Browse by Research Team

2008

Expression of CD175 (Tn), CD175s (sialosyl-Tn) and CD176 (Thomsen-Friedenreich antigen) on malignant human hematopoietic cells.
Cao, Y., Merling, A., Karsten, U., Goletz, S., Punzel, M., Kraft, R., Butschak, G. and Schwartz-Albiez, R.
International Journal of Cancer 123 (1): 89-99. 1 July 2008

Immunomagnetic enrichment of disseminated tumor cells in bone marrow and blood of breast cancer patients by the Thomsen-Friedenreich-Antigen.
Schindlbeck, C., Stellwagen, J., Jeschke, U., Karsten, U., Rack, B., Janni, W., Jueckstock, J., Tulusan, A., Sommer, H. and Friese, K.
Clinical and Experimental Metastasis 25 (3): 233-240. May 2008

2007

The Thomsen-Friedenreich disaccharide as antigen for in vivo tumor targeting with multivalent scFvs.
Ravn, P., Stahn, R., Danielczyk, A., Faulstich, D., Karsten, U. and Goletz, S.
Cancer Immunology Immunotherapy 56 (9): 1345-1357. September 2007

Prognostic impact of Thomsen-Friedenreich tumor antigen and disseminated tumor cells in the bone marrow of breast cancer patients.
Schindlbeck, C., Jeschke, U., Schulze, S., Karsten, U., Janni, W., Rack, B., Krajewski, S., Sommer, H. and Friese, K.
Breast Cancer Research and Treatment 101 (1): 17-25. January 2007

2006

PankoMab: a potent new generation anti-tumour MUC1 antibody.
Danielczyk, A., Stahn, R., Faulstich, D., Loeffler, A., Maerten, A., Karsten, U. and Goletz, S.
Cancer Immunology Immunotherapy 55 (11): 1337-1347. November 2006

Binding of galectin-1 (gal-1) to the Thomsen-Friedenreich (TF) antigen on trophoblast cells and inhibition of proliferation of trophoblast tumor cells in vitro by gal-1 or an anti-TF antibody.
Jeschke, U., Karsten, U., Wiest, I., Schulze, S., Kuhn, C., Friese, K. and Walzel, H.
Histochemistry and Cell Biology 126 (4): 437-444. October 2006

Detection, isolation and partial characterization of an immunostimulating glycoprotein from Rhodococcus fascians.
Butschak, G., Karsten, U., Schelhaas, U., Ott, H., Emmendoerffer, A., Niemeyer, B., Helmholz, H. and Goletz, S.
International Immunopharmacology 6 (9): 1441-1450. September 2006

2005

Glycodelin A and differentiation of first trimester trophoblast cells in vitro.
Jeschke, U., Richter, D.U., Reimer, T., Bergemann, C., Briese, V., Karsten, U., Mylonas, I., Kupka, M.S., Wiest, I. and Friese, K.
Archives of Gynecology and Obstetrics 272 (2): 151-159. 1 August 2005

What makes MUC1 a tumor antigen?
Karsten, U., von Mensdorff-Pouilly, S. and Goletz, S.
Tumor Biology 26 (4): 217-220. 6 July 2005

Characterisation of disseminated tumor cells in the bone marrow of breast cancer patients by the Thomsen-Friedenreich tumor antigen.
Schindlbeck, C., Jeschke, U., Schulze, S., Karsten, U., Janni, W., Rack, B., Sommer, H. and Friese, K.
Histochemistry and Cell Biology 123 (6): 631-637. 1 January 2005

Development of monoclonal and polyclonal antibodies and an ELISA for the determination of glycodelin in human serum, amniotic fluid and cystic fluid of benign and malignant ovarian tumors.
Jeschke, U., Bischof, A., Speer, R., Briese, V., Richter, D.U., Bergemann, C., Mylonas, I., Shabani, N., Friese, K. and Karsten, U.
Anticancer Research 25 (3): 1581-1589. 1 January 2005

Expression of the Thomsen-Friedenreich (TF) tumor antigen in human abort placentas.
Richter, D.U., Jeschke, U., Bergemann, C., Makovitzky, J., Luthen, F., Karsten, U. and Briese, V.
Anticancer Research 25 (3 A): 1675-1678. 1 January 2005

Stimulation of hCG protein and mRNA in first trimester villous cytotrophoblast cells in vitro by glycodelin A.
Jeschke, U., Karsten, U., Reimer, T., Richter, D.U., Bergemann, C., Briese, V., Mylonas, L. and Friese, K.
Journal of Perinatal Medicine 33 (3): 212-218. 1 January 2005

2004

Multivalent scFv display of phagemid repertoires for the selection of carbohydrate-specific antibodies and its application to the Thomsen-Friedenreich antigen.
Ravn, P., Danielczyk, A., Jensen, K.B., Kristensen, P., Christensen, P.A., Larsen, M., Karsten, U. and Goletz, S.
Journal of Molecular Biology 343 (4): 985-996. 29 October 2004

Binding patterns of DTR-specific antibodies reveal a glycosylation-conditioned tumor-specific epitope of the epithelial mucin (MUC1).
Karsten, U., Serttas, N., Paulsen, H., Danielczyk, A. and Goletz, S.
Glycobiology 14 (8): 681-692. 1 August 2004

Conformational changes in the rod domain of human keratin 8 following heterotypic association with keratin 18 and its implication for filament stability.
Waseem, A., Karsten, U., Leigh, I.M., Purkis, P., Waseem, N.H. and Lane, E.B.
Biochemistry 43 (5): 1283-1295. 1 January 2004

2003

DNA, kodierend fuer die variable Region eines anti-idiotypischen Antikoerpers.
Karsten, U.
DE59710821D ; EP0937105. 6 November 2003

Involvement of the Gal β1 - 3GalNAcβ structure in the recognition of apoptotic bodies by THP-1 cells.
Rapoport, E., Khaidukov, S., Baidina, O., Bojenko, V., Moiseeva, E., Pasynina, G., Karsten, U., Nifantev, N., LePendu, J. and Bovin, N.
European Journal of Cell Biology 82 (6): 295-302. June 2003

Identification of microsatellite instability and mismatch repair gene mutations in breast cancer cell lines.
Seitz, S., Wassmuth, P., Plaschke, J., Schackert, H.K., Karsten, U., Santibanez-Koref, M.F., Schlag, P.M. and Scherneck, S.
Genes Chromosomes & Cancer 37 (1): 29-35. May 2003

Thomsen-Friedenreich antigen: the "hidden" tumor antigen.
Goletz, S., Cao, Y., Danielczyk, A., Ravn, P., Schoeber, U. and Karsten, U.
Advances in Experimental Medicine and Biology 535 : 147-162. 1 January 2003

2002

Isolation and characterization of Thomsen-Friedenreich-specific antibodies from human serum.
Butschak, G. and Karsten, U.
Tumor Biology 23 (3): 113-122. May 2002

Expression of the Thomsen-Friedenreich antigen and of its putative carrier protein mucin 1 in the human placenta and in trophoblast cells in vitro.
Jeschke, U., Richter, D.U., Hammer, A., Briese, V., Friese, K. and Karsten, U.
Histochemistry and Cell Biology 117 (3): 219-226. 1 January 2002

Fast and sensitive immunodetection of carcinoma cells in sentinel nodes.
Karsten, U. and Stosiek, P.
Virchows Archiv 440 (3): 325-329. 1 January 2002

Selection of large diversities of antiidiotypic antibody fragments by phage display.
Goletz, S., Christensen, P.A., Kristensen, P., Blohm, D., Tomlinson, I., Winter, G. and Karsten, U.
Journal of Molecular Biology 315 (5): 1087-1097. 1 January 2002

CD175 Workshop Panel report.
Karsten, U.
In: Leucocyte Typing VII. White Cell Differentiation Antigens. Proceedings of the Seventh International Workshop and Conference held in Harrogate, United Kingdom. Univ. Press, Oxford, 202-203. 2002

CD176 Workshop Panel report.
Karsten, U.
In: Leucocyte Typing VII. White Cell Differentiation Antigens. Proceedings of the Seventh International Workshop and Conference held in Harrogate, United Kingdom. Univ. Press, Oxford, 202-203. 2002

Expression of Thomsen-Friedenreich-related carbohydrate antigens on human leukaemia cells.
Cao, Y., Karsten, U. and Schwartz-Albiez, R.
In: Leucocyte Typing VII. White Cell Differentiation Antigens. Proceedings of the Seventh International Workshop and Conference held in Harrogate, United Kingdom. Univ. Press, Oxford, 204-205. 2002

The fucosylated histo-blood group antigens Lewis Y and H type 2 (blood group 0) are expressed on CD34+ haematopoietic progenitors.
Cao, Y., Merling, A., Karsten, U. and Schwartz-Albiez, R.
In: Leucocyte Typing VII. White Cell Differentiation Antigens. Proceedings of the Seventh International Workshop and Conference held in Harrogate, United Kingdom. Univ. Press, Oxford, 199-201. 2002

2001

Vakzine gegen konformationsabhaengige Antigene sowie gegen Antigene, die keine oder nicht ausschliesslich Proteine oder Peptide sind.
Goletz, S. and Karsten, U.
DE10027695A1 ; EP1181058 ; WO0073430. 19 April 2001

Binding patterns of 51 monoclonal antibodies to peptide and carbohydrate epitopes of the epithelial mucin (MUC1) on tissue sections of adenolymphomas of the parotid (Warthin's tumours): role of epitope masking by glycans.
Cao, Y. and Karsten, U.
Histochemistry and Cell Biology 115 (4): 349-356. 1 January 2001

Immunoreactivity of monoclonal antibody BW835 represents a marker of progression and prognosis in early gastric cancer.
Baldus, S.E., Zirbes, T., Glossmann, J., Fromm, S., Hanisch, F.G., Moenig, S.P., Schroeder, W., Schneider, P.M., Flucke, U., Karsten, U., Thiele, J., Hoelscher, A.H. and Dienes, H.P.
Oncology 61 (2): 147-155. 1 January 2001

Impaired immunoglobulin M production by incubation of hybridoma cells with ethanol.
Muehlbauer, E., Karsten, U., Rottmann, M. and Rommelspacher, H.
Alcohol 24 (3): 179-187. 1 January 2001

The fucosylated histo-blood group antigens H type 2 (blood group O, CD173) and Lewis Y (CD174) are expressed on CD34+ hematopoietic progenitors but absent on mature lymphocytes.
Cao, Y., Merling, A., Karsten, U. and Schwartz-Albiez, R.
Glycobiology 11 (8): 677-683. 1 January 2001

1999

Monoklonale Antikoerper gegen Glycodelin A, Verfahren zu ihrer Herstellung und ihre Verwendung.
Jeschke, U., Karsten, U. and Haase, M.
DE19807389A1 ; DE19807389C2. 26 August 1999

Tumorvakzine fuer MUC1-positive Karzinome.
Karsten, U., Hanisch, F.G. and Paulsen, H.
DE19758400A1 ; EP1044018. 1 July 1999

Inhibition of liver metastases from neuraminidase-treated colon 26 cells by an anti-thomsen-friedenreich-specific monoclonal antibody.
Shigeoka, H., Karsten, U. and Okuno, K.
Tumor Biology 20 : 139-146. 1 January 1999

1998

Enhanced binding of antibodies to the DTR motif of MUC1 tandem repeat peptide is mediated by site-specific glycosylation.
Karsten, U., Diotel, C., Klich, G., Paulsen, H., Goletz, S., Mueller, S. and Hanisch, F.G.
Cancer Research 58 (12): 2541-2549. 15 June 1998

Vakzine gegen Kohlenhydrat-Antigene.
Karsten, U.
DE19627352A1 ; EP0937105. 2 January 1998

Immunohistochemical characterization of a panel of 56 antibodies with normal human small intestine, colon, and breast tissues.
Cao, Y., Karsten, U. and Hilgers, J.
Tumor Biology 19 (suppl 1) : 88-99. 1 January 1998

1997

Monoklonale Antikoerper gegen epitheliales Muzin (MUC1).
Karsten, U., Cao, Y., Haase, M., Kiefer, M. and Pecher, G.
DE19534630A1. 20 March 1997

A sequencing strategy for the localization of O-glycosylation sites of MUC1 tandem repeats by PSD-MALDI mass spectrometry.
Goletz, S., Thiede, B., Hanisch, F.G., Schultz, M., Mueller, S., Peter-Katalinic, J., Seitz, O. and Karsten, U.
Glycobiology 7 : 881-896. 1 January 1997

1996

Thomsen-Friedenreich-related carbohydrate antigens in normal adult human tissues: a systematic and comparative study.
Cao, Y., Stosiek, P., Springer, G.F. and Karsten, U.
Histochemistry and Cell Biology 106 (2): 197-207. 1 August 1996

1995

Monoklonale Antikoerper gegen das Thomsen-Friedenreich-Antigen, ihre Herstellung und ihre Verwendung zum Tumornachweis.
Karsten, U., Butschak, G., Haase, M. and Kiefer, M.
DE4329004A1. 9 March 1995