Article

Takotsubo-Syndrom: Kann die Grundlagenwissenschaft helfen? [Takotsubo syndrome: can basic science help?].
Bruns, Bastian, Frey, Norbert and Backs, Johannes
Kardiologie 20 (2): 147-152. March 2026

Lamin A/C-regulated cysteine catabolic flux modulates stem cell fate through epigenome reprogramming.
Wang, Yinuo, Shi, Haojie, Wittig, Janina, Ren, Yonggang, Cordero, Julio, Dewenter, Matthias, Mella, Jessica, Buchwalter, Abigail, Backs, Johannes, Wieland, Thomas, Heineke, Joerg, Fleming, Ingrid, Bibli, Sofia-Iris and Dobreva, Gergana
Nature Metabolism 8 (2): 431-453. February 2026

Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia.
Kaltenecker, Doris, Fisker Schmidt, Søren, Weber, Peter, Loft, Anne, Morigny, Pauline, Machado, Juliano, Geppert, Julia, Saul, Kerstin Beate, Benedikt, Pia, Molocea, Claudia-Eveline, Scott, Rachel, Haase, Kerstin, Martignoni, Marc E., Alfaro, Ana Jimena, Chow, Kan Kau, Simoes, Estefania, Pinhata Otoch, José, Lima, Joanna D.C.C., Swanton, Charles, Spielmann, Nadine, Hrabé de Angelis, Martin, Elsner, Markus, Ertürk, Ali, Dyar, Kenneth A., Rohm, Maria, Prokopchuk, Olga, Jamal-Hanjani, Mariam, Seelaender, Marilia, Backs, Johannes, Herzig, Stephan and Berriel Diaz, Mauricio
Cell 188 (17): 4549-4566. 21 August 2025

How to facilitate seamless translation from basic concepts to new heart failure drugs. A scientific statement of the Heart Failure Association of the ESC.
Tocchetti, C.G., González, A., Backs, J., Pollesello, P., Rainer, P.P., Schiattarella, G.G., Bellin, M., Begley, G., Bock Marquette, I., Balligand, J.L., Falcao-Pires, I., Gorczynski, R., Hirsch, E., Hulot, J.S., Klebl, B., Lyon, A.R., Maack, C., McKinsey, T.A., Müller, O.J., Lunde, I., Montgomery, R., Vergaro, G., Bayes-Genis, A., Thum, T., van der Meer, P., Van Laake, L., Ruschitzka, F., Seferovic, P., Coats, A.J., Metra, M., Rosano, G., Van Linthout, S. and de Boer, R.A.
European Journal of Heart Failure 27 (8): 1379-1392. August 2025

Mitochondrial NNT promotes diastolic dysfunction in cardiometabolic HFpEF.
Pepin, M.E., Konrad, P.J.M., Nazir, S., Bazgir, F., Maack, C., Nickel, A., Gorman, J., Hohl, M., Schreiter, F., Dewenter, M., de Britto Chaves Filho, A., Schulze, A., Karlstaedt, A., Frey, N., Seidman, C., Seidman, J. and Backs, J.
Circulation Research 136 (12): 1564-1578. 6 June 2025

Ca2+/calmodulin-dependent kinase IIδC-induced chronic heart failure does not depend on sarcoplasmic reticulum Ca2+ leak.
Dewenter, M., Seitz, T., Steinbrecher, J.H., Westenbrink, B.D., Ling, H., Lehnart, S.E., Wehrens, X.H.T., Backs, J., Brown, J.H., Maier, L.S. and Neef, S.
ESC Heart Failure 11 (4): 2191-2199. August 2024

Transverse aortic constriction multi-omics analysis uncovers pathophysiological cardiac molecular mechanisms.
Gjerga, E., Dewenter, M., Britto-Borges, T., Grosso, J., Stein, F., Eschenbach, J., Rettel, M., Backs, J. and Dieterich, C.
Database 2024 : baae060. 25 July 2024

Review

Metabo-epigenetic circuits of heart failure: chromatin-modifying enzymes as determinants of metabolic plasticity.
Pepin, Mark E., Gong, Xuemin, Schulze, Almut and Backs, Johannes
EMBO Molecular Medicine 18 (2): 362-380. 13 February 2026

Editorial

Adipokine-cardiomyocyte crosstalk: a 2-way street in HFpEF pathogenesis?
Frey, Norbert and Backs, Johannes
Journal of the American College of Cardiology 86 (16): 1243-1245. 21 October 2025

Preprint

CAMK2-NR4A1 signaling initiates metabolic substrate switching to induce heart failure with reduced ejection fraction.
Saadatmand, Alireza, Pepin, Mark, Chen, Zihao, Hartmann, Joshua, Sun, Qiang, Dewenter, Matthias, Nazir, Sumra, Paluvai, Harikrishnareddy, Hagenmüller, Marco, Haberkorn, Uwe, Schlicker, Lisa, Frias-Soler, Roberto Carlos, Tyedmers, Jens, Maack, Christoph, Schulze, Almut and Backs, Johannes
bioRxiv : 2025.10.16.682731. 16 October 2025

Somatic Hdac4-902fs mutations lead to loss of HDAC4 function through nonsensemediated mRNA degradation.
Paluvai, Harikrishnareddy, Pepin, Mark E., Schreiter, Friederike, Saadatmand, Alireza, Hagenmueller, Marco and Backs, Johannes
bioRxiv : 2025.10.14.682279. 15 October 2025

CAMK2D causes heart failure in RBM20 cardiomyopathy.
van den Hoogenhof, Maarten M.G., Duran, Javier, Britto-Borges, Thiago, Kemmling, Elena, Konrad, Laura, Lennermann, David C., Hartmann, Joshua, Schraft, Laura, Kornienko, Julia, Bock, Theresa, Krüger, Marcus, Dieterich, Christoph, Steinmetz, Lars M., Dewenter, Matthias and Backs, Johannes
bioRxiv : 2025.05.23.655557. 25 May 2025