Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Comorbidity and cardiovascular risk factors in multiple sclerosis

[thumbnail of Original Article]
Preview
PDF (Original Article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
1MB
[thumbnail of Supplementary Material] MS Word (Supplementary Material)
72kB

Item Type:Article
Title:Comorbidity and cardiovascular risk factors in multiple sclerosis
Creators Name:Barzegar, M., Samadzadeh, S., Kohandel, K., Shaygannejad, A., Abbasi Kasbi, N., Vaheb, S., Ghane Ezabadi, S., Mirmosayyab, O., Naser Moghadasi, A., Afshari-Safavi, A., Rezaeimanesh, N., Ghasemi, M., Shaygannejad, V., Sahraian, M.A. and Asgari, N.
Abstract:BACKGROUND AND OBJECTIVES: Cardiovascular diseases (CVD) and their risk factors supposedly occur frequently in patients with multiple sclerosis (pwMS). We investigated prevalence of comorbidity particularly CVD among pwMS. METHODS: Two cohorts from Tehran and Isfahan were investigated retrospectively with longitudinal follow up and were invited to participate prospectively with measurement of biomedical parameters including determination of metabolic syndrome (MetS), and insulin resistance (IR). The 10-year office-based Framingham risk score (FRS) was calculated. RESULTS: Out of 856 pwMS 329 (38.4%) had at least one comorbidity and 97 (11.3%) had > 2 diseases, i.e., multiple comorbidity. PwMS and comorbidity were older (p < 0.0001) and had higher age at MS onset (p < 0.0001) compared to the non-comorbidity group. The prevalence of comorbidity increased from 24.0% at age 15-29 years to 37.3% at 30-49 and to 52.6% at 50-76 years (p < 0.0001) and was associated with odds of EDSS ≥ 4. FRS was for men 7.1 (4.2, 10.5) and for women 2.0 (1.3, 3.4). Of 255 with prospective blood testing, 35 (13.7%) had MetS, and 106 (41.6%) had IR. CONCLUSION: A high prevalence of comorbidity, associated with disability and high FRS was observed in pwMS. Our data suggest that MetS and IR occur frequently in this population.
Keywords:Multiple Sclerosis, Comorbidity, Multiple Comorbidity, Cardiovascular Diseases
Source:Multiple Sclerosis Journal Experimental Translational and Clinical
ISSN:2055-2173
Publisher:Sage Publications
Volume:11
Number:2
Page Range:1-15
Date:24 June 2025
Official Publication:https://doi.org/10.1177/20552173251352735
PubMed:View item in PubMed

Repository Staff Only: item control page

Downloads

Downloads per month over past year

Open Access
MDC Library