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Radiofrequency applicator concepts for simultaneous MR imaging and hyperthermia treatment of glioblastoma multiforme: a 298 MHz(7.0 Tesla) thermal magnetic resonancesimulation study

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Item Type:Article
Title:Radiofrequency applicator concepts for simultaneous MR imaging and hyperthermia treatment of glioblastoma multiforme: a 298 MHz(7.0 Tesla) thermal magnetic resonancesimulation study
Creators Name:Oberacker, E. and Kuehne, A. and Nadobny, J. and Zschaeck, S. and Weihrauch, M. and Waiczies, H. and Ghadjar, P. and Wust, P. and Niendorf, T. and Winter, L.
Abstract:Glioblastoma multiforme is the most frequent and most aggressive malignant brain tumor with de facto no long term curation by the use of current multimodal therapeutic approaches. The efficacy of brachytherapy and enhancing interstitial hyperthermia has been demonstrated. RF heating at ultrahigh fields (B0=7.0T, f=298MHz) has the potential of delivering sufficiently large thermal dosage for hyperthermia of relatively large tumor areas. This work focuses on electromagnetic field (EMF) simulations and provides realistic applicator designs tailored for simultaneous RF heating and MRI. Our simulations took advantage of target volumes derived from patient data, and our preliminary results suggest that RF power can be focused to both a small tumor area and a large clinical target volume.
Keywords:Thermal Magnetic Resonance, RF Heating, Hyperthermia, Glioblastoma Multiforme, RF Applicator
Source:Current Directions in Biomedical Engineering
ISSN:2364-5504
Publisher:De Gruyter (Germany)
Volume:3
Number:2
Page Range:473-477
Date:September 2017
Official Publication:https://doi.org/10.1515/cdbme-2017-0100

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