Browse by Research Team

2011

Different roles of the human Orc6 protein in the replication initiation process.
Thomae, A.W. and Baltin, J. and Pich, D. and Deutsch, M.J. and Ravasz, M. and Zeller, K. and Gossen, M. and Hammerschmidt, W. and Schepers, A.
Cellular and Molecular Life Sciences 68 (22): 3741-3756. November 2011

Development of a BAC vector for integration-independent and tight regulation of transgenes in rodents via the Tet system.
Schoenig, K. and Kentner, D. and Gossen, M. and Baldinger, T. and Miao, J. and Welzel, K. and Vente, A. and Bartsch, D. and Bujard, H.
Transgenic Research 20 (3): 709-720. June 2011

2010

The power of reversibility regulating gene activities via tetracycline-controlled transcription.
Schoenig, K. and Bujard, H. and Gossen, M.
Methods in Enzymology 477 (C): 429-453. 2010

2009

Inducible expression of coding and inhibitory RNAs from retargetable genomic loci.
Weidenfeld, I. and Gossen, M. and Loew, R. and Kentner, D. and Berger, S. and Goerlich, D. and Bartsch, D. and Bujard, H. and Schoenig, K.
Nucleic Acids Research 37 (7): e50. April 2009

Binding of Drosophila ORC proteins to anaphase chromosomes requires cessation of mitotic cyclin-dependent kinase activity.
Baldinger, T. and Gossen, M.
Molecular and Cellular Biology 29 (1): 140-149. January 2009

Global analysis of cellular protein translation by pulsed SILAC.
Schwanhaeusser, B. and Gossen, M. and Dittmar, G. and Selbach, M.
Proteomics 9 (1): 205-209. January 2009

2008

Homogeneity and persistence of transgene expression by omitting antibiotic selection in cell line isolation.
Kaufman, W.L. and Kocman, I. and Agrawal, V. and Rahn, H.P. and Besser, D. and Gossen, M.
Nucleic Acids Research 36 (17): e111. October 2008

2007

Promoter crosstalk effects on gene expression.
Hampf, M. and Gossen, M.
Journal of Molecular Biology 365 (4): 911-920. 26 January 2007

2006

A protocol for combined Photinus and Renilla luciferase quantification compatible with protein assays.
Hampf, M. and Gossen, M.
Analytical Biochemistry 356 (1): 94-99. 1 September 2006

Conditional gene expression: Intelligent designs.
Gossen, M.
Gene Therapy 13 (17): 1251-1252. September 2006

A structural role for ATP in the formation and stability of the human origin recognition complex.
Ranjan, A. and Gossen, M.
Proceedings of the National Academy of Sciences of the United States of America 103 (13): 4864-4869. 28 March 2006

Stability and homogeneity of transgene expression in isogenic cells.
Liu, W. and Xiong, Y. and Gossen, M.
Journal of Molecular Medicine 84 (1): 57-64. January 2006

2004

Characterization of apoptosis-induced Mcm3 and Cdc6 cleavage reveals a proapoptotic effect for one Mcm3 fragment.
Schories, B. and Engel, K. and Doerken, B. and Gossen, M. and Bommert, K.
Cell Death and Differentiation 11 (8): 940-942. August 2004

2003

Prevalence of primary hyperaldosteronism in moderate to severe hypertension in the Central Europe region.
Strauch, B. and Zelinka, T. and Hampf, M. and Bernhardt, R. and Widimsky, J.
Journal of Human Hypertension 17 (5): 349-352. May 2003

Functional haplotypes of the RET proto-oncogene promoter are associated with Hirschsprung disease (HSCR).
Fitze, G. and Appelt, H. and Koenig, I.R. and Goergens, H. and Stein, U. and Walther, W. and Gossen, M. and Schreiber, M. and Ziegler, A. and Roesner, D. and Schackert, H.K.
Human Molecular Genetics 12 (24): 3207-3214. 1 January 2003

2002

Studying gene function in eukaryotes by conditional gene inactivation.
Gossen, M. and Bujard, H.
Annual Review of Genetics 36 : 153-173. December 2002

2001

Generation of tumor-associated cytotoxic T lymphocytes requires interleukin 4 from CD8+ T cells.
Schueler, T. and Kammertoens, T. and Preiss, S. and Debs, P. and Noben-Trauth, N. and Blankenstein, T.
Journal of Experimental Medicine 194 (12): 1767-1775. 17 December 2001

Tetracycline-inducible transcriptional inhibitor fusion proteins.
Bujard, H. and Gossen, M.
US6,271,348. 7 August 2001

Transgenic organisms having tetracycline-regulated transcriptional regulatory systems.
Bujard, H. and Gossen, M. and Salfeld, J.G. and Voss, J.W.
US6,242,667 ; US6,252,136. 5 June 2001

2000

Tetracycline-inducible transcriptional activator fusion proteins.
Bujard, H. and Gossen, M.
US6,136,954. 24 October 2000

Transcriptional activators with graded transactivation potential.
Baron, U. and Gossen, M. and Bujard, H.
US6,087,166 ; US6,271,341. 11 July 2000

The bovine papillomavirus E2 transactivator is stimulated by the E1 initiator through the E2 activation domain.
Parker, L.M. and Harris, S. and Gossen, M. and Botchan, M.R.
Virology 270 : 430-443. 10 May 2000

1999

Methods for producing tetracycline-regulated transgenic mice.
Bujard, H. and Gossen, M. and Salfeld, J.G. and Voss, J.W.
US5,922,927. 13 July 1999

Mice transgenic for a tetracycline-inducible transcriptional activator.
Bujard, H. and Gossen, M.
US5,912,411. 15 June 1999

Assembly of functionally active Drosophila origin recognition complex from recombinant proteins.
Chesnokov, I. and Gossen, M. and Remus, D. and Botchan, M.
Genes & Development 13 : 1289-1296. 15 May 1999

Methods for regulating gene expression.
Bujard, H. and Gossen, M.
US5,888,981 ; US6,004,941. 30 March 1999

Animals transgenic for a tetracycline-regulated transcriptional inhibitor.
Bujard, H. and Gossen, M.
US5,866,755. 2 February 1999

Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes.
Baron, U. and Schnappinger, D. and Helbl, V. and Gossen, M. and Hillen, W. and Bujard, H.
Proceedings of the National Academy of Sciences of the United States of America 96 : 1013-1018. 2 February 1999

Mice transgenic for a tetracycline-controlled transcriptional activator.
Bujard, H. and Gossen, M. and Salfeld, J.G. and Voss, J.W.
US5,859,310. 12 January 1999

1998

Competition for DNA binding sites between the short and long forms of E2 dimers underlies repression in bovine papillomavirus type 1 DNA replication control.
Lim, D.A. and Gossen, M. and Lehman, C.W. and Botchan, M.R.
Journal of Virology 72 : 1931-1940. 1 March 1998

Stimulation of cyclin-dependent kinase activity and G1- to S-phase transition in human lymphocytes by the human T-cell leukemia/lymphotropic virus type 1 Tax protein.
Schmitt, I. and Rosin, O. and Rohwer, P. and Gossen, M. and Grassmann, R.
Journal of Virology 72 (1): 633-640. 1 January 1998

1997

Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential.
Baron, U. and Gossen, M. and Bujard, H.
Nucleic Acids Research 25 (14): 2723-2729. 15 July 1997

Use of tetracycline-controlled gene expression systems to study mammalian cell cycle.
Freundlieb, S. and Baron, U. and Bonin, A.L. and Gossen, M. and Bujard, H.
Methods in Enzymology 283 : 159-173. 1 January 1997

1996

Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice.
Kistner, A. and Gossen, M. and Zimmermann, F. and Jerecic, J. and Ullmer, C. and Lubbert, H. and Bujard, H.
Proceedings of the National Academy of Sciences of the United States of America 93 (20): 10933-10938. 1 October 1996

1995

A Drosophila homolog of the yeast origin recognition complex.
Gossen, M. and Pak, D.T. and Hansen, S.K. and Acharya, J.K. and Botchan, M.R.
Science 270 (5242): 1674-1677. 8 December 1995

Separation of origin recognition complex functions by cross-species complementation.
Ehrenhofer-Murray, A.E. and Gossen, M. and Pak, D.T. and Botchan, M.R. and Rine, J.
Science 270 (5242): 1671-1674. 8 December 1995

Co-regulation of two gene activities by tetracycline via a bidirectional promoter.
Baron, U. and Freundlieb, S. and Gossen, M. and Bujard, H.
Nucleic Acids Research 23 (17): 3605-3606. 11 September 1995

Transcriptional activation by tetracyclines in mammalian cells.
Gossen, M. and Freundlieb, S. and Bender, G. and Muller, G. and Hillen, W. and Bujard, H.
Science 268 (5218): 1766-1769. 23 June 1995

Identification of mammalian cell clones exhibiting highly regulated expression from inducible promoters.
Kirchhoff, S. and Koster, M. and Wirth, M. and Schaper, F. and Gossen, M. and Bujard, H. and Hauser, H.
Trends in Genetics 11 (6): 219-220. June 1995

Tightly regulated and inducible expression of dominant interfering dynamin mutant in stably transformed HeLa cells.
Damke, H. and Gossen, M. and Freundlieb, S. and Bujard, H. and Schmid, S.L.
Methods in Enzymology 257 : 209-220. 1995

1994

Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter.
Furth, P.A. and Onge, S.T. and Boger, H. and Gruss, P. and Gossen, M. and Kistner, A. and Bujard, H. and Hennighausen, L.
Proceedings of the National Academy of Sciences of the United States of America 91 (20): 9302-9306. 27 September 1994

Displacement of housekeeping proteasome subunits by MHC-encoded LMPs: a newly discovered mechanism for modulating the multicatalytic proteinase complex.
Fruh, K. and Gossen, M. and Wang, K. and Bujard, H. and Peterson, P.A. and Yang, Y.
EMBO Journal 13 : 3236-3244. 15 July 1994

Photinus pyralis luciferase: vectors that contain a modified luc coding sequence allowing convenient transfer into other systems.
Bonin, A.L. and Gossen, M. and Bujard, H.
Gene 141 : 75-77. 8 April 1994

A chimeric transactivator allows tetracycline-responsive gene expression in whole plants.
Weinmann, P. and Gossen, M. and Hillen, W. and Bujard, H. and Gatz, C.
Plant Journal 5 (4): 559-569. April 1994

Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system.
Resnitzky, D. and Gossen, M. and Bujard, H. and Reed, S.I.
Molecular and Cellular Biology 14 (3): 1669-1679. 1 March 1994

1993

Anhydrotetracycline, a novel effector for tetracycline controlled gene expression systems in eukaryotic cells.
Gossen, M. and Bujard, H.
Nucleic Acids Research 21 (18): 4411-4412. 11 September 1993

1992

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.
Gossen, M. and Bujard, H.
Proceedings of the National Academy of Sciences of the United States of America 89 (12): 5547-5551. 15 June 1992