Browse by Research Team

2016

Immune modulation and prevention of autoimmune disease by repeated sequences from parasites linked to self antigens.
Puentes, F., Dickhaut, K., Hofstätter, M., Pfeil, J., Lauer, U., Hamann, A., Hoffmann, U., Falk, K. and Roetzschke, O.
Journal of Neuroimmune Pharmacology 11 (4): 749-762. December 2016

2013

Active suppression induced by repetitive self-epitopes protects against EAE development.
Puentes, F., Dickhaut, K., Hofstätter, M., Falk, K. and Roetzschke, O.
PLoS ONE 8 (5): e64888. 30 May 2013

2011

Characterization of structural features controlling the receptiveness of empty class II MHC molecules.
Rupp, B., Guenther, S., Makhmoor, T., Schlundt, A., Dickhaut, K., Gupta, S., Choudhary, I., Wiesmueller, K.H., Jung, G., Freund, C., Falk, K., Roetzschke, O. and Kuehne, R.
PLoS ONE 6 (4): e18662. 14 April 2011

2010

Bidirectional binding of invariant chain peptides to an MHC class II molecule.
Guenther, S., Schlundt, A., Sticht, J., Roske, Y., Heinemann, U., Wiesmueller, K.H., Jung, G., Falk, K., Roetzschke, O. and Freund, C.
Proceedings of the National Academy of Sciences of the United States of America 107 (51): 22219-22224. 21 December 2010

Regulatory T cells in transplantation: does extracellular adenosine triphosphate metabolism through CD39 play a crucial role?
Salcido-Ochoa, F., Tsang, J., Tam, P., Falk, K. and Roetzschke, O.
Transplantation Reviews 24 (2): 52-66. April 2010

2009

Enhancement of tumour-specific immune responses in vivo by 'MHC Loading-Enhancer' (MLE).
Dickhaut, K., Hoepner, S., Eckhard, J., Wiesmueller, K.H., Schindler, L., Jung, G., Falk, K. and Roetzschke, O.
PLoS ONE 4 (9): e6811. 7 September 2009

Absence of leucine zipper in the natural FOXP3Delta2Delta7 isoform does not affect dimerization but abrogates suppressive capacity.
Mailer, R.K., Falk, K. and Roetzschke, O.
PLoS ONE 4 (7): e6104. 1 July 2009

Regulatory T cells ameliorate angiotensin II-induced cardiac damage.
Kvakan, H., Kleinewietfeld, M., Qadri, F., Park, J.K., Fischer, R., Schwarz, I., Rahn, H.P., Plehm, R., Wellner, M., Elitok, S., Gratze, P., Dechend, R., Luft, F.C. and Mueller, D.N.
Circulation 119 (22): 2904-2912. 9 June 2009

A xenon-129 biosensor for monitoring MHC-peptide interactions.
Schlundt, A., Kilian, W., Beyermann, M., Sticht, J., Guenther, S., Hoepner, S., Falk, K., Roetzschke, O., Mitschang, L. and Freund, C.
Angewandte Chemie International Edition 48 (23): 4142-4145. 25 May 2009

In vivo-activated CD103+ Foxp3+ Tregs: of men and mice.
Roetzschke, O., Borsellino, G., Battistini, L., Falk, K. and Kleinewietfeld, M.
Blood 113 (9): 2119-2120. 26 February 2009

CD49d provides access to 'untouched' human Foxp3+ Treg free of contaminating effector cells.
Kleinewietfeld, M., Starke, M., Mitri, D.D., Borsellino, G., Battistini, L., Roetzschke, O. and Falk, K.
Blood 113 (4): 827-836. 22 January 2009

2008

Anchor side chains of short peptide fragments trigger ligand-exchange of class II MHC molecules.
Gupta, S., Hoepner, S., Rupp, B., Guenther, S., Dickhaut, K., Agarwal, N., Cardoso, M.C., Kuehne, R., Wiesmueller, K.H., Jung, G., Falk, K. and Roetzschke, O.
PLoS ONE 3 (3): e1814. 19 March 2008

Hydrolysis of extracellular ATP by CD39+ Treg cells: context matters!
Kleinewietfeld, M., Dimitri, D., Sternjak, A., Diamantini, A., Borsellino, G., Battistini, L., Roetzschke, O. and Falk, K.
Blood 111 (2): 965-966. 15 January 2008

2007

Design of protease-resistant myelin basic protein-derived peptides by cleavage site directed amino acid substitutions.
Burster, T., Marin-Esteban, V., Boehm, B.O., Dunn, S., Roetzschke, O., Falk, K., Weber, E., Verhelst, S.H., Kalbacher, H. and Driessen, C.
Biochemical Pharmacology 74 (10): 1514-1523. 15 November 2007

Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression.
Borsellino, G., Kleinewietfeld, M., Di Mitri, D., Sternjak, A., Diamantini, A., Giometto, R., Hoepner, S., Centonze, D., Bernardi, G., Dell'Acqua, M.L., Rossini, P.M., Battistini, L., Roetzschke, O. and Falk, K.
Blood 110 (4): 1225-1232. 15 August 2007

Multimerized T cell epitopes protect from experimental autoimmune diabetes by inducing dominant tolerance.
Piaggio, E., Mars, L.T., Cassan, C., Cabarrocas, J., Hofstätter, M., Desbois, S., Bergereau, E., Roetzschke, O., Falk, K. and Liblau, R.S.
Proceedings of the National Academy of Sciences of the United States of America 104 (22): 9393-9398. 29 May 2007

Interferon-gamma regulates cathepsin G activity in microglia-derived lysosomes and controls the proteolytic processing of myelin basic protein in vitro.
Burster, T., Becker, A., Poeschel, S., Oren, A., Baechle, D., Reich, M., Roetzschke, O., Falk, K., Boehm, B.O., Youssef, S., Kalbacher, H., Overkleeft, H., Tolosa, E. and Driessen, C.
Immunology 121 (1): 82-93. May 2007

2006

Small organic compounds enhance antigen-loading of class II MHC proteins by targeting the polymorphic P1 pocket.
Hoepner, S., Dickhaut, K., Hofstätter, M., Kraemer, H., Rueckerl, D., Soederhaell, J.A., Gupta, S., Marin-Esteban, V., Kuehne, R., Freund, C., Jung, G., Falk, K. and Roetzschke, O.
Journal of Biological Chemistry 281 (50): 38535-38542. 15 December 2006

Pillars article: allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature 1991. 351: 290-296.
Falk, K., Roetzschke, O., Stevanovic, S., Jung, G. and Rammensee, H.G.
Journal of Immunology 177 (5): 2741-2747. 1 September 2006

Aenderung des Beladungszustandes von MHC-Molekuelen [Change of the load state of MHC molecules].
Falk, K. and Roetzschke, O.
DE102004054545A1 ; WO0629891. 6 April 2006

Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR.
Bilic, I., Koesters, C., Unger, B., Sekimata, M., Hertweck, A., Maschek, R., Wilson, C.B. and Ellmeier, W.
Nature Immunology 7 (4): 392-400. April 2006

2005

CCR6 expression defines regulatory effector/memory-like cells within the CD25+CD4+ T cell subset.
Kleinewietfeld, M., Puentes, F., Borsellino, G., Battistini, L., Roetzschke, O. and Falk, K.
Blood 105 (7): 2877-2886. 1 January 2005

2004

'Chemical analogues' of HLA-DM can induce a peptide-receptive state in HLA-DR molecules.
Marin-Esteban, V., Falk, K. and Roetzschke, O.
Journal of Biological Chemistry 279 (49): 50684-50690. 20 September 2004

Production of neuroprotective NGF in astrocyte-T helper cell cocultures is upregulated following antigen recognition.
Oren, A., Falk, K., Roetzschke, O., Bechmann, I., Nitsch, R. and Gimsa, U.
Journal of Neuroimmunology 149 (1-2): 59-65. April 2004

Cathepsin G, and not the asparagine-specific endoprotease, controls the processing of myelin basic protein in lysosomes from human B lymphocytes.
Burster, T., Beck, A., Tolosa, E., Marin-Esteban, V., Roetzschke, O., Falk, K., Lautwein, A., Reich, M., Brandenburg, J., Schwarz, G., Wiendl, H., Melms, A., Lehmann, R., Stevanovic, S., Kalbacher, H. and Driessen, C.
Journal of Immunology 172 (9): 5495-5503. 1 January 2004

2003

TAP-independent antigen presentation on MHC class I molecules: lessons from Epstein-Barr virus.
Lautscham, G., Rickinson, A. and Blake, N.
Microbes and Infection 5 (4): 291-299. April 2003

Verfahren zur Verbesserung von immuntherapeutischen Verfahren [Method for improving methods of immunotherapy].
Falk, K., Roetzschke, O. and Strominger, J.
WO0316512. 27 February 2003

Small-molecular compounds enhance the loading of APC with encephalitogenic MBP protein.
Marin-Esteban, V., Falk, K. and Roetzschke, O.
Journal of Autoimmunity 20 (1): 63-69. February 2003

2002

A pH-sensitive histidine residue as control element for ligand release from HLA-DR molecules.
Roetzschke, O., Lau, J.M., Hofstätter, M., Falk, K. and Strominger, J.L.
Proceedings of the National Academy of Sciences of the United States of America 99 (26): 16946-16950. 24 December 2002

The final cut: how ERAP1 trims MHC ligands to size.
Falk, K. and Roetzschke, O.
Nature Immunology 3 (12): 1121-1122. December 2002

Ligand exchange of major histocompatibility complex class II proteins is triggered by H-bond donor groups of small molecules.
Falk, K., Lau, J.M., Santambrogio, L., Esteban, V.M., Puentes, F., Roetzschke, O. and Strominger, J.L.
Journal of Biological Chemistry 277 (4): 2709-2715. 1 January 2002

2001

IL-3 induces B7.2 (CD86) expression and costimulatory activity in human eosinophils.
Celestin, J., Roetzschke, O., Falk, K., Ramesh, N., Jabara, H., Strominger, J. and Geha, R.S.
Journal of Immunology 167 (11): 6097-6104. 1 December 2001

Vaccination, prevention, and treatment of experimental autoimmune neuritis (EAN) by an oligomerized T cell epitope.
Stienekemeier, M., Falk, K., Roetzschke, O., Weishaupt, A., Schneider, C., Toyka, K.V., Gold, R. and Strominger, J.L.
Proceedings of the National Academy of Sciences of the United States of America 98 (24): 13872-13877. 1 November 2001

Synthesis of linear and comb-like peptide constructs containing up to four copies of a T cell epitope and their capacity to stimulate T cells.
Mack, J., Falk, K., Roetzschke, O., Walk, T., Strominger, J.L. and Jung, G.
Journal of Peptide Science 7 : 338-345. 1 June 2001

2000

Antigen-specific elimination of T cells induced by oligomerized hemagglutinin (HA) 306-318.
Falk, K., Roetzschke, O. and Strominger, J.L.
European Journal of Immunology 30 (10): 3012-3020. 1 October 2000

Induction and suppression of an autoimmune disease by oligomerized T cell epitopes: enhanced in vivo potency of encephalitogenic peptides.
Falk, K., Roetzschke, O., Santambrogio, L., Dorf, M.E., Brosnan, C. and Strominger, J.L.
Journal of Experimental Medicine 191 (4): 717-730. 21 February 2000

1999

Conformational variants of class II MHC/peptide complexes induced by N- and C-terminal extensions of minimal peptide epitopes.
Roetzschke, O., Falk, K., Mack, J., Lau, J.M., Jung, G. and Strominger, J.L.
Proceedings of the National Academy of Sciences of the United States of America 96 : 7445-7450. 22 June 1999

1997

Superactivation of an immune response triggered by oligomerized T cell epitopes.
Roetzschke, O., Falk, K. and Strominger, J.L.
Proceedings of the National Academy of Sciences of the United States of America 94 (26): 14642-14647. 23 December 1997

The diversity of antigen-specific TCR repertoires reflects the relative complexity of epitopes recognized.
Maryanski, J.L., Casanova, J.L., Falk, K., Gournier, H., Jaulin, C., Kourilsky, P., Lemonnier, F.A., Luthy, R., Rammensee, H.G., Roetzschke, O., Servis, C. and Lopez, J.A.
Human Immunology 54 : 117-128. 1 May 1997

1996

Motif of HLA-B*3503 peptide ligands.
Steinle, A., Falk, K., Roetzschke, O., Gnau, V., Stevanovic, S., Jung, G., Schendel, D.J. and Rammensee, H.G.
Immunogenetics 43 : 105-107. 1 January 1996

1995

Peptide motifs of HLA-B51, -B52 and -B78 molecules, and implications for Behcet's disease.
Falk, K., Roetzschke, O., Takiguchi, M., Gnau, V., Stevanovic, S., Jung, G. and Rammensee, H.G.
International Immunology 7 (2): 223-228. 1 February 1995

Peptide motifs of HLA-B38 and B39 molecules.
Falk, K., Roetzschke, O., Takiguchi, M., Gnau, V., Stevanovic, S., Jung, G. and Rammensee, H.G.
Immunogenetics 41 : 162-164. 1 January 1995

Peptide motifs of HLA-B58, B60, B61, and B62 molecules.
Falk, K., Roetzschke, O., Takiguchi, M., Gnau, V., Stevanovic, S., Jung, G. and Rammensee, H.G.
Immunogenetics 41 : 165-168. 1 January 1995

Several HLA alleles share overlapping peptide specificities.
Sidney, J., del Guercio, M.F., Southwood, S., Engelhard, V.H., Appella, E., Rammensee, H.G., Falk, K., Roetzschke, O., Takiguchi, M. and Kubo, R.T.
Journal of Immunology 154 (1): 247-259. 1 January 1995

1994

Analysis of a naturally occurring HLA class I-restricted viral epitope.
Falk, K., Roetzschke, O., Stevanovic, S., Gnau, V., Sparbier, K., Jung, G., Rammensee, H.G. and Walden, P.
Immunology 82 : 337-342. 1 July 1994

Isolation of naturally processed peptides recognized by cytolytic T lymphocytes (CTL) on human melanoma cells in association with HLA-A2.1.
Wolfel, T., Schneider, J., Meyer Zum Buschenfelde, K.H., Rammensee, H.G., Roetzschke, O. and Falk, K.
International Journal of Cancer 57 : 413-418. 1 May 1994

Origin, structure and motifs of naturally processed MHC class II ligands.
Roetzschke, O. and Falk, K.
Current Opinion in Immunology 6 (1): 45-51. February 1994

Pool sequencing of natural HLA-DR, DQ, and DP ligands reveals detailed peptide motifs, constraints of processing, and general rules.
Falk, K., Roetzschke, O., Stevanovic, S., Jung, G. and Rammensee, H.G.
Immunogenetics 39 : 230-242. 1 January 1994

Dominant aromatic/aliphatic C-terminal anchor in HLA-B*2702 and B*2705 peptide motifs.
Roetzschke, O., Falk, K., Stevanovic, S., Gnau, V., Jung, G. and Rammensee, H.G.
Immunogenetics 39 (1): 74-77. 1994

Peptide motifs of HLA-A1, -A11, -A31, and -A33 molecules.
Falk, K., Roetzschke, O., Takiguchi, M., Grahovac, B., Gnau, V., Stevanovic, S., Jung, G. and Rammensee, H.G.
Immunogenetics 40 (3): 238-241. 1994

Peptide motifs of HLA-A3, -A24, and -B7 molecules as determined by pool sequencing.
Maier, R., Falk, K., Roetzschke, O., Maier, B., Gnau, V., Stevanovic, S., Jung, G., Rammensee, H.G. and Meyerhans, A.
Immunogenetics 40 (4): 306-308. 1994

1993

Allele-specific peptide ligand motifs of HLA-C molecules.
Falk, K., Roetzschke, O., Grahovac, B., Schendel, D., Stevanovic, S., Gnau, V., Jung, G., Strominger, J.L. and Rammensee, H.G.
Proceedings of the National Academy of Sciences of the United States of America 90 (24): 12005-12009. 15 December 1993

Natural peptide ligand motifs of two HLA molecules associated with myasthenia gravis.
Malcherek, G., Falk, K., Roetzschke, O., Rammensee, H.G., Stevanovic, S., Gnau, V., Jung, G. and Melms, A.
International Immunology 5 (10): 1229-1237. 1 October 1993

Both human and mouse cells expressing H-2Kb and ovalbumin process the same peptide, SIINFEKL.
Falk, K., Roetzschke, O., Faath, S., Goth, S., Graef, I., Shastri, N. and Rammensee, H.G.
Cellular Immunology 150 : 447-452. 1 September 1993

Comparison of the H-2Kk- and H-2Kkm1-restricted peptide motifs.
Norda, M., Falk, K., Roetzschke, O., Stevanovic, S., Jung, G. and Rammensee, H.G.
Journal of Immunotherapy 14 : 144-149. 1 August 1993

Consensus motifs and peptide ligands of MHC class I molecules.
Falk, K. and Roetzschke, O.
Seminars in Immunology 5 : 81-94. 1 April 1993

A prominent natural H-2 Kd ligand is derived from protein tyrosine kinase JAK1.
Harpur, A.G., Zimiecki, A., Wilks, A.F., Falk, K., Roetzschke, O. and Rammensee, H.G.
Immunology Letters 35 : 235-237. 1 March 1993

Qa-2 molecules are peptide receptors of higher stringency than ordinary class I molecules.
Roetzschke, O., Falk, K., Stevanovic, S., Grahovac, B., Soloski, M.J., Jung, G. and Rammensee, H.G.
Nature 361 (6413): 642-644. 18 February 1993

MHC molecules as peptide receptors.
Rammensee, H.G., Falk, K. and Roetzschke, O.
Current Opinion in Immunology 5 (1): 35-44. 1 February 1993

Peptide motifs of HLA-B35 and -B37 molecules.
Falk, K., Roetzschke, O., Grahovac, B., Schendel, D., Stevanovic, S., Jung, G. and Rammensee, H.G.
Immunogenetics 38 (2): 161-162. February 1993

Peptides naturally presented by MHC class I molecules.
Rammensee, H.G., Falk, K. and Roetzschke, O.
Annual Review of Immunology 11 : 213-244. 1 January 1993

Self tolerance of natural MHC class I ligands.
Rammensee, H.G., Roetzschke, O. and Falk, K.
International Reviews of Immunology 10 : 291-300. 1 January 1993

MHC class I-restricted antigen processing--lessons from natural ligands.
Rammensee, H.G., Roetzschke, O. and Falk, K.
Chemical Immunology 57 : 113-133. 1993

1992

Peptide motifs of closely related HLA class I molecules encompass substantial differences.
Roetzschke, O., Falk, K., Stevanovic, S., Jung, G. and Rammensee, H.G.
European Journal of Immunology 22 (9): 2453-2456. 1 September 1992

A self peptide naturally presented by both H-2Kb and H-2Kbm1 molecules demonstrates MHC restriction of self tolerance at the molecular level.
Falk, K., Roetzschke, O. and Rammensee, H.G.
International Immunology 4 : 321-325. 1 March 1992

Gene transfer experiments imply instructive role of major histocompatibility complex class I molecules in cellular peptide processing.
Wallny, H.J., Roetzschke, O., Falk, K., Haemmerling, G. and Rammensee, H.G.
European Journal of Immunology 22 : 655-659. 1 March 1992

Specificity of antigen processing for MHC class I restricted presentation is conserved between mouse and man.
Falk, K., Roetzschke, O. and Rammensee, H.G.
European Journal of Immunology 22 : 1323-1326. 1 January 1992