Browse by Research Team

2011

Different roles of the human Orc6 protein in the replication initiation process.
Thomae, A.W., Baltin, J., Pich, D., Deutsch, M.J., Ravasz, M., Zeller, K., Gossen, M., Hammerschmidt, W. and Schepers, A.
Cellular and Molecular Life Sciences 68 (22): 3741-3756. November 2011

Development of a BAC vector for integration-independent and tight regulation of transgenes in rodents via the Tet system.
Schoenig, K., Kentner, D., Gossen, M., Baldinger, T., Miao, J., Welzel, K., Vente, A., Bartsch, D. and Bujard, H.
Transgenic Research 20 (3): 709-720. June 2011

2010

The power of reversibility regulating gene activities via tetracycline-controlled transcription.
Schoenig, K., Bujard, H. and Gossen, M.
Methods in Enzymology 477 (C): 429-453. 2010

2009

Inducible expression of coding and inhibitory RNAs from retargetable genomic loci.
Weidenfeld, I., Gossen, M., Loew, R., Kentner, D., Berger, S., Goerlich, D., Bartsch, D., Bujard, H. and Schoenig, K.
Nucleic Acids Research 37 (7): e50. April 2009

Binding of Drosophila ORC proteins to anaphase chromosomes requires cessation of mitotic cyclin-dependent kinase activity.
Baldinger, T. and Gossen, M.
Molecular and Cellular Biology 29 (1): 140-149. January 2009

Global analysis of cellular protein translation by pulsed SILAC.
Schwanhaeusser, B., Gossen, M., Dittmar, G. and Selbach, M.
Proteomics 9 (1): 205-209. January 2009

2008

Homogeneity and persistence of transgene expression by omitting antibiotic selection in cell line isolation.
Kaufman, W.L., Kocman, I., Agrawal, V., Rahn, H.P., Besser, D. and Gossen, M.
Nucleic Acids Research 36 (17): e111. October 2008

2007

Promoter crosstalk effects on gene expression.
Hampf, M. and Gossen, M.
Journal of Molecular Biology 365 (4): 911-920. 26 January 2007

2006

A protocol for combined Photinus and Renilla luciferase quantification compatible with protein assays.
Hampf, M. and Gossen, M.
Analytical Biochemistry 356 (1): 94-99. 1 September 2006

Conditional gene expression: Intelligent designs.
Gossen, M.
Gene Therapy 13 (17): 1251-1252. September 2006

A structural role for ATP in the formation and stability of the human origin recognition complex.
Ranjan, A. and Gossen, M.
Proceedings of the National Academy of Sciences of the United States of America 103 (13): 4864-4869. 28 March 2006

Stability and homogeneity of transgene expression in isogenic cells.
Liu, W., Xiong, Y. and Gossen, M.
Journal of Molecular Medicine 84 (1): 57-64. January 2006

2004

Characterization of apoptosis-induced Mcm3 and Cdc6 cleavage reveals a proapoptotic effect for one Mcm3 fragment.
Schories, B., Engel, K., Doerken, B., Gossen, M. and Bommert, K.
Cell Death and Differentiation 11 (8): 940-942. August 2004

2003

Prevalence of primary hyperaldosteronism in moderate to severe hypertension in the Central Europe region.
Strauch, B., Zelinka, T., Hampf, M., Bernhardt, R. and Widimsky, J.
Journal of Human Hypertension 17 (5): 349-352. May 2003

Functional haplotypes of the RET proto-oncogene promoter are associated with Hirschsprung disease (HSCR).
Fitze, G., Appelt, H., Koenig, I.R., Goergens, H., Stein, U., Walther, W., Gossen, M., Schreiber, M., Ziegler, A., Roesner, D. and Schackert, H.K.
Human Molecular Genetics 12 (24): 3207-3214. 1 January 2003

2002

Studying gene function in eukaryotes by conditional gene inactivation.
Gossen, M. and Bujard, H.
Annual Review of Genetics 36 : 153-173. December 2002

2001

Generation of tumor-associated cytotoxic T lymphocytes requires interleukin 4 from CD8+ T cells.
Schueler, T., Kammertoens, T., Preiss, S., Debs, P., Noben-Trauth, N. and Blankenstein, T.
Journal of Experimental Medicine 194 (12): 1767-1775. 17 December 2001

Tetracycline-inducible transcriptional inhibitor fusion proteins.
Bujard, H. and Gossen, M.
US6,271,348. 7 August 2001

Transgenic organisms having tetracycline-regulated transcriptional regulatory systems.
Bujard, H., Gossen, M., Salfeld, J.G. and Voss, J.W.
US6,242,667 ; US6,252,136. 5 June 2001

2000

Tetracycline-inducible transcriptional activator fusion proteins.
Bujard, H. and Gossen, M.
US6,136,954. 24 October 2000

Transcriptional activators with graded transactivation potential.
Baron, U., Gossen, M. and Bujard, H.
US6,087,166 ; US6,271,341. 11 July 2000

The bovine papillomavirus E2 transactivator is stimulated by the E1 initiator through the E2 activation domain.
Parker, L.M., Harris, S., Gossen, M. and Botchan, M.R.
Virology 270 : 430-443. 10 May 2000

1999

Methods for producing tetracycline-regulated transgenic mice.
Bujard, H., Gossen, M., Salfeld, J.G. and Voss, J.W.
US5,922,927. 13 July 1999

Mice transgenic for a tetracycline-inducible transcriptional activator.
Bujard, H. and Gossen, M.
US5,912,411. 15 June 1999

Assembly of functionally active Drosophila origin recognition complex from recombinant proteins.
Chesnokov, I., Gossen, M., Remus, D. and Botchan, M.
Genes & Development 13 : 1289-1296. 15 May 1999

Methods for regulating gene expression.
Bujard, H. and Gossen, M.
US5,888,981 ; US6,004,941. 30 March 1999

Animals transgenic for a tetracycline-regulated transcriptional inhibitor.
Bujard, H. and Gossen, M.
US5,866,755. 2 February 1999

Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes.
Baron, U., Schnappinger, D., Helbl, V., Gossen, M., Hillen, W. and Bujard, H.
Proceedings of the National Academy of Sciences of the United States of America 96 : 1013-1018. 2 February 1999

Mice transgenic for a tetracycline-controlled transcriptional activator.
Bujard, H., Gossen, M., Salfeld, J.G. and Voss, J.W.
US5,859,310. 12 January 1999

1998

Competition for DNA binding sites between the short and long forms of E2 dimers underlies repression in bovine papillomavirus type 1 DNA replication control.
Lim, D.A., Gossen, M., Lehman, C.W. and Botchan, M.R.
Journal of Virology 72 : 1931-1940. 1 March 1998

Stimulation of cyclin-dependent kinase activity and G1- to S-phase transition in human lymphocytes by the human T-cell leukemia/lymphotropic virus type 1 Tax protein.
Schmitt, I., Rosin, O., Rohwer, P., Gossen, M. and Grassmann, R.
Journal of Virology 72 (1): 633-640. 1 January 1998

1997

Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential.
Baron, U., Gossen, M. and Bujard, H.
Nucleic Acids Research 25 (14): 2723-2729. 15 July 1997

Use of tetracycline-controlled gene expression systems to study mammalian cell cycle.
Freundlieb, S., Baron, U., Bonin, A.L., Gossen, M. and Bujard, H.
Methods in Enzymology 283 : 159-173. 1 January 1997

1996

Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice.
Kistner, A., Gossen, M., Zimmermann, F., Jerecic, J., Ullmer, C., Lubbert, H. and Bujard, H.
Proceedings of the National Academy of Sciences of the United States of America 93 (20): 10933-10938. 1 October 1996

1995

A Drosophila homolog of the yeast origin recognition complex.
Gossen, M., Pak, D.T., Hansen, S.K., Acharya, J.K. and Botchan, M.R.
Science 270 (5242): 1674-1677. 8 December 1995

Separation of origin recognition complex functions by cross-species complementation.
Ehrenhofer-Murray, A.E., Gossen, M., Pak, D.T., Botchan, M.R. and Rine, J.
Science 270 (5242): 1671-1674. 8 December 1995

Co-regulation of two gene activities by tetracycline via a bidirectional promoter.
Baron, U., Freundlieb, S., Gossen, M. and Bujard, H.
Nucleic Acids Research 23 (17): 3605-3606. 11 September 1995

Transcriptional activation by tetracyclines in mammalian cells.
Gossen, M., Freundlieb, S., Bender, G., Muller, G., Hillen, W. and Bujard, H.
Science 268 (5218): 1766-1769. 23 June 1995

Identification of mammalian cell clones exhibiting highly regulated expression from inducible promoters.
Kirchhoff, S., Koster, M., Wirth, M., Schaper, F., Gossen, M., Bujard, H. and Hauser, H.
Trends in Genetics 11 (6): 219-220. June 1995

Tightly regulated and inducible expression of dominant interfering dynamin mutant in stably transformed HeLa cells.
Damke, H., Gossen, M., Freundlieb, S., Bujard, H. and Schmid, S.L.
Methods in Enzymology 257 : 209-220. 1995

1994

Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter.
Furth, P.A., Onge, S.T., Boger, H., Gruss, P., Gossen, M., Kistner, A., Bujard, H. and Hennighausen, L.
Proceedings of the National Academy of Sciences of the United States of America 91 (20): 9302-9306. 27 September 1994

Displacement of housekeeping proteasome subunits by MHC-encoded LMPs: a newly discovered mechanism for modulating the multicatalytic proteinase complex.
Fruh, K., Gossen, M., Wang, K., Bujard, H., Peterson, P.A. and Yang, Y.
EMBO Journal 13 : 3236-3244. 15 July 1994

Photinus pyralis luciferase: vectors that contain a modified luc coding sequence allowing convenient transfer into other systems.
Bonin, A.L., Gossen, M. and Bujard, H.
Gene 141 : 75-77. 8 April 1994

A chimeric transactivator allows tetracycline-responsive gene expression in whole plants.
Weinmann, P., Gossen, M., Hillen, W., Bujard, H. and Gatz, C.
Plant Journal 5 (4): 559-569. April 1994

Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system.
Resnitzky, D., Gossen, M., Bujard, H. and Reed, S.I.
Molecular and Cellular Biology 14 (3): 1669-1679. 1 March 1994

1993

Anhydrotetracycline, a novel effector for tetracycline controlled gene expression systems in eukaryotic cells.
Gossen, M. and Bujard, H.
Nucleic Acids Research 21 (18): 4411-4412. 11 September 1993

1992

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.
Gossen, M. and Bujard, H.
Proceedings of the National Academy of Sciences of the United States of America 89 (12): 5547-5551. 15 June 1992