![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Tools
Tools
Preview |
PDF (Original Article)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
3MB |
![[thumbnail of Additional Files]](https://edoc.mdc-berlin.de/style/images/fileicons/other.png) |
Other (Additional Files)
46MB |
| Item Type: | Article |
|---|---|
| Title: | Chromatin accessibility dynamics across C. elegans development and ageing |
| Creators Name: | Jänes, J., Dong, Y., Schoof, M., Serizay, J., Appert, A., Cerrato, C., Woodbury, C., Chen, R., Gemma, C., Huang, N., Kissiov, D., Stempor, P., Steward, A., Zeiser, E., Sauer, S. and Ahringer, J. |
| Abstract: | An essential step for understanding the transcriptional circuits that control development and physiology is the global identification and characterization of regulatory elements. Here we present the first map of regulatory elements across the development and ageing of an animal, identifying 42,245 elements accessible in at least one C. elegans stage. Based on nuclear transcription profiles, we define 15,714 protein-coding promoters and 19,231 putative enhancers, and find that both types of element can drive orientation-independent transcription. Additionally, more than 1000 promoters produce transcripts antisense to protein coding genes, suggesting involvement in a widespread regulatory mechanism. We find that the accessibility of most elements changes during development and/or ageing and that patterns of accessibility change are linked to specific developmental or physiological processes. The map and characterization of regulatory elements across C. elegans life provides a platform for understanding how transcription controls development and ageing. |
| Keywords: | ATAC-seq, Chromatin Accessibility, Chromosomes, Enhancer, Gene Expression, Genetics, Genomics, Promoter, Regulatory Element, Animals, Caenorhabditis elegans |
| Source: | eLife |
| ISSN: | 2050-084X |
| Publisher: | eLife Sciences Publications |
| Volume: | 7 |
| Page Range: | e37344 |
| Date: | 26 October 2018 |
| Official Publication: | https://doi.org/10.7554/eLife.37344 |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
