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| Item Type: | Article |
|---|---|
| Title: | Better prognosis of gastric cancer patients with high levels of tumor infiltrating lymphocytes is counteracted by PD-1 expression |
| Creators Name: | Pötzsch, M., Berg, E., Hummel, M., Stein, U., von Winterfeld, M., Jöhrens, K., Rau, B., Daum, S. and Treese, C. |
| Abstract: | The prognostic potential of anti-tumor immune responses is becoming increasingly important in adenocarcinoma of the gastroesophageal junction and stomach (AGE/S) especially regarding the use of immune checkpoint inhibitors. This study analyzes for the first time the prognostic impact of tumor-infiltrating lymphocytes (TILs) and checkpoint inhibitors in a large Caucasian cohort in patients with AGE/S. We screened tissue samples from 438 therapy-naïve patients with AGE/S undergoing surgery between 1992 and 2005, examined in a tissue microarray (TMA) and stained against human CD3, CD4, CD8, PD-1, and PD-L1. Out of 438 tissue samples, 210 were eligible for multivariate analysis. This revealed that high infiltration with CD3(+), CD4(+), or CD8(+) TILs was associated with an increased overall survival in AGE/S patients, which could only be confirmed in multivariate analysis for CD3 (HR: 0.326; p = .023). Independent improved survival was limited to gastric cancer patients and to early tumor stages as long as TILs did not express PD-1 (HR: 1.522; p = .021). Subgroup analyses indicate that TIL-dependent anti-tumor immune response is only effective in gastric cancer patients in early stages of disease in PD-1 negative TILs. Combined analysis of PD-1 and CD3 could serve as a prognostic marker for the clinical outcome of gastric cancer patients and could also be of interest for immunotherapy. |
| Keywords: | Gastric Cancer, Tumor-Infiltrating Lymphocytes, PD-1, Biomarker |
| Source: | OncoImmunology |
| ISSN: | 2162-402X |
| Publisher: | Taylor & Francis |
| Volume: | 9 |
| Number: | 1 |
| Page Range: | 1824632 |
| Date: | 30 September 2020 |
| Official Publication: | https://doi.org/10.1080/2162402X.2020.1824632 |
| PubMed: | View item in PubMed |
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