![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Tools
Tools
Preview |
PDF (Preprint)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
8MB |
![[thumbnail of Supplementary Material]](https://edoc.mdc-berlin.de/style/images/fileicons/other.png) |
Other (Supplementary Material)
16MB |
| Item Type: | Preprint |
|---|---|
| Title: | IBDome: an integrated molecular, histopathological, and clinical atlas of inflammatory bowel diseases |
| Creators Name: | Plattner, C., Sturm, G., Kühl, A.A., Atreya, R., Carollo, S., Gronauer, R., Rieder, D., Günther, M., Ormanns, S., Manzl, C., Meneghetti, A.R., Hegazy, A.N., Patankar, J., Carrero, Z.I., Neurath, M.F., Kather, J.N., Becker, C., Siegmund, B. and Trajanoski, Z. |
| Abstract: | Multi-omic and multimodal datasets with detailed clinical annotations offer significant potential to advance our understanding of inflammatory bowel diseases (IBD), refine diagnostics, and enable personalized therapeutic strategies. In this multi-cohort study, we performed an extensive multi-omic and multimodal analysis of 1,002 clinically annotated IBD patients and non-IBD controls, incorporating whole-exome and RNA sequencing of normal and inflamed gut tissues, serum proteomics, and histopathological assessments from images of H&E-stained tissue sections. Transcriptomic profiles of normal and inflamed tissues revealed distinct site-specific inflammatory signatures in Crohn’s disease (CD) and ulcerative colitis (UC). Leveraging serum proteomics, we developed an inflammatory protein severity signature that reflects underlying intestinal molecular inflammation. Furthermore, foundation model-based deep learning accurately predicted histologic disease activity scores from images of H&E-stained intestinal tissue sections, offering a robust tool for clinical evaluation. Our integrative analysis highlights the potential of combining multi-omics and advanced computational approaches to improve our understanding and management of IBD. |
| Source: | bioRxiv |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Article Number: | 2025.03.26.645544 |
| Date: | 26 March 2025 |
| Additional Information: | Leif S.-H. Ludwig and Ashley Sanders are members of the TRR241 IBDome Consortium |
| Official Publication: | https://doi.org/10.1101/2025.03.26.645544 |
Repository Staff Only: item control page
