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Metabolic actions of natriuretic peptides and therapeutic potential in the metabolic syndrome

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Item Type:Review
Title:Metabolic actions of natriuretic peptides and therapeutic potential in the metabolic syndrome
Creators Name:Schlueter, N., de Sterke, A., Willmes, D.M., Spranger, J., Jordan, J. and Birkenfeld, A.L.
Abstract:Natriuretic peptides (NPs) are a group of peptide-hormones mainly secreted from the heart, signaling via c-GMP coupled receptors. NP are well known for their renal and cardiovascular actions, reducing arterial blood pressure as well as sodium reabsorption. Novel physiological functions have been discovered in recent years, including activation of lipolysis, lipid oxidation, and mitochondrial respiration. Together, these responses promote white adipose tissue browning, increase muscular oxidative capacity, particularly during physical exercise, and protect against diet-induced obesity and insulin resistance. Exaggerated NP release is a common finding in congestive heart failure. In contrast, NP deficiency is observed in obesity and in type-2 diabetes, pointing to an involvement of NP in the pathophysiology of metabolic disease. Based upon these findings, the NP system holds the potential to be amenable to therapeutical intervention against pandemic diseases such as obesity, insulin resistance, and arterial hypertension. Various therapeutic approaches are currently under development. This paper reviews the current knowledge on the metabolic effects of the NP system and discusses potential therapeutic applications.
Keywords:Natriuretic Peptides, ANP, BNP, Insulin Resistance, Diabetes, Obesity, Animals
Source:Pharmacology & Therapeutics
Publisher:Elsevier / Pergamon Press
Page Range:12-27
Date:October 2014
Additional Information:Copyright © 2014 Elsevier Inc. All rights reserved. This article is available under the Creative Commons CC-BY-NC-ND 3.0 license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed.
Official Publication:https://doi.org/10.1016/j.pharmthera.2014.04.007
PubMed:View item in PubMed

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