Cell

Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia.
Kaltenecker, Doris, Fisker Schmidt, Søren, Weber, Peter, Loft, Anne, Morigny, Pauline, Machado, Juliano, Geppert, Julia, Saul, Kerstin Beate, Benedikt, Pia, Molocea, Claudia-Eveline, Scott, Rachel, Haase, Kerstin ORCID: https://orcid.org/0000-0002-0944-5618, Martignoni, Marc E., Alfaro, Ana Jimena, Chow, Kan Kau, Simoes, Estefania, Pinhata Otoch, José, Lima, Joanna D.C.C., Swanton, Charles, Spielmann, Nadine, Hrabé de Angelis, Martin, Elsner, Markus, Ertürk, Ali, Dyar, Kenneth A., Rohm, Maria, Prokopchuk, Olga, Jamal-Hanjani, Mariam, Seelaender, Marilia, Backs, Johannes ORCID: https://orcid.org/0000-0002-2322-2699, Herzig, Stephan and Berriel Diaz, Mauricio
Cell 188 (17): 4549-4566. 21 August 2025

Circulation Research

Mitochondrial NNT promotes diastolic dysfunction in cardiometabolic HFpEF.
Pepin, M.E. ORCID: https://orcid.org/0000-0003-0114-560X, Konrad, P.J.M. ORCID: https://orcid.org/0009-0003-1522-3848, Nazir, S., Bazgir, F. ORCID: https://orcid.org/0000-0002-0689-7926, Maack, C. ORCID: https://orcid.org/0000-0003-3694-4559, Nickel, A., Gorman, J. ORCID: https://orcid.org/0000-0001-5969-4690, Hohl, M. ORCID: https://orcid.org/0000-0001-6946-9825, Schreiter, F. ORCID: https://orcid.org/0009-0002-7405-8064, Dewenter, M., de Britto Chaves Filho, A., Schulze, A. ORCID: https://orcid.org/0000-0002-8199-6422, Karlstaedt, A. ORCID: https://orcid.org/0000-0001-5689-3571, Frey, N. ORCID: https://orcid.org/0000-0001-7611-378X, Seidman, C. ORCID: https://orcid.org/0000-0001-6380-1209, Seidman, J. ORCID: https://orcid.org/0000-0002-9082-3566 and Backs, J. ORCID: https://orcid.org/0000-0002-2322-2699
Circulation Research 136 (12): 1564-1578. 6 June 2025

Database

Transverse aortic constriction multi-omics analysis uncovers pathophysiological cardiac molecular mechanisms.
Gjerga, E., Dewenter, M. ORCID: https://orcid.org/0000-0003-1335-4820, Britto-Borges, T., Grosso, J., Stein, F., Eschenbach, J., Rettel, M., Backs, J. ORCID: https://orcid.org/0000-0002-2322-2699 and Dieterich, C. ORCID: https://orcid.org/0000-0001-9468-6311
Database 2024 : baae060. 25 July 2024

EMBO Molecular Medicine

Metabo-epigenetic circuits of heart failure: chromatin-modifying enzymes as determinants of metabolic plasticity.
Pepin, Mark E. ORCID: https://orcid.org/0000-0003-0114-560X, Gong, Xuemin ORCID: https://orcid.org/0009-0006-3657-7954, Schulze, Almut and Backs, Johannes ORCID: https://orcid.org/0000-0002-2322-2699
EMBO Molecular Medicine 18 (2): 362-380. 13 February 2026

ESC Heart Failure

Ca2+/calmodulin-dependent kinase IIδC-induced chronic heart failure does not depend on sarcoplasmic reticulum Ca2+ leak.
Dewenter, M., Seitz, T., Steinbrecher, J.H., Westenbrink, B.D., Ling, H., Lehnart, S.E., Wehrens, X.H.T., Backs, J. ORCID: https://orcid.org/0000-0002-2322-2699, Brown, J.H., Maier, L.S. and Neef, S.
ESC Heart Failure 11 (4): 2191-2199. August 2024

European Journal of Heart Failure

How to facilitate seamless translation from basic concepts to new heart failure drugs. A scientific statement of the Heart Failure Association of the ESC.
Tocchetti, C.G. ORCID: https://orcid.org/0000-0001-5983-688X, González, A., Backs, J. ORCID: https://orcid.org/0000-0002-2322-2699, Pollesello, P., Rainer, P.P., Schiattarella, G.G. ORCID: https://orcid.org/0000-0002-7582-7171, Bellin, M., Begley, G., Bock Marquette, I., Balligand, J.L., Falcao-Pires, I., Gorczynski, R., Hirsch, E., Hulot, J.S., Klebl, B., Lyon, A.R., Maack, C., McKinsey, T.A., Müller, O.J., Lunde, I., Montgomery, R., Vergaro, G., Bayes-Genis, A., Thum, T., van der Meer, P., Van Laake, L., Ruschitzka, F., Seferovic, P., Coats, A.J., Metra, M., Rosano, G., Van Linthout, S. and de Boer, R.A.
European Journal of Heart Failure 27 (8): 1379-1392. August 2025

Journal of the American College of Cardiology

Adipokine-cardiomyocyte crosstalk: a 2-way street in HFpEF pathogenesis?
Frey, Norbert and Backs, Johannes ORCID: https://orcid.org/0000-0002-2322-2699
Journal of the American College of Cardiology 86 (16): 1243-1245. 21 October 2025

Kardiologie

Takotsubo-Syndrom: Kann die Grundlagenwissenschaft helfen? [Takotsubo syndrome: can basic science help?].
Bruns, Bastian, Frey, Norbert and Backs, Johannes ORCID: https://orcid.org/0000-0002-2322-2699
Kardiologie 20 (2): 147-152. March 2026

Nature Cardiovascular Research

CAMK2D causes heart failure in mice with RBM20 cardiomyopathy.
van den Hoogenhof, Maarten M.G. ORCID: https://orcid.org/0000-0003-2768-3457, Duran, Javier, Britto-Borges, Thiago, Sequeira, Vasco, Kemmling, Elena ORCID: https://orcid.org/0009-0001-4952-306X, Konrad, Laura, Schreiter, Friederike, Lennermann, David C., Hartmann, Joshua, Schraft, Laura, Kornienko, Julia, Bock, Theresa, Krüger, Marcus, Maack, Christoph, Dieterich, Christoph, Steinmetz, Lars M., Dewenter, Matthias and Backs, Johannes ORCID: https://orcid.org/0000-0002-2322-2699
Nature Cardiovascular Research 5 (5): 479-491. May 2026

Nature Metabolism

Lamin A/C-regulated cysteine catabolic flux modulates stem cell fate through epigenome reprogramming.
Wang, Yinuo ORCID: https://orcid.org/0000-0002-6653-6014, Shi, Haojie, Wittig, Janina ORCID: https://orcid.org/0009-0002-6091-7569, Ren, Yonggang, Cordero, Julio ORCID: https://orcid.org/0000-0002-2136-1783, Dewenter, Matthias, Mella, Jessica, Buchwalter, Abigail ORCID: https://orcid.org/0000-0001-7181-6961, Backs, Johannes ORCID: https://orcid.org/0000-0002-2322-2699, Wieland, Thomas ORCID: https://orcid.org/0000-0001-8262-8261, Heineke, Joerg ORCID: https://orcid.org/0000-0002-1541-3030, Fleming, Ingrid ORCID: https://orcid.org/0000-0003-1881-3635, Bibli, Sofia-Iris ORCID: https://orcid.org/0000-0001-7153-6628 and Dobreva, Gergana ORCID: https://orcid.org/0000-0002-4814-9416
Nature Metabolism 8 (2): 431-453. February 2026

SSRN

PRMT5 inhibition by the anti-cancer drug candidate GSK3326595 does not harm the murine heart.
Mauz, Victoria, Steinacher, Clara, Burhenne, Jürgen, Steimel, Kevin, Mertens, Christina, Muckenthaler, Martina U., Dewenter, Matthias and Backs, Johannes ORCID: https://orcid.org/0000-0002-2322-2699
SSRN : ssrn.5788041. 1 December 2025

bioRxiv

FYCO1 improves postischemic cardiac remodeling via enhanced autophagic flux and attenuation of proinflammatory signaling.
Senger, Frauke, Hille, Susanne S., Remes, Anca Kliesow, Baral, Tapan K., Martin-Garrido, Abel, Schmiedel, Nesrin, Kuhn, Christian, Müller, Oliver J., Rangrez, Ashraf Y., Backs, Johannes ORCID: https://orcid.org/0000-0002-2322-2699, Beisaw, Arica ORCID: https://orcid.org/0000-0002-6658-6978, Heineke, Jörg and Frey, Norbert
bioRxiv : 2026.03.17.712297. 18 March 2026

HDAC inhibition via suberoylanilide hydroxamic acid (SAHA) ameliorates Doxorubicin-induced cardiotoxicity.
Eksi, Benay, Finke, Daniel, Michel, Synje, Brauer, Jannek, Heckmann, Markus B., Valadan, Mohsen, Schanze, Leonard M., Sunder, Vighnesh, Katus, Hugo A., Frey, Norbert, Backs, Johannes ORCID: https://orcid.org/0000-0002-2322-2699 and Lehmann, Lorenz H.
bioRxiv : 2026.01.12.698976. 12 January 2026

Genomic G quadruplexes regulate mRNA splicing.
Mauz, Victoria, Britto-Borges, Thiago ORCID: https://orcid.org/0000-0002-6218-4429, Merkel, Tobias, Gjerga, Enio, Hartmann, Joshua, Snaebjörnsson, Marteinn Thor, Schreiter, Friederike, Oeing, Christian U., Sticht, Carsten, Sossalla, Samuel, Okun, Jürgen Günther, Stoecklin, Georg, Hentze, Matthias W., Furlong, Eileen E.M., Schulze, Almut, Dewenter, Matthias, Dieterich, Christoph and Backs, Johannes ORCID: https://orcid.org/0000-0002-2322-2699
bioRxiv : 2025.12.15.693900. 16 December 2025

CAMK2-NR4A1 signaling initiates metabolic substrate switching to induce heart failure with reduced ejection fraction.
Saadatmand, Alireza, Pepin, Mark ORCID: https://orcid.org/0000-0003-0114-560X, Chen, Zihao, Hartmann, Joshua, Sun, Qiang, Dewenter, Matthias, Nazir, Sumra, Paluvai, Harikrishnareddy, Hagenmüller, Marco, Haberkorn, Uwe, Schlicker, Lisa, Frias-Soler, Roberto Carlos, Tyedmers, Jens, Maack, Christoph, Schulze, Almut and Backs, Johannes ORCID: https://orcid.org/0000-0002-2322-2699
bioRxiv : 2025.10.16.682731. 16 October 2025

Somatic Hdac4-902fs mutations lead to loss of HDAC4 function through nonsensemediated mRNA degradation.
Paluvai, Harikrishnareddy, Pepin, Mark E. ORCID: https://orcid.org/0000-0003-0114-560X, Schreiter, Friederike, Saadatmand, Alireza, Hagenmueller, Marco and Backs, Johannes ORCID: https://orcid.org/0000-0002-2322-2699
bioRxiv : 2025.10.14.682279. 15 October 2025