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Diabetes, but not hypertension and obesity, is associated with postoperative cognitive dysfunction

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Item Type:Article
Title:Diabetes, but not hypertension and obesity, is associated with postoperative cognitive dysfunction
Creators Name:Lachmann, G., Feinkohl, I., Borchers, F., Ottens, T.H., Nathoe, H.M., Sauer, A.M., Dieleman, J.M., Radtke, F.M., van Dijk, D., Spies, C. and Pischon, T.
Abstract:BACKGROUND/AIMS: Older people undergoing surgery are at risk of developing postoperative cognitive dysfunction (POCD), but little is known of risk factors predisposing patients to POCD. Our objective was to estimate the risk of POCD associated with exposure to preoperative diabetes, hypertension, and obesity. METHODS: Original data from 3 randomised controlled trials (OCTOPUS, DECS, SuDoCo) were obtained for secondary analysis on diabetes, hypertension, baseline blood pressure, obesity (BMI ≥30 kg/m(2)), and BMI as risk factors for POCD in multiple logistic regression models. Risk estimates were pooled across the 3 studies. RESULTS: Analyses totalled 1,034 patients. POCD occurred in 5.2% of patients in DECS, in 9.4% in SuDoCo, and in 32.1% of patients in OCTOPUS. After adjustment for age, sex, surgery type, randomisation, obesity, and hypertension, diabetes was associated with a 1.84-fold increased risk of POCD (OR 1.84; 95% CI 1.14, 2.97; p = 0.01). Obesity, BMI, hypertension, and baseline blood pressure were each not associated with POCD in fully adjusted models (all p > 0.05). CONCLUSION: Diabetes, but not obesity or hypertension, is associated with increased POCD risk. Consideration of diabetes status may be helpful for risk assessment of surgical patients.
Keywords:Diabetes, Hypertension, Obesity, Postoperative Cognitive Dysfunction
Source:Dementia and Geriatric Cognitive Disorders
Page Range:193-206
Date:16 October 2018
Additional Information:Copyright © 2018 S. Karger AG, Basel
Official Publication:https://doi.org/10.1159/000492962
PubMed:View item in PubMed

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