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Synapsin autoantibodies during pregnancy are associated with fetal abnormalities

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Item Type:Article
Title:Synapsin autoantibodies during pregnancy are associated with fetal abnormalities
Creators Name:Bünger, I. and Talucci, I. and Kreye, J. and Höltje, M. and Makridis, K.L. and Foverskov Rasmussen, H. and van Hoof, S. and Cordero-Gomez, C. and Ullrich, T. and Sedlin, E. and Kreissner, K.O. and Hoffmann, C. and Milovanovic, D. and Turko, P. and Paul, F. and Meckies, J. and Verlohren, S. and Henrich, W. and Chaoui, R. and Maric, H.M. and Kaindl, A.M. and Prüss, H.
Abstract:Anti-neuronal autoantibodies can be transplacentally transferred during pregnancy and may cause detrimental effects on fetal development. It is unclear whether autoantibodies against synapsin-I, one of the most abundant synaptic proteins, are associated with developmental abnormalities in humans. We recruited a cohort of 263 pregnant women and detected serum synapsin-I IgG autoantibodies in 13.3% using cell-based assays. Seropositivity was strongly associated with abnormalities of fetal development including structural defects, intrauterine growth retardation, amniotic fluid disorders and neuropsychiatric developmental diseases in previous children (odds ratios of 3–6.5). Autoantibodies reached the fetal circulation and were mainly of IgG1/IgG3 subclasses. They bound to conformational and linear synapsin-I epitopes, five distinct epitopes were identified using peptide microarrays. The findings indicate that synapsin-I autoantibodies may be clinically useful biomarkers or even directly participate in the disease process of neurodevelopmental disorders, thus being potentially amenable to antibody-targeting interventional strategies in the future.
Keywords:Synapsin-I, Antineuronal Autoantibodies, Transplacental Transfer, Maternofetal Autoimmunity, Growth Retardation, Peptide Microarray
Source:Brain, Behavior & Immunity - Health
Page Range:100678
Date:November 2023
Official Publication:https://doi.org/10.1016/j.bbih.2023.100678
PubMed:View item in PubMed
Related to:
https://edoc.mdc-berlin.de/22131/Preprint version

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