Dysfunctional mitochondria in ageing T cells: a perspective on mitochondrial quality control mechanisms

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Item Type:	Review
Title:	Dysfunctional mitochondria in ageing T cells: a perspective on mitochondrial quality control mechanisms
Creators Name:	Luo, Lin, Lechuga-Vieco, Ana Victoria, Sattentau, Clara, Borsa, Mariana and Simon, Anna Katharina
Abstract:	Dysfunctional mitochondria are a hallmark of T cell ageing and contribute to organismal ageing. This arises from the accumulation of reactive oxygen species (ROS), impaired mitochondrial dynamics, and inefficient removal of dysfunctional mitochondria. Both cell-intrinsic and cell-extrinsic mechanisms for removing mitochondria and their byproducts have been identified in T cells. In this review, we explore how T cells manage mitochondrial damage through changes in mitochondrial metabolism, mitophagy, asymmetric mitochondrial inheritance, and mitochondrial transfer, highlighting the impact of these mechanisms on T cell ageing and overall organismal ageing. We also discuss current therapeutic strategies aimed at removing dysfunctional mitochondria and their byproducts and propose potential new therapeutic targets that may reverse immune ageing or organismal ageing.
Keywords:	T Cell Ageing, Mitochondrial Metabolism, Mitophagy, Asymmetric Cell Division, Mitochondrial Transfer, Animals
Source:	EMBO Reports
ISSN:	1469-221X
Publisher:	Springer Nature / EMBO Press
Volume:	26
Number:	18
Page Range:	4402-4418
Date:	23 September 2025
Official Publication:	https://doi.org/10.1038/s44319-025-00536-z
PubMed:	View item in PubMed

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