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| Item Type: | Review |
|---|---|
| Title: | Dysfunctional mitochondria in ageing T cells: a perspective on mitochondrial quality control mechanisms |
| Creators Name: | Luo, Lin, Lechuga-Vieco, Ana Victoria, Sattentau, Clara, Borsa, Mariana and Simon, Anna Katharina |
| Abstract: | Dysfunctional mitochondria are a hallmark of T cell ageing and contribute to organismal ageing. This arises from the accumulation of reactive oxygen species (ROS), impaired mitochondrial dynamics, and inefficient removal of dysfunctional mitochondria. Both cell-intrinsic and cell-extrinsic mechanisms for removing mitochondria and their byproducts have been identified in T cells. In this review, we explore how T cells manage mitochondrial damage through changes in mitochondrial metabolism, mitophagy, asymmetric mitochondrial inheritance, and mitochondrial transfer, highlighting the impact of these mechanisms on T cell ageing and overall organismal ageing. We also discuss current therapeutic strategies aimed at removing dysfunctional mitochondria and their byproducts and propose potential new therapeutic targets that may reverse immune ageing or organismal ageing. |
| Keywords: | T Cell Ageing, Mitochondrial Metabolism, Mitophagy, Asymmetric Cell Division, Mitochondrial Transfer, Animals |
| Source: | EMBO Reports |
| ISSN: | 1469-221X |
| Publisher: | Springer Nature / EMBO Press |
| Volume: | 26 |
| Number: | 18 |
| Page Range: | 4402-4418 |
| Date: | 23 September 2025 |
| Official Publication: | https://doi.org/10.1038/s44319-025-00536-z |
| PubMed: | View item in PubMed |
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