Cognition in patients with neuromyelitis optica spectrum disorders: a prospective multicentre study of 217 patients (CogniNMO-Study)

Hümmert, M.W.; Stern, C.; Paul, F.; Duchow, A.; Bellmann-Strobl, J.; Ayzenberg, I.; Schwake, C.; Kleiter, I.; Hellwig, K.; Jarius, S.; Wildemann, B.; Senel, M.; Berthele, A.; Giglhuber, K.; Luessi, F.; Grothe, M.; Klotz, L.; Schülke, R.; Gingele, S.; Faiss, J.H.; Walter, A.; Warnke, C.; Then Bergh, F.; Aktas, O.; Ringelstein, M.; Stellmann, J.P.; Häußler, V.; Havla, J.; Pellkofer, H.; Kümpfel, T.; Kopp, B.; Trebst, C.

Cognition in patients with neuromyelitis optica spectrum disorders: a prospective multicentre study of 217 patients (CogniNMO-Study)

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Item Type:	Article
Title:	Cognition in patients with neuromyelitis optica spectrum disorders: a prospective multicentre study of 217 patients (CogniNMO-Study)
Creators Name:	Hümmert, M.W., Stern, C., Paul, F., Duchow, A., Bellmann-Strobl, J., Ayzenberg, I., Schwake, C., Kleiter, I., Hellwig, K., Jarius, S., Wildemann, B., Senel, M., Berthele, A., Giglhuber, K., Luessi, F., Grothe, M., Klotz, L., Schülke, R., Gingele, S., Faiss, J.H., Walter, A., Warnke, C., Then Bergh, F., Aktas, O., Ringelstein, M., Stellmann, J.P., Häußler, V., Havla, J., Pellkofer, H., Kümpfel, T., Kopp, B. and Trebst, C.
Abstract:	BACKGROUND: There is limited and inconsistent information on the prevalence of cognitive impairment in neuromyelitis optica spectrum disorders (NMOSD). OBJECTIVE: To assess cognitive performance and changes over time in NMOSD. METHODS: This study included data from 217 aquaporin-4-IgG-seropositive (80%) and double-seronegative NMOSD patients. Cognitive functions measured by Symbol Digit Modalities Test (SDMT), Paced Auditory Serial-Addition Task (PASAT), and/or Multiple Sclerosis Inventory Cognition (MuSIC) were standardized against normative data (N = 157). Intraindividual cognitive performance at 1- and 2-year follow-up was analyzed. Cognitive test scores were correlated with demographic and clinical variables and assessed with a multiple linear regression model. RESULTS: NMOSD patients were impaired in SDMT (p = 0.007), MuSIC semantic fluency (p < 0.001), and MuSIC congruent speed (p < 0.001). No significant cognitive deterioration was found at follow-up. SDMT scores were related to motor and visual disability (p(Bon) < 0.05). No differences were found between aquaporin-4-IgG-seropositive and double-seronegative NMOSD. CONCLUSIONS: A subset of NMOSD patients shows impairment in visual processing speed and in semantic fluency regardless of serostatus, without noticeable changes during a 2-year observation period. Neuropsychological measurements should be adapted to physical and visual disabilities.
Keywords:	Neuromyelitis Optica Spectrum Disorders, Neuroimmunology, Cognition, Cognitive Neuropsychology
Source:	Multiple Sclerosis Journal
ISSN:	1352-4585
Publisher:	Sage Publications
Volume:	29
Number:	7
Page Range:	819-831
Date:	June 2023
Official Publication:	https://doi.org/10.1177/13524585231151212
PubMed:	View item in PubMed

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