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Effects of altered gravity on adrenergic-mediated cAMP signalling in intact cells.
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GPR3 ligands discovered through combined virtual and conformational biosensor-based screening.
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Journal of the American Chemical Society 148
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PERK retains a predominantly monomeric state under ER stress conditions.
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Journal of Molecular and Cellular Cardiology 214
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Ligand-specific activation trajectories dictate GPCR signalling in cells.
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Nature 650
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MRAP2 modifies the signaling and oligomerization state of the melanocortin-4 receptor.
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Nature Communications 16
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25 September 2025
Disruption of constitutive CXCR4 oligomers impairs oncogenic properties in lymphoid neoplasms.
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Pharmacological characterization of a clinical candidate, TG-0054, a small molecule inverse agonist targeting CXCR4.
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Cell swelling enhances ligand-driven β-adrenergic signaling.
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Nature Communications 15
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7 September 2024
The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration under stress conditions.
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PLoS Biology 22
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ADAM19 cleaves the PTH receptor and associates with brachydactyly type E.
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Life Science Alliance 7
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Impairment of the adrenergic reserve associated with exercise intolerance in a murine model of heart failure with preserved ejection fraction.
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Acta Physiologica 240
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Fluorescent tools for the imaging of dopamine D2-like receptors.
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Shedding light on the D(1)‐like receptors: a fluorescence‐based toolbox for visualization of the D(1) and D(5) receptors.
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Spatiotemporal GPCR signaling illuminated by genetically encoded fluorescent biosensors.
Kayser, C. ORCID: https://orcid.org/0000-0001-6877-2507, Melkes, B., Derieux, C. and Bock, A. ORCID: https://orcid.org/0000-0002-6344-6494
Current Opinion in Pharmacology 71
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Evaluation of pharmacological rescue of melanocortin-4 receptor nonsense mutations by aminoglycoside.
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Life 12
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Fluorescence spectroscopy of low-level endogenous β-adrenergic receptor expression at the plasma membrane of differentiating human iPSC-derived cardiomyocytes.
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Development of an indole-amide-based photoswitchable cannabinoid receptor subtype 1 (CB(1)R) "Cis-On" agonist.
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ACS Chemical Neuroscience 13
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17 August 2022
Functional modulation of PTH1R activation and signaling by RAMP2.
Nemec, K. ORCID: https://orcid.org/0000-0002-3555-5853, Schihada, H. ORCID: https://orcid.org/0000-0002-1889-1636, Kleinau, G. ORCID: https://orcid.org/0000-0003-2131-671X, Zabel, U., Grushevsky, E.O. ORCID: https://orcid.org/0000-0003-1779-8306, Scheerer, P. ORCID: https://orcid.org/0000-0001-5028-2075, Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510 and Maiellaro, I. ORCID: https://orcid.org/0000-0001-5595-8011
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The impact of membrane protein diffusion on GPCR signaling.
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Cells 11
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Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling.
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Cell 185
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Unraveling the hidden temporal range of fast β(2)-adrenergic receptor mobility by time-resolved fluorescence.
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Communications Biology 5
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Proteolytic cleavage of the extracellular domain affects signaling of parathyroid hormone 1 receptor.
Klenk, C., Hommers, L. and Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510
Frontiers in Endocrinology 13
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Real-time measurements of intracellular cAMP gradients using FRET-based cAMP nanorulers.
Kayser, C. ORCID: https://orcid.org/0000-0001-6877-2507, Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510 and Bock, A. ORCID: https://orcid.org/0000-0002-6344-6494
Methods in Molecular Biology 2483
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Dual-color fluorescence cross-correlation spectroscopy to study protein-protein interaction and protein dynamics in live cells.
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A versatile sub-nanomolar fluorescent ligand enables NanoBRET binding studies and single-molecule microscopy at the histamine H(3) receptor.
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Journal of Medicinal Chemistry 64
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12 August 2021
Visualization of β-adrenergic receptor dynamics and differential localization in cardiomyocytes.
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Proceedings of the National Academy of Sciences of the United States of America 118
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Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors.
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eLife 10
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21 April 2021
Quantitative spectroscopy of single molecule interaction times.
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Optics Letters 46
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1 April 2021
Determination of G-protein-coupled receptor oligomerization by molecular brightness analyses in single cells.
Işbilir, A. ORCID: https://orcid.org/0000-0002-9629-1150, Serfling, R., Möller, J. ORCID: https://orcid.org/0000-0001-8429-3784, Thomas, R. ORCID: https://orcid.org/0000-0001-8663-3682, De Faveri, C., Zabel, U., Scarselli, M., Beck-Sickinger, A.G., Bock, A. ORCID: https://orcid.org/0000-0002-6344-6494, Coin, I. ORCID: https://orcid.org/0000-0002-7722-004X, Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510 and Annibale, P. ORCID: https://orcid.org/0000-0003-3208-5347
Nature Protocols 16
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March 2021
Structural and functional characterization of allatostatin receptor type-C of Thaumetopoea pityocampa, a potential target for next-generation pest control agents.
Shahraki, A., Işbilir, A. ORCID: https://orcid.org/0000-0002-9629-1150, Dogan, B., Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510, Durdagi, S. ORCID: https://orcid.org/0000-0002-0426-0905 and Birgul-Iyison, N. ORCID: https://orcid.org/0000-0003-3511-3139
Journal of Chemical Information and Modeling 61
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22 February 2021
Bioluminescence in G protein-coupled receptors drug screening using nanoluciferase and halo-tag technology.
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Methods in Molecular Biology 2268
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Pharmacological characterization of the stick insect Carausius morosus allatostatin-C receptor with its endogenous agonist.
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ACS Omega 5
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The role of orthosteric building blocks of bitopic ligands for muscarinic M1 receptors.
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ACS Omega 5
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Advanced fluorescence microscopy reveals disruption of dynamic CXCR4 dimerization by subpocket-specific inverse agonists.
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17 November 2020
Ligand-specific allosteric coupling controls G-protein-coupled receptor signaling.
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ACS Pharmacology & Translational Science 3
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9 October 2020
Optical mapping of cAMP signaling at the nanometer scale.
Bock, A. ORCID: https://orcid.org/0000-0002-6344-6494, Annibale, P. ORCID: https://orcid.org/0000-0003-3208-5347, Konrad, C. ORCID: https://orcid.org/0000-0001-6877-2507, Hannawacker, A., Anton, S.E. ORCID: https://orcid.org/0000-0001-6600-3392, Maiellaro, I., Zabel, U., Sivaramakrishnan, S., Falcke, M. ORCID: https://orcid.org/0000-0001-7137-1114 and Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510
Cell 182
(6): 1519-1530.
17 September 2020
Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors.
Möller, J. ORCID: https://orcid.org/0000-0001-8429-3784, Isbilir, A. ORCID: https://orcid.org/0000-0002-9629-1150, Sungkaworn, T., Osberg, B. ORCID: https://orcid.org/0000-0002-9854-9901, Karathanasis, C., Sunkara, V., Grushevskyi, E.O. ORCID: https://orcid.org/0000-0003-1779-8306, Bock, A. ORCID: https://orcid.org/0000-0002-6344-6494, Annibale, P. ORCID: https://orcid.org/0000-0003-3208-5347, Heilemann, M. ORCID: https://orcid.org/0000-0002-9821-3578, Schütte, C. and Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510
Nature Chemical Biology 16
(9): 946-954.
September 2020
Establishing a sensitive fluorescence-based quantification method for cyclic nucleotides.
Gruteser, N., Kohlhas, V., Balfanz, S., Franzen, A., Günther, A., Offenhäusser, A., Müller, F., Nikolaev, V., Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510 and Baumann, A. ORCID: https://orcid.org/0000-0001-9456-7275
BMC Biotechnology 20
(1): 47.
27 August 2020
Kinetic analysis of the early signaling steps of the human chemokine receptor CXCR4.
Perpina-Viciano, C., Işbilir, A. ORCID: https://orcid.org/0000-0002-9629-1150, Zarca, A., Caspar, B., Kilpatrick, L.E., Hill, S.J., Smit, M.J., Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510 and Hoffmann, C.
Molecular Pharmacology 98
(2): 72-87.
August 2020
Unmasking features of the auto-epitope essential for β(1)-adrenoceptor activation by autoantibodies in chronic heart failure.
Wölfel, A., Sättele, M., Zechmeister, C., Nikolaev, V.O., Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510, Boege, F., Jahns, R. and Boivin-Jahns, V.
ESC Heart Failure 7
(4): 1830-1841.
August 2020
Development of a conformational histamine H(3) receptor biosensor for the synchronous screening of agonists and inverse agonists.
Schihada, H., Ma, X., Zabel, U., Vischer, H.F., Schulte, G., Leurs, R., Pockes, S. and Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510
ACS Sensors 5
(6): 1734-1742.
26 June 2020
Visualizing the functional 3D shape and topography of long noncoding RNAs by single-particle atomic force microscopy and in-solution hydrodynamic techniques.
Uroda, T., Chillón, I. ORCID: https://orcid.org/0000-0002-3107-8738, Annibale, P. ORCID: https://orcid.org/0000-0003-3208-5347, Teulon, J.M., Pessey, O., Karuppasamy, M., Pellequer, J.L. ORCID: https://orcid.org/0000-0002-8944-2715 and Marcia, M. ORCID: https://orcid.org/0000-0003-2430-0713
Nature Protocols 15
(6): 2107-2139.
June 2020
Linescan microscopy data to extract diffusion coefficient of a fluorescent species using a commercial confocal microscope.
Bathe-Peters, M. ORCID: https://orcid.org/0000-0002-9618-0856, Gmach, P. ORCID: https://orcid.org/0000-0002-5258-0321, Annibale, P. ORCID: https://orcid.org/0000-0003-3208-5347 and Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510
Data in Brief 29
: 105063.
April 2020
Differential signaling profiles of MC4R mutations with three different ligands.
Paisdzior, S., Dimitriou, I.M., Schöpe, P.C. ORCID: https://orcid.org/0000-0002-5512-8832, Annibale, P. ORCID: https://orcid.org/0000-0003-3208-5347, Scheerer, P. ORCID: https://orcid.org/0000-0001-5028-2075, Krude, H., Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510, Biebermann, H. and Kühnen, P. ORCID: https://orcid.org/0000-0003-0211-176X
International Journal of Molecular Sciences 21
(4): 1224.
12 February 2020
Vibrational spectroscopy as a powerful tool for follow-up immunoadsorption therapy treatment of dilated cardiomyopathy - a case report.
Huang, J., Ramoji, A., Guo, S., Bocklitz, T., Boivin-Jahns, V., Möller, J. ORCID: https://orcid.org/0000-0001-8429-3784, Kiehntopf, M., Noutsias, M., Popp, J. and Neugebauer, U.
Analyst 145
(2): 486-496.
15 November 2019
Conserved pseudoknots in lncRNA MEG3 are essential for stimulation of the p53 pathway.
Uroda, T., Anastasakou, E., Rossi, A., Teulon, J.M., Pellequer, J.L., Annibale, P. ORCID: https://orcid.org/0000-0003-3208-5347, Pessey, O., Inga, A., Chillón, I. and Marcia, M.
Molecular Cell 75
(5): 982-995.
5 September 2019
Quantitative single-residue bioorthogonal labeling of G protein-coupled receptors in live cells.
Serfling, R., Seidel, L., Bock, A. ORCID: https://orcid.org/0000-0002-6344-6494, Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510, Annibale, P. ORCID: https://orcid.org/0000-0003-3208-5347 and Coin, I. ORCID: https://orcid.org/0000-0002-7722-004X
ACS Chemical Biology 14
(6): 1141-1149.
21 June 2019
Stepwise activation of a class C GPCR begins with millisecond dimer rearrangement.
Grushevskyi, E.O. ORCID: https://orcid.org/0000-0003-1779-8306, Kukaj, T., Schmauder, R., Bock, A. ORCID: https://orcid.org/0000-0002-6344-6494, Zabel, U., Schwabe, T., Benndorf, K. and Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510
Proceedings of the National Academy of Sciences of the United States of America 116
(20): 10150-10155.
14 May 2019
A functional genetic variation of SLC6A2 repressor hsa-miR-579-3p upregulates sympathetic noradrenergic processes of fear and anxiety.
Hommers, L.G., Richter, J., Yang, Y., Raab, A., Baumann, C., Lang, K. ORCID: https://orcid.org/0000-0002-2663-5990, Schiele, M.A., Weber, H. ORCID: https://orcid.org/0000-0002-9421-1292, Wittmann, A., Wolf, C., Alpers, G.W., Arolt, V., Domschke, K., Fehm, L., Fydrich, T., Gerlach, A. ORCID: https://orcid.org/0000-0001-6794-5349, Gloster, A.T., Hamm, A.O., Helbig-Lang, S., Kircher, T., Lang, T., Pané-Farré, C.A., Pauli, P. ORCID: https://orcid.org/0000-0003-0692-6720, Pfleiderer, B. ORCID: https://orcid.org/0000-0002-1238-6225, Reif, A. ORCID: https://orcid.org/0000-0002-0992-634X, Romanos, M., Straube, B. ORCID: https://orcid.org/0000-0002-9837-0944, Ströhle, A., Wittchen, H.U., Frantz, S., Ertl, G., Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510, Lueken, U. and Deckert, J.
Translational Psychiatry 8
(1): 226.
19 October 2018
A universal bioluminescence resonance energy transfer sensor design enables high-sensitivity screening of GPCR activation dynamics.
Schihada, H., Vandenabeele, S., Zabel, U., Frank, M., Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510 and Maiellaro, I.
Communications Biology 1
: 105.
7 August 2018
Molecular details of dimerization kinetics reveal negligible populations of transient µ-opioid receptor homodimers at physiological concentrations.
Meral, D., Provasi, D., Prada-Gracia, D., Möller, J. ORCID: https://orcid.org/0000-0001-8429-3784, Marino, K., Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510 and Filizola, M. ORCID: https://orcid.org/0000-0002-4382-8276
Scientific Reports 8
(1): 7705.
16 May 2018
Increased fear learning, spatial learning as well as neophobia in Rgs2(-/-) mice.
Raab, A. ORCID: https://orcid.org/0000-0003-0959-6237, Popp, S., Lesch, K.P., Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510, Fischer, M., Deckert, J. and Hommers, L.
Genes Brain and Behavior 17
(4): e12420.
April 2018
All-optical microscope autofocus based on an electrically tunable lens and a totally internally reflected IR laser.
Bathe-Peters, M. ORCID: https://orcid.org/0000-0002-9618-0856, Annibale, P. ORCID: https://orcid.org/0000-0003-3208-5347 and Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510
Optics Express 26
(3): 2359-2368.
5 February 2018
Related GPCRs couple differently to G(s): preassociation between G protein and 5-HT(7) serotonin receptor reveals movement of Gα(s) upon receptor activation.
Andressen, K.W., Ulsund, A.H., Krobert, K.A., Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510, Buenemann, M. and Levy, F.O.
FASEB Journal 32
(2): 1059-1069.
5 February 2018
Evolutionary action and structural basis of the allosteric switch controlling β(2)AR functional selectivity.
Schönegge, A.M., Gallion, J., Picard, L.P., Wilkins, A.D., Le Gouill, C., Audet, M., Stallaert, W., Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510, Kimmel, M., Lichtarge, O. and Bouvier, M. ORCID: https://orcid.org/0000-0003-1128-0100
Nature Communications 8
(1): 2169.
18 December 2017
Single-molecule imaging reveals receptor-G protein interactions at cell surface hot spots.
Sungkaworn, T., Jobin, M.L., Burnecki, K. ORCID: https://orcid.org/0000-0002-1754-4472, Weron, A. ORCID: https://orcid.org/0000-0002-8584-9876, Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510 and Calebiro, D. ORCID: https://orcid.org/0000-0002-3811-1553
Nature 550
(7677): 543-547.
26 October 2017
Mapping the dynamics of the glucocorticoid receptor within the nuclear landscape.
Stortz, M., Presman, D.M. ORCID: https://orcid.org/0000-0003-4515-8058, Bruno, L., Annibale, P. ORCID: https://orcid.org/0000-0003-3208-5347, Dansey, M.V., Burton, G. ORCID: https://orcid.org/0000-0002-8559-7306, Gratton, E., Pecci, A. and Levi, V.
Scientific Reports 7
(1): 6219.
24 July 2017
Ligand-specific restriction of extracellular conformational dynamics constrains signaling of the M(2) muscarinic receptor.
Bermudez, M. ORCID: https://orcid.org/0000-0002-7421-3282, Bock, A. ORCID: https://orcid.org/0000-0002-6344-6494, Krebs, F., Holzgrabe, U. ORCID: https://orcid.org/0000-0002-0364-7278, Mohr, K., Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510 and Wolber, G. ORCID: https://orcid.org/0000-0002-5344-0048
ACS Chemical Biology 12
(7): 1743-1748.
21 July 2017
Book Section
Hypnotika und Sedativa.
Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510
In:
Arzneiverordnungs-Report 2020 : Aktuelle Daten, Kosten, Trends und Kommentare.
Springer, Berlin, Heidelberg, 571-582.
ISBN 978-3-662-62167-7
2020
Ophthalmika.
Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510
In:
Arzneiverordnungs-Report 2020 : Aktuelle Daten, Kosten, Trends und Kommentare.
Springer, Berlin, Heidelberg, 733-758.
ISBN 978-3-662-62168-4
2020
Psychopharmaka.
Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510
In:
Arzneiverordnungs-Report 2020 : Aktuelle Daten, Kosten, Trends und Kommentare.
Springer, Berlin, Heidelberg, 781-814.
ISBN 978-3-662-62168-4
2020
Is signaling specificity encoded in arrestin conformation?
Hoffmann, C., Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510 and Luttrell, L.M.
In:
The Structural Basis of Arrestin Functions.
Springer, Cham, Switzerland, 235-253.
ISBN 978-3-319-57552-0
25 May 2017
Conference or Workshop Item
Quantitative morphological analysis of the T-tubular network of ventricular cardiomyocytes using novel image processing tools.
Georgoula, K. ORCID: https://orcid.org/0009-0003-0527-0421, Sage, D. and Annibale, P. ORCID: https://orcid.org/0000-0003-3208-5347
In: European Conferences on Biomedical Optics 2023, 25-29 June 2023, Munich, Germany.
11 August 2023
All-in-one confocal and widefield fluorescence microscope to investigate membrane receptor dynamics.
Bathe-Peters, M. ORCID: https://orcid.org/0000-0002-9618-0856, Gmach, P. ORCID: https://orcid.org/0000-0002-5258-0321, Annibale, P. ORCID: https://orcid.org/0000-0003-3208-5347 and Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510
In: Imaging and Applied Optics Congress 2019 (COSI, IS, MATH, pcAOP), 24-27 Jun 2019, Munich, Germany.
2019
Was ist in der Medizin moeglich: Neue Therapien.
Lohse, M. ORCID: https://orcid.org/0000-0002-0599-3510
In: Medizin 4.0 - Zur Zukunft der digitalisierten Welt. IV. Interdisziplinaerer Kongress Berlin 2016 mit der Heinz Nixdorf-Stiftung - gemeinsam mit der Charite - Universitaetsmedizin Berlin, 1-2 June 2016, Berlin, Germany.
2017
Review
Viewpoints on the first transatlantic GPCR symposium for early-career investigators.
Bender, B.J., Bock, A. ORCID: https://orcid.org/0000-0002-6344-6494, Nesheva, D.N. and Perry-Hauser, N.A.
ACS Pharmacology & Translational Science 4
(5): 1705-1711.
8 October 2021
Allosteric coupling and biased agonism in G protein-coupled receptors.
Bock, A. ORCID: https://orcid.org/0000-0002-6344-6494 and Bermudez, M. ORCID: https://orcid.org/0000-0002-7421-3282
FEBS Journal 288
(8): 2513-2528.
April 2021
Atypical antipsychotics and metabolic syndrome: from molecular mechanisms to clinical differences.
Carli, M. ORCID: https://orcid.org/0000-0003-1447-4947, Kolachalam, S., Longoni, B., Pintaudi, A., Baldini, M., Aringhieri, S., Fasciani, I., Annibale, P. ORCID: https://orcid.org/0000-0003-3208-5347, Maggio, R. ORCID: https://orcid.org/0000-0003-4436-2356 and Scarselli, M.
Pharmaceuticals 14
(3): 238.
March 2021
Context-dependent signaling of CXC chemokine receptor 4
and atypical chemokine receptor 3.
Heuninck, J., Perpina Viciano, C., Işbilir, A. ORCID: https://orcid.org/0000-0002-9629-1150, Caspar, B., Capoferri, D., Briddon, S.J., Durroux, T., Hill, S.J., Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510, Milligan, G., Pin, J.P. and Hoffmann, C.
Molecular Pharmacology 96
(6): 778-793.
December 2019
Allosteric modulators targeting CNS muscarinic receptors.
Bock, A. ORCID: https://orcid.org/0000-0002-6344-6494, Schrage, R. and Mohr, K.
Neuropharmacology 136
(Part C): 427-437.
1 July 2018
Editorial
Spatial heterogeneity in molecular brightness.
Annibale, P. ORCID: https://orcid.org/0000-0003-3208-5347 and Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510
Nature Methods 17
(3): 273-275.
March 2020
Does divergent binding pocket closure drive ligand bias for class A GPCRs?
Bermudez, M. and Bock, A. ORCID: https://orcid.org/0000-0002-6344-6494
Trends in Pharmacological Sciences 40
(4): 236-239.
April 2019
A panoramic view on GPCRs: the 1st Berlin Symposium for Interdisciplinary GPCR research.
Bock, A. ORCID: https://orcid.org/0000-0002-6344-6494 and Bermudez, M. ORCID: https://orcid.org/0000-0002-7421-3282
Naunyn-Schmiedeberg's Archives of Pharmacology 391
(7): 769-771.
July 2018
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