Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

The economic burden of subjective cognitive decline, mild cognitive impairment and Alzheimer's dementia: excess costs and associated clinical and risk factors

[thumbnail of Original Article]
Preview
PDF (Original Article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
1MB
[thumbnail of Supplementary Information] Other (Supplementary Information)
17kB

Item Type:Article
Title:The economic burden of subjective cognitive decline, mild cognitive impairment and Alzheimer's dementia: excess costs and associated clinical and risk factors
Creators Name:Gläser, E., Kilimann, I., Platen, M., Hoffmann, W., Brosseron, F., Buerger, K., Coenjaerts, M., Düzel, E., Ewers, M., Fliessbach, K., Frommann, I., Gemenetzi, M., Glanz, W., Hellmann-Regen, J., Incesoy, E.I., Janowitz, D., Jessen, F., Peters, O., Priller, J., Ramirez, A., Schneider, A., Spottke, A., Spruth, E.J., Teipel, S., Wagner, M. and Michalowsky, B.
Abstract:BACKGROUND: With the availability of first disease-modifying treatments, evidence on costs across the entire Alzheimer's Continuum, especially for early disease stages, becomes increasingly important to inform healthcare planning, resource allocation, and policy decisions. This study assessed costs and cost-associated factors in patients with subjective cognitive decline (SCD), mild cognitive impairment (MCI) and Alzheimer's Disease (AD) dementia compared to healthy controls. METHODS: The German DELCODE cohort study assessed clinical data, healthcare resource use, and informal care provision. Costs were calculated from payer and societal perspectives using standardized unit costs, and multivariate regression analyses identified cost-associated factors. RESULTS: From a payer perspective, costs were elevated by 26% for SCD (adjusted mean 5,976€ [95%CI 4,598-7,355€]), 85% for MCI (8,795€ [6,200-11,391€]) and 36% for AD (6,454€ [2,796-10,111€]) compared to controls (4,754€ [3,586-5,922€]). Societal costs were elevated by 52% for SCD (adjusted mean 8,377€ [95%CI 6,009-10,746€]), 170% for MCI (14,886€ [9,524-20,248€]) and 307% for AD (22,481€ [9,994-34,969€]) compared to controls (5,522€ [3,814-7,230€]). APOE e4 negative patients showed higher costs compared to APOE e4 positive patients. Hypertension was associated with higher costs. CONCLUSIONS: Healthcare costs are already elevated in early subjective and objective cognitive impairment, driven by formal and informal care. The study emphasizes the importance of early interventions to reduce the economic burden and delay progression.
Keywords:Dementia, Cognition, Subjective Cognitive Decline, Mild Cognitive Impairment, Alzheimer’s Disease, Apolipoprotein E, Economics, Utilization, Cost
Source:Alzheimer's Research & Therapy
ISSN:1758-9193
Publisher:BioMed Central
Volume:17
Number:1
Page Range:142
Date:26 June 2025
Official Publication:https://doi.org/10.1186/s13195-025-01785-9
PubMed:View item in PubMed

Repository Staff Only: item control page

Downloads

Downloads per month over past year

Open Access
MDC Library