![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Tools
Tools
Preview |
PDF (Original Article)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
5MB |
Preview |
PDF (Supporting Information)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
4MB |
| Item Type: | Article |
|---|---|
| Title: | Incomplete transcriptional dosage compensation of chicken and platypus sex chromosomes is balanced by post-transcriptional compensation |
| Creators Name: | Lister, N.C., Milton, A.M., Patel, H.R., Waters, S.A., Hanrahan, B.J., McIntyre, K.L., Livernois, A.M., Horspool, W.B., Wee, L.K., Ringel, A.R., Mundlos, S., Robson, M.I., Shearwin-Whyatt, L., Grützner, F., Graves, J.A.M., Ruiz-Herrera, A. and Waters, P.D. |
| Abstract: | Heteromorphic sex chromosomes (XY or ZW) present problems of gene dosage imbalance between sexes and with autosomes. A need for dosage compensation has long been thought to be critical in vertebrates. However, this was questioned by findings of unequal mRNA abundance measurements in monotreme mammals and birds. Here, we demonstrate unbalanced mRNA levels of X genes in platypus males and females and a correlation with differential loading of histone modifications. We also observed unbalanced transcripts of Z genes in chicken. Surprisingly, however, we found that protein abundance ratios were 1:1 between the sexes in both species, indicating a post-transcriptional layer of dosage compensation. We conclude that sex chromosome output is maintained in chicken and platypus (and perhaps many other non therian vertebrates) via a combination of transcriptional and post-transcriptional control, consistent with a critical importance of sex chromosome dosage compensation. |
| Keywords: | Sex Chromosome, Dosage Compensation, Post-Transcriptional Control, Epigenetic, Animals, Chickens |
| Source: | Proceedings of the National Academy of Sciences of the United States of America |
| ISSN: | 0027-8424 |
| Publisher: | National Academy of Sciences |
| Volume: | 121 |
| Number: | 32 |
| Page Range: | e2322360121 |
| Date: | 6 August 2024 |
| Official Publication: | https://doi.org/10.1073/pnas.2322360121 |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
