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Article

Metabolic remodeling in cardiac hypertrophy and heart failure with reduced ejection fraction occurs independent of transcription factor EB in mice.
Dörmann, N., Hammer, E., Struckmann, K., Rüdebusch, J., Bartels, K., Wenzel, K., Schulz, J., Gross, S., Schwanz, S., Martin, E., Fielitz, B., Pablo Tortola, C., Hahn, A., Benkner, A., Völker, U., Felix, S.B and Fielitz, J.
Frontiers in Cardiovascular Medicine 10 : 1323760. 8 January 2024

SPSB1-mediated inhibition of TGF-β receptor-II impairs myogenesis in inflammation.
Li, Y., Dörmann, N., Brinschwitz, B., Kny, M., Martin, E., Bartels, K., Li, N., Giri, P.V., Schwanz, S., Boschmann, M., Hille, S., Fielitz, B., Wollersheim, T., Grunow, J., Felix, S.B., Weber-Carstens, S., Luft, F.C., Müller, O.J. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 14 (4): 1721-1736. August 2023

Muscular myostatin gene expression and plasma concentrations are decreased in critically ill patients.
Grunow, J.J., Reiher, K., Carbon, N.M., Engelhardt, L.J., Mai, K., Koch, S., Schefold, J.C., Z'Graggen, W., Schaller, S.J., Fielitz, J., Spranger, J., Weber-Carstens, S. and Wollersheim, T.
Critical Care 26 (1): 237. 3 August 2022

The transcription factor EB (TFEB) sensitizes the heart to chronic pressure overload.
Wundersitz, S., Pablo Tortola, C., Schmidt, S., Oliveira Vidal, R., Kny, M., Hahn, A., Zanders, L., Katus, H.A., Sauer, S., Butter, C., Luft, F.C., Müller, O.J. and Fielitz, J.
International Journal of Molecular Sciences 23 (11): 5943. 25 May 2022

Skeletal muscle derived Musclin protects the heart during pathological overload.
Szaroszyk, M., Kattih, B., Martin-Garrido, A., Trogisch, F.A., Dittrich, G.M., Grund, A., Abouissa, A., Derlin, K., Meier, M., Holler, T., Korf-Klingebiel, M., Völker, K., Macedo, T.G., Tortola, C.P., Boschmann, M., Huang, N., Froese, N., Zwadlo, C., Malek Mohammadi, M., Luo, X., Wagner, M., Cordero, J., Geffers, R., Batkai, S., Thum, T., Bork, N., Nikolaev, V.O., Müller, O.J., Katus, H.A., El-Armouche, A., Kraft, T., Springer, J., Dobreva, G., Wollert, K.C., Fielitz, J., von Haehling, S., Kuhn, M., Bauersachs, J. and Heineke, J.
Nature Communications 13 (1): 149. 10 January 2022

Physical performance and non-esterified fatty acids in men and women after transcatheter aortic valve implantation (TAVI).
Härdrich, M., Haase-Fielitz, A., Fielitz, J., Boschmann, M., Pivovarova-Ramich, O., Pfeiffer, A.F.H., Rudovich, N., Weylandt, K.H. and Butter, C.
Nutrients 14 (1): 203. 2 January 2022

Inhibition of the NLRP3/IL-1β axis protects against sepsis-induced cardiomyopathy.
Busch, K., Kny, M., Huang, N., Klassert, T.E., Stock, M., Hahn, A., Graeger, S., Todiras, M., Schmidt, S., Chamling, B., Willenbrock, M., Groß, S., Biedenweg, D., Heuser, A., Scheidereit, C., Butter, C., Felix, S.B., Otto, O., Luft, F.C., Slevogt, H. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 12 (6): 1653-1668. December 2021

Energy metabolites as biomarkers in ischemic and dilated cardiomyopathy.
Haas, J., Frese, K.S., Sedaghat-Hamedani, F., Kayvanpour, E., Tappu, R., Nietsch, R., Tugrul, O.F., Wisdom, M., Dietrich, C., Amr, A., Weis, T., Niederdränk, T., Murphy, M.P., Krieg, T., Dörr, M., Völker, U., Fielitz, J., Frey, N., Felix, S.B., Keller, A., Katus, H.A. and Meder, B.
International Journal of Molecular Sciences 22 (4): 1999. 18 February 2021

Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting.
Zanders, L., Kny, M., Hahn, A., Schmidt, S., Wundersitz, S., Todiras, M., Lahmann, I., Bandyopadhyay, A., Wollersheim, T., Kaderali, L., Luft, F.C., Birchmeier, C., Weber-Carstens, S. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 13 (1): 713-727. February 2021

Activation of tripartite motif containing 63 expression by transcription factor EB and transcription factor binding to immunoglobulin heavy chain enhancer 3 is regulated by protein kinase D and class IIa histone deacetylases.
Pablo Tortola, C., Fielitz, B., Li, Y., Rüdebusch, J., Luft, F.C. and Fielitz, J.
Frontiers in Physiology 11 : 550506. 13 January 2021

Serum amyloid A1 mediates myotube atrophy via Toll-like receptors.
Hahn, A., Kny, M., Pablo-Tortola, C., Todiras, M., Willenbrock, M., Schmidt, S., Schmoeckel, K., Jorde, I., Nowak, M., Jarosch, E., Sommer, T., Bröker, B.M., Felix, S.B., Scheidereit, C., Weber-Carstens, S., Butter, C., Luft, F.C. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 11 (1): 103-119. February 2020

Sugars make the difference - Glycosylation of cardiodepressant antibodies regulates their activity in dilated cardiomyopathy.
Reinke, Y., Könemann, S., Chamling, B., Gross, S., Weitmann, K., Hoffmann, W., Klingel, K., Nauck, M., Fielitz, J., Dörr, M. and Felix, S.B.
International Journal of Cardiology 292 : 156-159. 1 October 2019

DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy.
Nowak, M., Suenkel, B., Porras, P., Migotti, R., Schmidt, F., Kny, M., Zhu, X., Wanker, E.E., Dittmar, G., Fielitz, J. and Sommer, T.
Journal of Cell Science 132 (17): jcs233395. 6 September 2019

Muscle wasting and function after muscle activation and early protocol-based physiotherapy: an explorative trial.
Wollersheim, T., Grunow, J.J., Carbon, N.M., Haas, K., Malleike, J., Ramme, S.F., Schneider, J., Spies, C.D., Märdian, S., Mai, K., Spuler, S., Fielitz, J. and Weber-Carstens, S.
Journal of Cachexia Sarcopenia and Muscle 10 (4): 734-747. August 2019

Ninjurin1 regulates striated muscle growth and differentiation.
Kny, M., Csályi, K.D., Klaeske, K., Busch, K., Meyer, A.M., Merks, A.M., Darm, K., Dworatzek, E., Fliegner, D., Baczko, I., Regitz-Zagrosek, V., Butter, C., Luft, F.C., Panáková, D. and Fielitz, J.
PLoS ONE 14 (5): e0216987. 15 May 2019

HDAC4 mutations cause diabetes and induce β-cell FoxO1 nuclear exclusion.
Gong, M., Yu, Y., Liang, L., Vuralli, D., Froehler, S., Kuehnen, P., Du Bois, P., Zhang, J., Cao, A., Liu, Y., Hussain, K., Fielitz, J., Jia, S., Chen, W. and Raile, K.
Molecular Genetics & Genomic Medicine 7 (5): e602. May 2019

Short-chain fatty acid propionate protects from hypertensive cardiovascular damage.
Bartolomaeus, H., Balogh, A., Yakoub, M., Homann, S., Markó, L., Höges, S., Tsvetkov, D., Krannich, A., Wundersitz, S., Avery, E.G., Haase, N., Kräker, K., Hering, L., Maase, M., Kusche-Vihrog, K., Grandoch, M., Fielitz, J., Kempa, S., Gollasch, M., Zhumadilov, Z., Kozhakhmetov, S., Kushugulova, A., Eckardt, K.U., Dechend, R., Rump, L.C., Forslund, S.K., Müller, D.N., Stegbauer, J. and Wilck, N.
Circulation 139 (11): 1407-1421. 12 March 2019

Angiotensin-(1-7) receptor Mas in hemodynamic and thermoregulatory dysfunction after high-level spinal cord injury in mice: a pilot study.
Järve, A., Todiras, M., Kny, M., Fischer, F.I., Kraemer, J.F., Wessel, N., Plehm, R., Fielitz, J., Alenina, N. and Bader, M.
Frontiers in Physiology 9 : 1930. January 2019

Deletion of protein kinase D1 in pancreatic β-cells impairs insulin secretion in high-fat diet-fed mice.
Bergeron, V., Ghislain, J., Vivot, K., Tamarina, N., Philipson, L.H., Fielitz, J. and Poitout, V.
Diabetes 67 (1): 71-77. January 2018

Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1.
Pose-Utrilla, J., García-Guerra, L., Del Puerto, A., Martin, A., Jurado-Arjona, J., De León-Reyes, N.S., Gamir-Morralla, A., Sebastián-Serrano, A., García-Gallo, M., Kremer, L., Fielitz, J., Ireson, C., Pérez-Álvarez, M.J., Ferrer, I., Hernández, F., Ávila, J., Lasa, M., Campanero, M.R. and Iglesias, T.
Nature Communications 8 (1): 2275. 22 December 2017

Secreted frizzled-related protein 2 and inflammation-induced skeletal muscle atrophy.
Zhu, X., Kny, M., Schmidt, F., Hahn, A., Wollersheim, T., Kleber, C., Weber-Carstens, S. and Fielitz, J.
Critical Care Medicine 45 (2): e169-e183. February 2017

Deletion of Nlrp3 protects from inflammation-induced skeletal muscle atrophy.
Huang, N., Kny, M., Riediger, F., Busch, K., Schmidt, S., Luft, F.C., Slevogt, H. and Fielitz, J.
Intensive Care Medicine Experimental 5 (1): 3. 17 January 2017

Insulin regulates astrocytic glucose handling through cooperation with IGF-I.
Fernandez, A.M., Hernandez-Garzón, E., Perez-Domper, P., Perez-Alvarez, A., Mederos, S., Matsui, T., Santi, A., Trueba-Saiz, A., Garcia-Guerra, L., Pose-Utrilla, J., Fielitz, J., Olson, E.N., Fernandez de la Rosa, R., Garcia Garcia, L., Pozo, M.A., Iglesias, T., Araque, A., Soya, H., Perea, G., Martin, E.D. and Torres Aleman, I.
Diabetes 66 (1): 64-74. January 2017

Critical illness polyneuropathy in ICU patients is related to reduced motor nerve excitability caused by reduced sodium permeability.
Koch, S., Bierbrauer, J., Haas, K., Wolter, S., Grosskreutz, J., Luft, F.C., Spies, C.D., Fielitz, J. and Weber-Carstens, S.
Intensive Care Medicine Experimental 4 (1): 10. 20 May 2016

Muscle RING-finger 2 and 3 maintain striated-muscle structure and function.
Lodka, D., Pahuja, A., Geers-Knörr, C., Scheibe, R., Nowak, M., Hamati, J., Köhncke, C., Purfürst, B., Kanashova, T., Schmidt, S., Glass, D.J., Morano, I., Heuser, A., Kraft, T., Bassel-Duby, R., Olson, E.N., Dittmar, G., Sommer, T. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 7 (2): 165-180. May 2016

Angiotensin II induces skeletal muscle atrophy by activating TFEB-mediated MuRF1 expression.
Du Bois, P., Pablo Tortola, C., Lodka, D., Kny, M., Schmidt, F., Song, K., Schmidt, S., Bassel-Duby, R., Olson, E.N. and Fielitz, J.
Circulation Research 117 (5): 424-436. 14 August 2015

Identification of the GTPase-activating protein DEP domain containing 1B (DEPDC1B) as a transcriptional target of Pitx2.
Wu, D., Zhu, X., Jimenez-Cowell, K., Mold, A.J., Sollecito, C.C., Lombana, N., Jiao, M. and Wei, Q.
Experimental Cell Research 333 (1): 80-92. 10 April 2015

Induction of Ankrd1 in dilated cardiomyopathy correlates with the heart failure progression.
Bogomolovas, J., Brohm, K., Čelutkiené, J., Balčiūnaité, G., Bironaité, D., Bukelskiené, V., Daunoravičus, D., Witt, C.C., Fielitz, J., Grabauskiené, V. and Labeit, S.
BioMed Research International 2015 : 273936. 2015

The E3 ubiquitin ligase TRIM62 and inflammation-induced skeletal muscle atrophy.
Schmidt, F., Kny, M., Zhu, X., Wollersheim, T., Persicke, K., Langhans, C., Lodka, D., Kleber, C., Weber-Carstens, S. and Fielitz, J.
Critical Care 18 (5): 545. 29 September 2014

Inflammation-induced acute phase response in skeletal muscle and critical illness myopathy.
Langhans, C., Weber-Carstens, S., Schmidt, F., Hamati, J., Kny, M., Zhu, X., Wollersheim, T., Koch, S., Krebs, M., Schulz, H., Lodka, D., Saar, K., Labeit, S., Spies, C., Hubner, N., Spranger, J., Spuler, S., Boschmann, M., Dittmar, G., Butler-Browne, G., Mouly, V. and Fielitz, J.
PLoS ONE 9 (3): e92048. 20 March 2014

Dynamics of myosin degradation in intensive care unit-acquired weakness during severe critical illness.
Wollersheim, T., Woehlecke, J., Krebs, M., Hamati, J., Lodka, D., Luther-Schroeder, A., Langhans, C., Haas, K., Radtke, T., Kleber, C., Spies, C., Labeit, S., Schuelke, M., Spuler, S., Spranger, J., Weber-Carstens, S. and Fielitz, J.
Intensive Care Medicine 40 (4): 528-538. 15 February 2014

Critical illness myopathy and GLUT4 - significance of insulin and muscle contraction.
Weber-Carstens, S., Schneider, J., Wollersheim, T., Assmann, A., Bierbrauer, J., Marg, A., Al Hasani, H., Chadt, A., Wenzel, K., Koch, S., Fielitz, J., Kleber, C., Faust, K., Mai, K., Spies, C.D., Luft, F.C., Boschmann, M., Spranger, J. and Spuler, S.
American Journal of Respiratory and Critical Care Medicine 187 (4): 387-396. 15 February 2013

G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1.
Ferdaoussi, M., Bergeron, V., Zarrouki, B., Kolic, J., Cantley, J., Fielitz, J., Olson, E.N., Prentki, M., Biden, T., Macdonald, P.E. and Poitout, V.
Diabetologia 55 (10): 2682-2692. October 2012

Early type II fiber atrophy in intensive care unit patients with nonexcitable muscle membrane.
Bierbrauer, J., Koch, S., Olbricht, C., Hamati, J., Lodka, D., Schneider, J., Luther-Schroeder, A., Kleber, C., Faust, K., Wiesener, S., Spies, C.D., Spranger, J., Spuler, S., Fielitz, J. and Weber-Carstens, S.
Critical Care Medicine 40 (2): 647-650. February 2012

Skeletal muscle 11beta-HSD1 controls glucocorticoid-induced proteolysis and expression of E3 ubiquitin ligases atrogin-1 and MuRF-1.
Biedasek, K., Andres, J., Mai, K., Adams, S., Spuler, S., Fielitz, J. and Spranger, J.
PLoS ONE 6 (1): e16674. 31 January 2011

Myocyte enhancer factor 2 and class II histone deacetylases control a gender-specific pathway of cardioprotection mediated by the estrogen receptor.
van Rooij, E., Fielitz, J., Sutherland, L.B., Thijssen, V.L., Crijns, H.J., Dimaio, M.J., Shelton, J., De Windt, L.J., Hill, J.A. and Olson, E.N.
Circulation Research 106 (1): 155-165. 8 January 2010

Protein kinase D1 stimulates MEF2 activity in skeletal muscle and enhances muscle performance.
Kim, M.S., Fielitz, J., McAnally, J., Shelton, J.M., Lemon, D.D., McKinsey, T.A., Richardson, J.A., Bassel-Duby, R. and Olson, E.N.
Molecular and Cellular Biology 28 (11): 3600-3609. June 2008

Requirement of protein kinase D1 for pathological cardiac remodeling.
Fielitz, J., Kim, M.S., Shelton, J.M., Qi, X., Hill, J.A., Richardson, J.A., Bassel-Duby, R. and Olson, E.N.
Proceedings of the National Academy of Sciences of the United States of America 105 (8): 3059-3063. 26 February 2008

Up-regulation of PPARgamma in myocardial infarction.
Fliegner, D., Westermann, D., Riad, A., Schubert, C., Becher, E., Fielitz, J., Tschope, C. and Regitz-Zagrosek, V.
European Journal of Heart Failure 10 (1): 30-38. January 2008

Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3.
Fielitz, J., Kim, M.S., Shelton, J.M., Latif, S., Spencer, J.A., Glass, D.J., Richardson, J.A., Bassel-Duby, R. and Olson, E.N.
Journal of Clinical Investigation 117 (9): 2486-2495. September 2007

Inhibition of prolyl 4-hydroxylase prevents left ventricular remodelling in rats with thoracic aortic banding.
Fielitz, J., Philipp, S., Herda, L.R., Schuch, E., Pilz, B., Schubert, C., Gunzler, V., Willenbrock, R. and Regitz-Zagrosek, V.
European Journal of Heart Failure 9 (4): 336-342. April 2007

Loss of muscle-specific RING-finger 3 predisposes the heart to cardiac rupture after myocardial infarction.
Fielitz, J., van Rooij, E., Spencer, J.A., Shelton, J.M., Latif, S., van der Nagel, R., Bezprozvannaya, S., de Windt, L., Richardson, J.A., Bassel-Duby, R. and Olson, E.N.
Proceedings of the National Academy of Sciences of the United States of America 104 (11): 4377-4382. 13 March 2007

Stabilization of hypoxia inducible factor rather than modulation of collagen metabolism improves cardiac function after acute myocardial infarction in rats.
Philipp, S., Juergensen, J.S., Fielitz, J., Bernhardt, W.M., Weidemann, A., Schiche, A., Pilz, B., Dietz, R., Regitz-Zagrosek, V., Eckardt, K.U. and Willenbrock, R.
European Journal of Heart Failure 8 : 347-354. June 2006

Mechanisms of blood pressure variability-induced cardiac hypertrophy and dysfunction in mice with impaired baroreflex.
Martinka, P., Fielitz, J., Patzak, A., Regitz-Zagrosek, V., Persson, P.B. and Stauss, H.M.
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 288 (3): R767-R776. March 2005

Regulation of matrix metalloproteinases and their inhibitors in the left ventricular myocardium of patients with aortic stenosis.
Fielitz, J., Leuschner, M., Zurbruegg, H.R., Hannack, B., Pregla, R., Hetzer, R. and Regitz-Zagrosek, V.
Journal of Molecular Medicine 82 (12): 809-820. December 2004

Upregulation of myocardial estrogen receptors in human aortic stenosis.
Nordmeyer, J., Eder, S., Mahmoodzadeh, S., Martus, P., Fielitz, J., Bass, J., Bethke, N., Zurbruegg, H.R., Pregla, R., Hetzer, R. and Regitz-Zagrosek, V.
Circulation 110 (20): 3270-3275. 16 November 2004

A small molecular activator of cardiac hypertrophy uncovered in a chemical screen for modifiers of the calcineurin signaling pathway.
Bush, E., Fielitz, J., Melvin, L., Martinez-Arnold, M., McKinsey, T.A., Plichta, R. and Olson, E.N.
Proceedings of the National Academy of Sciences of the United States of America 101 (9): 2870-2875. 2 March 2004

Effects of therapeutic beta blockade on myocardial function and cardiac remodelling in congenital cardiac disease.
Buchhorn, R., Hulpke-Wette, M., Ruschewski, W., Ross, R.D., Fielitz, J., Pregla, R., Hetzer, R. and Regitz-Zagrosek, V.
Cardiology In The Young 13 (1): 36-43. February 2003

beta-receptor downregulation in congenital heart disease: a risk factor for complications after surgical repair?
Buchhorn, R., Hulpke-Wette, M., Ruschewski, W., Pregla, R., Fielitz, J., Hetzer, R. and Regitz-Zagrosek, V.
Annals of Thoracic Surgery 73 : 610-613. 1 February 2002

Neutral endopeptidase is activated in cardiomyocytes in human aortic valve stenosis and heart failure.
Fielitz, J., Dendorfer, A., Pregla, R., Ehler, E., Zurbruegg, H.R., Bartunek, J., Hetzer, R. and Regitz-Zagrosek, V.
Circulation 105 : 286-289. 22 January 2002

Activation of the cardiac renin-angiotensin system and increased myocardial collagen expression in human aortic valve disease.
Fielitz, J., Hein, S., Mitrovic, V., Pregla, R., Zurbruegg, H.R., Warnecke, C., Schaper, J., Fleck, E. and Regitz-Zagrosek, V.
Journal of the American College of Cardiology 37 (5): 1443-1449. April 2001

Angiotensin II directly increases transforming growth factor beta1 and osteopontin and indirectly affects collagen mRNA expression in the human heart.
Kupfahl, C., Pink, D., Friedrich, K., Zurbruegg, H.R., Neuss, M., Warnecke, C., Fielitz, J., Graf, K., Fleck, E. and Regitz-Zagrosek, V.
Cardiovascular Research 46 (3): 463-475. June 2000

Myocardial angiotensin receptors in human hearts.
Regitz-Zagrosek, V., Fielitz, J. and Fleck, E.
Basic Research in Cardiology 93 Suppl 2 : 37-42. 1998

Angiotensin receptor type 1 mRNA in human right ventricular endomyocardial biopsies: downregulation in heart failure.
Regitz-Zagrosek, V., Fielitz, J., Dreysse, R., Hildebrandt, A.G. and Fleck, E.
Cardiovascular Research 35 (1): 99-105. July 1997

Decreased expression of ventricular angiotensin receptor type 1 mRNA after human heart transplantation.
Regitz-Zagrosek, V., Fielitz, J., Hummel, M., Hildebrandt, A.G., Hetzer, R. and Fleck, E.
Journal of Molecular Medicine 74 (12): 777-782. December 1996

Review

Hidden agenda - the involvement of endoplasmic reticulum stress and unfolded protein response in inflammation-induced muscle wasting.
Kny, M. and Fielitz, J.
Frontiers in Immunology 13 : 878755. 9 May 2022

Out of control: the role of the ubiquitin proteasome system in skeletal muscle during inflammation.
Haberecht-Müller, S., Krüger, E. and Fielitz, J.
Biomolecules 11 (9): 1327. September 2021

Stimulation of soluble guanylyl cyclase (sGC) by riociguat attenuates heart failure and pathological cardiac remodelling.
Rüdebusch, J., Benkner, A., Nath, N., Fleuch, L., Kaderali, L., Grube, K., Klingel, K., Eckstein, G., Meitinger, T., Fielitz, J. and Felix, S.B.
British Journal of Pharmacology 179 (11): 2430-2442. June 2020

Letter

Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility.
Montgomery, R.L., Davis, C.A., Potthoff, M.J., Haberland, M., Fielitz, J., Qi, X., Hill, J.A., Richardson, J.A. and Olson, E.N.
Genes & Development 21 (14): 1790-1802. 15 July 2007

Editorial

Cancer cachexia-when proteasomal inhibition is not enough.
Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 7 (3): 239-245. June 2016