Browse by Research Team

2023

mRNA stability and m(6)A are major determinants of subcellular mRNA localization in neurons.
Loedige, I. and Baranovskii, A. and Mendonsa, S. and Dantsuji, S. and Popitsch, N. and Breimann, L. and Zerna, N. and Cherepanov, V. and Milek, M. and Ameres, S. and Chekulaeva, M.
Molecular Cell 83 (15): 2709-2725. 3 August 2023

First demonstration of miRNA-dependent mRNA decay.
Chekulaeva, M.
Nature Reviews Molecular Cell Biology 24 (3): 164. March 2023

Massively parallel identification of mRNA localization elements in primary cortical neurons.
Mendonsa, S. and von Kügelgen, N. and Dantsuji, S. and Ron, M. and Breimann, L. and Baranovskii, A. and Lödige, I. and Kirchner, M. and Fischer, M. and Zerna, N. and Bujanic, L. and Mertins, P. and Ulitsky, I. and Chekulaeva, M.
Nature Neuroscience 26 (3): 394-405. March 2023

2022

Multi-omics alleviates the limitations of panel sequencing for cancer drug response prediction.
Baranovskii, A. and Gündüz, I.B. and Franke, V. and Uyar, B. and Akalin, A.
Cancers 14 (22): 5604. 15 November 2022

Identifying tumor cells at the single-cell level using machine learning.
Dohmen, J. and Baranovskii, A. and Ronen, J. and Uyar, B. and Franke, V. and Akalin, A.
Genome Biology 23 (1): 123. 30 May 2022

Transcriptome analysis reveals high tumor heterogeneity with respect to re-activation of stemness and proliferation programs.
Baranovsky, A. and Ivanov, T. and Granovskaya, M. and Papatsenko, D. and Pervouchine, D.D.
PLoS ONE 17 (5): e0268626. 19 May 2022

The key features of SARS-CoV-2 leader and NSP1 required for viral escape of NSP1-mediated repression.
Bujanic, L. and Shevchuk, O. and von Kügelgen, N. and Kalinina, A. and Ludwik, K. and Koppstein, D. and Zerna, N. and Sickmann, A. and Chekulaeva, M.
RNA 28 (5): 766-779. May 2022

Novel targets, treatments, and advanced models for intracerebral haemorrhage.
Zille, M. and Farr, T.D. and Keep, R.F. and Römer, C. and Xi, G. and Boltze, J.
EBioMedicine 76 : 103880. 12 February 2022

2021

Charcot-Marie-Tooth mutation in glycyl-tRNA synthetase stalls ribosomes in a pre-accommodation state and activates integrated stress response.
Mendonsa, S. and von Kuegelgen, N. and Bujanic, L. and Chekulaeva, M.
Nucleic Acids Research 49 (17): 10007-10017. 27 September 2021

A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion.
Witte, F. and Ruiz-Orera, J. and Ciolli Mattioli, C. and Blachut, S. and Adami, E. and Schulz, J.F. and Schneider-Lunitz, V. and Hummel, O. and Patone, G. and Mücke, M.B. and Šilhavý, Jan and Heinig, M. and Bottolo, L. and Sanchis, D. and Vingron, M. and Chekulaeva, M. and Pravenec, M. and Hubner, N. and van Heesch, S.
Genome Biology 22 (1): 191. 28 June 2021

MACC1 regulates clathrin-mediated endocytosis and receptor recycling of transferrin receptor and EGFR in colorectal cancer.
Imbastari, F. and Dahlmann, M. and Sporbert, A. and Ciolli Mattioli, C. and Mari, T. and Scholz, F. and Timm, L. and Twamley, S. and Migotti, R. and Walther, W. and Dittmar, G. and Rehm, A. and Stein, U.
Cellular and Molecular Life Sciences 78 (7): 3525-3542. April 2021

Viruses and endogenous retroviruses as roots for neuroinflammation and neurodegenerative diseases.
Römer, C.
Frontiers in Neuroscience 15 : 648629. 12 March 2021

2020

Conservation of a core neurite transcriptome across neuronal types and species.
von Kügelgen, N. and Chekulaeva, M.
Wiley Interdisciplinary Reviews: RNA 11 (4): e1590. July 2020

Trans control of cardiac mRNA translation in a protein length-dependent fashion.
Witte, F. and Ruiz-Orera, J. and Ciolli Mattioli, C. and Blachut, S. and Adami, E. and Schulz, J.F. and Schneider-Lunitz, V. and Hummel, O. and Patone, G. and Mücke, M.B. and Šilhavý, J. and Heinig, M. and Bottolo, L. and Sanchis, D. and Vingron, M. and Chekulaeva, M. and Pravenec, M. and Hubner, N. and van Heesch, S.
bioRxiv : 020.06.05.133298. 6 June 2020

2019

Roles of long noncoding RNAs and circular RNAs in translation.
Chekulaeva, M. and Rajewsky, N.
Cold Spring Harbor Perspectives in Biology 11 (6): a032680. 3 June 2019

Genome-wide analysis of RNA and protein localization and local translation in mESC-derived neurons.
Ludwik, K.A. and von Kuegelgen, N. and Chekulaeva, M.
Methods 162-163 : 31-41. June 2019

Alternative 3' UTRs direct localization of functionally diverse protein isoforms in neuronal compartments.
Ciolli Mattioli, C. and Rom, A. and Franke, V. and Imami, K. and Arrey, G. and Terne, M. and Woehler, A. and Akalin, A. and Ulitsky, I. and Chekulaeva, M.
Nucleic Acids Research 47 (5): 2560-2573. 18 March 2019

2017

RNA localization is a key determinant of neurite-enriched proteome.
Zappulo, A. and van den Bruck, D. and Ciolli Mattioli, C. and Franke, V. and Imami, K. and McShane, E. and Moreno-Estelles, M. and Calviello, L. and Filipchyk, A. and Peguero-Sanchez, E. and Müller, T. and Woehler, A. and Birchmeier, C. and Merino, E. and Rajewsky, N. and Ohler, U. and Mazzoni, E.O. and Selbach, M. and Akalin, A. and Chekulaeva, M.
Nature Communications 8 (1): 583. 19 September 2017

Translation of circRNAs.
Pamudurti, N.R. and Bartok, O. and Jens, M. and Ashwal-Fluss, R. and Stottmeister, C. and Ruhe, L. and Hanan, M. and Wyler, E. and Perez-Hernandez, D. and Ramberger, E. and Shenzis, S. and Samson, M. and Dittmar, G. and Landthaler, M. and Chekulaeva, M. and Rajewsky, N. and Kadener, S.
Molecular Cell 66 (1): 9-21. 6 April 2017

Conservation of miRNA-mediated silencing mechanisms across 600 million years of animal evolution.
Mauri, M. and Kirchner, M. and Aharoni, R. and Ciolli Mattioli, C. and van den Bruck, D. and Gutkovitch, N. and Modepalli, V. and Selbach, M. and Moran, Y. and Chekulaeva, M.
Nucleic Acids Research 45 (2): 938-950. 25 January 2017

2016

Eyes on translation.
Chekulaeva, M. and Landthaler, M.
Molecular Cell 63 (6): 918-925. 15 September 2016

2014

Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation study.
Libri, V. and Yandim, C. and Athanasopoulos, S. and Loyse, N. and Natisvili, T. and Law, P.P. and Chan, P.K. and Mohammad, T. and Mauri, M. and Tam, K.T. and Leiper, J. and Piper, S. and Ramesh, A. and Parkinson, M.H. and Huson, L. and Giunti, P. and Festenstein, R.
Lancet 384 (9942): 504-513. 9 August 2014

2011

miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs.
Chekulaeva, M. and Mathys, H. and Zipprich, J.T. and Attig, J. and Colic, M. and Parker, R. and Filipowicz, W.
Nature Structural & Molecular Biology 18 (11): 1218-1226. 7 October 2011

2010

The GW/WG repeats of Drosophila GW182 function as effector motifs for miRNA-mediated repression.
Chekulaeva, M. and Parker, R. and Filipowicz, W.
Nucleic Acids Research 38 (19): 6673-6683. October 2010

Human Pat1b connects deadenylation with mRNA decapping and controls the assembly of processing bodies.
Ozgur, S. and Chekulaeva, M. and Stoecklin, G.
Molecular and Cellular Biology 30 (17): 4308-4323. September 2010

2009

Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells.
Chekulaeva, M. and Filipowicz, W.
Current Opinion in Cell Biology 21 (3): 452-460. June 2009

Multiple independent domains of dGW182 function in miRNA-mediated repression in Drosophila.
Chekulaeva, M. and Filipowicz, W. and Parker, R.
RNA 15 (5): 794-803. May 2009

2006

Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles.
Chekulaeva, M. and Hentze, M.W. and Ephrussi, A.
Cell 124 (3): 521-533. 10 February 2006

2004

Drosophila development: RNA interference ab ovo.
Chekulaeva, M. and Ephrussi, A.
Current Biology 14 (11): R428-R430. 8 June 2004