Browse by Research Team

Aging

Knockdown of Indy/CeNac2 extends Caenorhabditis elegans life span by inducing AMPK/aak-2.
Schwarz, F., Karadeniz, Z., Fischer-Rosinsky, A., Willmes, D.M., Spranger, J. and Birkenfeld, A.L.
Aging 7 (8): 553-567. August 2015

American Journal of Respiratory and Critical Care Medicine

Critical illness myopathy and GLUT4 - significance of insulin and muscle contraction.
Weber-Carstens, S., Schneider, J., Wollersheim, T., Assmann, A., Bierbrauer, J., Marg, A., Al Hasani, H., Chadt, A., Wenzel, K., Koch, S., Fielitz, J., Kleber, C., Faust, K., Mai, K., Spies, C.D., Luft, F.C., Boschmann, M., Spranger, J. and Spuler, S.
American Journal of Respiratory and Critical Care Medicine 187 (4): 387-396. 15 February 2013

Arteriosclerosis Thrombosis and Vascular Biology

Plasma γ-glutamyltransferase, cysteinyl-glycine, and oxidized low-density lipoprotein: a pathway associated with myocardial infarction risk?
Drogan, D., Weikert, C., Dierkes, J., Klipstein-Grobusch, K., Buijsse, B., Moehlig, M., Pfeiffer, A.F., Pischon, T., Spranger, J. and Boeing, H.
Arteriosclerosis Thrombosis and Vascular Biology 30 (10): 2053-2058. October 2010

Cell Metabolism

Interindividual variation in DNA methylation at a putative POMC metastable epiallele is associated with obesity.
Kuehnen, P., Handke, D., Waterland, R.A., Hennig, B.J., Silver, M., Fulford, A.J., Dominguez-Salas, P., Moore, S.E., Prentice, A.M., Spranger, J., Hinney, A., Hebebrand, J., Heppner, F.L., Walzer, L., Groetzinger, C., Gromoll, J., Wiegand, S., Grueters, A. and Krude, H.
Cell Metabolism 24 (3): 502-509. 13 September 2016

Cerebral Cortex

Caloric restriction in older adults - differential effects of weight loss and reduced weight on brain structure and function.
Prehn, K., Jumpertz von Schwartzenberg, R., Mai, K., Zeitz, U., Witte, A.V., Hampel, D., Szela, A.M., Fabian, S., Grittner, U., Spranger, J. and Floeel, A.
Cerebral Cortex 27 (3): 1765-1778. 1 March 2017

Clinical Chemistry

Untargeted metabolic profiling identifies altered serum metabolites of type 2 diabetes mellitus in a prospective, nested case control study.
Drogan, D., Dunn, W.B., Lin, W., Buijsse, B., Schulze, M.B., Langenberg, C., Brown, M., Floegel, A., Dietrich, S., Rolandsson, O., Wedge, D.C., Goodacre, R., Forouhi, N.G., Sharp, S.J., Spranger, J., Wareham, N.J. and Boeing, H.
Clinical Chemistry 61 (3): 487-497. March 2015

Clinical Endocrinology

Chemerin and prediction of diabetes mellitus type 2.
Bobbert, T., Schwarz, F., Fischer-Rosinsky, A., Maurer, L., Moehlig, M., Pfeiffer, A.F.H., Mai, K. and Spranger, J.
Clinical Endocrinology 82 (6): 838-843. June 2015

Arginine vasopressin-dependent and AVP-independent mechanisms of renal fluid absorption during thirsting despite glucocorticoid-mediated vasopressin suppression.
Ufer, F., Diederich, S., Pedersen, E.B., Spranger, J., Pfeiffer, A.F.H., Baehr, V. and Mai, K.
Clinical Endocrinology 78 (3): 431-437. March 2013

Critical Care

Risk factors in critical illness myopathy during the early course of critical illness: a prospective observational study.
Weber-Carstens, S., Deja, M., Koch, S., Spranger, J., Bubser, F., Wernecke, K.D., Spies, C.D., Spuler, S. and Keh, D.
Critical Care 14 (3): R119. 18 June 2010

Critical Care Medicine

Early type II fiber atrophy in intensive care unit patients with nonexcitable muscle membrane.
Bierbrauer, J., Koch, S., Olbricht, C., Hamati, J., Lodka, D., Schneider, J., Luther-Schroeder, A., Kleber, C., Faust, K., Wiesener, S., Spies, C.D., Spranger, J., Spuler, S., Fielitz, J. and Weber-Carstens, S.
Critical Care Medicine 40 (2): 647-650. February 2012

Deutsches Aerzteblatt International

Skepticism is unjustified.
Abholz, H.H., Egidi, G., Mueller, U.A. and Spranger, J.
Deutsches Aerzteblatt International 111 (25): 433. 20 June 2014

Diabetes

Free fatty acids link metabolism and regulation of the insulin-sensitizing fibroblast growth factor-21.
Mai, K., Andres, J., Biedasek, K., Weicht, J., Bobbert, T., Sabath, M., Meinus, S., Reinecke, F., Moehlig, M., Weickert, M.O., Clemenz, M., Pfeiffer, A.F., Kintscher, U., Spuler, S. and Spranger, J.
Diabetes 58 (7): 1532-1538. July 2009

Endocrinology Diabetes and Metabolism Case Reports

Palliative treatment of uncontrollable hypercalcemia due to parathyrotoxicosis: denosumab as rescue therapy.
Jumpertz von Schwartzenberg, R., Elbelt, U., Ventz, M., Mai, K., Kienitz, T., Maurer, L, Rose, T., Rueckert, J.C., Strasburger, C.J. and Spranger, J.
Endocrinology Diabetes and Metabolism Case Reports 2015 : 150082. 29 October 2015

European Journal of Clinical Pharmacology

Influences of levodopa on adipose tissue and skeletal muscle metabolism in patients with idiopathic Parkinson's disease.
Adams, F., Boschmann, M., Lobsien, E., Kupsch, A., Lipp, A., Franke, G., Leisse, M.C., Janke, J., Gottschalk, S., Spranger, J. and Jordan, J.
European Journal of Clinical Pharmacology 64 (9): 863-870. September 2008

European Journal of Epidemiology

Comparison of relative and attributable risk of myocardial infarction and stroke according to C-reactive protein and low-density lipoprotein cholesterol levels.
Pischon, T., Moehlig, M., Hoffmann, K., Spranger, J., Weikert, C., Willich, S.N., Pfeiffer, A.F. and Boeing, H.
European Journal of Epidemiology 22 (7): 429-438. July 2007

Experimental and Clinical Endocrinology & Diabetes

Circulating insulin-like growth factor binding protein-3 predicts one-year outcome after ischemic stroke.
Ebinger, M., Ipsen, N., Leonards, C.O., Empl, L., Hanne, L., Liman, T., Mai, K., Strasburger, C.J., Spranger, J. and Endres, M.
Experimental and Clinical Endocrinology & Diabetes 123 (8): 461-465. September 2015

Intensive Care Medicine

Dynamics of myosin degradation in intensive care unit-acquired weakness during severe critical illness.
Wollersheim, T., Woehlecke, J., Krebs, M., Hamati, J., Lodka, D., Luther-Schroeder, A., Langhans, C., Haas, K., Radtke, T., Kleber, C., Spies, C., Labeit, S., Schuelke, M., Spuler, S., Spranger, J., Weber-Carstens, S. and Fielitz, J.
Intensive Care Medicine 40 (4): 528-538. 15 February 2014

International Journal of Obesity

Hypoxia and exercise interactions on skeletal muscle insulin sensitivity in obese subjects with metabolic syndrome: results of a randomized controlled trial.
Mai, K., Klug, L., Rakova, N., Piper, S.K., Mähler, A., Bobbert, T., Schulz-Menger, J., Spranger, J., Boschmann, M. and Luft, F.C.
International Journal of Obesity 44 (5): 1119-1128. May 2020

Journal of Clinical Bioinformatics

A distinct metabolic signature predicts development of fasting plasma glucose.
Hische, M., Larhlimi, A., Schwarz, F., Fischer-Rosinsky, A., Bobbert, T., Assmann, A., Catchpole, G.S., Pfeiffer, A.F.H., Willmitzer, L., Selbig, J. and Spranger, J.
Journal of Clinical Bioinformatics 2 : 3. 2 February 2012

Journal of Clinical Endocrinology and Metabolism

Glucagon decreases IGF-1 bioactivity in humans, independently of insulin, by modulating its binding proteins.
Sarem, Z., Bumke-Vogt, C., Mahmoud, A.M., Assefa, B., Weickert, M.O., Adamidou, A., Baehr, V., Frystyk, J., Moehlig, M., Spranger, J., Lieske, S., Birkenfeld, A.L., Pfeiffer, A.F.H. and Arafat, A.M.
Journal of Clinical Endocrinology and Metabolism 102 (9): 3480-3490. 1 September 2017

Weight loss partially restores glucose-driven betatrophin response in humans.
Maurer, L., Brachs, S., Decker, A.M., Brachs, M., Leupelt, V., Jumpertz von Schwartzenberg, R., Ernert, A., Bobbert, T., Krude, H., Spranger, J. and Mai, K.
Journal of Clinical Endocrinology and Metabolism 101 (11): 4014-4020. November 2016

Molecular and clinical evidence for an ARMC5 tumor syndrome: concurrent inactivating germline and somatic mutations are associated with both primary macronodular adrenal hyperplasia and meningioma.
Elbelt, U., Trovato, A., Kloth, M., Gentz, E., Finke, R., Spranger, J., Galas, D., Weber, S., Wolf, C., Koenig, K., Arlt, W., Buettner, R., May, P., Allolio, B. and Schneider, J.G.
Journal of Clinical Endocrinology and Metabolism 100 (1): E119-E128. January 2015

Reference intervals for insulin-like growth factor-1 (IGF-1) from birth to senescence: results from a multicenter study using a new automated chemiluminescence IGF-1 immunoassay conforming to recent international recommendations.
Bidlingmaier, M., Friedrich, N., Emeny, R.T., Spranger, J., Wolthers, O.D., Roswall, J., Koerner, A., Obermayer-Pietsch, B., Huebener, C., Dahlgren, J., Frystyk, J., Pfeiffer, A.F.H., Doering, A., Bielohuby, M., Wallaschofski, H. and Arafat, A.M.
Journal of Clinical Endocrinology and Metabolism 99 (5): 1712-1721. May 2014

The impact of insulin-independent, glucagon-induced suppression of total ghrelin on satiety in obesity and type 1 diabetes mellitus.
Arafat, A.M., Weickert, M.O., Adamidou, A., Otto, B., Perschel, F.H., Spranger, J., Moehlig, M. and Pfeiffer, A.F.H.
Journal of Clinical Endocrinology and Metabolism 98 (10): 4133-4142. October 2013

Metabolism

ANP system activity predicts variability of fat mass reduction and insulin sensitivity during weight loss.
Brachs, M., Wiegand, S., Leupelt, V., Ernert, A., Kintscher, U., Jumpertz von Schwarzenberg, R., Decker, A.M., Bobbert, T., Hübner, N., Chen, W., Krude, H., Spranger, J. and Mai, K.
Metabolism 65 (6): 935-943. June 2016

NeuroImage

Interactions between neural decision-making circuits predict long-term dietary treatment success in obesity.
Weygandt, M., Spranger, J., Leupelt, V., Maurer, L., Bobbert, T., Mai, K. and Haynes, J.D.
NeuroImage 184 : 520-534. 1 January 2019

Impulse control in the dorsolateral prefrontal cortex counteracts post-diet weight regain in obesity.
Weygandt, M., Mai, K., Dommes, E., Ritter, K., Leupelt, V., Spranger, J. and Haynes, J.D.
NeuroImage 109 : 318-327. 1 April 2015

Oxidative Medicine and Cellular Longevity

Insulin-like growth factor (IGF) binding protein-2, independently of IGF-1, induces GLUT-4 translocation and glucose uptake in 3T3-L1 adipocytes.
Assefa, B., Mahmoud, A.M., Pfeiffer, A.F.H., Birkenfeld, A.L., Spranger, J. and Arafat, A.M.
Oxidative Medicine and Cellular Longevity 2017 : 3035184. 20 December 2017

PLoS ONE

Renal function is independently associated with circulating betatrophin.
Maurer, L., Schwarz, F., Fischer-Rosinsky, A., Schlueter, N., Brachs, S., Moehlig, M., Pfeiffer, A., Mai, K., Spranger, J. and Bobbert, T.
PLoS ONE 12 (3): e0173197. 3 March 2017

Inflammation-induced acute phase response in skeletal muscle and critical illness myopathy.
Langhans, C., Weber-Carstens, S., Schmidt, F., Hamati, J., Kny, M., Zhu, X., Wollersheim, T., Koch, S., Krebs, M., Schulz, H., Lodka, D., Saar, K., Labeit, S., Spies, C., Hubner, N., Spranger, J., Spuler, S., Boschmann, M., Dittmar, G., Butler-Browne, G., Mouly, V. and Fielitz, J.
PLoS ONE 9 (3): e92048. 20 March 2014

Sexual dimorphic regulation of body weight dynamics and adipose tissue lipolysis.
Benz, V., Bloch, M., Wardat, S., Boehm, C., Maurer, L., Mahmoodzadeh, S., Wiedmer, P., Spranger, J., Foryst-Ludwig, A. and Kintscher, U.
PLoS ONE 7 (5): e37794. 25 May 2012

Skeletal muscle 11beta-HSD1 controls glucocorticoid-induced proteolysis and expression of E3 ubiquitin ligases atrogin-1 and MuRF-1.
Biedasek, K., Andres, J., Mai, K., Adams, S., Spuler, S., Fielitz, J. and Spranger, J.
PLoS ONE 6 (1): e16674. 31 January 2011

Pharmacology & Therapeutics

Metabolic actions of natriuretic peptides and therapeutic potential in the metabolic syndrome.
Schlueter, N., de Sterke, A., Willmes, D.M., Spranger, J., Jordan, J. and Birkenfeld, A.L.
Pharmacology & Therapeutics 144 (1): 12-27. October 2014

The Journal of clinical endocrinology and metabolism

Plasma resistin levels and risk of myocardial infarction and ischemic stroke.
Weikert, C., Westphal, S., Berger, K., Dierkes, J., Moehlig, M., Spranger, J., Rimm, E.B., Willich, S.N., Boeing, H. and Pischon, T.
The Journal of clinical endocrinology and metabolism 93 (7): 2647-2653. July 2008

Tropical Medicine & International Health

High prevalence of anaemia among African migrants in Germany persists after exclusion of iron deficiency and erythrocyte polymorphisms.
Mueller, S.A., Amoah, S.K.B., Meese, S., Spranger, J. and Mockenhaupt, F.P.
Tropical Medicine & International Health 20 (9): 1180-1189. September 2015