility and FSH synthesis in gonadotrope-specific Foxl2 knockout mice.
Tran, S., Zhou, X., Lafleur, C., Calderon, M.J., Ellsworth, B.S., Kimmins, S., Boehm, U., Treier, M., Boerboom, D. and Bernard, D.J.
Molecular Endocrinology 27 (3): 407-421. March 2013

Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashion.
Mitchell, J.C., McGoldrick, P., Vance, C., Hortobagyi, T., Sreedharan, J., Rogelj, B., Tudor, E.L., Smith, B.N., Klasen, C., Miller, C.C.J., Cooper, J.D., Greensmith, L. and Shaw, C.E.
Acta Neuropathologica 125 (2): 273-288. February 2013

2012

Sexual dimorphic regulation of body weight dynamics and adipose tissue lipolysis.
Benz, V., Bloch, M., Wardat, S., Boehm, C., Maurer, L., Mahmoodzadeh, S., Wiedmer, P., Spranger, J., Foryst-Ludwig, A. and Kintscher, U.
PLoS ONE 7 (5): e37794. 25 May 2012

2011

Loss of R-spondin1 and Foxl2 amplifies female-to-male sex reversal in XX mice.
Auguste, A., Chassot, A.A., Gregoire, E.P., Renault, L., Pannetier, M., Treier, M., Pailhoux, E. and Chaboissier, M.C.
Sexual Development 5 (6): 304-317. 22 November 2011

Forkhead transcription factors in ovarian function.
Uhlenhaut, N.H. and Treier, M.
Reproduction 142 (4): 489-495. October 2011

Transient development of ovotestes in XX Sox9 transgenic mice.
Gregoire, E.P., Lavery, R., Chassot, A.A., Akiyama, H., Treier, M., Behringer, R.R. and Chaboissier, M.C.
Developmental Biology 349 (1): 65-77. 1 January 2011

2010

Molecular mechanisms in renal degenerative disease.
Vasyutina, E. and Treier, M.
Seminars in Cell & Developmental Biology 21 (8): 831-837. October 2010

2009

Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation.
Uhlenhaut, N.H., Jakob, S., Anlag, K., Eisenberger, T., Sekido, R., Kress, J., Treier, A.C., Klugmann, C., Klasen, C., Holter, N.I., Riethmacher, D., Schütz, G., Cooney, A.J., Lovell-Badge, R. and Treier, M.
Cell 139 (6): 1130-1142. 11 December 2009

Chromosomal microarray mapping suggests a role for BSX and Neurogranin in neurocognitive and behavioral defects in the 11q terminal deletion disorder (Jacobsen syndrome).
Coldren, C.D., Lai, Z., Shragg, P., Rossi, E., Glidewell, S.C., Zuffardi, O., Mattina, T., Ivy, D.D., Curfs, L.M., Mattson, S.N., Riley, E.P., Treier, M. and Grossfeld, P.D.
Neurogenetics 10 (2): 89-95. April 2009

The bHLH transcription factor Olig3 marks the dorsal neuroepithelium of the hindbrain and is essential for the development of brainstem nuclei.
Storm, R., Cholewa-Waclaw, J., Reuter, K., Broehl, D., Sieber, M., Treier, M., Mueller, T. and Birchmeier, C.
Development 136 (2): 295-305. January 2009

2008

Transcriptional regulators in kidney disease: gatekeepers of renal homeostasis.
Uhlenhaut, N.H. and Treier, M.
Trends in Genetics 24 (7): 361-371. July 2008

Bsx, a novel hypothalamic factor linking feeding with locomotor activity, is regulated by energy availability.
Nogueiras, R., López, M., Lage, R., Perez-Tilve, D., Pfluger, P., Mendieta-Zerón, H., Sakkou, M., Wiedmer, P., Benoit, S.C., Datta, R., Dong, J.Z., Culler, M., Sleeman, M., Vidal-Puig, A., Horvath, T., Treier, M., Diéguez, C. and Tschöp, M.H.
Endocrinology 149 (6): 3009-3015. 1 June 2008

2007

Characterization of progenitor domains in the developing mouse thalamus.
Vue, T.Y., Aaker, J., Taniguchi, A., Kazemzadeh, C., Skidmore, J.M., Martin, D.M., Martin, J.F., Treier, M. and Nakagawa, Y.
Journal of Comparative Neurology 505 (1): 73-91. 1 November 2007

Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis.
Attanasio, M., Uhlenhaut, N.H., Sousa, V.H., O'Toole, J.F., Otto, E., Anlag, K., Klugmann, C., Treier, A.C., Helou, J., Sayer, J.A., Seelow, D., Nürnberg, G., Becker, C., Chudley, A.E., Nürnberg, P., Hildebrandt, F. and Treier, M.
Nature Genetics 39 (8): 1018-1024. August 2007

A role for brain-specific homeobox factor Bsx in the control of hyperphagia and locomotory behavior.
Sakkou, M., Wiedmer, P., Anlag, K., Hamm, A., Seuntjens, E., Ettwiller, L., Tschöp, M.H. and Treier, M.
Cell Metabolism 5 (6): 450-463. 6 June 2007

Bmp and Wnt/beta-catenin signals control expression of the transcription factor Olig3 and the specification of spinal cord neurons.
Zechner, D., Muller, T., Wende, H., Walther, I., Taketo, M.M., Crenshaw, E.B., Treier, M., Birchmeier, W. and Birchmeier, C.
Developmental Biology 303 (1): 181-190. 1 March 2007

2006

Murine inner cell mass-derived lineages depend on Sall4 function.
Elling, U., Klasen, C., Eisenberger, T., Anlag, K. and Treier, M.
Proceedings of the National Academy of Sciences of the United States of America 103 (44): 16319-16324. 31 October 2006

Foxl2 function in ovarian development.
Uhlenhaut, N.H. and Treier, M.
Molecular Genetics and Metabolism 88 (3): 225-234. July 2006

2005

Lack of an adrenal cortex in Sf1 mutant mice is compatible with the generation and differentiation of chromaffin cells.
Gut, P., Huber, K., Lohr, J., Brühl, B., Oberle, S., Treier, M., Ernsberger, U., Kalcheim, C. and Unsicker, K.
Development 132 (20): 4611-4619. October 2005

The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord.
Muller, T., Anlag, K., Wildner, H., Britsch, S., Treier, M. and Birchmeier, C.
Genes & Development 19 (6): 733-743. 1 January 2005

2004

The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance.
Schmidt, D., Ovitt, C.E., Anlag, K., Fehsenfeld, S., Gredsted, L., Treier, A.C. and Treier, M.
Development 131 (4): 933-942. 15 February 2004

2001

Hedgehog signaling is required for pituitary gland development.
Treier, M., O'Connell, S., Gleiberman, A., Price, J., Szeto, D.P., Burgess, R., Chuang, P.T., McMahon, A.P. and Rosenfeld, M.G.
Development 128 (3): 377-386. 1 February 2001

2000

Multistep signaling and transcriptional requirements for pituitary organogenesis in vivo.
Rosenfeld, M.G., Briata, P., Dasen, J., Gleiberman, A.S., Kioussi, C., Lin, C., O'Connell, S.M., Ryan, A., Szeto, D.P. and Treier, M.
Recent Progress in Hormone Research 55 : 1-13; discussion 13-14. 2000

1999

Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development.
Kioussi, C., O'Connell, S., St-Onge, L., Treier, M., Gleiberman, A.S., Gruss, P. and Rosenfeld, M.G.
Proceedings of the National Academy of Sciences of the United States of America 96 (25): 14378-14382. 7 December 1999

Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types.
Dasen, J.S., O'Connell, S.M., Flynn, S.E., Treier, M., Gleiberman, A.S., Szeto, D.P., Hooshmand, F., Aggarwal, A.K. and Rosenfeld, M.G.
Cell 97 (5): 587-598. 28 May 1999

1998

Multistep signaling requirements for pituitary organogenesis in vivo.
Treier, M., Gleiberman, A.S., O'Connell, S.M., Szeto, D.P., McMahon, J.A., McMahon, A.P. and Rosenfeld, M.G.
Genes & Development 12 (11): 1691-1704. 1 June 1998

1997

Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases.
Musti, A.M., Treier, M. and Bohmann, D.
Science 275 (5298): 400-402. 17 January 1997

1996

The hypothalamic-pituitary axis: co-development of two organs.
Treier, M. and Rosenfeld, M.G.
Current Opinion in Cell Biology 8 (6): 833-843. December 1996

Differential regulation of c-Jun and JunD by ubiquitin-dependent protein degradation.
Musti, A.M., Treier, M., Peverali, F.A. and Bohmann, D.
Biological Chemistry 377 (10): 619-624. October 1996

Identification of a novel family of ubiquitin-conjugating enzymes with distinct amino-terminal extensions.
Matuschewski, K., Hauser, H.P., Treier, M. and Jentsch, S.
Journal of Biological Chemistry 271 (5): 2789-2794. 2 February 1996

1995

JUN cooperates with the ETS domain protein pointed to induce photoreceptor R7 fate in the Drosophila eye.
Treier, M., Bohmann, D. and Mlodzik, M.
Cell 83 (5): 753-760. 1 December 1995

Intramolecular signal transduction in c-Jun.
Papavassiliou, A.G., Treier, M. and Bohmann, D.
EMBO Journal 14 (9): 2014-2019. 1 May 1995

1994

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain.
Treier, M., Staszewski, L.M. and Bohmann, D.
Cell 78 (5): 787-798. 9 September 1994

Repression of AP-1-stimulated transcription by c-Ets-1.
Goldberg, Y., Treier, M., Ghysdael, J. and Bohmann, D.
Journal of Biological Chemistry 269 (24): 16566-16573. 17 June 1994

1992

Targeted degradation of c-Fos, but not v-Fos, by a phosphorylation-dependent signal on c-Jun.
Papavassiliou, A.G., Treier, M., Chavrier, C. and Bohmann, D.
Science 258 (5090): 1941-1944. 18 December 1992

Drosophila UbcD1 encodes a highly conserved ubiquitin‐conjugating enzyme involved in selective protein degradation.
Treier, M., Seufert, W. and Jentsch, S.
EMBO Journal 11 (1): 367-372. January 1992

1989

Comparison of the gap segmentation gene hunchback between Drosophila melanogaster and Drosophila virilis reveals novel modes of evolutionary change.
Treier, M., Pfeifle, C. and Tautz, D.
EMBO Journal 8 (5): 1517-1525. May 1989