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| Item Type: | Article |
|---|---|
| Title: | 7T MRI in natalizumab-associated PML and ongoing MS disease activity: a case study |
| Creators Name: | Sinnecker, T., Othman, J., Kühl, M., Mekle, R., Selbig, I., Niendorf, T., Kunkel, A., Wienecke, P., Kern, P., Paul, F., Faiss, J. and Wuerfel, J. |
| Abstract: | OBJECTIVE: To assess the ability of ultra-high-field MRI to distinguish early progressive multifocal leukoencephalopathy (PML) from multiple sclerosis (MS) lesions in a rare case of simultaneous presentation of natalizumab-associated PML and ongoing MS activity. METHODS: Advanced neuroimaging including 1.5T, 3T, and 7T MRI with a spatial resolution of up to 0.08 mm(3) was performed. RESULTS: 7T MRI differentiated between PML-related and MS-related brain damage in vivo. Ring-enhancing MS plaques displayed a central vein, whereas confluent PML lesions were preceded by punctate or milky way-like T2 lesions. CONCLUSIONS: Given the importance of early diagnosis of treatment-associated PML, future systematic studies are warranted to assess the value of highly resolving MRI in differentiating between early PML- and MS-induced brain parenchymal lesions. |
| Source: | Neurology Neuroimmunology & Neuroinflammation |
| ISSN: | 2332-7812 |
| Publisher: | American Academy of Neurology |
| Volume: | 2 |
| Number: | 6 |
| Page Range: | e171 |
| Date: | December 2015 |
| Official Publication: | https://doi.org/10.1212/NXI.0000000000000171 |
| PubMed: | View item in PubMed |
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