Browse by Research Team

2024

Covalent penicillin-protein conjugates elicit anti-drug antibodies that are clonally and functionally restricted.
Deimel, L.P., Moynié, L., Sun, G., Lewis, V., Turner, A., Buchanan, C.J., Burnap, S.A., Kutuzov, M., Kobras, C.M., Demyaneko, Y., Mohammed, S., Stracy, M., Struwe, W.B., Baldwin, A.J., Naismith, J., Davis, B.G. and Sattentau, Q.J.
Nature Communications 15 (1): 6851. 10 August 2024

Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis.
Drexhage, L.Z., Zhang, S., Dupont, M., Ragaller, F., Sjule, E., Cabezas-Caballero, J., Deimel, L.P., Robertson, H., Russell, R.A., Dushek, O., Sezgin, E., Karaji, N. and Sattentau, Q.J.
Nature Communications 15 (1): 541. 15 January 2024

2023

Profound structural conservation of chemically cross-linked HIV-1 envelope glycoprotein experimental vaccine antigens.
Martin, G.M., Russell, R.A., Mundsperger, P., Harris, S., Jovanoska, L., Trajano, L.F., Schiffner, T., Fabian, K., Tolazzi, M., Scarlatti, G., McFarlane, L., Cheeseman, H., Aldon, Y., Schermer, E.E., Breemen, M., Sliepen, K., Katinger, D., Kunert, R., Sanders, R.W., Shattock, R., Ward, A.B. and Sattentau, Q.J.
NPJ Vaccines 8 (1): 101. 13 July 2023

2022

Intranasal SARS-CoV-2 spike-based immunisation adjuvanted with polyethyleneimine elicits mucosal and systemic humoral responses in mice.
Deimel, L.P., Liu, X., Gilbert-Jaramillo, J., Liu, S., James, W.S. and Sattentau, Q.J.
Journal of Immunological Methods 511 : 113380. December 2022

Glycans in HIV-1 vaccine design - engaging the shield.
Deimel, L.P., Xue, X. and Sattentau, Q.J.
Trends in Microbiology 30 (9): 866-881. September 2022

Pathogen-sugar interactions revealed by universal saturation transfer analysis.
Buchanan, C.J., Gaunt, B., Harrison, P.J., Yang, Y., Liu, J., Khan, A., Giltrap, A.M., Le Bas, A., Ward, P.N., Gupta, K., Dumoux, M., Tan, T.K., Schimaski, L., Daga, S., Picchiotti, N., Baldassarri, M., Benetti, E., Fallerini, C., Fava, F., Giliberti, A., Koukos, P.I., Davy, M.J., Lakshminarayanan, A., Xue, X., Papadakis, G., Deimel, L.P., Casablancas-Antràs, V., Claridge, T.D.W., Bonvin, A.M.J.J., Sattentau, Q.J., Furini, S., Gori, M., Huo, J., Owens, R.J., Schaffitzel, C., Berger, I., Renieri, A., Naismith, J.H., Baldwin, A.J. and Davis, B.G.
Science 377 (6604): eabm3125. 22 July 2022

Shared sugars - parasite glycan homology in HIV-1 vaccine design.
Deimel, L.P. and Sattentau, Q.J.
Trends in Parasitology 38 (7): 498-500. July 2022

Vaccine-associated enhanced disease and pathogenic human coronaviruses.
Gartlan, C., Tipton, T., Salguero, F.J., Sattentau, Q., Gorringe, A. and Carroll, M.W.
Frontiers in Immunology 13 : 882972. 4 April 2022

High thermostability improves neutralizing antibody responses induced by native-like HIV-1 envelope trimers.
Del Moral-Sánchez, I., Russell, R.A., Schermer, E.E., Cottrell, C.A., Allen, J.D., Torrents de la Peña, A., LaBranche, C.., Kumar, S., Crispin, M., Ward, A.B., Montefiori, D.C., Sattentau, Q.J., Sliepen, K. and Sanders, R.W.
NPJ Vaccines 7 (1): 27. 28 February 2022

2021

Human MAIT cells respond to and suppress HIV-1.
Phetsouphanh, C., Phalora, P., Hackstein, C.P., Thornhill, J., Munier, C.M.L., Meyerowitz, J., Murray, L., VanVuuren, C., Goedhals, D., Drexhage, L., Moore, R., Sattentau, Q.J., Mak, J.Y., Fairlie, D.P., Fidler, S., Kelleher, A.D., Frater, J. and Klenerman, P.
eLife 10 : e50324. 24 December 2021

Immunological and pathological outcomes of SARS-CoV-2 challenge following formalin-inactivated vaccine in ferrets and rhesus macaques.
Bewley, K.R., Gooch, K., Thomas, K.M., Longet, S., Wiblin, N., Hunter, L., Chan, K., Brown, P., Russell, R. A., Ho, C., Slack, G., Humphries, H.E., Alden, L., Allen, L., Aram, M., Baker, N., Brunt, E., Cobb, R., Fotheringham, S., Harris, D., Kennard, C., Leung, S., Ryan, K., Tolley, H., Wand, N., White, A., Sibley, L., Sarfas, C., Pearson, G., Rayner, E., Xue, X., Lambe, T., Charlton, S., Gilbert, S., Sattentau, Q.J., Gleeson, F., Hall, Y., Funnell, S., Sharpe, S., Salguero, F.J., Gorringe, A. and Carroll, M.
Science Advances 7 (37): eabg7996. 10 September 2021

Interplay of diverse adjuvants and nanoparticle presentation of native-like HIV-1 envelope trimers.
Sliepen, K., Schermer, E., Bontjer, I., Burger, J.A., Lévai, R.F., Mundsperger, P., Brouwer, P.J.M., Tolazzi, M., Farsang, A., Katinger, D., Moore, J.P., Scarlatti, G., Shattock, R.J., Sattentau, Q.J. and Sanders, R.W.
NPJ Vaccines 6 (1): 103. 17 August 2021

Stepwise conformational stabilization of a HIV-1 Clade C consensus envelope trimer immunogen impacts the profile of vaccine-induced antibody responses.
Hauser, A., Carnell, G., Held, K., Sulbaran, G., Tischbierek, N., Rogers, L., Pollakis, G., Tonks, P., Hoelscher, M., Ding, S., Sanders, R.W., Geldmacher, C., Sattentau, Q., Weissenhorn, W., Heeney, J.L., Peterhoff, D. and Wagner, R.
Vaccines 9 (7): 750. 6 July 2021

Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization.
Turner, H.L., Andrabi, R., Cottrell, C.A., Richey, S.T., Song, G., Callaghan, S., Anzanello, F., Moyer, T.J., Abraham, W., Melo, M., Silva, M., Scaringi, N., Rakasz, E.G., Sattentau, Q.J., Irvine, D.J., Burton, D.R. and Ward, A.B.
Science Advances 7 (31): eabh2791. July 2021

Augmenting the immune response against a stabilized HIV-1 Clade C envelope trimer by silica nanoparticle delivery.
Peterhoff, D., Thalhauser, S., Sobczak, J.M., Mohsen, M.O., Voigt, C., Seifert, N., Neckermann, P., Hauser, A., Ding, S., Sattentau, Q., Bachmann, M.F., Breunig, M. and Wagner, R.
Vaccines 9 (6): 642. 11 June 2021

The role and uses of antibodies in COVID-19 infections: a living review.
Scourfield, D.C., Reed, S.G., Quastel, M., Alderson, J., Bart, V.M.T., Teijeira Crespo, A., Jones, R., Pring, E., Richter, F.C. and Burnell, S.E.A.
Oxford Open Immunology 2 (1): iqab003. 28 January 2021

2020

Macrophage Cell-Cell Interactions Promoting HIV-1 Infection.
Dupont, M. and Sattentau, Q.J.
Viruses 12 (5): 492. 28 April 2020

2019

Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies.
LaBranche, C.C., Henderson, R., Hsu, A., Behrens, S., Chen, X., Zhou, T., Wiehe, K., Saunders, K.O., Alam, S.M., Bonsignori, M., Borgnia, M.J., Sattentau, Q.J., Eaton, A., Greene, K., Gao, H., Liao, H.X., Williams, W.B., Peacock, J., Tang, H., Perez, L.G., Edwards, R.J., Kepler, T.B., Korber, B.T., Kwong, P.D., Mascola, J.R., Acharya, P., Haynes, B.F. and Montefiori, D.C.
PLoS Pathogens 15 (9): e1008026. 17 September 2019

2018

HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRC01-class broadly neutralizing antibodies.
LaBranche, C.C., McGuire, A.T., Gray, M.D., Behrens, S., Chen, X., Zhou, T., Sattentau, Q.J., Peacock, J., Eaton, A., Greene, K., Gao, H., Tang, H., Perez, L.G., Saunders, K.O., Kwong, P.D., Mascola, J.R., Haynes, B.F., Stamatatos, L. and Montefiori, D.C.
PLoS Pathogens 14 (11): e1007431. 5 November 2018

RNA helicase DDX1 converts RNA G-quadruplex structures into R-loops to promote IgH class switch recombination.
Ribeiro de Almeida, C., Dhir, S., Dhir, A., Moghaddam, A.E., Sattentau, Q., Meinhart, A. and Proudfoot, N.J.
Molecular Cell 70 (4): 650-662. 17 May 2018

Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins.
Schiffner, T., Pallesen, J., Russell, R.A., Dodd, J., de Val, N., LaBranche, C.C., Montefiori, D., Tomaras, G.D., Shen, X., Harris, S.L., Moghaddam, A.E., Kalyuzhniy, O., Sanders, R.W., McCoy, L.E., Moore, J.P., Ward, A.B. and Sattentau, Q.J.
PLoS Pathogens 14 (5): e1006986. 10 May 2018

How has microbiology changed over the past 25 years?
Doolittle, W.F., Finlay, B.B., Fischetti, V.A., Kaufmann, S.H.E., Sasakawa, C. and Sattentau, Q.
Trends in Microbiology 26 (4): 246-250. April 2018

2017

Efferocytosis of pathogen-infected cells.
Karaji, N. and Sattentau, Q.J.
Frontiers in Immunology 8 : 1863. 22 December 2017

Stabilized HIV-1 envelope glycoprotein trimers for vaccine use.
Medina-Ramírez, M., Sanders, R.W. and Sattentau, Q.J.
Current Opinion in HIV and AIDS 12 (3): 241-249. May 2017

Astrocytes resist hiv-1 fusion but engulf infected macrophage material.
Russell, R.A., Chojnacki, J., Jones, D.M., Johnson, E., Do, T., Eggeling, C., Padilla-Parra, S. and Sattentau, Q.J.
Cell Reports 18 (6): 1473-1483. 7 February 2017

2016

Sterile inflammation induced by Carbopol elicits robust adaptive immune responses in the absence of pathogen-associated molecular patterns.
Gartlan, K.H., Krashias, G., Wegmann, F., Hillson, W.R., Scherer, E.M., Greenberg, P.D., Eisenbarth, S.C., Moghaddam, A.E. and Sattentau, Q.J.
Vaccine 34 (19): 2188-2196. 27 April 2016

The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation.
Kabat, A.M., Harrison, O.J., Riffelmacher, T., Moghaddam, A.E., Pearson, C.F., Laing, A., Abeler-Dörner, L., Forman, S.P., Grencis, R.K., Sattentau, Q., Simon, A.K., Pott, J. and Maloy, K.J.
eLife 5 : e12444. 11 March 2016

Macrophages and HIV-1: an unhealthy constellation.
Sattentau, Q.J. and Stevenson, M.
Cell Host & Microbe 19 (3): 304-310. 9 March 2016

Chemical cross-linking stabilizes native-like HIV-1 envelope glycoprotein trimer antigens.
Schiffner, T., de Val, N., Russell, R.A., de Taeye, S.W., de la Peña, A.T., Ozorowski, G., Kim, H.J., Nieusma, T., Brod, F., Cupo, A., Sanders, R.W., Moore, J.P., Ward, A.B. and Sattentau, Q.J.
Journal of Virology 90 (2): 813-828. 15 January 2016

2015

The carbomer-lecithin adjuvant Adjuplex has potent immunoactivating properties and elicits protective adaptive immunity against influenza virus challenge in mice.
Wegmann, F., Moghaddam, A.E., Schiffner, T., Gartlan, K.H., Powell, T.J., Russell, R.A., Baart, M., Carrow, E.W. and Sattentau, Q.J.
Clinical and Vaccine Immunology 22 (9): 1004-1012. 9 September 2015

Structural repertoire of HIV-1-neutralizing antibodies targeting the CD4 supersite in 14 donors.
Zhou, T., Lynch, R.M., Chen, L., Acharya, P., Wu, X., Doria-Rose, N.A., Joyce, M.G., Lingwood, D., Soto, C., Bailer, R.T., Ernandes, M.J., Kong, R., Longo, N.S., Louder, M.K., McKee, K., O'Dell, S., Schmidt, S.D., Tran, L., Yang, Z., Druz, A., Luongo, T.S., Moquin, S., Srivatsan, S., Yang, Y., Zhang, B., Zheng, A., Pancera, M., Kirys, T., Georgiev, I.S., Gindin, T., Peng, H.P., Yang, A.S., Mullikin, J.C., Gray, M.D., Stamatatos, L., Burton, D.R., Koff, W.C., Cohen, M.S., Haynes, B.F., Casazza, J.P., Connors, M., Corti, D., Lanzavecchia, A., Sattentau, Q.J., Weiss, R.A., West, A.P., Bjorkman, P.J., Scheid, J.F., Nussenzweig, M.C., Shapiro, L., Mascola, J.R. and Kwong, P.D.
Cell 161 (6): 1280-92. 4 June 2015

Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs: Complete protection of rhesus monkeys from mucosal SHIV challenge.
Sholukh, A.M., Watkins, J.D., Vyas, H.K., Gupta, S., Lakhashe, S.K., Thorat, S., Zhou, M., Hemashettar, G., Bachler, B.C., Forthal, D.N., Villinger, F., Sattentau, Q.J., Weiss, R.A., Agatic, G., Corti, D., Lanzavecchia, A., Heeney, J.L. and Ruprecht, R.M.
Vaccine 33 (17): 2086-95. 21 April 2015

2014

Macrophage infection via selective capture of HIV-1-infected CD4(+) T cells.
Baxter, A.E., Russell, R.A., Duncan, C.J.A., Moore, M.D., Willberg, C.B., Pablos, J.L., Finzi, A., Kaufmann, D.E., Ochsenbauer, C., Kappes, J.C., Groot, F. and Sattentau, Q.J.
Cell Host & Microbe 16 (6): 711-721. 10 December 2014

Comparison of neutralizing antibody responses elicited from highly diverse polyvalent heterotrimeric HIV-1 gp140 cocktail immunogens versus a monovalent counterpart in rhesus macaques.
Bowles, E.J., Schiffner, T., Rosario, M., Needham, G.A., Ramaswamy, M., McGouran, J., Kessler, B., LaBranche, C., McMichael, A.J., Montefiori, D., Sattentau, Q.J., Hanke, T. and Stewart-Jones, G.B.E.
PLoS ONE 9 (12): e114709. 9 December 2014

Dry roasting enhances peanut-induced allergic sensitization across mucosal and cutaneous routes in mice.
Moghaddam, A.E., Hillson, W.R., Noti, M., Gartlan, K.H., Johnson, S., Thomas, B., Artis, D. and Sattentau, Q.J.
Journal of Allergy and Clinical Immunology 134 (6): 1453-1456. December 2014

Polyethyleneimine is a potent systemic adjuvant for glycoprotein antigens.
Sheppard, N.C., Brinckmann, S.A., Gartlan, K.H., Puthia, M., Svanborg, C., Krashias, G., Eisenbarth, S.C., Flavell, R.A., Sattentau, Q.J. and Wegmann, F.
International Immunology 26 (10): 531-538. October 2014

Refocussing antibody responses by chemical modification of vaccine antigens.
Schiffner, T., Leonavicius, K., Schuster, H., Kim, H.J., Kong, L., Saliba, R., Brod, F., Wegmann, F., Huang, P.S., Stewart-Jones, G.B., Schief, W.R., Ward, A.B., Moore, J.P., Sanders, R.W., Davis, B.G. and Sattentau, Q.J.
AIDS Research and Human Retroviruses 30 (S1): A66-A67. October 2014

Immunogen design to focus the B-cell repertoire.
Sattentau, Q.J.
Current Opinion in HIV and AIDS 9 (3): 217-223. May 2014

High-multiplicity HIV-1 infection and neutralizing antibody evasion mediated by the macrophage-T cell virological synapse.
Duncan, C.J.A., Williams, J.P., Schiffner, T., Gärtner, K., Ochsenbauer, C., Kappes, J., Russell, R.A., Frater, J. and Sattentau, Q.J.
Journal of Virology 88 (4): 2025-2034. February 2014

2013

Cell-to-cell spread of HIV-1 and evasion of neutralizing antibodies.
Schiffner, T., Sattentau, Q.J. and Duncan, C.J.A.
Vaccine 31 (49): 5789-97. 2 December 2013

Envelope glycoprotein trimers as HIV-1 vaccine immunogens.
Sattentau, Q.J.
Vaccines 1 (4): 497-512. 28 October 2013

Immune focusing and enhanced neutralization induced by HIV-1 gp140 chemical cross-linking.
Schiffner, T., Kong, L., Duncan, C.J.A., Back, J.W., Benschop, J.J., Shen, X., Huang, P.S., Stewart-Jones, G.B., DeStefano, J., Seaman, M.S., Tomaras, G.D., Montefiori, D.C., Schief, W.R. and Sattentau, Q.J.
Journal of Virology 87 (18): 10163-10172. 15 September 2013

High multiplicity HIV-1 cell-to-cell transmission from macrophages to CD4+ T cells limits antiretroviral efficacy.
Duncan, C.J.A., Russell, R.A. and Sattentau, Q.J.
AIDS 27 (14): 2201-2206. 10 September 2013

Multiple proviral integration events after virological synapse-mediated HIV-1 spread.
Russell, R.A., Martin, N., Mitar, I., Jones, E. and Sattentau, Q.J.
Virology 443 (1): 143-149. 15 August 2013

The HIV-1-containing macrophage compartment: a perfect cellular niche?
Tan, J. and Sattentau, Q.J.
Trends in Microbiology 21 (8): 405-412. 8 August 2013

Thymic stromal lymphopoietin–elicited basophil responses promote eosinophilic esophagitis.
Noti, M., Wojno, E.D.T., Kim, B.S., Siracusa, M.C., Giacomin, P.R., Nair, M.G., Benitez, A.J., Ruymann, K.R., Muir, A.B., Hill, D.A., Chikwava, K.R., Moghaddam, A.E., Sattentau, Q.J., Alex, A., Zhou, C., Yearley, J.H., Menard-Katcher, P., Kubo, M., Obata-Ninomiya, K., Karasuyama, H., Comeau, M.R., Brown-Whitehorn, T., de Waal Malefyt, R., Sleiman, P.M., Hakonarson, H., Cianferoni, A., Falk, G.W., Wang, M.L., Spergel, J.M. and Artis, D.
Nature Medicine 19 (8): 1005-1013. August 2013

Development of prophylactic vaccines against HIV-1.
Schiffner, T., Sattentau, Q.J. and Dorrell, L.
Retrovirology 10 : 72. 17 July 2013

Anti-HIV IgA isotypes: differential virion capture and inhibition of transcytosis are linked to prevention of mucosal R5 SHIV transmission.
Watkins, J.D., Sholukh, A.M., Mukhtar, M.M., Siddappa, N.B., Lakhashe, S.K., Kim, M., Reinherz, E.L., Gupta, S., Forthal, Do.N., Sattentau, Q.J., Villinger, F., Corti, D. and Ruprecht, R.M.
AIDS 27 (9): F13-F20. 1 June 2013

2010

Potent adaptive immune responses induced against HIV-1 gp140 and influenza virus HA by a polyanionic carbomer.
Krashias, G., Simon, A.K., Wegmann, F., Kok, W.L., Ho, L.P., Stevens, D., Skehel, J., Heeney, J.L., Moghaddam, A.E. and Sattentau, Q.J.
Vaccine 28 (13): 2482-9. 16 March 2010

2008

Efficient HIV-1 transmission from macrophages to T cells across transient virological synapses.
Groot, F., Welsch, S. and Sattentau, Q.J.
Blood 111 (9): 4660-3. 1 May 2008