Mechanistic insights into the basis of widespread RNA localization

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Item Type:	Review
Title:	Mechanistic insights into the basis of widespread RNA localization
Creators Name:	Chekulaeva, M.
Abstract:	The importance of subcellular mRNA localization is well established, but the underlying mechanisms mostly remain an enigma. Early studies suggested that specific mRNA sequences recruit RNA-binding proteins (RBPs) to regulate mRNA localization. However, despite the observation of thousands of localized mRNAs, only a handful of these sequences and RBPs have been identified. This suggests the existence of alternative, and possibly predominant, mechanisms for mRNA localization. Here I re-examine currently described mRNA localization mechanisms and explore alternative models that could account for its widespread occurrence.
Keywords:	Cell Polarity, RNA Metabolism, RNA, Systems Biology, Transcriptomics, Animals
Source:	Nature Cell Biology
ISSN:	1465-7392
Publisher:	Nature Publishing Group
Volume:	26
Number:	7
Page Range:	1037-1046
Date:	July 2024
Additional Information:	Copyright © Springer Nature Limited 2024.
Official Publication:	https://doi.org/10.1038/s41556-024-01444-5
PubMed:	View item in PubMed

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