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| Item Type: | Preprint |
|---|---|
| Title: | Bimodal dendritic processing in basket cells drives distinct memory-related oscillations |
| Creators Name: | Tzilivaki, A., Larkum, M.E. and Schmitz, D. |
| Abstract: | Hippocampal oscillations regulate distinct memory stages and behavioral states, yet the mechanisms by which interneurons contribute to these rhythms remain elusive. Here, we establish a novel link between the bimodal nonlinear dendritic processing of PV+ fast-spiking basket cells (FSBCs) and hippocampal oscillations. Our model predicts that FSBCs can flexibly adjust their activity without changes in synaptic input quantity, leveraging their supralinear and sublinear dendritic branches to selectively shape network dynamics. Supralinear dendritic activation enhances high-frequency oscillations, while sublinear dendritic activation amplifies slow oscillatory power, dynamically modulating the excitation/inhibition (E/I) balance. These findings reveal a previously unrecognized role of FSBC dendritic integration in memory-related oscillatory dynamics, offering new insights into the cellular mechanisms governing hippocampal rhythm generation. |
| Keywords: | Interneurons, Learning And Memory, Hippocampal Oscillations, Dendrites, Biophysical Model |
| Source: | bioRxiv |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Article Number: | 2024.09.11.612262v2 |
| Date: | 21 February 2025 |
| Official Publication: | https://doi.org/10.1101/2024.09.11.612262 |
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