Browse by Research Team

2012

Proteolytic processing of the protein tyrosine phosphatase alpha extracellular domain is mediated by ADAM17/TACE.
Kapp, K., Siemens, J., Haering, H.U. and Lammers, R.
European Journal of Cell Biology 91 (9): 687-693. September 2012

Sonic hedgehog lineage in the mouse hypothalamus: from progenitor domains to hypothalamic regions.
Alvarez-Bolado, G., Paul, F.A. and Blaess, S.
Neural Development 7 : 4. 20 January 2012

2011

Sensory transduction, the gateway to perception: mechanisms and pathology.
Lechner, S.G. and Siemens, J.
EMBO Reports 12 (4): 292-295. 1 April 2011

2010

A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain.
Bohlen, C.J., Priel, A., Zhou, S., King, D., Siemens, J. and Julius, D.
Cell 141 (5): 834-845. 28 May 2010

2007

4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1.
Trevisani, M., Siemens, J., Materazzi, S., Bautista, D.M., Nassini, R., Campi, B., Imamachi, N., Andre, E., Patacchini, R., Cottrell, G.S., Gatti, R., Basbaum, A.I., Bunnett, N.W., Julius, D. and Geppetti, P.
Proceedings of the National Academy of Sciences of the United States of America 104 (33): 13519-13524. 14 August 2007

TRPA1 mediates formalin-induced pain.
McNamara, C.R., Mandel-Brehm, J., Bautista, D.M., Siemens, J., Deranian, K.L., Zhao, M., Hayward, N.J., Chong, J.A., Julius, D., Moran, M.M. and Fanger, C.M.
Proceedings of the National Academy of Sciences of the United States of America 104 (33): 13525-13530. 14 August 2007

The menthol receptor TRPM8 is the principal detector of environmental cold.
Bautista, D.M., Siemens, J., Glazer, J.M., Tsuruda, P.R., Basbaum, A.I., Stucky, C.L., Jordt, S.E. and Julius, D.
Nature 448 (7150): 204-208. 12 July 2007

Extracellular domain splice variants of a transforming protein tyrosine phosphatase alpha mutant differentially activate Src-kinase dependent focus formation.
Kapp, K., Siemens, J., Weyrich, P., Schulz, J.B., Haering, H.U. and Lammers, R.
Genes to Cells 12 (1): 63-73. January 2007

2006

Spider toxins activate the capsaicin receptor to produce inflammatory pain.
Siemens, J.E., Zhou, S., Piskorowski, R., Nikai, T., Lumpkin, E.A., Basbaum, A.I., King, D. and Julius, D.
Nature 444 (7116): 208-212. 9 November 2006

2004

Cadherin 23 is a component of the tip link in hair-cell stereocilia.
Siemens, J., Lillo, C., Dumont, R.A., Reynolds, A., Williams, D.S., Gillespie, P.G. and Mueller, U.
Nature 428 (6986): 950-955. 29 April 2004

Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells.
Soellner, C., Rauch, G.J., Siemens, J., Geisler, R., Schuster, S.C., Mueller, U. and Nicolson, T.
Nature 428 (6986): 955-959. 29 April 2004

2002

The Usher syndrome proteins cadherin 23 and harmonin form a complex by means of PDZ-domain interactions.
Siemens, J., Kazmierczak, P., Reynolds, A., Sticker, M., Littlewood-Evans, A. and Mueller, U.
Proceedings of the National Academy of Sciences of the United States of America 99 (23): 14946-14951. 12 November 2002

2001

Genes, deafness, and balance disorders.
Siemens, J., Littlewood-Evans, A., Senften, M. and Mueller, U.
Gene Function and Disease 2 (2-3): 76-82. 2 October 2001

The sound of silence - diseases that cause deafness and disequilibrium.
Siemens, J., Littlewood-Evans, A. and Mueller, U.
B.I.F. Futura 16 : 222-228. 2001