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| Item Type: | Review |
|---|---|
| Title: | Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB) |
| Creators Name: | Blois, S.M., Verlohren, S., Wu, G., Clark, G., Dell, A., Haslam, S.M. and Barrientos, G. |
| Abstract: | Growing evidence suggests that galectins, an evolutionarily conserved family of glycan-binding proteins, fulfill key roles in pregnancy including blastocyst implantation, maternal-fetal immune tolerance, placental development, and maternal vascular expansion, thereby establishing a healthy environment for the growing fetus. In this review, we comprehensively present the function of galectins in shaping cellular circuits that characterize a healthy pregnancy. We describe the current understanding of galectins in term and preterm labor and discuss how the galectin-glycan circuits contribute to key immunological pathways sustaining maternal tolerance and preventing microbial infections. A deeper understanding of the glycoimmune pathways regulating early events in preterm birth could offer the broader translational potential for the treatment of this devastating syndrome. |
| Keywords: | Galectins, Preterm Birth, Microbial Infections, Glycans |
| Source: | Seminars in Immunopathology |
| ISSN: | 1863-2297 |
| Publisher: | Springer |
| Volume: | 42 |
| Number: | 4 |
| Page Range: | 469-486 |
| Date: | August 2020 |
| Official Publication: | https://doi.org/10.1007/s00281-020-00801-4 |
| PubMed: | View item in PubMed |
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