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What do you most hope spatial molecular profiling will help us understand? Part 2.
Yanai, I. and Fertig, E.J. and Li, M. and Coscia, F. and Klughammer, J. and Nie, Q. and Chen, J. and Coskun, A.F.
Cell Systems 14 (7): 543-546. 19 July 2023

Proteomic profiling of colorectal adenomas identifies a predictive risk signature for development of metachronous advanced colorectal neoplasia.
Bech, J.M. and Terkelsen, T. and Bartels, A.S. and Coscia, F. and Doll, S. and Zhao, S. and Zhang, Z. and Brünner, N. and Lindebjerg, J. and Madsen, G.I. and Fang, X. and Mann, M. and Moreira, J.M.A.
Gastroenterology 165 (1): 121-132.e5. July 2023


The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition.
Zonderland, G. and Vanzo, R. and Amitash, S. and Martín-Doncel, E. and Coscia, F. and Mund, A. and Lerdrup, M. and Benada, J. and Boos, D. and Toledo, L.
Molecular Cell 82 (18): 3350-3365. 15 September 2022

Deep Visual Proteomics defines single-cell identity and heterogeneity.
Mund, A. and Coscia, F. and Kriston, A. and Hollandi, R. and Kovács, F. and Brunner, A.D. and Migh, E. and Schweizer, L. and Santos, A. and Bzorek, M. and Naimy, S. and Rahbek-Gjerdrum, L.M. and Dyring-Andersen, B. and Bulkescher, J. and Lukas, C. and Eckert, M.A. and Lengyel, E. and Gnann, C. and Lundberg, E. and Horvath, P. and Mann, M.
Nature Biotechnology 40 (8): 1231-1240. August 2022

Identification of early neurodegenerative pathways in progressive multiple sclerosis.
Kaufmann, M. and Schaupp, A.L. and Sun, R. and Coscia, F. and Dendrou, C.A. and Cortes, A. and Kaur, G. and Evans, H.G. and Mollbrink, A. and Navarro, J.F. and Sonner, J.K. and Mayer, C. and DeLuca, G.C. and Lundeberg, J. and Matthews, P.M. and Attfield, K.E. and Friese, M.A. and Mann, M. and Fugger, L.
Nature Neuroscience 25 (7): 944-955. July 2022

A knowledge graph to interpret clinical proteomics data.
Santos, A. and Colaço, A.R. and Nielsen, A.B. and Niu, L. and Strauss, M. and Geyer, P.E. and Coscia, F. and Albrechtsen, N.J.W. and Mundt, F. and Jensen, L.J. and Mann, M.
Nature Biotechnology 40 (5): 692-702. 22 May 2022

K27-linked ubiquitylation promotes p97 substrate processing and is essential for cell proliferation.
Shearer, R.F. and Typas, D. and Coscia, F. and Schovsbo, S. and Kruse, T. and Mund, A. and Mailand, N.
EMBO Journal 41 (9): e110145. 2 May 2022

Ultra-high sensitivity mass spectrometry quantifies single-cell proteome changes upon perturbation.
Brunner, A.D. and Thielert, M. and Vasilopoulou, C. and Ammar, C. and Coscia, F. and Mund, A. and Hoerning, O.B. and Bache, N. and Apalategui, A. and Lubeck, M. and Richter, S. and Fischer, D.S. and Raether, O. and Park, M.A. and Meier, F. and Theis, F.J. and Mann, M.
Molecular Systems Biology 18 (3): e10798. 1 March 2022


Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities.
Kruse, T. and Benz, C. and Garvanska, D.H. and Lindqvist, R. and Mihalic, F. and Coscia, F. and Inturi, R. and Sayadi, A. and Simonetti, L. and Nilsson, E. and Ali, M. and Kliche, J. and Moliner Morro, A. and Mund, A. and Andersson, E. and McInerney, G. and Mann, M. and Jemth, P. and Davey, N.E. and Överby, A.K. and Nilsson, J. and Ivarsson, Y.
Nature Communications 12 (1): 6761. 19 November 2021

Molecular response to PARP1 inhibition in ovarian cancer cells as determined by mass spectrometry based proteomics.
Franz, A. and Coscia, F. and Shen, C. and Charaoui, L. and Mann, M. and Sander, C.
Journal of Ovarian Research 14 (1): 140. 22 October 2021

Homology-directed repair protects the replicating genome from metabolic assaults.
Somyajit, K. and Spies, J. and Coscia, F. and Kirik, U. and Rask, M.B. and Lee, J.H. and Neelsen, K.J. and Mund, A. and Jensen, L.J. and Paull, T.T. and Mann, M. and Lukas, J.
Developmental Cell 56 (4): 461-477. 22 February 2021

AI-driven Deep Visual Proteomics defines cell identity and heterogeneity.
Mund, A. and Coscia, F. and Hollandi, R. and Kovács, F. and Kriston, A. and Brunner, A.D. and Bzorek, M. and Naimy, S. and Rahbek Gjerdrum, L.M. and Dyring-Andersen, B. and Bulkescher, J. and Lukas, C. and Gnann, C. and Lundberg, E. and Horvath, P. and Mann, M.
bioRxiv : 2021.01.25.427969. 27 January 2021


Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin.
Dyring-Andersen, B. and Løvendorf, M.B. and Coscia, F. and Santos, A. and Møller, L.B.P. and Colaço, A.R. and Niu, L. and Bzorek, M. and Doll, S. and Andersen, J.L. and Clark, R.A. and Skov, L. and Teunissen, M.B.M. and Mann, M.
Nature Communications 11 (1): 5587. 5 November 2020

FAM111 protease activity undermines cellular fitness and is amplified by gain-of-function mutations in human disease.
Hoffmann, S. and Pentakota, S. and Mund, A. and Haahr, P. and Coscia, F. and Gallo, M. and Mann, M. and Taylor, N.M. and Mailand, N.
EMBO Reports 21 (10): e50662. 5 October 2020

A streamlined mass spectrometry-based proteomics workflow for large-scale FFPE tissue analysis.
Coscia, F. and Doll, S. and Bech, J.M. and Schweizer, L. and Mund, A. and Lengyel, E. and Lindebjerg, J. and Madsen, G.I. and Moreira, J.M. and Mann, M.
Journal of Pathology 251 (1): 100-112. May 2020


Mesothelial cell HIF1α expression is metabolically downregulated by metformin to prevent oncogenic tumor-stromal crosstalk.
Hart, P.C. and Kenny, H.A. and Grassl, N. and Watters, K.M. and Litchfield, L.M. and Coscia, F. and Blaženović, I. and Ploetzky, L. and Fiehn, O. and Mann, M. and Lengyel, E. and Romero, I.L.
Cell Reports 29 (12): 4086-4098. 17 December 2019

Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts.
Eckert, M.A. and Coscia, F. and Chryplewicz, A. and Chang, J.W. and Hernandez, K.M. and Pan, S. and Tienda, S.M. and Nahotko, D.A. and Li, G. and Blaženović, I. and Lastra, R.R. and Curtis, M. and Yamada, S.D. and Perets, R. and McGregor, S.M. and Andrade, J. and Fiehn, O. and Moellering, R.E. and Mann, M. and Lengyel, E.
Nature 569 (7758): 723-728. 30 May 2019

Efficient mitotic checkpoint signaling depends on integrated activities of Bub1 and the RZZ complex.
Zhang, G. and Kruse, T. and Guasch Boldú, C. and Garvanska, D.H. and Coscia, F. and Mann, M. and Barisic, M. and Nilsson, J.
EMBO Journal 38 (7): e100977. 1 April 2019


Multi-level proteomics identifies CT45 as a chemosensitivity mediator and immunotherapy target in ovarian cancer.
Coscia, F. and Lengyel, E. and Duraiswamy, J. and Ashcroft, B. and Bassani-Sternberg, M. and Wierer, M. and Johnson, A. and Wroblewski, K. and Montag, A. and Yamada, S.D. and López-Méndez, B. and Nilsson, J. and Mund, A. and Mann, M. and Curtis, M.
Cell 175 (1): 159-170. 20 September 2018

Rapid proteomic analysis for solid tumors reveals LSD1 as a drug target in an end-stage cancer patient.
Doll, S. and Kriegmair, M.C. and Santos, A. and Wierer, M. and Coscia, F. and Neil, H.M. and Porubsky, S. and Geyer, P.E. and Mund, A. and Nuhn, P. and Mann, M.
Molecular Oncology 12 (8): 1296-1307. August 2018


Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status.
Coscia, F. and Watters, K.M. and Curtis, M. and Eckert, M.A. and Chiang, C.Y. and Tyanova, S. and Montag, A. and Lastra, R.R. and Lengyel, E. and Mann, M.
Nature Communications 7 : 12645. 26 August 2016


Regulated intramembrane proteolysis and degradation of murine epithelial cell adhesion molecule mEpCAM.
Hachmeister, M. and Bobowski, K.D. and Hogl, S. and Dislich, B. and Fukumori, A. and Eggert, C. and Mack, B. and Kremling, H. and Sarrach, S. and Coscia, F. and Zimmermann, W. and Steiner, H. and Lichtenthaler, S.F. and Gires, O.
PLoS ONE 8 (8): e71836. 29 August 2013


A novel inhibitory domain of Helicobacter pylori protein CagA reduces CagA effects on host cell biology.
Pelz, C. and Steininger, S. and Weiss, C. and Coscia, F. and Vogelmann, R.
Journal of Biological Chemistry 286 (11): 8999-9008. 18 March 2011

This list was generated on Sun Oct 1 02:24:36 2023 CEST.
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