![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Tools
Tools
Preview |
PDF (Article)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
3MB |
Preview |
PDF (Supplemental Information)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
3MB |
| Item Type: | Article |
|---|---|
| Title: | Involvement of mossy cells in sharp wave-ripple activity in vitro |
| Creators Name: | Swaminathan, A., Wichert, I., Schmitz, D. and Maier, N. |
| Abstract: | The role of mossy cells (MCs) of the hippocampal dentate area has long remained mysterious. Recent research has begun to unveil their significance in spatial computation of the hippocampus. Here, we used an in vitro model of sharp wave-ripple complexes (SWRs), which contribute to hippocampal memory formation, to investigate MC involvement in this fundamental population activity. We find that a significant fraction of MCs (~47%) is recruited into the active neuronal network during SWRs in the CA3 area. Moreover, MCs receive pronounced, ripple-coherent, excitatory and inhibitory synaptic input. Finally, we find evidence for SWR-related synaptic activity in granule cells that is mediated by MCs. Given the widespread connectivity of MCs within and between hippocampi, our data suggest a role for MCs as a hub functionally coupling the CA3 and the DG during ripple-associated computations. |
| Keywords: | Mossy Cell, Sharp Wave-Ripple Complex, Hippocampus, Hilus, Dentate Gyrus, Learning, Animals, Mice |
| Source: | Cell Reports |
| ISSN: | 2211-1247 |
| Publisher: | Cell Press / Elsevier |
| Volume: | 23 |
| Number: | 9 |
| Page Range: | 2541-2549 |
| Date: | 29 May 2018 |
| Official Publication: | https://doi.org/10.1016/j.celrep.2018.04.095 |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
