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Article

AI-guided pipeline for protein-protein interaction drug discovery identifies an SARS-CoV-2 inhibitor.
Trepte, P. and Secker, C. and Olivet, J. and Blavier, J. and Kostova, S. and Maseko, S.B. and Minia, I. and Silva Ramos, E. and Cassonnet, P. and Golusik, S. and Zenkner, M. and Beetz, S. and Liebich, M.J. and Scharek, N. and Schutz, A. and Sperling, M. and Lisurek, M. and Wang, Y. and Spirohn, K. and Hao, T. and Calderwood, M.A. and Hill, D.E. and Landthaler, M. and Choi, S.G. and Twizere, J.C. and Vidal, M. and Wanker, E.E.
Molecular Systems Biology 20 (4): 428-457. 2 April 2024

Structure-based design of xanthine-imidazopyridines and -imidazothiazoles as highly potent and in vivo efficacious tryptophan hydroxylase inhibitors.
Specker, E. and Wesolowski, R. and Schütz, A. and Matthes, S. and Mallow, K. and Wasinska-Kalwa, M. and Winkler, L. and Oder, A. and Alenina, N. and Pleimes, D. and von Kries, J.P. and Heinemann, U. and Bader, M. and Nazaré, M.
Journal of Medicinal Chemistry 66 (21): 14866-14896. 9 November 2023

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor.
Aguirre, T. and Hostachy, S. and Dornan, G.L. and Neuenschwander, M. and Seyffarth, C. and Haucke, V. and Schütz, A. and von Kries, J.P. and Fiedler, D.
eLife 21 : RP88982. 16 October 2023

Structure-based design of xanthine-benzimidazole derivatives as novel and potent tryptophan hydroxylase inhibitors.
Specker, E. and Matthes, S. and Wesolowski, R. and Schütz, A. and Grohmann, M. and Alenina, N. and Pleimes, D. and Mallow, K. and Neuenschwander, M. and Gogolin, A. and Weise, M. and Pfeifer, J. and Ziebart, N. and Heinemann, U. and von Kries, J.P. and Nazaré, M. and Bader, M.
Journal of Medicinal Chemistry 65 (16): 11126-11149. 25 August 2022

Community-wide experimental evaluation of the PROSS stability-design method.
Peleg, Y. and Vincentelli, R. and Collins, B.M. and Chen, K.E. and Livingstone, E.K. and Weeratunga, S. and Leneva, N. and Guo, Q. and Remans, K. and Perez, K. and Bjerga, G.E.K. and Larsen, Ø. and Vaněk, O. and Skořepa, O. and Jacquemin, S. and Poterszman, A. and Kjaer, S. and Christodoulou, E. and Albeck, S. and Dym, O. and Ainbinder, E. and Unger, T. and Schuetz, A. and Matthes, S. and Bader, M. and de Marco, A. and Storici, P. and Semrau, M.S. and Stolt-Bergner, P. and Aigner, C. and Suppmann, S. and Goldenzweig, A. and Fleishman, S.J.
Journal of Molecular Biology 433 (13): 166964. 25 June 2021

Phenylalanine-hydroxylase contributes to serotonin synthesis in mice.
Mordhorst, A. and Dhandapani, P. and Matthes, S. and Mosienko, V. and Rothe, M. and Todiras, M. and Self, J. and Schunck, W.H. and Schütz, A. and Bader, M. and Alenina, N.
FASEB Journal 35 (6): e21648. June 2021

Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family.
Ming, Q. and Roske, Y. and Schuetz, A. and Walentin, K. and Ibraimi, I. and Schmidt-Ott, K.M. and Heinemann, U.
Nucleic Acids Research 46 (4): 2082-2095. 28 February 2018

Different inhibitory potencies of oseltamivir carboxylate, zanamivir, and several tannins on bacterial and viral neuraminidases as assessed in a cell-free fluorescence-based enzyme inhibition assay.
Quosdorf, S. and Schuetz, A. and Kolodziej, H.
Molecules 22 (11): 1989. 17 November 2017

Crystal structure of the tricellulin C-terminal coiled-coil domain reveals a unique mode of dimerization.
Schuetz, A. and Radusheva, V. and Krug, S.M. and Heinemann, U.
Annals of the New York Academy of Sciences 1405 (1): 147-159. October 2017

Tricellulin is a target of the ubiquitin ligase Itch.
Jennek, S. and Mittag, S. and Reiche, J. and Westphal, J.K. and Seelk, S. and Dörfel, M.J. and Pfirrmann, T. and Friedrich, K. and Schütz, A. and Heinemann, U. and Huber, O.
Annals of the New York Academy of Sciences 1397 (1): 157-168. June 2017

Functional interaction of CCAAT/enhancer-binding-protein-α basic region mutants with E2F transcription factors and DNA.
Kowenz-Leutz, E. and Schuetz, A. and Liu, Q. and Knoblich, M. and Heinemann, U. and Leutz, A.
Biochimica et Biophysica Acta - Gene Regulatory Mechanisms 1859 (7): 841-847. July 2016

RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.
Murakawa, Y. and Hinz, M. and Mothes, J. and Schuetz, A. and Uhl, M. and Wyler, E. and Yasuda, T. and Mastrobuoni, G. and Friedel, C.C. and Dölken, L. and Kempa, S. and Schmidt-Supprian, M. and Blüthgen, N. and Backofen, R. and Heinemann, U. and Wolf, J. and Scheidereit, C. and Landthaler, M.
Nature Communications 6 : 7367. 14 July 2015

Light-switched inhibitors of protein tyrosine phosphatase PTP1B based on phosphonocarbonyl phenylalanine as photoactive phosphotyrosine mimetic.
Wagner, S. and Schütz, A. and Rademann, J.
Bioorganic and Medicinal Chemistry 23 (12): 2839-2847. 15 June 2015

Roquin binding to target mRNAs involves a winged helix-turn-helix motif.
Schuetz, A. and Murakawa, Y. and Rosenbaum, E. and Landthaler, M. and Heinemann, U.
Nature Communications 5 : 5701. 11 December 2014

Benzoylphosphonate-based photoactive phosphopeptide mimetics for modulation of protein tyrosine phosphatases and highly specific labeling of SH2 domains.
Horatscheck, A. and Wagner, S. and Ortwein, J. and Kim, B.G. and Lisurek, M. and Beligny, S. and Schuetz, A. and Rademann, J.
Angewandte Chemie International Edition 51 (37): 9441-9447. 10 September 2012

Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations.
Kirchner, F. and Schuetz, A. and Boldt, L.H. and Martens, K. and Dittmar, G. and Haverkamp, W. and Thierfelder, L. and Heinemann, U. and Gerull, B.
Circulation Cardiovascular Genetics 5 (4): 400-411. 1 August 2012

The Lin28 cold-shock domain remodels pre-let-7 microRNA.
Mayr, F. and Schütz, A. and Dge, N. and Heinemann, U.
Nucleic Acids Research 40 (15): 7492-7506. 1 August 2012

Structural and biochemical basis of Yos9 protein dimerization and possible contribution to self-association of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation ubiquitin-ligase complex.
Hanna, J. and Schütz, A. and Zimmermann, F. and Behlke, J. and Sommer, T. and Heinemann, U.
Journal of Biological Chemistry 287 (11): 8633-8640. 9 March 2012

The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation.
von Eyss, B. and Maaskola, J. and Memczak, S. and Möllmann, K. and Schuetz, A. and Loddenkemper, C. and Tanh, M.D. and Otto, A. and Muegge, K. and Heinemann, U. and Rajewsky, N. and Ziebold, U.
EMBO Journal 31 (4): 972-985. 15 February 2012

The structure of the Klf4 DNA-binding domain links to self-renewal and macrophage differentiation.
Schuetz, A. and Nana, D. and Rose, C. and Zocher, G. and Milanovic, M. and Koenigsmann, J. and Blasig, R. and Heinemann, U. and Carstanjen, D.
Cellular and Molecular Life Sciences 68 (18): 3121-3131. September 2011

Expression of protein complexes using multiple E. coli protein co-expression systems: a benchmarking study.
Busso, D. and Peleg, Y. and Heidebrecht, T. and Romier, C. and Jacobovitch, Y. and Dantes, A. and Salim, L. and Troesch, E. and Schuetz, A. and Heinemann, U. and Folkers, G.E. and Geerlof, A. and Wilmanns, M. and Polewacz, A. and Quedenau, C. and Büssow, K. and Adamson, R. and Blagova, E. and Walton, J. and Cartwright, J.L. and Bird, L.E. and Owens, R.J. and Berrow, N.S. and Wilson, K.S. and Sussman, J.L. and Perrakis, A. and Celie, P.H.
Journal of Structural Biology 175 (2): 159-170. August 2011

Repression of transcriptional activity of C/EBPα by E2F-DP complexes.
Zaragoza, K. and Bégay, V. and Schuetz, A. and Heinemann, U. and Leutz, A.
Molecular and Cellular Biology 30 (9): 2293-2304. May 2010

Usa1 functions as a scaffold of the HRD-ubiquitin ligase.
Horn, S.C. and Hanna, J. and Hirsch, C. and Volkwein, C. and Schütz, A. and Heinemann, U. and Sommer, T. and Jarosch, E.
Molecular Cell 36 (5): 782-793. 11 December 2009

Clinical variability in distal spinal muscular atrophy type 1 (DSMA1): determination of steady-state IGHMBP2 protein levels in five patients with infantile and juvenile disease.
Guenther, U.P. and Handoko, L. and Varon, R. and Stephani, U. and Tsao, C.Y. and Mendell, J.R. and Lützkendorf, S. and Hübner, C. and von Au, K. and Jablonka, S. and Dittmar, G. and Heinemann, U. and Schuetz, A. and Schuelke, M.
Journal of Molecular Medicine 87 (1): 31-41. January 2009

Patent

Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same.
Max-Delbrück-Centrum für Molekulare Medizin.
WO/2016/135199. 1 September 2016

Review

A concise guide to choosing suitable gene expression systems for recombinant protein production.
Schütz, A. and Bernhard, F. and Berrow, N. and Buyel, J.F. and Ferreira-da-Silva, F. and Haustraete, J. and van den Heuvel, J. and Hoffmann, J.E. and de Marco, A. and Peleg, Y. and Suppmann, S. and Unger, T. and Vanhoucke, M. and Witt, S. and Remans, K.
STAR Protocols 4 (4): 102572. 15 December 2023

Structural features of tight-junction proteins.
Heinemann, U. and Schuetz, A.
International Journal of Molecular Sciences 20 (23): 6020. 29 November 2019

Protein production and purification.
Gräslund, S. and Nordlund, P. and Weigelt, J. and Hallberg, M. and Bray, J. and Gileadi, O. and Knapp, S. and Oppermann, U. and Arrowsmith, C. and Hui, R. and Ming, J. and dhe-Paganon, S. and Park, H.W. and Savchenko, A. and Yee, A. and Edwards, A. and Vincentelli, R. and Cambillau, C. and Kim, R. and Kim, S.H. and Rao, Z. and Shi, Y. and Terwilliger, T.C. and Kim, C.Y. and Hung, L.W. and Waldo, G.S. and Peleg, Y. and Albeck, S. and Unger, T. and Dym, O. and Prilusky, J. and Sussman, J.L. and Stevens, R.C. and Lesley, S.A. and Wilson, I.A. and Joachimiak, A. and Collart, F. and Dementieva, I. and Donnelly, M.I. and Eschenfeldt, W.H. and Kim, Y.M. and Stols, L. and Wu, R. and Zhou, M. and Burley, S.K. and Emtage, J.S. and Sauder, J.M. and Thompson, D. and Bain, K. and Luz, J. and Gheyi, T. and Zhang, F. and Atwell, S. and Almo, S.C. and Bonanno, J.B. and Fiser, A. and Swaminathan, S. and Studier, F.W. and Chance, M.R. and Sali, A. and Acton, T.B. and Xiao, R. and Zhao, L. and Ma, L.C. and Hunt, J.F. and Tong, L. and Cunningham, K. and Inouye, M. and Anderson, S. and Janjua, H. and Shastry, R. and Ho, C.K. and Wang, D. and Wang, H. and Jiang, M. and Montelione, G.T. and Stuart, D.I. and Owens, R.J. and Daenke, S. and Schütz, A. and Heinemann, U. and Yokoyama, S. and Büssow, K. and Gunsalus, K.C.
Nature Methods 5 (2): 135-146. February 2008