Browse by Research Team

2023

Network analysis of large-scale ImmGen and Tabula Muris datasets highlights metabolic diversity of tissue mononuclear phagocytes.
Gainullina, A., Mogilenko, D.A., Huang, L.H., Todorov, H., Narang, V., Kim, K.W., Yng, L.S., Kent, A., Jia, B., Seddu, K., Krchma, K., Wu, J., Crozat, K., Tomasello, E., Dress, R., See, P., Scott, C., Gibbings, S., Bajpai, G., Desai, J.V., Maier, B., This, S., Wang, P., Aguilar, S.V., Poupel, L., Dussaud, S., Zhou, T.A., Angeli, V., Blander, J.M., Choi, K., Dalod, M., Dzhagalov, I., Gautier, E.L., Jakubzick, C., Lavine, K., Lionakis, M.S., Paidassi, H., Sieweke, M.H., Ginhoux, F., Guilliams, M., Benoist, C., Merad, M., Randolph, G.J., Sergushichev, A. and Artyomov, M.N.
Cell Reports 42 (2): 112046. 28 February 2023

2022

Long-term culture-expanded alveolar macrophages restore their full epigenetic identity after transfer in vivo.
Subramanian, S., Busch, C.J.L., Molawi, K., Geirsdottir, L., Maurizio, J., Vargas Aguilar, S., Belahbib, H., Gimenez, G., Yuda, R.A.A., Burkon, M., Favret, J., Gholamhosseinian Najjar, S., de Laval, B., Kandalla, P.K., Sarrazin, S., Alexopoulou, L. and Sieweke, M.H.
Nature Immunology 23 (3): 458-468. March 2022

2021

TLR7 signaling drives the development of Sjögren's syndrome.
Wang, Y., Roussel-Queval, A., Chasson, L., Hanna Kazazian, N., Marcadet, L., Nezos, A., Sieweke, M.H., Mavragani, C. and Alexopoulou, L.
Frontiers in Immunology 12 : 676010. 24 May 2021

Trained immunity, tolerance, priming and differentiation: distinct immunological processes.
Divangahi, M., Aaby, P.r, Khader, S.A., Barreiro, L.B., Bekkering, S., Chavakis, T., van Crevel, R., Curtis, N., DiNardo, A.R., Dominguez-Andres, J., Duivenvoorden, R., Fanucchi, S., Fayad, Z., Fuchs, E., Hamon, M., Jeffrey, K.L., Khan, N., Joosten, L.A.B., Kaufmann, E., Latz, E., Matarese, G., van der Meer, J.W.M., Mhlanga, M., Moorlag, S.J.C.F.M., Mulder, W.J.M., Naik, S., Novakovic, B., O'Neill, L., Ochando, J., Ozato, K., Riksen, N.P., Sauerwein, R., Sherwood, E.R., Schlitzer, A., Schultze, J.L., Sieweke, M.H., Benn, C.S., Stunnenberg, H., Sun, J., van de Veerdonk, F.L., Weis, S., Williams, D.L., Xavier, R. and Netea, M.G.
Nature Immunology 22 (1): 2-6. January 2021

2020

Open Source ImmGen: network perspective on metabolic diversity among mononuclear phagocytes.
Gainullina, A., Huang, L.H., Todorov, H., Kim, K., Yng, L.S., Kent, A., Jia, B., Seddu, K., Krchma, K., Wu, J., Crozat, K., Tomasello, E., Narang, V., Dress, R., See, P., Scott, C., Gibbings, S., Bajpai, G., Desai, J.V., Maier, B., This, S., Wang, P., Aguilar, S.V., Poupel, L., Dussaud, S., Zhou, T.A., Angeli, V., Blander, J.M., Choi, K., Dalod, M., Dzhagalov, I., Gautier, E.L., Jakubzick, C., Lavine, K., Lionakis, M.S., Paidassi, H., Sieweke, M.H., Ginhoux, Fl., Guilliams, M., Benoist, C., Merad, M., Randolph, G.J., Sergushichev, A. and Artyomov, M.N.
bioRxiv : 2020.07.15.204388. 16 July 2020

C/EBPβ-dependent epigenetic memory induces trained immunity in hematopoietic stem cells.
de Laval, B., Maurizio, J., Kandalla, P.K., Brisou, G., Simonnet, L., Huber, C., Gimenez, G., Matcovitch-Natan, O., Reinhardt, S., David, E., Mildner, A., Leutz, A., Nadel, B., Bordi, C., Amit, I., Sarrazin, S. and Sieweke, M.H.
Cell Stem Cell 26 (5): 657-674. May 2020

2019

Bhlhe40 and Bhlhe41 transcription factors regulate alveolar macrophage self-renewal and identity.
Rauschmeier, R., Gustafsson, C., Reinhardt, A., A-Gonzalez, N., Tortola, L., Cansever, D., Subramanian, S., Taneja, R., Rossner, M.J., Sieweke, M.H., Greter, M., Månsson, R., Busslinger, M. and Kreslavsky, T.
EMBO Journal 38 (19): e101233. 1 October 2019

Isolation and long-term cultivation of mouse alveolar macrophages.
Busch, C. J.-L., Favret, J., Geirsdóttir, L., Molawi, K. and Sieweke, M.H.
Bio-protocol 9 (14) 20 July 2019

Characterization of mouse adult testicular macrophage populations by immunofluorescence imaging and flow cytometry.
Mossadegh-Keller, N. and Sieweke, M.H.
Bio-protocol 9 (5): e3178. 5 March 2019

2018

Testicular macrophages: guardians of fertility.
Mossadegh-Keller, Noushin and Sieweke, M.H.
Cellular Immunology 330 : 120-125. August 2018

c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4(+) T cells.
Gabryšová, L., Alvarez-Martinez, M., Luisier, R., Cox, L.S., Sodenkamp, J., Hosking, C., Pérez-Mazliah, D., Whicher, C., Kannan, Y., Potempa, K., Wu, X., Bhaw, L., Wende, H., Sieweke, M.H., Elgar, G., Wilson, M., Briscoe, J., Metzis, V., Langhorne, J., Luscombe, N.M. and O'Garra, A.
Nature Immunology 19 (5): 497-507. May 2018

2017

Trained macrophages support hygiene hypothesis.
de Laval, B. and Sieweke, M.H.
Nature Immunology 18 (12): 1279-1280. 16 November 2017

Developmental origin and maintenance of distinct testicular macrophage populations.
Mossadegh-Keller, N., Gentek, R., Gimenez, G., Bigot, S., Mailfert, S. and Sieweke, M.H.
Journal of Experimental Medicine 214 (10): 2829-2841. 2 October 2017

SIRT1 regulates macrophage self-renewal.
Imperatore, F., Maurizio, J., Vargas Aguilar, S., Busch, C.J., Favret, J., Kowenz-Leutz, E., Cathou, W., Gentek, R., Perrin, P., Leutz, A., Berruyer, C. and Sieweke, M.H.
EMBO Journal 36 (16): 2353-2372. 15 August 2017

2016

DNA damage signaling instructs polyploid macrophage fate in granulomas.
Herrtwich, L., Nanda, I., Evangelou, K., Nikolova, T., Horn, V., Sagar, Erny, D., Stefanowski, J., Rogell, L., Klein, C., Gharun, K., Follo, M., Seidl, M., Kremer, B., Münke, N., Senges, J., Fliegauf, M., Aschman, T., Pfeifer, D., Sarrazin, S., Sieweke, M.H., Wagner, D., Dierks, C., Haaf, T., Ness, T., Zaiss, M.M., Voll, R.E., Deshmukh, S.D., Prinz, M., Goldmann, T., Hölscher, C., Hauser, A.E., Lopez-Contreras, A.J., Grün, D., Gorgoulis, V., Diefenbach, A., Henneke, P. and Triantafyllopoulou, A.
Cell 167 (5): 1264-1280. 17 November 2016

Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line.
Chu, V.T., Graf, R., Wirtz, T., Weber, T., Favret, J., Li, X., Petsch, K., Tran, N.T., Sieweke, M.H., Berek, C., Kühn, R. and Rajewsky, K.
Proceedings of the National Academy of Sciences of the United States of America 113 (44): 12514-12519. 1 November 2016

M-CSF improves protection against bacterial and fungal infections after hematopoietic stem/progenitor cell transplantation.
Kandalla, P.K., Sarrazin, S., Molawi, K., Berruyer, C., Redelberger, D., Favel, A., Bordi, C., de Bentzmann, S. and Sieweke, M.H.
Journal of Experimental Medicine 213 (11): 2269-2279. 10 October 2016

Microglia development follows a stepwise program to regulate brain homeostasis.
Matcovitch-Natan, O., Winter, D.R., Giladi, A., Vargas Aguilar, S., Spinrad, A., Sarrazin, S., Ben-Yehuda, H., David, E., Zelada González, F., Perrin, P., Keren-Shaul, H., Gury, M., Lara-Astaiso, D., Thaiss, C.A., Cohen, M., Bahar Halpern, K., Baruch, K., Deczkowska, A., Lorenzo-Vivas, E., Itzkovitz, S., Elinav, E., Sieweke, M.H., Schwartz, M. and Amit, I.
Science 353 (6301): aad8670. 19 August 2016

Eosinophils and mast cells: a lineage apart.
Sarrazin, S. and Sieweke, M.H.
Nature Immunology 17 (6): 609-611. 19 May 2016

Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells.
Soucie, E.L., Weng, Z., Geirsdóttir, L., Molawi, K., Maurizio, J., Fenouil, R., Mossadegh-Keller, N., Gimenez, G., VanHille, L., Beniazza, M., Favret, J., Berruyer, C., Perrin, P., Hacohen, N., Andrau, J.C., Ferrier, P., Dubreuil, P., Sidow, A. and Sieweke, M.H.
Science 351 (6274): aad5510. 12 February 2016

2015

Molecular profiling of CD8 T cells in autochthonous melanoma identifies Maf as driver of exhaustion.
Giordano, M., Henin, C., Maurizio, J., Imbratta, C., Bourdely, P., Buferne, M., Baitsch, L., Vanhille, L., Sieweke, M.H., Speiser, D.E., Auphan-Anezin, N., Schmitt-Verhulst, A.M. and Verdeil, G.
EMBO Journal 34 (15): 2042-2058. 4 August 2015

Monocytes compensate Kupffer cell loss during bacterial infection.
Molawi, K. and Sieweke, M.H.
Immunity 42 (1): 10-12. 20 January 2015

Waddington's Valleys and Captain Cook's Islands.
Sieweke, M.H.
Cell Stem Cell 16 (1): 7-8. 8 January 2015

Epigenetic control of myeloid cell differentiation, identity and function.
Álvarez-Errico, D., Vento-Tormo, R., Sieweke, M. and Ballestar, E.
Nature Reviews Immunology 15 (1): 7-17. January 2015

2014

Tissue macrophage identity and self-renewal.
Gentek, R., Molawi, K. and Sieweke, M.H.
Immunological Reviews 262 (1): 56-73. November 2014

Progressive replacement of embryo-derived cardiac macrophages with age.
Molawi, K., Wolf, Y., Kandalla, P.K., Favret, J., Hagemeyer, N., Frenzel, K., Pinto, A.R., Klapproth, K., Henri, S., Malissen, B., Rodewald, H.R., Rosenthal, N.A., Bajenoff, M., Prinz, M., Jung, S. and Sieweke, M.H.
Journal of Experimental Medicine 211 (11): 2151-2158. 20 October 2014

Design of a bZip transcription factor with homo/heterodimer-induced DNA-binding preference.
Pogenberg, V., Consani Textor, L., Vanhille, L., Holton, S.J., Sieweke, M.H. and Wilmanns, M.
Structure 22 (3): 466-477. 4 March 2014

2013

Beyond stem cells: self-renewal of differentiated macrophages.
Sieweke, M.H. and Allen, J.E.
Science 342 (6161): 1242974. 22 November 2013

M-CSF instructs myeloid lineage fate in single haematopoietic stem cells.
Mossadegh-Keller, N., Sarrazin, S., Kandalla, P.K., Espinosa, L., Stanley, E.R., Nutt, S.L., Moore, J. and Sieweke, M.H.
Nature 497 (7448): 239-243. 9 May 2013

Transcriptional control of macrophage identity, self-renewal, and function.
Molawi, K. and Sieweke, M.H.
Advances in Immunology 120 : 269-300. 2013