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| Item Type: | Article |
|---|---|
| Title: | Cognitive function in patients with myelin oligodendrocyte glycoprotein antibody-associated disease |
| Creators Name: | Rust, Rebekka, Asseyer, Susanna, Schindler, Patrick, Chien, Claudia, Rekers, Sophia, Finke, Carsten, Oertel, Frederike Cosima, Ruprecht, Klemens, Jarius, Sven, Wildemann, Brigitte, Chavarro, Velina, Schmitz-Hübsch, Tanja, Paul, Friedemann and Sperber, Pia Sophie |
| Abstract: | BACKGROUND: Data on cognition in adult patients with myelin oligodendrocyte glycoprotein antibody-associated disease (pwMOGAD) are scarce. OBJECTIVE: To examine cognitive function in pwMOGAD and assess relative risks (RR) for cognitive impairment (CImp) in pwMOGAD relative to healthy controls (HC), aquaporin 4-immunoglobulin G positive neuromyelitis optica spectrum disorders (pwAQP4+NMOSD), and double-seronegative NMOSD (pwdsNMOSD) compared to HC. METHODS: Data derived from a cohort with neuroimmunological disorders. Cognitive performance was assessed using Rao's brief repeatable battery of neuropsychological tests, compared to HC using confounder-adjusted linear regressions. CImp was defined as performing two standard deviations below the HC mean in any subtest. RR for CImp was calculated using generalized linear models. RESULTS: We evaluated cognitive performance of 21 pwMOGAD and 25 HC. CImp was additionally determined in 43 pwAQP4+NMOSD and 15 pwdsNMOSD. PwMOGAD performed worse on Selective Reminding Test, and the symbol digit modalities test compared to HC. Adjusted RR for CImp were 1.9 (95% CI 0.9-4.1) in pwMOGAD, 1.9 (95% CI 1.0-3.9) in pwAQP4+NMOSD and 2.1 (95% CI 0.9-4.6) in pwdsNMOSD. CONCLUSION: pwMOGAD performed worse in information processing speed, verbal learning, storage and retrieval compared to HC. RR for CImp in pwMOGAD compared to HC was similar to that estimated for pwAQP4+NMOSD and pwdsNMOSD. |
| Keywords: | Cognitive Function, Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD), Symbol, Digit Modalities Test (SDMT), Brief Repeatable Battery of Neuropsychological Tests (BRB-N) |
| Source: | Journal of Neurology |
| ISSN: | 0340-5354 |
| Publisher: | Springer |
| Volume: | 273 |
| Number: | 1 |
| Page Range: | 61 |
| Date: | 6 January 2026 |
| Official Publication: | https://doi.org/10.1007/s00415-025-13582-3 |
| PubMed: | View item in PubMed |
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