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| Item Type: | Article |
|---|---|
| Title: | Impact of sex on clinical outcome in early multiple sclerosis |
| Creators Name: | Gottwald, N.S., Asseyer, S., Chien, C., Brasanac, J., Nauman, A.T., Rust, R., Schmitz-Hübsch, T., Bellmann-Strobl, J., Ruprecht, K., Paul, F., Regitz-Zagrosek, V., Gold, S.M. and Sperber, P.S. |
| Abstract: | BACKGROUND: Previous evidence suggests sex differences in the clinical course of relapsing remitting multiple sclerosis (RRMS), but comprehensive early-stage prospective studies are lacking. We aim to quantify the impact of sex on clinical outcomes in early-stage RRMS. METHODS: Utilizing prospective cohort data, we assessed the impact of biological sex on time-to-relapse, disability progression (Expanded Disability Status Scale [EDSS]), extremity function (Nine-Hole Peg Test, Timed-25-food walk test), cognition (Paced Auditory Serial Addition Test, Symbol Digit Modalities Test), quality-of-life (Hamburg Quality of Life Questionnaire in Multiple Sclerosis, Short-Form-36), fatigue (Fatigue Severity Scale, Fatigue Scale for Motor and Cognitive functions), and depression (Beck Depression Inventory-II) in clinically isolated syndrome (CIS) or RRMS patients. Inclusion was within 12 months of symptom onset. Linear, negative binomial, mixed, and Cox models estimated male vs. female effects at the four-year follow-up including baseline-to-follow-up course. RESULTS: We included 149 patients (65.1 % female). Eighty-five completed four-year follow-up. No sex differences in time-to-relapse emerged (HR = 0.91;95 %CI = 0.53-1.58). Males had no increased risk of EDSS worsening (OR = 0.75;95 %CI = 0.21-2.35) compared to females. Similarly, minor/no sex differences emerged in other outcomes. CONCLUSIONS: Four years after first manifestation, neither disease activity (disability progression and relapse rate) nor patient-reported outcomes showed sex-related disparities in this early-MS-cohort. |
| Keywords: | Relapsing-Remitting Multiple Sclerosis, Sex Differences, Relapses, Disability Progression, Cognition, Quality of Life, Fatigue, Depressive Symptoms |
| Source: | Multiple Sclerosis and Related Disorders |
| ISSN: | 2211-0348 |
| Publisher: | Elsevier |
| Volume: | 88 |
| Page Range: | 105749 |
| Date: | August 2024 |
| Official Publication: | https://doi.org/10.1016/j.msard.2024.105749 |
| PubMed: | View item in PubMed |
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