Browse by Research Team

2024

Next generation concepts in dermal delivery, theranostics, and preclinical testing.
Hedtrich, S. and Calderón, M.
Advanced Drug Delivery Reviews : 115482. 29 November 2024 (In Press)

Modulating the mucosal drug delivery efficiency of polymeric nanogels tuning their redox response and surface charge.
Udabe, J., Muñoz‐Juan, A., Tafech, B., Orellano, M.S., Hedtrich, S., Laromaine, A. and Calderón, M.
Advanced Functional Materials 34 (45): 2407044. 5 November 2024

TENM4 is an essential transduction component for touch and pain.
Khallaf, M.A., Huang, A.T.L., Dalmasso, L., Chakrabarti, S., Groeneveld, R., Sierra, Y.A.B., Garcia-Contreras, J.A., Schutz, A., Bégay, V., Hedtrich, S., Zhong, W., Popp, O., Mertins, P. and Lewin, G.R.
bioRxiv : 2024.10.10.617546. 12 October 2024

Exploring mechanisms of lipid nanoparticle-mucus interactions in healthy and cystic fibrosis conditions.
Tafech, B., Rokhforouz, M.R., Leung, J., Sung, M.M., Lin, P.J., Sin, D.D., Lauster, D., Block, S., Quon, B.S., Tam, Y., Cullis, P., Feng, J.J. and Hedtrich, S.
Advanced Healthcare Materials 13 (18): e2304525. 17 July 2024

Disrupting TSLP-TSLP receptor interactions via putative small molecule inhibitors yields a novel and efficient treatment option for atopic diseases.
Adhikary, P.P., Idowu, T., Tan, Z., Hoang, C., Shanta, S., Dumbani, M., Mappalakayil, L., Awasthi, B., Bermudez, M., Weiner, J., Beule, D., Wolber, G., Page, B.D. and Hedtrich, S.
EMBO Molecular Medicine 16 (7): 1630-1656. 15 July 2024

Intranasal delivery of low-dose anti-CD124 antibody enhances treatment of chronic rhinosinusitis with nasal polyps.
Wu, J., Jones, N., Chao, P.H., Chan, V., Hohenwarter, L., Wu, A., Bergamo, M., Rodríguez-Rodríguez, C., Saatchi, K., Liang, A., Häfeli, U.O., Tan, Z., Hedtrich, S., Andrew, L.J. and Li, S.D.
Biomaterials 308 : 122567. July 2024

Extracellular matrix remodeling in atopic dermatitis harnesses the onset of an asthmatic phenotype and is a potential contributor to the atopic march.
Graff, P., Woerz, D., Wilzopolski, J., Voss, A., Sarrazin, J., Blimkie, T.M., Weiner, J., Kershaw, O., Panwar, P., Hackett, T., Lau, S., Brömme, D., Beule, D., Lee, Y.A., Hancock, R.E.W., Gruber, A.D., Bäumer, W. and Hedtrich, S.
Journal of Investigative Dermatology 144 (5): 1010-1021. May 2024

Systemic delivery of proteins using novel peptides via the sublingual route.
Wu, J., Jones, N., Hohenwarter, L., Zhao, F., Chan, V., Tan, Z., Carlaw, T., Morin, T., Li, J., Kaur, T., Andrew, L.J., Ross, C.J.D., Hedtrich, S. and Li, S.D.
Journal of Controlled Release 368 : 290-302. April 2024

Surface modification of lipid nanoparticles for gene therapy.
Tafech, B., Mohabatpour, F. and Hedtrich, S.
Journal of Gene Medicine 26 (1): e3642. January 2024

2023

Lipid nanoparticle-mediated hit-and-run approaches yield efficient and safe in situ gene editing in human skin.
Bolsoni, J., Liu, D., Mohabatpour, F., Ebner, R., Sadhnani, G., Tafech, B., Leung, J., Shanta, S., An, K., Morin, T., Chen, Y., Arguello, A., Choate, K., Jan, E., Ross, C.J.D., Brambilla, D., Witzigmann, D., Kulkarni, J., Cullis, P.R. and Hedtrich, S.
ACS Nano 17 (21): 22046-22059. 14 November 2023

Efficient skin interactions of graphene derivatives: challenge, opportunity or both?
Zabihi, F., Tu, Z., Kaessmeyer, S., Schumacher, F., Rancan, F., Kleuser, B., Boettcher, C., Ludwig, K., Plendl, J., Hedtrich, S., Vogt, A. and Haag, R.
Nanoscale Advances 5 (21): 5923-5931. 7 November 2023

Human disease models in drug development.
Loewa, A., Feng, J.J. and Hedtrich, S.
Nature Reviews Bioengineering 11 May 2023 (In Press)

2022

A similarity scaling approach for organ-on-chip devices.
Feng, J.J. and Hedtrich, S.
Lab on a Chip 22 (19): 3663-3667. 7 October 2022

Introducing the Molecular Pharmaceutics special issue on “tiny things, big impact: nanomedicine in Canada”.
Li, S.D., Wasan, E., Bally, M. and Hedtrich, S.
Molecular Pharmaceutics 19 (6): 1657-1658. 6 June 2022

Preclinical testing of dendritic core-multishell nanoparticles in inflammatory skin equivalents.
Graff, P., Hönzke, S., Joshi, A.A., Yealland, G., Fleige, E., Unbehauen, M., Schäfer-Korting, M., Hocke, A., Haag, R. and Hedtrich, S.
Molecular Pharmaceutics 19 (6): 1795-1802. 6 June 2022

Small, cationic antifungal proteins from filamentous fungi inhibit Candida albicans growth in 3D skin infection models.
Holzknecht, J., Dubrac, S., Hedtrich, S., Galgóczy, L. and Marx, F.
Microbiology Spectrum 10 (3): e0029922. June 2022

A naked eye-invisible ratiometric fluorescent microneedle tattoo for real-time monitoring of inflammatory skin conditions.
Babity, S., Couture, F., Campos, E.V.R., Hedtrich, S., Hagen, R., Fehr, D., Bonmarin, M. and Brambilla, D.
Advanced Healthcare Materials 11 (6): e2102070. March 2022

Influence of nanogel amphiphilicity on dermal delivery: balancing surface hydrophobicity and network rigidity.
Gruber, Al., Joshi, A.A., Graff, P., Cuéllar-Camacho, J.L., Hedtrich, S. and Klinger, D.
Biomacromolecules 23 (1): 112-127. 10 January 2022

2021

Beyond Ca(2+) signalling: the role of TRPV3 in the transport of NH(4).
Liebe, H., Liebe, F., Sponder, G., Hedtrich, S. and Stumpff, F.
Pflugers Archiv 473 (12): 1859-1884. December 2021

Characterization of an ester-based core-multishell (CMS) nanocarrier for the topical application at the oral mucosa.
Dommisch, H., Stolte, K.N., Jager, J., Vogel, K., Müller, R., Hedtrich, S., Unbehauen, M., Haag, R. and Danker, K.
Clinical Oral Investigations 25 (10): 5795-5805. October 2021

The delivery challenge of genome editing in human epithelia.
Calderón, M. and Hedtrich, S.
Advanced Healthcare Materials 10 (19): e2100847. October 2021

Hydrogels containing budesonide-loaded nanoparticles to facilitate percutaneous absorption for atopic dermatitis treatment applications.
Campos, E.V.R., Proença, P.L.F., Costa, T.G.d., de Lima, R., Hedtrich, S., Fraceto, L.F. and de Araujo, D.R.
ACS Applied Polymer Materials 3 (9): 4436-4449. 10 September 2021

Design and testing of efficient mucus-penetrating nanogels-pitfalls of preclinical testing and lessons learned.
Charbaji, R., Kar, M., Theune, L.E., Bergueiro, J., Eichhorst, A., Navarro, L., Graff, P., Stumpff, F., Calderón, M. and Hedtrich, S.
Small 17 (23): e2007963. 10 June 2021

Gene delivery to the skin - how far have we come?
Ain, Q.U., Campos, E.V.R., Huynh, A., Witzigmann, D. and Hedtrich, S.
Trends in Biotechnology 39 (5): 474-487. May 2021

Sulfoxide-functionalized nanogels inspired by the skin penetration properties of DMSO.
Işık, D., Joshi, A.A., Guo, X., Rancan, F., Klossek, A., Vogt, A., Rühl, E., Hedtrich, S. and Klinger, D.
Biomaterials science 9 (3): 712-725. 7 February 2021

TSLP as druggable target - a silver-lining for atopic diseases?
Adhikary, P.P., Tan, Z., Page, B.D.G. and Hedtrich, S.
Pharmacology & Therapeutics 217 : 107648. January 2021

COVID-19 highlights the model dilemma in biomedical research.
Adhikary, P.P., Ul Ain, Q., Hocke, A.C. and Hedtrich, S.
Nature Reviews Materials 6 (5): 374-376. 2021

2020

Impact of intercellular crosstalk between epidermal keratinocytes and dermal fibroblasts on skin homeostasis.
Jevtić, M., Löwa, A., Nováčková, A., Kováčik, A., Kaessmeyer, S., Erdmann, G., Vávrová, K. and Hedtrich, S.
Biochimica et Biophysica Acta - Molecular Cell Research 1867 (8): 118722. August 2020

Protein corona formation and its influence on biomimetic magnetite nanoparticles.
Peigneux, A., Glitscher, E.A., Charbaji, R., Weise, C., Wedepohl, S., Calderón, M., Jimenez-Lopez, C. and Hedtrich, S.
Journal of Materials Chemistry B 8 (22): 4870-4882. 14 June 2020

Fibroblasts from atopic dermatitis patients trigger inflammatory processes and hyperproliferation in human skin equivalents.
Löwa, A., Graff, P., Kaessmeyer, S. and Hedtrich, S.
Journal of the European Academy of Dermatology and Venereology 34 (6): e262-e265. June 2020

Non-ionic PEG-oligoglycerol dendron conjugated nano-carriers for dermal drug delivery.
Rashmi, Zabihi, F., Singh, A.K., Achazi, K., Schade, B., Hedtrich, S., Haag, R. and Sharma, S.K.
International Journal of Pharmaceutics 580 : 119212. 30 April 2020

Polypeptide-corticosteroid conjugates as a topical treatment approach to psoriasis.
Dolz-Pérez, I., Sallam, M.A., Masiá, E., Morelló-Bolumar, D., Pérez Del Caz, M.D., Graff, P., Abdelmonsif, D., Hedtrich, S., Nebot, V.J. and Vicent, M.J.
Journal of Controlled Release 318 : 210-222. February 2020

Investigation of TEMPO partitioning in different skin models as measured by EPR spectroscopy - insight into the stratum corneum.
Elpelt, A., Ivanov, D., Nováčková, A., Kováčik, A., Sochorová, M., Saeidpour, S., Teutloff, C., Lohan, S.B., Lademann, J., Vávrová, K., Hedtrich, S. and Meinke, M.C.
Journal of Magnetic Resonance 310 : 106637. January 2020

2019

Insight into the redox status of inflammatory skin equivalents as determined by EPR spectroscopy.
Elpelt, A., Albrecht, S., Teutloff, C., Hüging, M., Saeidpour, S., Lohan, S.B., Hedtrich, S. and Meinke, M.C.
Chemico-Biological Interactions 310 : 108752. 1 September 2019

Critical parameters for the controlled synthesis of nanogels suitable for temperature-triggered protein delivery.
Theune, L.E., Charbaji, R., Kar, M., Wedepohl, S., Hedtrich, S. and Calderón, M.
Materials Science and Engineering C: Materials for Biological Applications 100 : 141-151. July 2019

Regenerative potential of adipocytes in hypertrophic scars is mediated by myofibroblast reprogramming.
Hoerst, K., van den Broek, L., Sachse, C., Klein, O., von Fritschen, U., Gibbs, S. and Hedtrich, S.
Journal of Molecular Medicine 97 (6): 761-775. 1 June 2019

One-pot synthesis of poly(glycerol-co-succinic acid) nanogels for dermal delivery.
Zabihi, F., Koeppe, H., Achazi, K., Hedtrich, S. and Haag, R.
Biomacromolecules 20 (5): 1867-1875. 13 May 2019

Histological and functional comparisons of four anatomical regions of porcine skin with human abdominal skin.
Khiao In, M., Richardson, K.C., Loewa, A., Hedtrich, S., Kaessmeyer, S. and Plendl, J.
Anatomia Histologia Embryologia 48 (3): 207-217. May 2019

Serine protease mauritanicain from euphorbia mauritanica and phorbol-12-myristate-13-acetate modulate the IL-8 release in fibroblasts and HaCaT keratinocytes.
Guenther, F., Maus, D., Hedtrich, S. and Melzig, M.F.
Planta Medica 85 (7): 578-582. May 2019

Transglutaminase 1 replacement therapy successfully mitigates the autosomal recessive congenital ichthyosis phenotype in full-thickness skin disease equivalents.
Plank, R., Yealland, G., Miceli, E., Lima Cunha, D., Graff, P., Thomforde, S., Gruber, R., Moosbrugger-Martinz, V., Eckl, K., Calderón, M., Hennies, H.C. and Hedtrich, S.
Journal of Investigative Dermatology 139 (5): 1191-1195. May 2019

Supramolecular nanogels fabricated via host-guest molecular recognition as penetration enhancer for dermal drug delivery.
Gao, L., Zabihi, F., Ehrmann, S., Hedtrich, S. and Haag, R.
Journal of Controlled Release 300 : 64-72. 28 April 2019

Quantification and characterization of radical production in human, animal and 3D skin models during sun irradiation measured by EPR spectroscopy.
Albrecht, S., Elpelt, A., Kasim, C., Reble, C., Mundhenk, L., Pischon, H., Hedtrich, S., Witzel, C., Lademann, J., Zastrow, L., Beckers, I. and Meinke, M.C.
Free Radical Biology and Medicine 131 : 299-308. 1 February 2019

3D organ models-Revolution in pharmacological research?
Weinhart, M., Hocke, A., Hippenstiel, S., Kurreck, J. and Hedtrich, S.
Pharmacological Research 139 : 446-451. January 2019

Lyophilization of synthetic gene carriers.
Kasper, J.C., Hedtrich, S. and Friess, W.
Methods in Molecular Biology 1943 (2): 211-225. 2019

2018

Effect of delivery platforms structure on the epidermal antigen transport for topical vaccination.
Sonzogni, A.S., Yealland, G., Kar, M., Wedepohl, S., Gugliotta, L.M., Gonzalez, V.D.G., Hedtrich, S., Calderón, M. and Minari, R.J.
Biomacromolecules 19 (12): 4607-4616. 10 December 2018

Synthesis of poly(lactide-co-glycerol) as a biodegradable and biocompatible polymer with high loading capacity for dermal drug delivery.
Zabihi, F., Graff, P., Schumacher, F., Kleuser, B., Hedtrich, S. and Haag, R.
Nanoscale 10 (35): 16848-16856. 21 September 2018

Alternatives to animal testing in basic and preclinical research of atopic dermatitis.
Löwa, A., Jevtić, M., Gorreja, F. and Hedtrich, S.
Experimental Dermatology 27 (5): 476-483. May 2018

Crosstalk between core-multishell nanocarriers for cutaneous drug delivery and antigen-presenting cells of the skin.
Edlich, A., Volz, P., Brodwolf, R., Unbehauen, M., Mundhenk, L., Gruber, A.D., Hedtrich, S., Haag, R., Alexiev, U. and Kleuser, B.
Biomaterials 162 : 60-70. April 2018

Generation of full-thickness skin equivalents using hair follicle-derived primary human keratinocytes and fibroblasts.
Löwa, A., Vogt, A., Kaessmeyer, S. and Hedtrich, S.
Journal of Tissue Engineering and Regenerative Medicine 12 (4): e2134-e2146. April 2018

Characterization of hyperbranched core-multishell nanocarriers as an innovative drug delivery system for the application at the oral mucosa.
Jager, J., Obst, K., Lohan, S.B., Viktorov, J., Staufenbiel, S., Renz, H., Unbehauen, M., Haag, R., Hedtrich, S., Teutloff, C., Meinke, M..C., Danker, K. and Dommisch, H.
Journal of periodontal research 53 (1): 57-65. February 2018

How effective is tacrolimus in the imiquimod-induced mouse model of psoriasis?
Pischon, H., Radbruch, M., Ostrowski, A., Schumacher, F., Hönzke, S., Kleuser, B., Hedtrich, S., Fluhr, J.W., Gruber, A.D. and Mundhenk, L.
The Journal of investigative dermatology 138 (2): 455-458. February 2018

Enhanced topical delivery of dexamethasone by β-cyclodextrin decorated thermoresponsive nanogels.
Giulbudagian, M., Hönzke, S., Bergueiro, J., Işık, D., Schumacher, F., Saeidpour, S., Lohan, S.B., Meinke, M.C., Teutloff, C., Schäfer-Korting, M., Yealland, G., Kleuser, B., Hedtrich, S. and Calderón, M.
Nanoscale 10 (1): 469-479. 7 January 2018

Breaking the barrier - potent anti-inflammatory activity following efficient topical delivery of etanercept using thermoresponsive nanogels.
Giulbudagian, M., Yealland, G., Hönzke, S., Edlich, A., Geisendörfer, B., Kleuser, B., Hedtrich, S. and Calderón, M.
Theranostics 8 (2): 450-463. 1 January 2018

Human pulmonary 3D models for translational research.
Zscheppang, K., Berg, J., Hedtrich, S., Verheyen, L., Wagner, D.E., Suttorp, N., Hippenstiel, S. and Hocke, A.C.
Biotechnology Journal 13 (1): 1700341. January 2018

2017

One-pot and gram-scale synthesis of biodegradable polyglycerols under ambient conditions: nanocarriers for intradermal drug delivery.
Mohammadifar, E., Zabihi, F., Tu, Z., Hedtrich, S., Nemati Kharat, A., Adeli, M. and Haag, R.
Polymer Chemistry 8 (47): 7375-7383. 21 December 2017

Alkaline poly(ethylene glycol)-based hydrogels for a potential use as bioactive wound dressings.
Koehler, J., Verheyen, L., Hedtrich, S., Brandl, F.P. and Goepferich, A.M.
Journal of Biomedical Materials Research Part A 105 (12): 3360-3368. December 2017

Influence of the skin barrier on the penetration of topically-applied dexamethasone probed by soft X-ray spectromicroscopy.
Yamamoto, K., Klossek, A., Flesch, R., Rancan, F., Weigand, M., Bykova, I., Bechtel, M., Ahlberg, S., Vogt, A., Blume-Peytavi, U., Schrade, P., Bachmann, S., Hedtrich, S., Schäfer-Korting, M. and Rühl, E.
European Journal of Pharmaceutics and Biopharmaceutics 118 : 30-37. September 2017

Development of a perfusion platform for dynamic cultivation of in vitro skin models.
Strüver, K., Friess, W. and Hedtrich, S.
Skin pharmacology and physiology 30 (4): 180-189. August 2017

Specific uptake mechanisms of well-tolerated thermoresponsive polyglycerol-based nanogels in antigen-presenting cells of the skin.
Edlich, Alexander, Gerecke, C., Giulbudagian, M., Neumann, F., Hedtrich, S., Schäfer-Korting, M., Ma, N., Calderon, M. and Kleuser, B.
European Journal of Pharmaceutics and Biopharmaceutics 116 : 155-163. July 2017

Protein corona formation on colloidal polymeric nanoparticles and polymeric panogels: impact on cellular uptake, toxicity, immunogenicity, and drug release properties.
Obst, K., Yealland, G., Balzus, B., Miceli, E., Dimde, M., Weise, C., Eravci, M., Bodmeier, R., Haag, R., Calderón, M., Charbaji, N. and Hedtrich, S.
Biomacromolecules 18 (6): 1762-1771. 12 June 2017

Formulation and ex vivo evaluation of polymeric nanoparticles for controlled delivery of corticosteroids to the skin and the corneal epithelium.
Balzus, B., Sahle, F.F., Hönzke, S., Gerecke, C., Schumacher, F., Hedtrich, S., Kleuser, B. and Bodmeier, R.
European Journal of Pharmaceutics and Biopharmaceutics 115 : 122-130. June 2017

pH-modulating poly(ethylene glycol)/alginate hydrogel dressings for the treatment of chronic wounds.
Koehler, J., Wallmeyer, L., Hedtrich, S., Goepferich, A.M. and Brandl, F.P.
Macromolecular Bioscience 17 (5): 1600369. May 2017

Data-based modeling of drug penetration relates human skin barrier function to the interplay of diffusivity and free-energy profiles.
Schulz, R., Yamamoto, K., Klossek, A., Flesch, R., Hönzke, S., Rancan, F., Vogt, A., Blume-Peytavi, U., Hedtrich, S., Schäfer-Korting, M., Rühl, E. and Netz, R.R.
Proceedings of the National Academy of Sciences of the United States of America 114 (14): 3631-3636. 4 April 2017

TSLP is a direct trigger for T cell migration in filaggrin-deficient skin equivalents.
Wallmeyer, L., Dietert, K., Sochorová, M., Gruber, A.D., Kleuser, B., Vávrová, K. and Hedtrich, S.
Scientific Reports 7 (1): 774. 4 April 2017

Biocompatibility and characterization of polyglycerol-based thermoresponsive nanogels designed as novel drug-delivery systems and their intracellular localization in keratinocytes.
Gerecke, C., Edlich, A., Giulbudagian, M., Schumacher, F., Zhang, N., Said, A., Yealland, G., Lohan, S.B., Neumann, F., Meinke, M.C., Ma, N., Calderón, M., Hedtrich, S., Schäfer-Korting, M. and Kleuser, B.
Nanotoxicology 11 (2): 267-277. March 2017

NHE1 expression at wound margins increases time-dependently during physiological healing.
Haverkampf, S., Heider, J., Weiß, K.T., Haubner, F., Ettl, T., Schreml, J., Hedtrich, S., von Süßkind-Schwendi, M., Berneburg, M., Karrer, S., Dissemond, J. and Schreml, S.
Experimental dermatology 26 (2): 124-126. February 2017

Stratum corneum targeting by dendritic core-multishell-nanocarriers in a mouse model of psoriasis.
Pischon, H., Radbruch, M., Ostrowski, A., Volz, P., Gerecke, C., Unbehauen, M., Hönzke, S., Hedtrich, S., Fluhr, J.W., Haag, R., Kleuser, B., Alexiev, U., Gruber, A.D. and Mundhenk, L.
Nanomedicine: Nanotechnology, Biology and Medicine 13 (1): 317-327. January 2017

2016

Core-multishell nanocarriers: transport and release of dexamethasone probed by soft x-ray spectromicroscopy.
Yamamoto, K., Klossek, A., Flesch, R., Ohigashi, T., Fleige, E., Rancan, F., Frombach, J., Vogt, A., Blume-Peytavi, U., Schrade, P., Bachmann, S., Haag, R., Hedtrich, S., Schäfer-Korting, M., Kosugi, N. and Rühl, E.
Journal of Controlled Release 242 : 64-70. 28 November 2016

Ethyl cellulose nanocarriers and nanocrystals differentially deliver dexamethasone into intact, tape-stripped or sodium lauryl sulfate-exposed ex vivo human skin - assessment by intradermal microdialysis and extraction from the different skin layers.
Döge, N., Hönzke, S., Schumacher, F., Balzus, B., Colombo, M., Hadam, S., Rancan, F., Blume-Peytavi, U., Schäfer-Korting, M., Schindler, A., Rühl, E., Skov, P.S., Church, M.K., Hedtrich, S., Kleuser, B., Bodmeier, R. and Vogt, A.
Journal of Controlled Release 242 : 25-34. 28 November 2016

Influence of Th2 cytokines on the cornified envelope, tight junction proteins, and ß-defensins in filaggrin-deficient skin equivalents.
Hönzke, S., Wallmeyer, L., Ostrowski, A., Radbruch, M., Mundhenk, L., Schäfer-Korting, M. and Hedtrich, S.
Journal of Investigative Dermatology 136 (3): 631-639. March 2016

2015

Stimulation of PPARα normalizes the skin lipid ratio and improves the skin barrier of normal and filaggrin deficient reconstructed skin.
Wallmeyer, L., Lehnen, D., Eger, N., Sochorová, M., Opálka, L., Kováčik, A., Vávrová, K. and Hedtrich, S.
Journal of Dermatological Science 80 (2): 102-10. 2 December 2015

Recent advances in topical delivery of proteins and peptides mediated by soft matter nanocarriers.
Witting, M., Obst, K., Friess, W. and Hedtrich, S.
Biotechnology Advances 33 (6 Pt 3): 1355-1369. 1 November 2015

Thermosensitive dendritic polyglycerol-based nanogels for cutaneous delivery of biomacromolecules.
Witting, M., Molina, M., Obst, K., Plank, R., Eckl, K.M., Hennies, H.C., Calderón, M., Friess, W. and Hedtrich, S.
Nanomedicine: Nanotechnology, Biology and Medicine 11 (5): 1179-87. July 2015

Selective probing of the penetration of dexamethasone into human skin by soft x-ray spectromicroscopy.
Yamamoto, K., Flesch, R., Ohigashi, T., Hedtrich, S., Klossek, A., Patoka, P., Ulrich, G., Ahlberg, S., Rancan, F., Vogt, A., Blume-Peytavi, U., Schrade, P., Bachmann, S., Schäfer-Korting, M., Kosugi, N. and Rühl, E.
Analytical Chemistry 87 (12): 6173–6179. 16 June 2015

Feasibility study for intraepidermal delivery of proteins using a solid microneedle array.
Witting, M., Obst, K., Pietzsch, M., Friess, W. and Hedtrich, S.
International Journal of Pharmaceutics 486 (1-2): 52-58. 30 May 2015

Interactions of hyaluronic acid with the skin and implications for the dermal delivery of biomacromolecules.
Witting, M., Boreham, A., Brodwolf, R., Vávrová, K., Alexiev, U., Friess, W. and Hedtrich, S.
Molecular Pharmaceutics 12 (5): 1391-1401. 4 May 2015

Synthesis of multiarm star copolymers based on polyglycerol cores with polylactide arms and their application as nanocarriers.
Adeli, M., Namazi, H., Du, F., Hönzke, S., Hedtrich, S., Keilitz, J. and Haag, R.
RSC Advances 5 (20): 14958-14966. 2015

The effect of endothelialization on the epidermal differentiation in human three-dimensional skin constructs – A morphological study.
Khiao In, M., Wallmeyer, L., Hedtrich, S., Richardson, K.C., Plendl, J. and Kaessmeyer, S.
Clinical Hemorheology and Microcirculation 61 (2): 157-174. 2015

2014

Impact of structural differences in hyperbranched polyglycerol–polyethylene glycol nanoparticles on dermal drug delivery and biocompatibility.
Kumar, S., Alnasif, N., Fleige, E., Kurniasih, I., Kral, V., Haase, A., Luch, A., Weindl, G., Haag, R., Schäfer-Korting, M. and Hedtrich, S.
European Journal of Pharmaceutics and Biopharmaceutics 88 (3): 625-34. November 2014

Penetration of normal, damaged and diseased skin--an in vitro study on dendritic core-multishell nanotransporters.
Alnasif, Nesrin, Zoschke, Christian, Fleige, Emanuel, Brodwolf, Robert, Boreham, Alexander, Rühl, Eckart, Eckl, K.M., Merk, Hans-Friedrich, Hennies, H.C., Alexiev, Ulrike, Haag, Rainer, Küchler, S. and Schäfer-Korting, Monika
Journal of Controlled Release 185 : 45-50. 10 July 2014

Luminescent dual sensors reveal extracellular pH-gradients and hypoxia on chronic wounds that disrupt epidermal repair.
Schreml, S., Meier, R.J., Kirschbaum, M., Kong, S.C., Gehmert, S., Felthaus, O., Küchler, S., Sharpe, J.R., Wöltje, K., Weiß, K.T., Albert, M., Seidl, U., Schröder, J., Morsczeck, C., Prantl, L., Duschl, C., Pedersen, S.F., Gosau, M., Berneburg, M., Wolfbeis, O.S., Landthaler, M. and Babilas, P.
Theranostics 4 (7): 721-735. July 2014

Improving topical non-melanoma skin cancer treatment: In vitro efficacy of a novel guanosine-analog phosphonate.
Ali-von Laue, C., Zoschke, C., Do, N., Lehnen, D., Küchler, S., Mehnert, W., Blaschke, T., Kramer, K.D., Plendl, J., Weindl, G., Korting, H.C., Hoeller Obrigkeit, D., Merk, H.F. and Schäfer-Korting, M.
Skin Pharmacology and Physiology 27 (4): 173. May 2014

Increased cutaneous absorption reflects impaired barrier function of reconstructed skin models mimicking keratinisation disorders.
Eckl, K.M., Weindl, G., Ackermann, K., Küchler, S., Casper, R., Radowski, M.R., Haag, R., Hennies, H.C. and Schäfer-Korting, M.
Experimental Dermatology 23 (4): 286-288. April 2014

Filaggrin deficiency leads to impaired lipid profile and altered acidification pathways in a 3D skin construct.
Vávrová, K., Henkes, D., Strüver, K., Sochorová, M., Školová, B., Witting, M.Y., Friess, W., Schreml, S., Meier, R.J., Schäfer-Korting, M., Fluhr, J.W. and Küchler, S.
The Journal of Investigative Dermatology 134 (3): 746-753. March 2014

2013

Polyglycerol coatings of glass vials for protein resistance.
Höger, K., Becherer, T., Qiang, W., Haag, R., Friess, W. and Küchler, S.
European Journal of Pharmaceutics and Biopharmaceutics 85 (3 Pt A): 756-764. November 2013

Formulation development of lyophilized, long-term stable siRNA/oligoaminoamide polyplexes.
Kasper, J.C., Troiber, C., Küchler, S., Wagner, E. and Friess, W.
European Journal of Pharmaceutics and Biopharmaceutics 85 (2): 294-305. October 2013

Surfactant free preparation of biodegradable dendritic polyglycerol nanogels by inverse nanoprecipitation for encapsulation and release of pharmaceutical biomacromolecules.
Steinhilber, D., Witting, M., Zhang, X., Staegemann, M., Paulus, F., Friess, W., Küchler, S. and Haag, R.
Journal of Controlled Release 169 (3): 289-295. 10 August 2013

Comparison of four different particle sizing methods for siRNA polyplex characterization.
Troiber, C., Kasper, J.C., Milani, S., Scheible, M., Martin, I., Schaubhut, F., Küchler, S., Rädler, J., Simmel, F.C., Friess, W. and Wagner, E.
European Journal of Pharmaceutics and Biopharmaceutics 84 (2): 255-264. June 2013

Targeting inflammation and wound healing by opioids.
Stein, C. and Küchler, S.
Trends in Pharmacological Sciences 34 (6): 303-12. June 2013

Reconstructed skin models as emerging tools for drug absorption studies.
Küchler, S., Strüver, K. and Friess, W.
Expert Opinion on Drug Metabolism & Toxicology 9 (10): 1255-1263. 2013